Hourly variability of cerebrospinal fluid biomarkers in Alzheimer's disease subjects and healthy older volunteers.
SourceNeurobiology of Aging, 33, 4, (2012), pp. 831.e1-9
1 april 2012
Article / Letter to editor
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Laboratory of Genetic, Endocrine and Metabolic Diseases
Epidemiology, Biostatistics & HTA
Neurobiology of Aging
SubjectDCN MP - Plasticity and memory; DCN NN - Brain networks and neuronal communication; DCN PAC - Perception action and control NCEBP 11: Alzheimer Centre; NCEBP 14: Cardiovascular diseases; NCEBP 2: Evaluation of complex medical interventions; NCEBP 6: Quality of nursing and allied health care; NCEBP 7: Effective primary care and public health ONCOL 2: Age-related aspects of cancer; NCEBP 6: Quality of nursing and allied health care
Large hour-to-hour variability has previously been demonstrated in the cerebrospinal fluid (CSF) concentrations of Alzheimer's disease (AD) biomarkers amyloid beta(42) (Abeta(42)) and Abeta(40) in healthy younger subjects. We investigated the within-subject variability over 36 hours in CSF Abeta and tau proteins, in older subjects and AD patients. Six patients with mild stage AD (59-85 years, Mini Mental State Examination (MMSE) 16-26) and 6 healthy older volunteers (64-77 years) received an intrathecal catheter from which, during 36 hours, each hour 6 mL of CSF was drawn. Concentrations of Abeta(42), Abeta(40), total tau, and phosphorylated tau were determined and the variability was analyzed. Within-subject variability within 3-hour periods was assessed as the coefficient of variation, which was comparable for these 4 biomarkers in controls (4.2%-4.6%) and AD (3.1%-5.8%). Variability over 12 hour periods was 5.3% to 9.5%. These findings suggest that CSF biomarker variability is relatively low in healthy older controls and AD patients. Furthermore, continuous sampling of CSF proved to be a useful and robust method, which may also be used to investigate AD pathogenesis and to evaluate pharmacotherapeutic interventions.
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