Favorable outcome of chronic disseminated candidiasis in four pediatric patients with hematological malignancies.
Publication year
2012Source
Medical Mycology, 50, 3, (2012), pp. 315-9ISSN
Annotation
01 april 2012
Publication type
Article / Letter to editor
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Organization
Paediatrics - OUD tm 2017
Medical Microbiology
Journal title
Medical Mycology
Volume
vol. 50
Issue
iss. 3
Page start
p. 315
Page end
p. 9
Subject
N4i 2: Invasive mycoses and compromised host; N4i 2: Invasive mycoses and compromised host NCMLS 1: Infection and autoimmunity; ONCOL 2: Age-related aspects of cancer; ONCOL 2: Age-related aspects of cancer NCMLS 2: Immune RegulationAbstract
Four children were diagnosed with chronic disseminated candidiasis (CDC) during treatment for hematological malignancies. All presented with persistent fever, not responsive to broad-spectrum antibiotics, abdominal distension and hepatosplenomegaly. Two children needed artificial ventilation because of respiratory insufficiency. The time between onset of neutropenic fever and diagnosis of CDC ranged from 20-49 days. Ultrasound and computed tomography failed to demonstrate CDC during the neutropenic phase. All children needed a liver or spleen biopsy to establish the diagnosis of CDC. Three of four patients continued chemotherapy during treatment for the fungal infection. All patients had a favorable outcome, both in terms of the invasive Candida infections, as well as their underlying malignancies.
This item appears in the following Collection(s)
- Academic publications [238441]
- Faculty of Medical Sciences [90373]
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