Infliximab in Crohn's disease-associated toxic megacolon
SourceJournal of Clinical Gastroenterology, 46, 4, (2012), pp. 321-3
Article / Letter to editor
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Journal of Clinical Gastroenterology
SubjectIGMD 2: Molecular gastro-enterology and hepatology
Refractory medical treatment of Crohn disease-associated toxic megacolon usually requires surgery, which carries substantial morbidity and mortality. We report a case of a woman with steroid and antibiotic-refractory fulminant Crohn colitis and ileitis, complicated by a toxic megacolon, who was successfully treated with infliximab. Infliximab induced rapid clinical response and remission, thereby avoiding emergency (ileo) colectomy. This is the first report of treatment of Crohn disease-associated toxic megacolon with infliximab.
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