Identifying effector molecules, cells, and cytokines of innate immunity in OA

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Title:	Identifying effector molecules, cells, and cytokines of innate immunity in OA
Author(s):	Bosch, M.H.J. van den; Lent, P.L.E.M. van ; Kraan, P.M. van der
Publication year:	2020
Source:	Osteoarthritis and Cartilage, vol. 28, iss. 5, (2020), pp. 532-543
ISSN:	1063-4584
DOI:	https://doi.org/10.1016/j.joca.2020.01.016
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/220924
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Subject:	Radboudumc 5: Inflammatory diseases RIMLS: Radboud Institute for Molecular Life Sciences Tijdelijke code tbv inlezen publicaties Radboudumc - Alleen voor gebruik door Radboudumc
Organization:	Rheumatology
Journal title:	Osteoarthritis and Cartilage
Volume:	vol. 28
Issue:	iss. 5
Page start:	p. 532
Page end:	p. 543
Abstract:	Inflammatory changes are observed in affected joints of osteoarthritis (OA) patients and are thought to be involved in the pathology that develops along OA progression. This narrative review provides an overview of the various cell types that are present in the joint during OA and which alarmins, cytokines, chemokines, growth factors, and other mediators they produce. Moreover, the involvement of more systemic processes like inflammaging and its associated cellular senescence in the context of OA are discussed.