Family environment is associated with HPA-axis activity in adolescents. The TRAILS study.
SourceBiological Psychology, 89, 2, (2012), pp. 460-466
1 februari 2012
Article / Letter to editor
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PI Group Memory and Emotion
F.C. Donders Centre for Cognitive Neuroimaging
SubjectDCN PAC - Perception action and control; DCN PAC - Perception action and control NCEBP 9 - Mental health
The purpose of the present study was to investigate the developmental programming part of the theory of biological sensitivity to context using family environmental factors and hypothalamus-pituitary-adrenal (HPA) axis functioning. Specifically, we investigated whether perceived parenting (Rejection and Emotional Warmth) and socio-economic status (SES) predicted basal cortisol levels and the cortisol awakening response (CAR). In a population-based cohort of 1594 adolescents (mean age=11.08, SD=0.54) we assessed salivary cortisol, SES and perceived parenting. Perceived parental Emotional Warmth showed an inverse, linear association with basal cortisol levels. In addition, there was a curvilinear relationship between SES and both basal cortisol levels and the CAR. Our findings with regard to basal cortisol levels confirmed our hypothesis: lower basal HPA-axis activity in both high and low SES families compared to intermediate SES families.
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