[From gene to disease; deletion of the DAZ-gene from the Y-chromosome in oligo- or azoospermia ]

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Title:	[From gene to disease; deletion of the DAZ-gene from the Y-chromosome in oligo- or azoospermia ]
Author(s):	Tuerlings, J.H.A.M. ; Hoefsloot, L.H. ; Kremer, J.A.M.
Publication year:	2001
Source:	Nederlands Tijdschrift voor Geneeskunde, vol. 145, iss. 32, (2001), pp. 1552-1553
ISSN:	0028-2162
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/120735
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Subject:	Elucidation of hereditary disorders and their molecular diagnosis Prevention of disorders in human reproduction: (Patho)Physiological, endocrinological and methabolic aspects Opheldering van erfelijke ziekten en hun moleculaire diagnostiek Preventie van stoornissen in de menselijke voortplanting: (Patho-)fysiologische, endocriene en metabole aspecten.
Organization:	Human Genetics Gynaecology
Journal title:	Nederlands Tijdschrift voor Geneeskunde
Volume:	vol. 145
Issue:	iss. 32
Page start:	p. 1552
Page end:	p. 1553
Abstract:	DAZ gene deletions at the azoospermia factor (AZF) locus on the Y chromosome, have been implicated as one of the major causes of idiopathic male subfertility. Deletions of the entire DAZ gene have been reported in azoospermia as well as in oligozoospermia. The DAZ gene encodes a RNA binding protein which is expressed exclusively in germ cells. The exact biological role and function of the DAZ protein has yet to be resolved.