Interobserver reliability and diagnostic performance of Chiari II malformation measures in MR imaging--part 2.
Publication year
2012Source
Child's Nervous System, 28, 7, (2012), pp. 987-95ISSN
Annotation
01 juli 2012
Publication type
Article / Letter to editor

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Organization
Paediatrics - OUD tm 2017
Neurology
Radiology
Health Evidence
Former Organization
Epidemiology, Biostatistics & HTA
Journal title
Child's Nervous System
Volume
vol. 28
Issue
iss. 7
Page start
p. 987
Page end
p. 95
Subject
DCN MP - Plasticity and memory; IGMD 5: Health aging / healthy living; NCEBP 12: Human Reproducion IGMD 3: Genomic disorders and inherited multi-system disorders; NCEBP 2: Evaluation of complex medical interventionsAbstract
PURPOSE: Brain MR imaging is essential in the assessment of Chiari II malformation in clinical and research settings concerning spina bifida. However, the interpretation of MR images of the malformation is not always straightforward. Morphometric analyses of the extent of Chiari II malformation may improve the assessment. In an attempt to select appropriate morphometric measures for this purpose, we investigated the interobserver reliability and diagnostic performance of several morphometric measures of Chiari II malformation on MR images. METHODS: Brain MR images of 79 children [26 with open spinal dysraphism, 17 with closed spinal dysraphism, and 36 without spinal dysraphism; mean age 10.6 (SD 3.2; range, 6-16) years] were evaluated. All children had been assessed for Chiari II malformation (defined as cerebellar herniation in combination with open spinal dysraphism; n = 23). Three observers blindly and independently reviewed the MR images for 21 measures of the cerebellum, brainstem, and posterior fossa in three planes. The interobserver reliability was assessed by an agreement index (AI = 1 - RRE) and the diagnostic performance by receiver operating characteristic analyses. RESULTS: Reliability was good for most measures, except for the degree of herniation of the vermis and tonsil. Most values differed statistically significantly between children with and without Chiari II malformation. The measures mamillopontine distance and cerebellar width showed excellent diagnostic performance. CONCLUSIONS: Morphometric measures may reliably quantify the morphological distortions of Chiari II malformation on MR images and provide additional tools to assess the severity of Chiari II malformation in clinical and research settings.
This item appears in the following Collection(s)
- Academic publications [203856]
- Faculty of Medical Sciences [80326]
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