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Title: Clinical features of patients with nodal marginal zone lymphoma compared to follicular lymphoma: similar presentation, but differences in prognostic factors and rate of transformation
Author(s): Brand, M. van den; Velden, W.J.F.M. van der ; Diets, I.J. ; Ector, G.I.C.G.; Haan, A.F.J. de; Stevens, W.B.C. ; Hebeda, K.M. ; Groenen, P.J.T.A. ; Krieken, J.H.J.M. van
Publication year: 2016
Source: Leukemia & Lymphoma, vol. 57, iss. 7, (2016), pp. 1649-1656
ISSN: 1042-8194
DOI: https://doi.org/10.3109/10428194.2015.1106535
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/172129   http://hdl.handle.net/2066/172129

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Subject: Radboudumc 0: Other Research RIHS: Radboud Institute for Health Sciences
Radboudumc 14: Tumours of the digestive tract RIMLS: Radboud Institute for Molecular Life Sciences
Radboudumc 2: Cancer development and immune defence RIMLS: Radboud Institute for Molecular Life Sciences
Radboudumc 5: Inflammatory diseases RIHS: Radboud Institute for Health Sciences
Radboudumc 9: Rare cancers RIHS: Radboud Institute for Health Sciences
Radboudumc 9: Rare cancers RIMLS: Radboud Institute for Molecular Life Sciences
Organization: Pathology
Haematology
Human Genetics
Health Evidence
Journal title:
Leukemia & Lymphoma
Volume: vol. 57
Issue: iss. 7
Page start: p. 1649
Page end: p. 1656
Abstract:
Nodal marginal zone lymphoma (NMZL) is a rare type of B-cell non-Hodgkin lymphoma. This study assessed the clinical features of 56 patients with NMZL in comparison to 46 patients with follicular lymphoma (FL). Patients with NMZL and FL had a largely similar clinical presentation, but patients with FL had a higher disease stage at presentation, more frequent abdominal lymphadenopathy and bone marrow involvement, and showed more common transformation into diffuse large B-cell lymphoma (DLBCL) during the course of disease. Overall survival and event-free survival were similar for patients with NMZL and FL, but factors associated with worse prognosis differed between the two groups. Transformation into DLBCL was associated with a significantly poorer outcome in both groups, but the phenotypes were different: DLBCL arising in FL was mainly of germinal center B-cell phenotype, whereas DLBCL arising in NMZL was mainly of non-germinal center B-cell phenotype.

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