Inducing targeted failure in cadaveric testing of 3-segment spinal units with and without simulated metastases

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Title:	Inducing targeted failure in cadaveric testing of 3-segment spinal units with and without simulated metastases
Author(s):	Groenen, K.H.J.; Janssen, D.W. ; Linden, Y.M. van der; Kooloos, J.G.M. ; Homminga, J.; Verdonschot, N.J. ; Tanck, E.J.
Publication year:	2018
Source:	Medical Engineering & Physics, vol. 51, (2018), pp. 104-110
ISSN:	1350-4533
DOI:	https://doi.org/10.1016/j.medengphy.2017.11.007
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/191244
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Subject:	Radboudumc 0: Other Research DCMN: Donders Center for Medical Neuroscience Radboudumc 10: Reconstructive and regenerative medicine RIHS: Radboud Institute for Health Sciences Tijdelijke code tbv inlezen publicaties Radboudumc - Alleen voor gebruik door Radboudumc
Organization:	Orthopaedics Anatomy Radboudumc Extern
Journal title:	Medical Engineering & Physics
Volume:	vol. 51
Page start:	p. 104
Page end:	p. 110
Abstract:	We propose an experimental setup and protocol able to induce targeted failure of the middle vertebra in 3-segment spinal units and to capture the specimens' deformation in their post-failure state. Sixteen 3-segment spinal units with and without artificial metastases were destructively tested in axial compression using one of two failure criteria; either: (A) A clear drop in force (>10-15% of peak force) (n=4); or (B) A minimum displacement of 5mm (n=12). Subsequently, the specimens were fully fixated in polymethylmethacrylate (PMMA), thereby preserving their post-failure state. Pre- and post-experiment computed tomography (CT) scans were acquired to determine the occurrence of failure in one of the vertebral bodies. All specimens were successfully fixated in their post-failure state. When applying failure criterion A, two specimens showed signs of failure. When applying failure criterion B, all specimens showed signs of failure; in 9 out of 12 specimens this occurred in the middle vertebrae only. In conclusion, this research provides an experimental setup and protocol able to induce targeted failure of 3-segment spinal units and to capture the specimens' deformation in their post-failure state. Furthermore, this study illustrates the importance of an adequate failure criterion for successful simulation of vertebral fractures in an experimental setup.