European 2--a clonal complex of Mycobacterium bovis dominant in the Iberian Peninsula.
SourceInfection, Genetics and Evolution, 12, 4, (2012), pp. 866-72
01 juni 2012
Article / Letter to editor
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Infection, Genetics and Evolution
SubjectN4i 3: Poverty-related infectious diseases NCMLS 1: Infection and autoimmunity; NCMLS 4: Energy and redox metabolism IGMD 8: Mitochondrial medicine
Mycobacterium bovis isolates from the Iberian Peninsula are dominated by strains with spoligotype patterns deleted for spacer 21. Whole-genome sequencing of three Spanish strains with spacer 21 missing in their spoligotype pattern revealed a series of SNPs and subsequent screening of a selection of these SNPs identified one in gene guaA that is specific to these strains. This group of strains from the Iberian Peninsula missing spoligotype spacer 21 represents a new clonal complex of M. bovis, defined by the SNP profile with a distinct spoligotype signature. We have named this clonal complex European 2 (Eu2) and found that it was present at low frequency in both France and Italy and absent from the British Isles.
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