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Title: Serum and BAL macrophage migration inhibitory factor levels in HIV infected Tanzanians with pulmonary tuberculosis or other lung diseases.
Author(s): Kibiki, G.S. ; Ven, A.J.A.M. van der ; Geurts-Moespot, A. ; Shao, J.F.; Calandra, T; Sweep, C.G.J. ; Dolmans, W.M.V.
Publication year: 2007
Source: Clinical Immunology, vol. 123, iss. 1, (2007), pp. 60-65
ISSN: 1521-6616
DOI: https://doi.org/10.1016/j.clim.2006.12.004
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/51582   https://hdl.handle.net/2066/51582

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Subject: IGMD 6: Hormonal regulation
N4i 1: Pathogenesis and modulation of inflammation
N4i 3: Poverty-related infectious diseases
NCEBP 13: Infectious diseases and international health
NCMLS 1: Infection and autoimmunity
ONCOL 3: Translational research
ONCOL 5: Aetiology, screening and detection
UMCN 4.1: Microbial pathogenesis and host defense
UMCN 5.2: Endocrinology and reproduction
Organization: Internal Medicine
Chemical Endocrinology
Journal title:
Clinical Immunology
Volume: vol. 123
Issue: iss. 1
Page start: p. 60
Page end: p. 65
Abstract:
Macrophage migration inhibitory factor (MIF) activates macrophages, promotes delayed-type hypersensitivity reaction, and regulates Th1/Th2 balance in inflammatory response. Serum MIF concentration is high in patients with pulmonary tuberculosis (PTB). Higher MIF levels are associated with high mortality. No study has addressed MIF levels and its role in PTB/HIV-co infection. We determined serum and BAL MIF levels in Tanzanian HIV-infected patients with and without PTB, and correlated the levels with 1-month outcome. We compared with serum MIF levels of HIV seronegative patients with PTB and of healthy controls. All HIV-infected patients irrespective of PTB infection had significantly higher serum MIF levels than HIV-seronegative patients with PTB, and than healthy controls. In HIV seropositive patients low serum MIF levels were associated with high 1-month mortality. In conclusion, HIV infection was associated with elevated serum MIF levels regardless of PTB. Low serum MIF levels were associated with high mortality.

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