Association between COMT Val158Met genotype and EEG alpha peak frequency tested in two independent cohorts

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Title:	Association between COMT Val158Met genotype and EEG alpha peak frequency tested in two independent cohorts
Author(s):	Veth, C.P.M. ; Arns, M.W. ; Drinkenburg, W.; Talloen, W.; Peeters, P.J.; Gordon, E.; Buitelaar, J.K.
Publication year:	2014
Source:	Psychiatry Research, vol. 219, iss. 1, (2014), pp. 221-224
ISSN:	0165-1781
DOI:	https://doi.org/10.1016/j.psychres.2014.05.021
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/136046
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Subject:	Radboudumc 0: Other Research DCMN: Donders Center for Medical Neuroscience Radboudumc 13: Stress-related disorders RIHS: Radboud Institute for Health Sciences Radboudumc 7: Neurodevelopmental disorders DCMN: Donders Center for Medical Neuroscience
Organization:	Psychiatry Cognitive Neuroscience
Journal title:	Psychiatry Research
Volume:	vol. 219
Issue:	iss. 1
Page start:	p. 221
Page end:	p. 224
Abstract:	This study could not confirm the association between the Catechol-O-Methyltransferase Val158Met polymorphism (COMT) and electroencephalographic (EEG) alpha peak frequency (APF) in two independent cohorts of 187 (96 depressed and 91 healthy participants) and 413 healthy participants. If COMT and APF play a role in depression or antidepressant treatment response, they do not have a shared pathway. We emphasize the importance of publishing null-findings for obtaining more accurate overall estimates of genetic effects.