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Title: Short mucin 6 alleles are associated with H pylori infection.
Author(s): Nguyen, T.T.U. ; Janssen, M.J.R. ; Gritters, P.; Morsche, R.H.M. te ; Drenth, J.P.H. ; Asten, H.A.G.H. van ; Laheij, R.J.F. ; Jansen, J.B.M.J.
Publication year: 2006
Source: World Journal of Gastroenterology, vol. 12, iss. 37, (2006), pp. 6021-6025
ISSN: 1007-9327
Related links: http://www.wjgnet.com/1007-9327/12/6021.asp
DOI: https://doi.org/10.3748/wjg.v12.i37.6021
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/49314   https://hdl.handle.net/2066/49314

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Subject: EBP 3: Effective Primary Care and Public Health
IGMD 2: Molecular gastro-enterology and hepatology
N4i 3: Poverty-related infectious diseases
NCMLS 5: Membrane transport and intracellular motility
UMCN 4.1: Microbial pathogenesis and host defense
UMCN 5.1: Genetic defects of metabolism
Organization: Paediatrics - OUD tm 2017
Gastroenterology
Internal Medicine
Journal title:
World Journal of Gastroenterology
Volume: vol. 12
Issue: iss. 37
Page start: p. 6021
Page end: p. 6025
Abstract:
AIM: To investigate the relationship between mucin 6 (MUC6) VNTR length and H pylori infection. METHODS: Blood samples were collected from patients visiting the Can Tho General Hospital for upper gastrointestinal endoscopy. DNA was isolated from whole blood, the repeated section was cut out using a restriction enzyme (Pvu II) and the length of the allele fragments was determined by Southern blotting. H pylori infection was diagnosed by (14)C urea breath test. For analysis, MUC6 allele fragment length was dichotomized as being either long (> 13.5 kbp) or short (< or = 13.5 kbp) and patients were classified according to genotype [long-long (LL), long-short (LS), short-short (SS)]. RESULTS: 160 patients were studied (mean age 43 years, 36% were males, 58% H pylori positive). MUC6 Pvu II-restricted allele fragment lengths ranged from 7 to 19 kbp. Of the patients with the LL, LS, SS MUC6 genotype, 43% (24/56), 57% (25/58) and 76% (11/46) were infected with H pylori, respectively (P = 0.003). CONCLUSION: Short MUC6 alleles are associated with H pylori infection.

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