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Title: Disseminated aspergillosis in an adolescent with acute lymphoblastic leukemia.
Author(s): Zwitserloot, A.M.; Warris, A. ; Hek, L.G.F.M. van 't ; Die, C.E. van ; Verweij, P.E. ; Mavinkurve-Groothuis, A.M.C.
Publication year: 2008
Source: Pediatric Blood & Cancer, vol. 51, iss. 3, (2008), pp. 423-426
ISSN: 1545-5009
DOI: https://doi.org/10.1002/pbc.21601
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/70488   https://hdl.handle.net/2066/70488

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Subject: N4i 2: Invasive mycoses and compromised host
NCMLS 1: Infection and autoimmunity
UMCN 1.1: Functional Imaging
UMCN 1.4: Immunotherapy, gene therapy and transplantation
UMCN 4.1: Microbial pathogenesis and host defense
Organization: Paediatrics - OUD tm 2017
Intensive Care
Radiology
Medical Microbiology
Journal title:
Pediatric Blood & Cancer
Volume: vol. 51
Issue: iss. 3
Page start: p. 423
Page end: p. 426
Abstract:
Disseminated aspergillosis in immunocompromised patients has a mortality rate of almost 100%. Despite the development of new antifungal agents, the outcome of disseminated aspergillosis has only improved slightly, particular in patients with central nervous system (CNS) involvement. The use of combination antifungal therapy might improve the dismal outcome of disseminated aspergillosis. We describe a critically ill adolescent with acute lymphoblastic leukemia who was successfully treated with voriconazole and caspofungin for disseminated aspergillosis with involvement of the lung, brain and thyroid gland.

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