Association between thyroid function, thyroid autoimmunity, and state and trait factors of depression

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Title:	Association between thyroid function, thyroid autoimmunity, and state and trait factors of depression
Author(s):	van de Ven, A.C.; Muntjewerff, J.W.; Netea-Maier, R.T. ; de Vegt, F. ; Ross, H.A. ; Sweep, C.G.J. ; Kiemeney, L.A. ; Vos, P.E. ; Buitelaar, J.K. ; Hermus, A.R.M.M. ; Heijer, M. den ; Janzing, J.G.
Publication year:	2012
Source:	Acta Psychiatrica Scandinavica, vol. 126, iss. 5, (2012), pp. 377-384
ISSN:	0001-690X
DOI:	https://doi.org/10.1111/j.1600-0447.2012.01870.x
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/110014
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Subject:	DCN NN - Brain networks and neuronal communication DCN PAC - Perception action and control DCN PAC - Perception action and control NCEBP 9 - Mental health IGMD 5: Health aging / healthy living NCEBP 14: Cardiovascular diseases IGMD 6: Hormonal regulation IGMD 6: Hormonal regulation ONCOL 3: Translational research IGMD 6: Hormonal regulation ONCOL 5: Aetiology, screening and detection NCEBP 1: Molecular epidemiology ONCOL 5: Aetiology, screening and detection NCEBP 9: Mental health IGMD 6: Hormonal regulation NCEBP 1: Molecular epidemiology ONCOL 5: Aetiology, screening and detection
Organization:	Internal Medicine Psychiatry Health Evidence Laboratory of Genetic, Endocrine and Metabolic Diseases Urology Neurology PI Group MR Techniques in Brain Function Cognitive Neuroscience
Former Organization:	Epidemiology, Biostatistics & HTA F.C. Donders Centre for Cognitive Neuroimaging
Journal title:	Acta Psychiatrica Scandinavica
Volume:	vol. 126
Issue:	iss. 5
Page start:	p. 377
Page end:	p. 384
Abstract:	van de Ven AC, Muntjewerff J-W, Netea-Maier RT, de Vegt F, Ross HA, Sweep FCGJ, Kiemeney LA, Vos PE, Buitelaar JK, Hermus ARMM, den Heijer M, Janzing JGE. Association between thyroid function, thyroid autoimmunity, and state and trait factors of depression. Objective: The aim of this study was to investigate whether thyroid function and thyroid peroxidase antibodies (TPOAb) are associated with depression, when using both state and trait parameters of depression. Method: In 1125 participants of the Nijmegen Biomedical Study, thyroid-stimulating hormone (TSH), free thyroxine (FT(4) ), and TPOAb were measured twice. The Beck Depression Inventory (BDI), a self-reported lifetime diagnosis of depression, and the neuroticism scale of the Eysenck Personality Questionnaire Revised Short Scale (EPQ-RSS) were used to evaluate the presence of state and trait features of depression. Results: We found no association between TSH and FT(4) levels and BDI score, current depression, lifetime diagnosis of depression, and EPQ-RSS neuroticism score. Subjects with TPOAb had higher EPQ-RSS neuroticism scores in comparison with subjects without TPOAb, mean score 4.1 vs. 3.2 (regression coefficient 0.70; 95% CI 0.1-1.3; P-value 0.02 after adjustment for confounders). The prevalence of a lifetime diagnosis of depression was higher in subjects with positive TPOAb in comparison with participants without TPOAb: 24.2% vs. 16.7% (relative risk 1.4; 95% CI 1.0-2.1; P-value 0.04 after adjustment for confounders). Conclusion: Thyroid peroxidase antibodies are positively associated with trait markers of depression. The presence of TPOAb may be a vulnerability marker for depression.