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Title: MRP1 mediates folate transport and antifolate sensitivity in Plasmodium falciparum
Author(s): Rijpma, S.R. ; Velden, M. van der; Bilos, A. ; Jansen, R.S.; Mahakena, S.; Russel, F.G. ; Sauerwein, R.W. ; Wetering, K. van de; Koenderink, J.B.
Publication year: 2016
Source: FEBS Letters, vol. 590, iss. 4, (2016), pp. 482-492
ISSN: 1873-3468
DOI: https://doi.org/10.1002/1873-3468.12079
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/170847   https://hdl.handle.net/2066/170847

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Subject: Radboudumc 11: Renal disorders RIMLS: Radboud Institute for Molecular Life Sciences
Radboudumc 4: lnfectious Diseases and Global Health RIHS: Radboud Institute for Health Sciences
Radboudumc 4: lnfectious Diseases and Global Health RIMLS: Radboud Institute for Molecular Life Sciences
Organization: Medical Microbiology
Pharmacology-Toxicology
IMM - Institute for Molecules and Materials
Journal title:
FEBS Letters
Volume: vol. 590
Issue: iss. 4
Page start: p. 482
Page end: p. 492
Abstract:
Multidrug resistance-associated proteins (MRP) of Plasmodium falciparum have been associated with altered drug sensitivity. Knowledge on MRP substrate specificity is indispensible for the characterization of resistance mechanisms and identifying its physiological roles. An untargeted metabolomics approach detected decreased folate concentrations in red blood cells infected with schizont stage parasites lacking expression of MRP1. Furthermore, a tenfold decrease in sensitivity toward the folate analog methotrexate was detected for parasites lacking MRP1. PfMRP1 is involved in the export of folate from parasites into red blood cells and is therefore a relevant factor for efficient malaria treatment through the folate pathway.

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