Humoral and cellular immune responses after influenza vaccination in patients with chronic fatigue syndrome
Publication year
2012Source
BMC Immunology, 13, (2012), pp. 71ISSN
Publication type
Article / Letter to editor
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Organization
Radiology
Tumorimmunology
Medical Oncology
Anesthesiology
Internal Medicine
Medical Microbiology
Journal title
BMC Immunology
Volume
vol. 13
Page start
p. 71
Page end
p. 71
Subject
IGMD 5: Health aging / healthy living; N4i 1: Pathogenesis and modulation of inflammation NCMLS 1: Infection and autoimmunity; NCEBP 10: Human Movement & Fatigue; NCEBP 7: Effective primary care and public health ONCOL 2: Age-related aspects of cancer; NCEBP 8: Psychological determinants of chronic illness; NCMLS 2: Immune Regulation; NCMLS 2: Immune Regulation ONCOL 3: Translational research; NCMLS 3: Tissue engineering and pathology; ONCOL 3: Translational research; ONCOL 3: Translational research NCMLS 2: Immune RegulationAbstract
ABSTRACT: BACKGROUND: Chronic fatigue syndrome (CFS) is a clinical condition characterized by severe and disabling fatigue that is medically unexplained and lasts longer than 6 months. Although it is possible to effectively treat CFS, the nature of the underlying physiology remains unclear. Various studies have sought evidence for an underlying disturbance in immunity. The aim of this study was to compare the humoral and cellular immune responses upon influenza vaccination in CFS patients and healthy controls. RESULTS: Identical antibody titers were observed in CFS patients and healthy controls. Patients and controls demonstrated similar seroprotection rates against all three virus-strains of the influenza vaccine, both pre- and post-vaccination. Functional T cell reactivity was observed in both CFS patients and healthy controls. CFS patients showed a non-significant, numerically lower cellular proliferation at baseline compared to controls. Vaccination induced a significant increase in cellular proliferation in CFS patients, but not in healthy controls. Cytokine production and the number of regulatory T cells were comparable in patients and controls. CONCLUSIONS: The humoral and cellular immune responses upon influenza vaccination were comparable in CFS patients and healthy controls. Putative aberrations in immune responses in CFS patients were not evident for immunity towards influenza. Standard seasonal influenza vaccination is thus justified and, when indicated, should be recommended for patients suffering from CFS.
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- Academic publications [238430]
- Electronic publications [122512]
- Faculty of Medical Sciences [90359]
- Open Access publications [97507]
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