TY  - JOUR
AU  - Prange, K.H.M.
AU  - Mandoli, A.
AU  - Kuznetsova, T.
AU  - Wang, S.
AU  - Sotoca, A.M.
AU  - Marneth, A.E.
AU  - Van der Reijden, B.A.
AU  - Stunnenberg, H.
AU  - Martens, J.H.A.
PY  - 2017
UR  - https://hdl.handle.net/2066/168892
TI  - MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia
EP  - 11
SN  - 0950-9232
SP  - 1
JF  - Oncogene
PS  - 11 p.
DO  - https://doi.org/10.1038/onc.2016.488
L1  - https://repository.ubn.ru.nl/bitstream/handle/2066/168892/168892.pdf?sequence=1
ER  - 
TY  - JOUR
AU  - van den Boom, V.
AU  - Maat, H.
AU  - Geugien, M.
AU  - Lopez, A.R.
AU  - Sotoca, A.M.
AU  - Jaques, J.
AU  - Brouwers-Vos, A.Z.
AU  - Fusetti, F.
AU  - Groen, R.W.J.
AU  - Yuan, H.P.
AU  - Martens, A.C.M.
AU  - Stunnenberg, H.G.
AU  - Vellenga, E.
AU  - Martens, J.H.A.
AU  - Schuringa, J.J.
PY  - 2016
UR  - https://hdl.handle.net/2066/156956
TI  - Non-canonical PRC1.1 Targets Active Genes Independent of H3K27me3 and Is Essential for Leukemogenesis
EP  - 346
SN  - 2211-1247
IS  - iss. 2
SP  - 332
JF  - Cell Reports
VL  - vol. 14
DO  - https://doi.org/10.1016/j.celrep.2015.12.034
L1  - https://repository.ubn.ru.nl/bitstream/handle/2066/156956/156956.pdf?sequence=1
ER  - 
TY  - GEN
AU  - Zoelen, E.J.J. van
PY  - 2016
UR  - https://hdl.handle.net/2066/162611
PB  - Nijmegen : Radboud Universiteit
TI  - Celbiologie, een bewuste keuze?
N1  - Rede uitgesproken bij het afscheid als hoogleraar Celbiologie aan de Faculteit der Natuurwetenschappen, Wiskunde en Informatica van de Radboud Universiteit, 18 november 2016
PS  - 27 p.
ER  - 
TY  - JOUR
AU  - Sotoca Covaleda, A.M.
AU  - Prange, K.H.M.
AU  - Reijnders, B.
AU  - Mandoli, A.
AU  - Nguyen, L.N.
AU  - Stunnenberg, H.G.
AU  - Martens, J.H.A.
PY  - 2015
UR  - https://hdl.handle.net/2066/145003
TI  - The oncofusion protein FUS-ERG targets key hematopoietic regulators and modulates the all-trans retinoic acid signaling pathway in t(16;21) acute myeloid leukemia
EP  - 1976
SN  - 0950-9232
SP  - 1965
JF  - Oncogene
VL  - vol. 35
DO  - https://doi.org/10.1038/onc.2015.261
ER  - 
TY  - THES
AU  - Meijer, I.M.J.
PY  - 2014
SN  - 97890902
UR  - https://hdl.handle.net/2066/122889
PB  - [S.l. : s.n.]
TI  - Ubiquitination and deubiquitination of ERBB receptors
N1  - Radboud Universiteit Nijmegen, 24 januari 2014
N1  - Promotor : Zoelen, E.J.J. van 
Co-promotor : Leeuwen, J.E.M. van
PS  - 223 p.
L1  - https://repository.ubn.ru.nl/bitstream/handle/2066/122889/122889.pdf?sequence=1
ER  - 
TY  - JOUR
AU  - Oliveira, J.M.P.F. de
AU  - Oliveira, H.
AU  - Pinho, S.
AU  - Pimentel, F.
AU  - Almeida, L.
AU  - Zoelen, E.J.J. van
AU  - Santos, C. dos
PY  - 2014
UR  - https://hdl.handle.net/2066/135376
TI  - Cytotoxic and genotoxic activity of fisetin (3, 3 ', 4 ', 7-tetrahydroxyflavone) in an osteosarcoma in vitro model
EP  - 1412
SN  - 0032-0943
IS  - iss. 16
SP  - 1412
JF  - Planta Medica
VL  - vol. 80
DO  - https://doi.org/10.1055/s-0034-1394662
ER  - 
TY  - JOUR
AU  - Oliveira, J.M.P.F. de
AU  - Almeida, L.
AU  - Pimentel, F.
AU  - Zoelen, E.J.J. van
AU  - Santos, C. dos
PY  - 2014
UR  - https://hdl.handle.net/2066/135421
TI  - Analysis of stably expressed genes with low-dose etoposide for toxicological studies in osteosarcoma
EP  - 1452
SN  - 0032-0943
IS  - iss. 16
SP  - 1451
JF  - Planta Medica
VL  - vol. 80
DO  - https://doi.org/10.1055/s-0034-1394784
ER  - 
TY  - JOUR
AU  - Blok, E.J.
AU  - Kuppen, P.J.
AU  - Leeuwen, J.E. van
AU  - Sier, C.F.
PY  - 2013
UR  - https://hdl.handle.net/2066/111474
TI  - Cytoplasmic Overexpression of HER2: a Key Factor in Colorectal Cancer
EP  - 51
SN  - 1179-5549
SP  - 41
JF  - Clinical Medicine Insights: Oncology
VL  - vol. 7
DO  - http://dx.doi.org/10.4137/cmo.s10811
L1  - https://repository.ubn.ru.nl/bitstream/handle/2066/111474/111474.pdf?sequence=1
ER  - 
TY  - JOUR
AU  - Rietjens, I.M.C.M.
AU  - Sotoca Covaleda, A.M.
AU  - Vervoort, J.
AU  - Louisse, J.
PY  - 2013
UR  - https://hdl.handle.net/2066/111537
TI  - Mechanisms underlying the dualistic mode of action of major soy isoflavones in relation to cell proliferation and cancer risks
EP  - 113
SN  - 1613-4125
IS  - iss. 1
SP  - 100
JF  - Molecular Nutrition & Food Research (Formerly Nahrung/Food)
VL  - vol. 57
DO  - https://doi.org/10.1002/mnfr.201200439
ER  - 
TY  - JOUR
AU  - Meijer, I.M.J.
AU  - Rotterdam, W. van
AU  - Zoelen, E.J.J. van
AU  - Leeuwen, J.E.M. van
PY  - 2013
UR  - https://hdl.handle.net/2066/103221
TI  - Cbl and Itch binding sites in ERBB4 CYT-1 and CYT-2 mediate K48- and K63-polyubiquitination, respectively
EP  - 478
SN  - 0898-6568
IS  - iss. 2
SP  - 470
JF  - Cellular Signalling
VL  - vol. 25
DO  - https://doi.org/10.1016/j.cellsig.2012.11.008
ER  - 
TY  - CHAP
AU  - Sotoca, A.M.
AU  - Weber, M.
AU  - Zoelen, E.J.J. van
PY  - 2013
UR  - https://hdl.handle.net/2066/103443
PB  - Hershey : IGI Global
TI  - Gene Expression Regulation underlying Osteo-, Adipo-, and Chondro-Genic Lineage Commitment of Human Mesenchymal Stem Cells
EP  - 94
SN  - 9781466625068
SP  - 76
CT  - Daskalaki, A. (ed.), Medical Advancements in Aging and Regenerative Technologies: Clinical Tools and Applications
DO  - https://doi.org/10.4018/978-1-4666-2506-8.ch004
ER  - 
TY  - JOUR
AU  - Meijer, I.M.
AU  - Kerperien, J.
AU  - Sotoca, A.M.
AU  - Zoelen, Joop van
AU  - Leeuwen, J.E. van
PY  - 2013
UR  - https://hdl.handle.net/2066/111442
TI  - The Usp8 deubiquitination enzyme is post-translationally modified by tyrosine and serine phosphorylation
EP  - 930
SN  - 0898-6568
IS  - iss. 4
SP  - 919
JF  - Cellular Signalling
VL  - vol. 25
DO  - https://doi.org/10.1016/j.cellsig.2013.01.003
ER  - 
TY  - JOUR
AU  - Hupkes, M.
AU  - Azevedo, R.
AU  - Jansen, H.
AU  - Zoelen, Joop van
AU  - Dechering, K.J.
PY  - 2013
UR  - https://hdl.handle.net/2066/111520
TI  - Identification of Novel Bacterial M.SssI DNA Methyltransferase Inhibitors
EP  - 355
SN  - 1087-0571
IS  - iss. 3
SP  - 348
JF  - Journal of Biomolecular Screening
VL  - vol. 18
DO  - https://doi.org/10.1177/1087057112465009
ER  - 
TY  - JOUR
AU  - Sotoca, A.M.
AU  - Roelofs-Hendriks, J.
AU  - Boeren, S.
AU  - Kraan, P.M. van der
AU  - Vervoort, J.
AU  - Zoelen, E.J.J. van
AU  - Piek, E.
PY  - 2013
UR  - https://hdl.handle.net/2066/122879
TI  - Comparative proteome approach demonstrates that platelet-derived growth factor C and D efficiently induce proliferation while maintaining multipotency of hMSCs
EP  - 2662
SN  - 0014-4827
IS  - iss. 17
SP  - 2649
JF  - Experimental Cell Research
VL  - vol. 319
DO  - https://doi.org/10.1016/j.yexcr.2013.07.027
ER  - 
TY  - JOUR
AU  - Weber, M.
AU  - Henkel, S.
AU  - Vlaic, S.
AU  - Guthke, R.
AU  - Zoelen, Joop van
AU  - Driesch, D.
PY  - 2013
UR  - https://hdl.handle.net/2066/111523
TI  - Inference of dynamical gene-regulatory networks based on time-resolved multi-stimuli multi-experiment data applying NetGenerator V2.0
EP  - 16
SN  - 1752-0509
IS  - iss. 1
SP  - 1
JF  - BMC Systems Biology
VL  - vol. 7
DO  - https://doi.org/10.1186/1752-0509-7-1
L1  - https://repository.ubn.ru.nl/bitstream/handle/2066/111523/111523.pdf?sequence=1
ER  - 
TY  - JOUR
AU  - Weber, M.
AU  - Sotoca, A.M.
AU  - Kupfer, P.
AU  - Guthke, R.
AU  - Zoelen, E.J.J. van
PY  - 2013
UR  - https://hdl.handle.net/2066/122885
AB  - B
TI  - Dynamic modelling of microrna regulation during mesenchymal stem cell differentiation
SN  - 1752-0509
IS  - iss. 1
SP  - 124
JF  - BMC Systems Biology
VL  - vol. 7
DO  - https://doi.org/10.1186/1752-0509-7-124
L1  - https://repository.ubn.ru.nl/bitstream/handle/2066/122885/122885.pdf?sequence=1
ER  - 
TY  - JOUR
AU  - Weber, M.
AU  - Henkel, S.G.
AU  - Vlaic, S.
AU  - Guthke, R.
AU  - Zoelen, Joop van
AU  - Driesch, D.
PY  - 2013
UR  - https://hdl.handle.net/2066/227601
TI  - Inference of dynamical gene-regulatory networks based on time-resolved multi-stimuli multi-experiment data applying NetGenerator V2.0
EP  - 1(28)
SN  - 1752-0509
IS  - iss. 1
SP  - 1(1)
JF  - BMC Systems Biology
VL  - vol. 7
DO  - https://doi.org/10.1186/1752-0509-7-1
L1  - https://repository.ubn.ru.nl/bitstream/handle/2066/227601/227601.pdf?sequence=1
ER  - 
TY  - JOUR
AU  - Hensen, S.M.M.
AU  - Heldens, L.
AU  - Enckevort, C.M.W. van
AU  - Genesen, S.T. van
AU  - Pruijn, G.J.M.
AU  - Lubsen, N.H.
PY  - 2013
UR  - https://hdl.handle.net/2066/111502
TI  - Activation of the antioxidant response in methionine deprived human cells results in an HSF1-independent increase in HSPA1A mRNA levels
EP  - 1251
SN  - 0300-9084
IS  - iss. 6
SP  - 1245
JF  - Biochimie
VL  - vol. 95
DO  - https://doi.org/10.1016/j.biochi.2013.01.017
ER  - 
TY  - JOUR
AU  - Hensen, S.M.
AU  - Heldens, L.
AU  - Genesen, S.T. van
AU  - Pruijn, G.J.M.
AU  - Lubsen, N.H.
PY  - 2013
UR  - https://hdl.handle.net/2066/122421
TI  - A delayed antioxidant response in heat-stressed cells expressing a non-DNA binding HSF1 mutant
EP  - 473
SN  - 1355-8145
IS  - iss. 4
SP  - 455
JF  - Cell Stress & Chaperones
VL  - vol. 18
N1  - 10 juni 2013
DO  - https://doi.org/10.1007/s12192-012-0400-0
ER  - 
TY  - CHAP
AU  - Zoelen, E.J.J. van
PY  - 2012
UR  - https://hdl.handle.net/2066/103404
PB  - Brasov : Transilvania University Press
TI  - Growth control in normal cells, tumor cells and stem cells
EP  - 22
SP  - 15
CT  - Chesca, A. (ed.), Growth control in normal cells, tumor cells and stem cells
ER  - 
TY  - JOUR
AU  - Meijer, I.M.J.
AU  - Rotterdam, W. van
AU  - Zoelen, Joop van
AU  - Leeuwen, J.E. van
PY  - 2012
UR  - https://hdl.handle.net/2066/103684
TI  - Recycling of EGFR and ErbB2 is associated with impaired Hrs tyrosine phosphorylation and decreased deubiquitination by AMSH
EP  - 1988
SN  - 0898-6568
SP  - 1981
JF  - Cellular Signalling
VL  - vol. 24
DO  - https://doi.org/10.1016/j.cellsig.2012.07.006
ER  - 
TY  - JOUR
AU  - Heldens, G.
AU  - Davidson, E.N
AU  - Vitters, E.L
AU  - Schreurs, B.W
AU  - Piek, E.
AU  - Berg, W.B. van den
AU  - Kraan, P.M. van der
PY  - 2012
UR  - https://hdl.handle.net/2066/93779
TI  - Catabolic Factors and Osteoarthritis-Conditioned Medium Inhibit Chondrogenesis of Human Mesenchymal Stem Cells
EP  - 54
SN  - 1937-3341
IS  - iss. 1-2
SP  - 45
JF  - Tissue Engineering Part A
VL  - vol. 18
DO  - https://doi.org/10.1089/ten.tea.2011.0083
ER  - 
TY  - THES
AU  - Dernison, M.M.
PY  - 2012
SN  - 9789461914125
UR  - https://hdl.handle.net/2066/100592
PB  - [S.l. : s.n.]
TI  - Pacemaking activity in normal rat kidney fibroblasts
N1  - Radboud Universiteit Nijmegen, 13 november 2012
N1  - Promotores : Zoelen, E.J.J. van, Gielen, C.C.A.M. 
Co-promotor : Theuvenet, A.P.R.
PS  - 190 p.
L1  - https://repository.ubn.ru.nl/bitstream/handle/2066/100592/100592.pdf?sequence=1
ER  - 
TY  - JOUR
AU  - Almirza, W.H.M.A.
AU  - Peters, P.H.J.
AU  - Zoelen, E.J.J. van
AU  - Theuvenet, A.P.R.
PY  - 2012
UR  - https://hdl.handle.net/2066/94044
TI  - Role of Trpc channels, Stim1 and Orai1 in PGF(2 alpha)-induced calcium signaling in NRK fibroblasts
EP  - 21
SN  - 0143-4160
IS  - iss. 1
SP  - 12
JF  - Cell Calcium
VL  - vol. 51
DO  - https://doi.org/10.1016/j.ceca.2011.10.001
L1  - https://repository.ubn.ru.nl/bitstream/handle/2066/94044/94044.pdf?sequence=1
ER  - 
TY  - JOUR
AU  - Hensen, S.M.M.
AU  - Heldens, L.
AU  - Enckevort, C.M.W. van
AU  - Genesen, S.T. van
AU  - Pruijn, G.J.M.
AU  - Lubsen, N.H.
PY  - 2012
UR  - https://hdl.handle.net/2066/103412
TI  - Heat shock factor 1 is inactivated by amino acid deprivation
EP  - 755
SN  - 1355-8145
IS  - iss. 6
SP  - 743
JF  - Cell Stress & Chaperones
VL  - vol. 17
DO  - https://doi.org/10.1007/s12192-012-0347-1
ER  - 
TY  - JOUR
AU  - Watering, F.C.J. van de
AU  - Beucken, J.J.J.P van den
AU  - Woning, S.P. van der
AU  - Briest, A.
AU  - Eek, A.
AU  - Qureshi, H.
AU  - Winnubst, L.
AU  - Boerman, O.C.
AU  - Jansen, J.B.M.J.
PY  - 2012
UR  - https://hdl.handle.net/2066/108847
AB  - Bone morphogenic protein-2 (BMP-2) is a well-known growth factor that can improve the biological performance of bone substitute materials. BMP-2 produced via bacterial expression systems are non-glycosylated (ng) whereas native and recombinant equivalents produced in mammalian cell expression systems are glycosylated (g) proteins. ngBMP-2 is less soluble, resulting in lower BMP-2 release from carriers as used as bone substitute materials. This seems promising for reducing the amount of included growth factor in bone substitute materials. Hence, it was hypothesized that ngBMP-2 would induce formation of the same amount of bone at an ectopic site at lower dosage as gBMP-2. To that end, gBMP-2 and ngBMP-2 were firstly in vitro comparatively evaluated for biological activity and release from a calcium phosphate (CaP) based bone substitute material. Thereafter, an ectopic implantation model in rats was used, in which gBMP-2 and ngBMP2 were loaded in various dosages (2-20 mug/implant) on the CaP-based bone substitute material and implanted for 4 and 12 weeks. The results revealed that both the in vitro biological activity of and the in vitro release of ngBMP-2 are lower compared to gBMP2. Upon ectopic implantation, however, ngBMP-2 loaded implants induced more bone formation at lower concentrations from 4-weeks onward compared to gBMP-2 equivalents, indicating the value of ngBMP-2 as a potential alternative for mammalian produced recombinant BMP-2 for bone regenerative therapies.
TI  - Non-glycosylated BMP-2 can induce ectopic bone formation at lower concentrations compared to glycosylated BMP-2.
EP  - 77
SN  - 0168-3659
IS  - iss. 1
SP  - 69
JF  - Journal of Controlled Release
VL  - vol. 159
DO  - https://doi.org/10.1016/j.jconrel.2011.12.041
ER  - 
TY  - JOUR
AU  - Jenks, B.G.
AU  - Galas, L.
AU  - Kuribara, M.
AU  - Desrues, L.
AU  - Kidane, A.H.
AU  - Vaudry, H.
AU  - Scheenen, W.J.J.M.
AU  - Roubos, E.W.
AU  - Tonon, M.C.
PY  - 2011
UR  - https://hdl.handle.net/2066/84446
TI  - Analysis of the melanotrope cell neuroendocrine interface in two amphibian species, Rana ridibunda and Xenopus laevis: A celebration of 35 years of collaborative research
EP  - 67
SN  - 0016-6480
IS  - iss. 1
SP  - 57
JF  - General and Comparative Endocrinology
VL  - vol. 170
PS  - 11 p.
DO  - https://doi.org/10.1016/j.ygcen.2010.09.022
ER  - 
TY  - JOUR
AU  - Hupkes, M.
AU  - Someren, E.P. van
AU  - Middelkamp, S.H.A.
AU  - Piek, E.
AU  - Zoelen, Joop van
AU  - Dechering, K.J.
PY  - 2011
UR  - https://hdl.handle.net/2066/91686
TI  - DNA methylation restricts spontaneous multi-lineage differentiation of mesenchymal progenitor cells, but is stable during growth factor-induced terminal differentiation
EP  - 849
SN  - 0167-4889
IS  - iss. 5
SP  - 839
JF  - Biochimica et Biophysica Acta. Molecular Cell Research
VL  - vol. 1813
PS  - 11 p.
DO  - https://doi.org/10.1016/j.bbamcr.2011.01.022
L1  - https://repository.ubn.ru.nl/bitstream/handle/2066/91686/91686.pdf?sequence=1
ER  - 
TY  - JOUR
AU  - Hupkes, M.
AU  - Jonsson, M.K.
AU  - Scheenen, W.J.J.M.
AU  - Rotterdam, W. van
AU  - Sotoca Covaleda, A.M.
AU  - Someren, E.P. van
AU  - Heyden, M.A. van der
AU  - Veen, T.A. van
AU  - Ravestein-Van Os, R.I. van
AU  - Bauerschmidt, S.
AU  - Piek, E.
AU  - Ypey, D.L.
AU  - Zoelen, E.J.J. van
AU  - Dechering, K.J.
PY  - 2011
UR  - https://hdl.handle.net/2066/91778
TI  - Epigenetics: DNA demethylation promotes skeletal myotube maturation
EP  - 3872
SN  - 0892-6638
IS  - iss. 11
SP  - 3861
JF  - The Faseb Journal
VL  - vol. 25
DO  - https://doi.org/10.1096/fj.11-186122
ER  - 
TY  - JOUR
AU  - Vrolix, K.
AU  - Niks, E.H.
AU  - Panse, R. Le
AU  - Ostaijen-ten Dam, M.M. van
AU  - Muris, A.H.
AU  - Zijde, C.M. Jol-van der
AU  - Tol, M.J.D. van
AU  - Losen, M.
AU  - Molenaar, P.C.
AU  - Zoelen, E.J.J. van
AU  - Berrih-Aknin, S.
AU  - Baets, M.H. De
AU  - Verschuuren, J.
AU  - Martinez-Martinez, P.
PY  - 2011
UR  - https://hdl.handle.net/2066/92264
TI  - Reduced thymic expression of ErbB receptors without auto-antibodies against synaptic ErbB in myasthenia gravis
EP  - 165
SN  - 0165-5728
IS  - iss. 1-2
SP  - 158
JF  - Journal of Neuroimmunology
VL  - vol. 232
DO  - https://doi.org/10.1016/j.jneuroim.2010.10.024
ER  - 
TY  - JOUR
AU  - Kuribara, M.
AU  - Kidane, A.H.
AU  - Vos, G.A.
AU  - Gouw, D. de
AU  - Roubos, E.W.
AU  - Scheenen, W.J.J.M.
AU  - Jenks, B.G.
PY  - 2011
UR  - https://hdl.handle.net/2066/91803
TI  - Extracellular-signal regulated kinase regulates production of pro-opiomelanocortin in pituitary melanotroph cells.
EP  - 268
SN  - 0953-8194
IS  - iss. 3
SP  - 261
JF  - Journal of Neuroendocrinology
VL  - vol. 23
N1  - 1 maart 2011
DO  - https://doi.org/10.1111/j.1365-2826.2010.02103.x
ER  - 
TY  - THES
AU  - Damen, E.
PY  - 2010
SN  - 9789090254098
UR  - https://hdl.handle.net/2066/77567
PB  - [S.l. : s.n.]
TI  - The role of the retromer complex in receptor trafficking
N1  - RU Radboud Universiteit Nijmegen, 5 juli 2010
PS  - 245 p.
L1  - https://repository.ubn.ru.nl/bitstream/handle/2066/77567/77567.pdf?sequence=1
ER  - 
TY  - THES
AU  - Woning, S.P. van der
PY  - 2010
SN  - 9789090249636
UR  - https://hdl.handle.net/2066/74880
PB  - [S.l. : s.n.]
TI  - Molecular mechanisms that underlie the receptor specificity of ErbB ligands
N1  - RU Radboud Universiteit Nijmegen, 12 januari 2010
PS  - 243 p.
L1  - https://repository.ubn.ru.nl/bitstream/handle/2066/74880/74880.pdf?sequence=1
ER  - 
TY  - JOUR
AU  - Hageman, J.
AU  - Rujano, M.A.
AU  - Waarde, M. van
AU  - Kakkar, V.
AU  - Dirks, R.P.
AU  - Govorukhina, N.
AU  - Oosterveld-Hut, H.M.J.
AU  - Lubsen, N.H.
AU  - Kampinga, H.H.
PY  - 2010
UR  - https://hdl.handle.net/2066/84379
TI  - A dnajb chaperone subfamily with hdac-dependent activities suppresses toxic protein aggregation
EP  - 369
SN  - 1097-2765
IS  - iss. 3
SP  - 355
JF  - Molecular Cell
VL  - vol. 37
PS  - 15 p.
DO  - http://dx.doi.org/10.1016/j.molcel.2010.01.001
ER  - 
TY  - JOUR
AU  - Haan, J.R. de
AU  - Wehrens, H.R.M.J.
AU  - Bauerschmidt, S.
AU  - Schaik, R.C. Van
AU  - Piek, E.
AU  - Buydens, L.M.C.
PY  - 2010
UR  - https://hdl.handle.net/2066/83312
TI  - Beyond single p-value cut-offs: Methods to improve decision making in GO enrichment analysis of microarray experiments
EP  - 18
SN  - 1443-2250
IS  - iss. 1
SP  - 1
JF  - Online Journal of Bioinformatics
VL  - vol. 11
PS  - 18 p.
ER  - 
TY  - JOUR
AU  - Dimke, H.
AU  - Wijst, J.A.J. van der
AU  - Alexander, T.
AU  - Meijer, I.M.J.
AU  - Mulder, G.M.
AU  - Goor, H. van
AU  - Tejpar, S.
AU  - Hoenderop, J.G.J.
AU  - Bindels, R.J.M.
PY  - 2010
UR  - https://hdl.handle.net/2066/88763
AB  - A mutation in pro-EGF causes isolated hypomagnesemia, and monoclonal antibodies targeting the extracellular domain of the EGF receptor (EGFR) affect epithelial Mg(2+) transport. The effect of the EGFR tyrosine kinase inhibitor erlotinib on Mg(2+) homeostasis, however, remains unknown. Here, we injected C57BL/6 mice with erlotinib for 23 days and observed a small but significant decrease in serum Mg(2+) concentrations at days 16 and 23, but the fractional excretion of Mg(2+) remained unchanged after 23 days. Semiquantitative immunohistochemical evaluation did not reveal detectable changes in renal expression of transient receptor potential melastatin 6 (TRPM6) protein, the channel that mediates Mg(2+) reabsorption. Patch clamp analysis in TRPM6-expressing cells demonstrated that 30 muM erlotinib inhibited EGF-induced changes in TRPM6 current density and tyrosine phosphorylation of EGFR; 0.3 muM erlotinib did not have these effects. Furthermore, 30 muM erlotinib inhibited EGF-stimulated increases in the mobile fraction of endomembrane TRPM6 channels. In summary, erlotinib can influence Mg(2+) handling but its effect on the systemic Mg(2+) concentration seems less potent than that observed with antibody-based EGFR inhibitors. These data suggest that typical human dosages of erlotinib are unlikely to severely affect serum Mg(2+) concentrations.
TI  - Effects of the EGFR Inhibitor Erlotinib on Magnesium Handling.
EP  - 1316
SN  - 1046-6673
IS  - iss. 8
SP  - 1309
JF  - Journal of the American Society of Nephrology
VL  - vol. 21
N1  - 1 augustus 2010
DO  - https://doi.org/10.1681/ASN.2009111153
L1  - https://repository.ubn.ru.nl/bitstream/handle/2066/88763/88763.pdf?sequence=1
ER  - 
TY  - JOUR
AU  - Piek, E.
AU  - Sleumer, L.S.
AU  - Someren, E.P. van
AU  - Heuver, L.
AU  - Haan, J.R. de
AU  - Grijs, I. de
AU  - Gilissen, C.F.H.A.
AU  - Hendriks, J.M.
AU  - van Ravestein-van Os, R.I.
AU  - Bauerschmidt, S.
AU  - Dechering, K.J.
AU  - Zoelen, E.J.J. van
PY  - 2010
UR  - https://hdl.handle.net/2066/84264
TI  - Osteo-transcriptomics of human mesenchymal stem cells: Accelerated gene expression and osteoblast differentiation induced by vitamin d reveals c-myc as an enhancer of bmp2-induced osteogenesis
EP  - 627
SN  - 8756-3282
IS  - iss. 3
SP  - 613
JF  - Bone
VL  - vol. 46
PS  - 15 p.
DO  - https://doi.org/10.1016/j.bone.2009.10.024
ER  - 
TY  - JOUR
AU  - Haan, J.R. de
AU  - Piek, E.
AU  - Schaik, R.C. Van
AU  - Vlieg, J. de
AU  - Bauerschmidt, S.
AU  - Buydens, L.M.C.
AU  - Wehrens, H.R.M.J.
PY  - 2010
UR  - https://hdl.handle.net/2066/83407
TI  - Integrating gene expression and go classification for pca by preclustering
EP  - 10
SN  - 1471-2105
SP  - 1
JF  - BMC Bioinformatics
VL  - vol. 11
PS  - 10 p.
DO  - https://doi.org/10.1186/1471-2105-11-158
L1  - https://repository.ubn.ru.nl/bitstream/handle/2066/83407/83407.pdf?sequence=1
ER  - 
TY  - JOUR
AU  - Vaes, B.L.T.
AU  - Lute, C.
AU  - Woning, S.P. van der
AU  - Piek, E.
AU  - Vermeer, J.
AU  - Blom, H.J.
AU  - Mathers, J.C.
AU  - Muller, M.
AU  - Groot, L. de
AU  - Steegenga, W.T.
PY  - 2010
UR  - https://hdl.handle.net/2066/83427
TI  - Inhibition of methylation decreases osteoblast differentiation via a non-DNA-dependent methylation mechanism
EP  - 523
SN  - 8756-3282
IS  - iss. 2
SP  - 514
JF  - Bone
VL  - vol. 46
PS  - 10 p.
DO  - https://doi.org/10.1016/j.bone.2009.09.033
ER  - 
TY  - JOUR
AU  - Meijer, I.M.J.
AU  - Leeuwen, J.E.M. van
PY  - 2010
UR  - https://hdl.handle.net/2066/83789
TI  - Erbb2 is a target for usp8-deiated deubquitination
EP  - 467
SN  - 0898-6568
IS  - iss. 2
SP  - 458
JF  - Cellular Signalling
VL  - vol. 23
PS  - 10 p.
DO  - https://doi.org/10.1016/j.cellsig.2010.10.023
ER  - 
TY  - JOUR
AU  - Almirza, W.H.M.
AU  - Peters, P.H.J.
AU  - Meerwijk, W.P.M. van
AU  - Zoelen, E.J.J. van
AU  - Theuvenet, A.P.R.
PY  - 2010
UR  - https://hdl.handle.net/2066/83828
TI  - Different roles of inositol 1,4,5-trisphosphate receptor subtypes in prostaglandin f-2 alpha-induced calcium oscillations and pacemaking activity of nrk fibroblasts
EP  - 553
SN  - 0143-4160
IS  - iss. 6
SP  - 544
JF  - Cell Calcium
VL  - vol. 47
DO  - https://doi.org/10.1016/j.ceca.2010.05.004
ER  - 
TY  - JOUR
AU  - Dimke, H.
AU  - Wijst, J.A.J. van der
AU  - Alexander, T.
AU  - Meijer, I.M.J.
AU  - Mulder, G.M.
AU  - Goor, H. van
AU  - Tejpar, S.
AU  - Hoenderop, J.G.J.
AU  - Bindels, R.J.
PY  - 2010
UR  - https://hdl.handle.net/2066/84268
TI  - Effects of the egfr inhibitor erlotinib on magnesium handling
EP  - 1316
SN  - 1046-6673
IS  - iss. 8
SP  - 1309
JF  - Journal of the American Society of Nephrology
VL  - vol. 21
PS  - 18 p.
DO  - https://doi.org/10.1681/ASN.2009111153
L1  - https://repository.ubn.ru.nl/bitstream/handle/2066/84268/84268.pdf?sequence=1
ER  - 
TY  - JOUR
AU  - Dernison, M.M.
AU  - Almirza, W.H.M.A.
AU  - Kusters, J.M.A.M.
AU  - Meerwijk, W.P.M. van
AU  - Gielen, C.C.A.M.
AU  - Zoelen, E.J.J. van
AU  - Theuvenet, A.P.R.
PY  - 2010
UR  - https://hdl.handle.net/2066/84300
TI  - Growth-dependent modulation of capacitative calcium entry in normal rat kidney fibroblasts
EP  - 1053
SN  - 0898-6568
IS  - iss. 7
SP  - 1044
JF  - Cellular Signalling
VL  - vol. 22
PS  - 10 p.
DO  - https://doi.org/10.1016/j.cellsig.2010.02.007
ER  - 
TY  - JOUR
AU  - Sundvall, M.
AU  - Veikkolainen, V.
AU  - Kurppa, K.
AU  - Salah, Z.
AU  - Tvorogov, D.
AU  - Zoelen, Joop van
AU  - Aqeilan, R.
AU  - Elenius, K.
PY  - 2010
UR  - https://hdl.handle.net/2066/83476
TI  - Cell death or survival promoted by alternative isoforms of erbb4
EP  - 4286
SN  - 1059-1524
IS  - iss. 23
SP  - 4275
JF  - Molecular Biology of the Cell
VL  - vol. 21
PS  - 12 p.
DO  - https://doi.org/10.1091/mbc.E10-04-0332
L1  - https://repository.ubn.ru.nl/bitstream/handle/2066/83476/83476.pdf?sequence=1
ER  - 
TY  - JOUR
AU  - Dirks, R.P.H.
AU  - Geel, R. van
AU  - Hensen, S.M.M.
AU  - Genesen, S.T. van
AU  - Lubsen, N.H.
PY  - 2010
UR  - https://hdl.handle.net/2066/83587
TI  - Manipulating heat shock factor-1 in xenopus tadpoles: Neuronal tissues are refractory to exogenous expression
SN  - 1932-6203
IS  - iss. 4
JF  - PLoS One
VL  - vol. 5
PS  - 10 p.
DO  - https://doi.org/10.1371/journal.pone.0010158
L1  - https://repository.ubn.ru.nl/bitstream/handle/2066/83587/83587.pdf?sequence=1
ER  - 
TY  - JOUR
AU  - Heldens, L.
AU  - Dirks, R.P.H.
AU  - Hensen, S.M.M.
AU  - Onnekink, C.
AU  - Genesen, S.T. van
AU  - Rustenburg, F.
AU  - Lubsen, N.H.
PY  - 2010
UR  - https://hdl.handle.net/2066/83516
TI  - Co-chaperones are limiting in a depleted chaperone network
EP  - 4048
SN  - 1420-682X
IS  - iss. 23
SP  - 4035
JF  - Cellular and Molecular Life Sciences
VL  - vol. 67
PS  - 4 p.
DO  - https://doi.org/10.1007/s00018-010-0430-7
ER  - 
TY  - JOUR
AU  - Kappe, G.
AU  - Purkiss, A.G.
AU  - Genesen, S.T. van
AU  - Slingsby, C
AU  - Lubsen, N.H.
PY  - 2010
UR  - https://hdl.handle.net/2066/83594
TI  - Explosive expansion of beta gamma-crystallin genes in the ancestral vertebrate (vol 71, 219, 2010)
EP  - 318
SN  - 0022-2844
IS  - iss. 4
SP  - 317
JF  - Journal of Molecular Evolution
VL  - vol. 71
PS  - 2 p.
DO  - https://doi.org/10.1007/s00239-010-9387-2
ER  - 
TY  - JOUR
AU  - Kappe, G.
AU  - Purkiss, A.G.
AU  - Genesen, S.T. van
AU  - Slingsby, C
AU  - Lubsen, N.H.
PY  - 2010
UR  - https://hdl.handle.net/2066/83598
TI  - Explosive expansion of beta gamma-crystallin genes in the ancestral vertebrate
EP  - 230
SN  - 0022-2844
IS  - iss. 3
SP  - 219
JF  - Journal of Molecular Evolution
VL  - vol. 71
PS  - 12 p.
DO  - https://doi.org/10.1007/s00239-010-9379-2
ER  -