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Title: TRPM7 Is Required for Breast Tumor Cell Metastasis.
Author(s): Middelbeek, J.A.J. ; Kuipers, A.J. ; Henneman, L.; Visser, D.; Eidhof, I.; Horssen, R. van ; Wieringa, B. ; Canisius, S.V.M.; Zwart, W.; Wessels, L.F.; Sweep, C.G.J. ; Bult, P. ; Span, P.N. ; Leeuwen, F.N. van ; Jalink, K.
Publication year: 2012
Source: Cancer Research, vol. 72, iss. 16, (2012), pp. 4250-4261
ISSN: 0008-5472
DOI: https://doi.org/10.1158/0008-5472.CAN-11-3863
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/109674   http://hdl.handle.net/2066/109674

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Subject: IGMD 6: Hormonal regulation ONCOL 5: Aetiology, screening and detection
NCMLS 4: Energy and redox metabolism IGMD 8: Mitochondrial medicine
ONCOL 2: Age-related aspects of cancer
ONCOL 2: Age-related aspects of cancer NCMLS 2: Immune Regulation
ONCOL 3: Translational research
Organization: Paediatrics
Laboratory of Genetic, Endocrine and Metabolic Diseases
Cell Biology (UMC)
Pathology
Radiation Oncology
Journal title:
Cancer Research
Volume: vol. 72
Issue: iss. 16
Page start: p. 4250
Page end: p. 4261
Abstract:
TRPM7 encodes a Ca(2+)-permeable nonselective cation channel with kinase activity. TRPM7 has been implicated in control of cell adhesion and migration, but whether TRPM7 activity contributes to cancer progression has not been established. Here we report that high levels of TRPM7 expression independently predict poor outcome in breast cancer patients and that it is functionally required for metastasis formation in a mouse xenograft model of human breast cancer. Mechanistic investigation revealed that TRPM7 regulated myosin II-based cellular tension, thereby modifying focal adhesion number, cell-cell adhesion and polarized cell movement. Our findings therefore suggest that TRPM7 is part of a mechanosensory complex adopted by cancer cells to drive metastasis formation. Cancer Res; 72(16); 4250-61. (c)2012 AACR.

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