Fulltext present in this item

Thumbnail
Fulltext: 70675.pdf
Format: PDF
Description: publisher's version
Embargo: until further notice
Title: Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules.
Author(s): Russel, F.G.M. ; Koenderink, J.B. ; Masereeuw, R.
Publication year: 2008
Source: Trends in Pharmacological Sciences, vol. 29, iss. 4, (2008), pp. 200-207
Number of Pages: 8 p.
ISSN: 0165-6147
DOI: https://doi.org/10.1016/j.tips.2008.01.006
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/70675   https://hdl.handle.net/2066/70675

Display more details
Subject: IGMD 9: Renal disorder
N4i 1: Pathogenesis and modulation of inflammation
N4i 3: Poverty-related infectious diseases
NCMLS 2: Metabolism, transport and motion
NCMLS 5: Membrane transport and intracellular motility
Synthetic Organic Chemistry
UMCN 5.4: Renal disorders
Organization: IMM - Institute for Molecules and Materials
Pharmacology-Toxicology
Former Organization: Pharmacology/Toxicology
Journal title:
Trends in Pharmacological Sciences
Volume: vol. 29
Issue: iss. 4
Page start: p. 200
Page end: p. 207
Abstract:
Multidrug resistance protein (MRP) 4 is a member of the MRP/ABCC subfamily of ATP-binding cassette transporters, which are capable of pumping a wide variety of endogenous and xenobiotic organic anionic compounds out of the cell. In addition to its role in the body distribution and renal excretion of a wide variety of antiviral, cytostatic, antibiotic and cardiovascular drugs, MRP4/ABCC4 has the remarkable ability to transport molecules involved in cellular signalling. These molecules include cyclic nucleotides, eicosanoids, urate and conjugated steroids. The unique structure, regulation and dual localisation of MRP4 in polarised cells could be connected with a key function in cellular protection and extracellular signalling pathways. This review focuses on recent insights into the versatile transport function of MRP4 and its potential as a new therapeutic target to modulate various pathophysiological signalling processes.

This item appears in the following Collection(s)

Browse

Statistics