Model-based administration of inhalation anaesthesia. 2. Exploring the system model.

There is no fulltext present in this item.

Title:	Model-based administration of inhalation anaesthesia. 2. Exploring the system model.
Author(s):	Lerou, J.G.C. ; Booij, L.H.D.J.
Publication year:	2001
Source:	British Journal of Anaesthesia, vol. 86, iss. 1, (2001), pp. 29-3-37
ISSN:	0007-0912
DOI:	http://dx.doi.org/10.1093/bja/86.1.29
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/155946
Display more details
Subject:	Control Systems in Anaesthesiology Sturingssystemen in de anesthesiologie
Organization:	Anesthesiology
Journal title:	British Journal of Anaesthesia
Volume:	vol. 86
Issue:	iss. 1
Page start:	p. 29-3
Page end:	p. 37
Classification:	Anesthesia and Analgesia (Non MeSH)ArousalCardiovascular AgentsCentral Nervous System AgentsConsciousnessIntraoperative CareNeurotransmitters and Neurotransmitter Agents (Non MeSH)Peripheral Nervous System Agents (Non MeSH)Postoperative CareReflexSensationSleep
Abstract:	We explored our model by displaying its new capabilities, testing its sensitivity to variations in input data and illustrating its use. Its multiple-gas character allows simulation of the mechanisms governing concentration and second gas effects. Simulating the volume of a standing bellows makes it possible to test algorithms for automated closed-circuit anaesthesia. Using desflurane, the model's sensitivity to changes in blood/gas partition coefficient (range 0.42-0.576), cardiac output and minute ventilation was analysed. The model was very sensitive to changes in blood solubility; other results agreed with those reported previously. An alveolar isoflurane tension of 1% atm was rapidly attained and maintained, even using 0.5 litres min(-1) of fresh gas, when isoflurane was 'co-administered' through a vaporizer set to 3.5 vol% and a single aliquot (1.25 ml liquid) injected into the expiratory limb. As a result of its credibility and capabilities, the model is to be tested in the clinical setting.