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Title: High-Level Pan-Azole-Resistant Aspergillosis
Author(s): Ingen, J. van ; Lee, H.A.L. van der ; Rijs, A.J.M.M.; Snelders, E. ; Melchers, W.J.G. ; Verweij, P.E.
Publication year: 2015
Source: Journal of Clinical Microbiology, vol. 53, iss. 7, (2015), pp. 2343-2345
ISSN: 0095-1137
DOI: https://doi.org/10.1128/JCM.00502-15
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/152983   https://hdl.handle.net/2066/152983

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Subject: Radboudumc 17: Women's cancers RIMLS: Radboud Institute for Molecular Life Sciences
Radboudumc 4: lnfectious Diseases and Global Health RIHS: Radboud Institute for Health Sciences
Radboudumc 4: lnfectious Diseases and Global Health RIMLS: Radboud Institute for Molecular Life Sciences
Organization: Medical Microbiology
Journal title:
Journal of Clinical Microbiology
Volume: vol. 53
Issue: iss. 7
Page start: p. 2343
Page end: p. 2345
Abstract:
High-level pan-azole-resistant Aspergillus fumigatus was recovered from four patients with chronic lung disease. In one patient, the development of progressive resistance followed long-term azole therapy and switching between antifungal azoles. The high-level pan-azole-resistant phenotypes were not associated with a specific cyp51A gene mutation. New strategies that avoid the development of progressive azole resistance are needed.

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