Subject:
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111 000 Intention & Action 130 000 Cognitive Neurology & Memory 230 Affective Neuroscience Action, intention, and motor control DCN MP - Plasticity and memory DCN PAC - Perception action and control IGMD 3: Genomic disorders and inherited multi-system disorders DI-BCB_DCC_Theme 2: Perception, Action and Control Experimental Psychopathology and Treatment IGMD 3: Genomic disorders and inherited multi-system disorders DCN MP - Plasticity and memory ONCOL 3: Translational research NCMLS 2: Immune Regulation |
Organization:
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SW OZ BSI KLP PI Group Intention and Action Psychiatry PI Group Motivational & Cognitive Control Cognitive Neuroscience PI Group Memory and Emotion Nuclear Medicine Human Genetics SW OZ DCC CO PI Group Affective Neuroscience |
Former Organization:
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F.C. Donders Centre for Cognitive Neuroimaging
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Journal title:
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The Journal of Neuroscience
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Abstract:
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After a threatening event, the risk of developing social psychopathologies is increased in short-allele (s) carriers of the serotonin transporter gene. The amygdala becomes overresponsive to emotional stimuli, an effect that could be driven by local hypersensitivity or by reduced prefrontal regulation. This study distinguishes between these two hypotheses by using dynamic causal modeling of fMRI data acquired in a preselected cohort of human s-carriers and homozygous long-allele carriers. Increased amygdala activity in s-carriers originates from reduced prefrontal inhibitory regulation when social emotional behavior needs to be controlled, suggesting a mechanism for increased vulnerability to psychopathologies.
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