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Publication year
2012Source
European Journal of Pain, 16, 1, (2012), pp. 61-71ISSN
Annotation
01 januari 2012
Publication type
Article / Letter to editor
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Organization
Anesthesiology
Cognitive Neuroscience
Neurophysiology
Anatomy
Former Organization
Cellular Animal Physiology
Journal title
European Journal of Pain
Volume
vol. 16
Issue
iss. 1
Page start
p. 61
Page end
p. 71
Subject
DCN MP - Plasticity and memory N4i 1: Pathogenesis and modulation of inflammation; Neurophysiology; DCN MP - Plasticity and memory NCEBP 7: Effective primary care and public healthAbstract
Neuropathic pain is often accompanied by stress, anxiety and depression. Although there is evidence for involvement of corticotropin-releasing factor (CRF), the detailed neuronal basis of these pain-related mood alterations is unknown. This study shows that peripheral mononeuropathy was accompanied by changes in limbic forebrain CRF, but did not lead to changes in the functioning of the hypothalamo-pituitary-adrenal axis and the midbrain Edinger-Westphal centrally projecting (EWcp) neuron population, which play main roles in the organism's response to acute pain. Twenty-four days after chronic constriction injury (CCI) of the rat sciatic nerve, the oval bed nucleus of the stria terminalis (BSTov) contained substantially more Crf mRNA as did the central amygdala (CeA), which, in addition, possessed more CRF. In contrast, Crf mRNA and CRF contents of the hypothalamic paraventricular nucleus (PVN) were unaffected by CCI. Similarly, EWcp neurons, producing the CRF family member urocortin 1 (Ucn1) and constitutively activated by various stressors including acute pain, did not show an effect of CCI on Ucn1 mRNA or Ucn1. Also, the immediate early gene products cFos and deltaFosB in the EWcp were unaffected by CCI. These results indicate that neuropathic pain does not act via the HPA-axis or the EWcp, but includes a main role of Crf in the limbic system, which is in clear contrast to stressors like acute and chronic pain, which primarily act on the PVN and the EWcp.
This item appears in the following Collection(s)
- Academic publications [238441]
- Electronic publications [122518]
- Faculty of Medical Sciences [90373]
- Faculty of Science [34986]
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