Hypertension is Related to the Microstructure of the Corpus Callosum: The RUN DMC Study
until further notice
SourceJournal of Alzheimer's Disease, 32, 3, (2012), pp. 623-631
Article / Letter to editor
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PI Group MR Techniques in Brain Function
F.C. Donders Centre for Cognitive Neuroimaging
Journal of Alzheimer's Disease
Subject150 000 MR Techniques in Brain Function; DCN MP - Plasticity and memory NCEBP 9 - Mental Health; DCN NN - Brain networks and neuronal communication; DCN NN - Brain networks and neuronal communication NCEBP 9 - Mental health; DCN PAC - Perception action and control
Vascular factors play a role in the etiology of Alzheimer's disease (AD), presumably due to emergence of white matter lesions. However, important white matter structures involved in the etiology of AD, including the corpus callosum (CC), remain invariably free from macroscopical white matter lesions, although loss of microstructural integrity assessed with diffusion tensor imaging (DTI) has been described in the CC. Vascular factors have been related to these microstructural white matter changes too, but little is known about their effect on the CC. In 499 subjects with cerebral small vessel disease, aged 50-85 years, we cross-sectionally investigated the relation between hypertension, hypertension treatment status, the microstructural integrity of the CC using DTI, and the attendant cognitive performance. Fractional anisotropy and mean diffusivity were calculated in four substructures of the CC (genu, anterior body, posterior body, and splenium). Differences between groups were calculated with analysis of variance, adjusted for age, gender, and cardiovascular risk factors. Compared with normotensive subjects, hypertensive subjects had a lower fractional anisotropy in the splenium and a significant higher mean diffusivity in both the anterior body and the splenium; this was most noticeable in treated uncontrolled hypertensive subjects. Furthermore we found that microstructural integrity of the CC was related to global cognition. Of this relation, 14 to 60% was explained by the mediating effect of small vessel disease elsewhere in the white matter. Our findings indicate that adequate blood pressure treatment might postpone these changes and the attendant cognitive dysfunction.
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