CNTNAP2 and language processing in healthy individuals as measured with ERPs
Publication year
2012Author(s)
Number of pages
8 p.
Source
PLoS One, 7, 10, (2012), article e46995ISSN
Publication type
Article / Letter to editor
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Organization
SW OZ DCC BO
SW OZ BSI OLO
Nederlandse Taal en Cultuur
SW OZ DCC PL
Journal title
PLoS One
Volume
vol. 7
Issue
iss. 10
Languages used
English (eng)
Subject
Brain imaging research; DI-BCB_DCC_Theme 1: Language and Communication; First Language Acquisition; Learning and Plasticity; PsycholinguisticsAbstract
The genetic FOXP2-CNTNAP2 pathway has been shown to be involved in the language capacity. We investigated whether a common variant of CNTNAP2 (rs7794745) is relevant for syntactic and semantic processing in the general population by using a visual sentence processing paradigm while recording ERPs in 49 healthy adults. While both AA homozygotes and T-carriers showed a standard N400 effect to semantic anomalies, the response to subject-verb agreement violations differed across genotype groups. T-carriers displayed an anterior negativity preceding the P600 effect, whereas for the AA group only a P600 effect was observed. These results provide another piece of evidence that the neuronal architecture of the human faculty of language is shaped differently by effects that are genetically determined.
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- Academic publications [238426]
- Electronic publications [122508]
- Faculty of Arts [29387]
- Faculty of Social Sciences [29483]
- Open Access publications [97504]
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