Harnessing human plasmacytoid dendritic cells as professional APCs
Publication year
2012Source
Cancer Immunology Immunotherapy, 61, 8, (2012), pp. 1279-88ISSN
Publication type
Article / Letter to editor
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Organization
Tumorimmunology
Medical Oncology
Journal title
Cancer Immunology Immunotherapy
Volume
vol. 61
Issue
iss. 8
Page start
p. 1279
Page end
p. 88
Subject
NCMLS 2: Immune Regulation; NCMLS 3: Tissue engineering and pathology; ONCOL 3: Translational research NCMLS 2: Immune RegulationAbstract
The plasmacytoid dendritic cell (pDC) constitutes a unique DC subset that links the innate and adaptive arm of the immune system. Whereas the unique capability of pDCs to produce large amounts of type I IFNs in response to pathogen recognition is generally accepted,their antigen-presenting function is often neglected since most studies on antigen presentation are aimed at other DC subsets. Recently, pDCs were demonstrated capable to present antigen leading to protective tumor immunity. In this review, we discuss how pDCs could be exploited in the fight against cancer by analyzing their capacity to capture,process and (cross-) present antigen.
This item appears in the following Collection(s)
- Academic publications [238430]
- Electronic publications [122512]
- Faculty of Medical Sciences [90359]
- Open Access publications [97507]
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