TY - JOUR AU - Chu, G. AU - Seelig, J. AU - Trinks-Roerdink, Emmy M. AU - Geersing, G.J. AU - Rutten, F.H. AU - Groot, J.R. de AU - Huisman, M.V. AU - Hemels, M.E.W. PY - 2020 UR - https://hdl.handle.net/2066/225355 AB - In recent years, as more and more experience has been gained with prescribing direct oral anticoagulants (DOACs), new research initiatives have emerged in the Netherlands to improve the safety and appropriateness of DOAC treatment for stroke prevention in patients with atrial fibrillation (AF). These initiatives address several contemporary unresolved issues, such as inappropriate dosing, non-adherence and the long-term management of DOAC treatment. Dutch initiatives have also contributed to the development and improvement of risk prediction models. Although fewer bleeding complications (notably intracranial bleeding) are in general seen with DOACs in comparison with vitamin K antagonists, to successfully identify patients with high bleeding risk and to tailor anticoagulant treatment accordingly to mitigate this increased bleeding risk, is one of the research aims of recent and future years. This review highlights contributions from the Netherlands that aim to address these unresolved issues regarding the anticoagulant management in AF in daily practice, and provides a narrative overview of contemporary stroke and bleeding risk assessment strategies. TI - Antithrombotic management of patients with atrial fibrillation-Dutch anticoagulant initiatives anno 2020 EP - 24 SN - 1568-5888 IS - iss. Suppl 1 SP - 19 JF - Netherlands Heart Journal VL - vol. 28 DO - https://doi.org/10.1007/s12471-020-01446-6 ER - TY - JOUR AU - Smaardijk, V.R. AU - Mommersteeg, P.M. AU - Kop, W.J. AU - Adlam, D. AU - Maas, A.H.E.M. PY - 2020 UR - https://hdl.handle.net/2066/225499 AB - Aims: Spontaneous coronary artery dissection (SCAD) is increasingly recognised as a cause of myocardial infarction, but psychological characteristics of patients with SCAD have not yet been extensively investigated. We assessed the prevalence of a broad range of psychological and clinical factors, and their inter-relationships in patients with a history of SCAD. Furthermore, we investigated whether specific clusters of patients with SCAD can be identified. Methods: Participants were recruited between March and May 2019 from a Dutch SCAD database and completed online questionnaires. Clinical information was verified by review of medical records. Participants were predominantly female (172/183; 94%). Analyses focused on the 172 female patients (mean age 52.0 ± 7.5 years, 37% postmenopausal). Results: The most common comorbidities of SCAD were migraine (52%), fibromuscular dysplasia (FMD; 29%), chronic pain (29%), and tinnitus (28%). Six women (3%) had pregnancy-associated SCAD. Traditional cardiovascular risk factors were rare (<10%), except for hypertension (31%). Psychological assessment indicated high levels of perceived stress (PSS-10 ≥14; 50%), fatigue (FAS-10 ≥22; 56%), and a frequent history of burnout (25%). The prevalence of depression (9%) and anxiety (12%) was relatively low. Three clusters were identified: (A) FMD and chronic non-ischaemic conditions (tinnitus, chronic pain, and irritable bowel syndrome); (B) migraine; and (C) none of these conditions. Conclusion: This study shows that perceived stress and fatigue are common in patients with SCAD, in addition to prevalent comorbid FMD, migraine, tinnitus, and non-ischaemic pain conditions. These factors may add to developing tailored rehabilitation programmes for patients with SCAD. Electronic supplementary material: The online version of this article (10.1007/s12471-020-01437-7) contains supplementary material, which is available to authorized users. TI - Psychological and clinical characteristics of female patients with spontaneous coronary artery dissection EP - 491 SN - 1568-5888 IS - iss. 9 SP - 485 JF - Netherlands Heart Journal VL - vol. 28 DO - https://doi.org/10.1007/s12471-020-01437-7 ER - TY - JOUR AU - Aarts, G.W.A. AU - Mol, J.H.Q. AU - Camaro, C. AU - Lemkes, J. AU - Royen, N. van AU - Damman, P. PY - 2020 UR - https://hdl.handle.net/2066/225500 AB - In the past year, a number of important papers have been published on non-ST-elevation acute coronary syndrome, highlighting progress in clinical care. The current review focuses on early diagnosis and risk stratification using biomarkers and advances in intracoronary imaging. TI - Recent developments in diagnosis and risk stratification of non-ST-elevation acute coronary syndrome EP - 92 SN - 1568-5888 IS - iss. Suppl 1 SP - 88 JF - Netherlands Heart Journal VL - vol. 28 DO - https://doi.org/10.1007/s12471-020-01457-3 ER - TY - JOUR AU - Hoef, T.P. van de AU - Waard, G.A. de AU - Meuwissen, M. AU - Voskuil, M. AU - Chamuleau, S.A. AU - Royen, N. van AU - Piek, J.J. PY - 2020 UR - https://hdl.handle.net/2066/225464 AB - Invasive coronary physiology has been applied since the early days of percutaneous transluminal coronary angioplasty, and has become a rapidly emerging field of research. Many physiology indices have been developed, tested in clinical studies, and are now applied in daily clinical practice. Recent clinical practice guidelines further support the use of advanced invasive physiology methods to optimise the diagnosis and treatment of patients with acute and chronic coronary syndromes. This article provides a succinct review of the history of invasive coronary physiology, the basic concepts of currently available physiological parameters, and will particularly highlight the Dutch contribution to this field of invasive coronary physiology. TI - Invasive coronary physiology: a Dutch tradition EP - 107 SN - 1568-5888 IS - iss. Suppl 1 SP - 99 JF - Netherlands Heart Journal VL - vol. 28 DO - https://doi.org/10.1007/s12471-020-01461-7 ER - TY - JOUR AU - Konst, R.E. AU - Meeder, J.G. AU - Wittekoek, M.E. AU - Maas, A.H.E.M. AU - Appelman, Y. AU - Piek, J.J. AU - Hoef, T.P. van de AU - Damman, P. AU - Elias-Smale, S.E. PY - 2020 UR - https://hdl.handle.net/2066/225465 AB - Ischaemia with no obstructive coronary arteries (INOCA) is a common ischaemic heart disease with a female preponderance, mostly due to underlying coronary vascular dysfunction comprising coronary microvascular dysfunction and/or epicardial coronary vasospasm. Since standard ischaemia detection tests and coronary angiograms are not suitable to diagnose coronary vascular dysfunction, INOCA is often overlooked in current cardiology practice. Future research, including large outcome trials, is much awaited. Yet, adequate diagnosis is possible and treatment options are available and vital to reduce symptoms and most probably improve cardiovascular prognosis. This review intends to give a brief overview of the clinical presentation, underlying pathophysiology, and the diagnostic and treatment options in patients with suspected INOCA. TI - Ischaemia with no obstructive coronary arteries EP - 72 SN - 1568-5888 IS - iss. Suppl 1 SP - 66 JF - Netherlands Heart Journal VL - vol. 28 DO - https://doi.org/10.1007/s12471-020-01451-9 ER - TY - JOUR AU - Bouma, B.J. AU - Sieswerda, G.T. AU - Post, M.C. AU - Ebels, T. AU - Kimmenade, R.R. van AU - Winter, R.J. de AU - Mulder, B. J. M. PY - 2020 UR - https://hdl.handle.net/2066/225482 AB - Congenital heart disease (CHD) affects 0.8% of live births and over the past decades technical improvements and large-scale repair has led to increased survival into adulthood of over 95% of the new-born. A new group of patients, those who survived their congenital heart defect, has emerged but late complications including heart failure, pulmonary hypertension (PH), arrhythmias, aneurysms and endocarditis appeared numerous, with a huge impact on mortality and morbidity. However, innovations over the past years have changed the landscape of adult CHD dramatically. In the diagnostic process important improvements have been made in the use of MRI, biomarkers, e‑health concepts and 3D visualisation of anatomy. Care is now concentrated in specialised centres, with a continuous emphasis on education and the introduction of weekly multidisciplinary consultations on diagnosis and intervention. Surgery and percutaneous intervention have been refined and new concepts applied, further reducing the burden of the congenital malformations. Research has matured from case series to global networks. Currently, adults with CHD are still facing high risks of early mortality and morbidity. By global collaboration and continuous education and development and innovation of our diagnostic and therapeutic arsenal, we will improve the perspectives of these young patients. TI - New developments in adult congenital heart disease EP - 49 SN - 1568-5888 IS - iss. Suppl 1 SP - 44 JF - Netherlands Heart Journal VL - vol. 28 DO - https://doi.org/10.1007/s12471-020-01455-5 ER - TY - JOUR AU - Aarts, G.W.A. AU - Wulp, K. van der AU - Camaro, C. PY - 2020 UR - https://hdl.handle.net/2066/225489 AB - In the majority of patients with chest pain, an acute coronary syndrome (ACS) can be ruled out. However, early recognition of an ACS is required in order to start treatment as soon as possible and reduce risks associated with myocardial ischaemia. Because of the lack of pre-hospital protocols to rule out an ACS, patients with a suspected ACS are transported to the emergency department, where the HEART score can be used to estimate the risk of major adverse cardiac events (MACE). Patients with a low HEART score have a low risk of MACE. A point-of-care (POC) troponin measurement enables ambulance paramedics to calculate the HEART score in the pre-hospital setting. POC troponin measurement and HEART score assessment have several potential advantages, including early recognition of an ACS and identification of high-risk patients before hospital arrival. Moreover, pre-hospital rule-out of an ACS could prevent unnecessary emergency department visits. The safety and cost-effectiveness of referring low-risk patients with a normal POC troponin value to the general practitioner are currently being investigated in the ARTICA randomised trial. This point-of-view article demonstrates one of the potential advantages of early detection of an ACS. TI - Pre-hospital point-of-care troponin measurement: a clinical example of its additional value EP - 519 SN - 1568-5888 IS - iss. 10 SP - 514 JF - Netherlands Heart Journal VL - vol. 28 DO - https://doi.org/10.1007/s12471-020-01434-w ER - TY - JOUR AU - Heuvel, F.M.A. van den AU - Vos, J.L. AU - Koop, Y. AU - Dijk, A.P.J. van AU - Duijnhouwer, A.L. AU - Mast, Q. de AU - Veerdonk, F.L. van de AU - Bosch, F.H. AU - Netea, M.G. AU - Hoogerwerf, J.J. AU - Hoefsloot, W. AU - Tjwa, E.T. AU - Korte, C.L. de AU - Kimmenade, R.R.J. van AU - Nijveldt, R. PY - 2020 UR - https://hdl.handle.net/2066/221441 TI - Cardiac function in relation to myocardial injury in hospitalised patients with COVID-19 EP - 417 SN - 1568-5888 IS - iss. 7-8 SP - 410 JF - Netherlands Heart Journal VL - vol. 28 DO - https://doi.org/10.1007/s12471-020-01458-2 ER - TY - JOUR AU - Pustjens, T.F.S. AU - Appelman, Y. AU - Damman, P. AU - Berg, J.M. ten AU - Jukema, J.W. AU - Winter, R.J. de AU - Agema, W.R.P. AU - Wielen, M.L. van der AU - Arslan, F. AU - Rasoul, S. AU - Hof, A.W.J. van ’t PY - 2020 UR - https://hdl.handle.net/2066/220920 AB - Patients with myocardial infarction and non-obstructive coronary arteries (MINOCA), defined as angiographic stenosis <50%, represent a conundrum given the many potential underlying aetiologies. Possible causes of MINOCA can be subdivided into coronary, myocardial and non-cardiac disorders. MINOCA is found in up to 14% of patients presenting with an acute coronary syndrome. Clinical outcomes including mortality, and functional and psychosocial status, are comparable to those of patients with myocardial infarction and obstructive coronary arteries. However, many uncertainties remain regarding the definition, clinical features and management of these patients. This position paper of the Dutch ACS working group of the Netherlands Society of Cardiology aims to stress the importance of considering MINOCA as a dynamic working diagnosis and to guide the clinician in the management of patients with MINOCA by proposing a clinical diagnostic algorithm. TI - Guidelines for the management of myocardial infarction/injury with non-obstructive coronary arteries (MINOCA): a position paper from the Dutch ACS working group EP - 130 SN - 1568-5888 IS - iss. 3 SP - 116 JF - Netherlands Heart Journal VL - vol. 28 DO - https://doi.org/10.1007/s12471-019-01344-6 ER - TY - JOUR AU - Zwart, B. de AU - Berg, J.M. ten AU - Hof, A.W.J. van ’t AU - Tonino, P.A.L. AU - Appelman, Y. AU - Liem, A.H. AU - Arslan, F. AU - Waltenberger, J. AU - Jukema, J.W. AU - Winter, R.J. de AU - Damman, P. PY - 2020 UR - https://hdl.handle.net/2066/220929 AB - An early invasive strategy in patients who have acute coronary syndrome without ST-elevation (NSTE-ACS) can improve clinical outcome in high-risk subgroups. According to the current guidelines of the European Society of Cardiology (ESC), the majority of NSTE-ACS patients are classified as "high-risk". We propose to prioritise patients with a global registry of acute coronary events (GRACE) risk score >140 over patients with isolated troponin rise or electrocardiographic changes and a GRACE risk score <140. We also acknowledge that same-day transfer for all patients at a high risk is not necessary in the Netherlands since the majority of Dutch cardiology departments are equipped with a catheterisation laboratory where diagnostic coronary angiography is routinely performed in NSTE-ACS patients. Therefore, same-day transfer should be restricted to true high-risk patients (in addition to those NSTE-ACS patients with very high-risk (VHR) criteria) in centres without coronary angiography capabilities. TI - Indications for an early invasive strategy in NSTE-ACS patients EP - 135 SN - 1568-5888 IS - iss. 3 SP - 131 JF - Netherlands Heart Journal VL - vol. 28 DO - https://doi.org/10.1007/s12471-019-01337-5 ER - TY - JOUR AU - Broek, L.M. van den AU - Westra, S.W. AU - Evertz, R. AU - Boulaksil, M. PY - 2020 UR - https://hdl.handle.net/2066/220935 TI - Lead detour SN - 1568-5888 IS - iss. 1 SP - 56 JF - Netherlands Heart Journal VL - vol. 28 DO - https://doi.org/10.1007/s12471-019-01321-z ER - TY - JOUR AU - Broek, L.M. van den AU - Westra, S.W. AU - Evertz, R. AU - Boulaksil, M. PY - 2020 UR - https://hdl.handle.net/2066/220937 TI - Lead detour SN - 1568-5888 IS - iss. 1 SP - 51 JF - Netherlands Heart Journal VL - vol. 28 DO - https://doi.org/10.1007/s12471-019-01320-0 ER - TY - JOUR AU - Duijnhouwer, A.L. AU - Lemmers, J.M.J. AU - Smit, J. AU - Haren-Willems, J.H. Van AU - Knaapen-Hans, H.K.A. AU - Cate, T.J.F. ten AU - Hagmolen Of ten Have, Wanda AU - Boer, M.J. de AU - Roos-Hesselink, J. AU - Vonk, M.C. AU - Dijk, A.P.J. van PY - 2020 UR - https://hdl.handle.net/2066/229214 AB - BACKGROUND: Pulmonary artery (PA) dilatation is often seen in pulmonary hypertension (PH) and is considered a long-term consequence of elevated pressure. The PA dilates over time and therefore may reflect disease severity and duration. Survival is related to the stage of the disease at the time of diagnosis and therefore PA diameter might be used to predict prognosis. This study evaluates the outcome of patients with pulmonary arterial hypertension (PAH) and chronic thrombo-embolic pulmonary hypertension (CTEPH) and investigates whether PA diameter at the time of diagnosis is associated with mortality. METHODS: Patients visiting an outpatient clinic of a tertiary centre between 2004 and 2018 with a cardiac catheterisation confirmed diagnosis of PAH or CTEPH and a CT scan available for PA diameter measurement were included. PA diameter and established predictors of survival were collected (New York Heart Association (NYHA) class, N‑terminal pro-brain natriuretic peptide (NT-proBNP) level and 6‑min walking distance (6MWD)). RESULTS: In total 217 patients were included (69% female, 71% NYHA class ≥III). During a median follow-up of 50 (22-92) months, 54% of the patients died. Overall survival was 87% at 1 year, 70% at 3 years and 58% at 5 years. The mean PA diameter was 34.2 ± 6.2 mm and was not significantly different among all the diagnosis groups. We found a weak correlation between PA diameter and mean PA pressure ( r = 0.23, p < 0.001). Male sex, higher age, shorter 6MWD and higher NT-proBNP level were independently associated with mortality, but PA diameter was not. CONCLUSION: The prognosis of PAH and CTEPH is still poor. Known predictors of survival were confirmed, but PA diameter at diagnosis was not associated with survival in PAH or CTEPH patients. TI - The outcome of pulmonary hypertension and its association with pulmonary artery dilatation EP - 655 SN - 1568-5888 IS - iss. 12 SP - 645 JF - Netherlands Heart Journal VL - vol. 28 DO - https://doi.org/10.1007/s12471-020-01467-1 ER - TY - JOUR AU - Hoedemaker, N.P.G. AU - Winter, R.J. de AU - Kommer, G.J. AU - Giesbers, H. AU - Adams, R. AU - Bosch, S.E. AU - Damman, P. PY - 2020 UR - https://hdl.handle.net/2066/229151 AB - INTRODUCTION: In patients with ST-elevation myocardial infarction (STEMI), percutaneous coronary intervention (PCI)-mediated reperfusion is preferred over pharmacoinvasive reperfusion with fibrinolysis if transfer to a PCI centre can be ensured in ≤120 min. We evaluated the ambulance driving time to primary PCI centres in the Netherlands and assessed to what extent ambulance driving times were impacted by the expansion of off-site PCI centres. METHODS AND RESULTS: We calculated the driving routes from every Dutch postal code to the nearest PCI centre with (on-site) or without (off-site) surgical back-up. We used data from ambulance records to estimate the ambulance driving time on each route. There were 16 on-site and 14 off-site PCI centres. The median (interquartile range) time to on-site PCI centres was 18.8 min (12.2-26.3) compared with 14.9 min (8.9-20.9) to any PCI centre (p <n0.001). In postal code areas that were impacted by the initiation of off-site PCI, the median driving time decreased from 25.4 (18.2-33.1) to 14.7 min (8.9-20.9) (p <n0.001). Ambulance driving times of >120 min were only seen in non-mainland areas. CONCLUSION: Based on a computational model, timely ambulance transfer to a PCI centre within 120 min is available to almost all STEMI patients in the Netherlands. Expansion of off-site PCI has significantly reduced the driving time to PCI centres. TI - Expansion of off-site percutaneous coronary intervention centres significantly reduces ambulance driving time to primary PCI in the Netherlands EP - 594 SN - 1568-5888 IS - iss. 11 SP - 584 JF - Netherlands Heart Journal VL - vol. 28 DO - https://doi.org/10.1007/s12471-020-01466-2 ER - TY - JOUR AU - Dort, D.I.M. van AU - Peij, K.R.A.H. AU - Manintveld, O.C. AU - Hoeks, S.E. AU - Morshuis, W.J. AU - Royen, N. van AU - Cate, T.J.F. ten AU - Geuzebroek, G.S.C. PY - 2020 UR - https://hdl.handle.net/2066/218101 AB - The Impella percutaneous mechanical circulatory support device is designed to augment cardiac output and reduce left ventricular wall stress and aims to improve survival in cases of cardiogenic shock. In this meta-analysis we investigated the haemodynamic effects of the Impella device in a clinical setting. We systematically searched all articles in PubMed/Medline and Embase up to July 2019. The primary outcomes were cardiac power (CP) and cardiac power index (CPI). Survival rates and other haemodynamic data were included as secondary outcomes. For the critical appraisal, we used a modified version of the U.S. Department of Health and Human Services quality assessment form. The systematic review included 12 studies with a total of 596 patients. In 258 patients the CP and/or CPI could be extracted. Our meta-analysis showed an increase of 0.39W [95% confidence interval (CI): 0.24, 0.54], (p= 0.01) and 0.22W/m(2) (95% CI: 0.18, 0.26), (p< 0.01) for the CP and CPI, respectively. The overall survival rate was 56% (95% CI: 0.50, 0.62), (p= 0.09). The quality of the studies was moderate, mostly due to the presence of confounders. Our study suggests that in patients with cardiogenic shock, Impella support seems effective in augmenting CP(I). This study merely investigates the haemodynamic effectiveness of the Impella device and does not reflect the complete clinical impact for the patient. TI - Haemodynamic efficacy of microaxial left ventricular assist device in cardiogenic shock: a systematic review and meta-analysis EP - 189 SN - 1568-5888 IS - iss. 4 SP - 179 JF - Netherlands Heart Journal VL - vol. 28 DO - https://doi.org/10.1007/s12471-019-01351-7 ER - TY - JOUR AU - Arts-Birstonaite, I. AU - Jaspers Focks, J. AU - Camaro, C. AU - Nijveldt, R. PY - 2020 UR - https://hdl.handle.net/2066/229089 TI - A hypertrophic senile heart EP - 618 SN - 1568-5888 IS - iss. 11 SP - 617 JF - Netherlands Heart Journal VL - vol. 28 DO - https://doi.org/10.1007/s12471-020-01370-9 ER - TY - JOUR AU - Spoormans, E.M. AU - Lemkes, J.S. AU - Janssens, G.N. AU - Hoeven, N.W. Van Der AU - Bonnes, J.L. AU - Royen, N. van PY - 2020 UR - https://hdl.handle.net/2066/225406 AB - Out-of-hospital cardiac arrest (OHCA) is a major cause of death. Although the aetiology of cardiac arrest can be diverse, the most common cause is ischaemic heart disease. Coronary angiography and percutaneous coronary intervention, if indicated, has been associated with improved long-term survival for patients with initial shockable rhythm. However, in patients without ST-segment elevation on the post-resuscitation electrocardiogram, the optimal timing of performing this invasive procedure is uncertain. One important challenge that clinicians face is to appropriately select patients that will benefit from immediate coronary angiography, yet avoid unnecessary delay of intensive care support and targeted temperature management. Observational studies have reported contradictory results and until recently, randomised trials were lacking. The Coronary Angiography after Cardiac Arrest without ST-segment elevation (COACT) was the first randomised trial that provided comparative information between coronary angiography treatment strategies. This literature review will provide the current knowledge and gaps in the literature regarding optimal care for patients successfully resuscitated from OHCA in the absence of ST-segment elevation and will primarily focus on the role and timing of coronary angiography in this high-risk patient population. TI - The role of coronary angiography in out-of-hospital cardiac arrest patients in the absence of ST-segment elevation: A literature review EP - 114 SN - 1568-5888 IS - iss. Suppl 1 SP - 108 JF - Netherlands Heart Journal VL - vol. 28 DO - https://doi.org/10.1007/s12471-020-01460-8 ER - TY - JOUR AU - Boulaksil, M. AU - Mellema, J.E.M. AU - Cate, T.J.F. ten PY - 2019 UR - https://hdl.handle.net/2066/209420 TI - Dark clouds of contrast EP - 519 SN - 1568-5888 IS - iss. 10 SP - 518 JF - Netherlands Heart Journal VL - vol. 27 DO - https://doi.org/10.1007/s12471-019-1258-x L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/209420/209420.pdf?sequence=1 ER - TY - JOUR AU - Janssen, E.B.N.J. AU - Leeuw, P.W. de AU - Maas, A.H.E.M. PY - 2019 UR - https://hdl.handle.net/2066/209370 AB - Spontaneous coronary artery dissection (SCAD) represents around 25% of cases of acute coronary syndromes (ACS) in women aged 40-65 years who have few or no traditional cardiovascular risk factors. It is assumed that the incidence is underestimated, as the angiographic appearance of SCAD may often mimic atherosclerosis. This review aims to examine SCAD by focusing on the associated predisposing factors and precipitating stressors in this heterogeneous patient population, as well as the best treatment approach and the prognosis. Progressive knowledge has improved our current understanding of SCAD, but more awareness among clinicians is necessary. Recently, two position papers from the European Society of Cardiology (ESC) and the American Heart Association (AHA) have been released, which will be summarised in brief. TI - Spontaneous coronary artery dissections and associated predisposing factors: a narrative review EP - 251 SN - 1568-5888 IS - iss. 5 SP - 246 JF - Netherlands Heart Journal VL - vol. 27 DO - https://doi.org/10.1007/s12471-019-1235-4 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/209370/209370.pdf?sequence=1 ER - TY - JOUR AU - Bosman, L.P. AU - Verstraelen, T.E. AU - Lint, F.H.M. van AU - Cox, M.G.P.J. AU - Groeneweg, J.A. AU - Mast, T.P. AU - Evertz, R. AU - Wong, L. AU - Groot, N. de AU - Berg, M.P van den AU - Vink, A. AU - Yap, S.C. PY - 2019 UR - https://hdl.handle.net/2066/208928 TI - The Netherlands Arrhythmogenic Cardiomyopathy Registry: design and status update EP - 486 SN - 1568-5888 IS - iss. 10 SP - 480 JF - Netherlands Heart Journal VL - vol. 27 DO - https://doi.org/10.1007/s12471-019-1270-1 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/208928/208928.pdf?sequence=1 ER - TY - JOUR AU - Aribas, E. AU - Elias-Smale, S.E. AU - Duncker, D.J. AU - Piek, J.J. AU - Ikram, M.A. AU - Appelman, Y. AU - Lennep, J.E.Roeters van AU - Kavousi, M. PY - 2019 UR - https://hdl.handle.net/2066/203601 TI - Questionnaire survey on cardiologists' view and management of coronary microvascular disease in clinical practice EP - 262 SN - 1568-5888 IS - iss. 5 SP - 252 JF - Netherlands Heart Journal VL - vol. 27 DO - https://doi.org/10.1007/s12471-019-1274-x L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/203601/203601.pdf?sequence=1 ER - TY - JOUR AU - Tieleman, R.G. AU - Hemels, M.E.W. PY - 2019 UR - https://hdl.handle.net/2066/202675 TI - Mobile health: solution or a threat? EP - 17 SN - 1568-5888 IS - iss. 1 SP - 16 JF - Netherlands Heart Journal VL - vol. 27 DO - https://doi.org/10.1007/s12471-018-1206-1 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/202675/202675.pdf?sequence=1 ER - TY - JOUR AU - Nas, J. AU - Thannhauser, J. AU - Boer, M.J. de AU - Bonnes, J.L. AU - Brouwer, M.A. PY - 2019 UR - https://hdl.handle.net/2066/202691 TI - Reply to the letter by Calle and Mpotos: Why not try harder to prove that automated external defibrillators save lives? EP - 225 SN - 1568-5888 IS - iss. 4 SP - 224 JF - Netherlands Heart Journal VL - vol. 27 DO - https://doi.org/10.1007/s12471-019-1249-y L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/202691/202691.pdf?sequence=1 ER - TY - JOUR AU - Hoedemaker, N.P.G. AU - Damman, P. AU - Bosker, H.A. AU - Danse, P.W. AU - Liem, A.H. AU - Geerdes, B. AU - Laarhoven, H. van AU - Winter, R.J. de PY - 2019 UR - https://hdl.handle.net/2066/202706 AB - BACKGROUND: European Society of Cardiology (ESC) guidelines recommend same-day transfer to a percutaneous coronary intervention (PCI) centre for angiography in high-risk (ESC-HR) patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). We describe the treatment patterns of NSTE-ACS patients presenting at non-PCI centres and evaluate the logistical consequences of adopting same-day transfer. METHODS: From August 2016 until January 2017, all consecutive NSTE-ACS patients presenting at 23 non-PCI centres in the Netherlands were recorded. We built an online case report form in collaboration with the National Cardiovascular Database Registry to collect information on risk stratification by the attending physician, timing and location of angiography, and treatment. RESULTS: We included 871 patients (mean age 69.1+/- 12.8). 55.8% were considered ESC-HR. Overall, angiography at non-PCI centres was 55.1% and revascularisation was 54.1%. Among ESC-HR patients, angiography at non-PCI centres was 51.4% and revascularisation was 54.9%. Angiography <24h was 55.6% in patients with angiography at a non-PCI centre and 74.3% in patients with angiography at a PCI-centre. Assuming patients would receive similar treatment, adoption of same-day transfer would increase transfers of ESC-HR patients who undergo PCI (44.3%), but also increases transfers of medically treated patients (36.2%) and patients awaiting coronary bypass artery grafting (9.1%). CONCLUSIONS: In this registry of NSTE-ACS patients at non-PCI centres, the majority of ESC-HR patients underwent angiography at a non-PCI centre. Same-day transfer occurred in one-quarter of the ESC-HR patients, despite guideline recommendation. Nonselective adoption of same-day transfer to a PCI centre would increase transfers of ESC-HR patients who undergo PCI, however, equally increases transfers of patients who are medically treated. TI - Treatment patterns of non-ST-elevation acute coronary syndrome patients presenting at non-PCI centres in the Netherlands and possible logistical consequences of adopting same-day transfer to PCI centres: a registry-based evaluation EP - 199 SN - 1568-5888 IS - iss. 4 SP - 191 JF - Netherlands Heart Journal VL - vol. 27 DO - https://doi.org/10.1007/s12471-019-1229-2 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/202706/202706.pdf?sequence=1 ER - TY - JOUR AU - Damman, P. AU - Piek, J.J. PY - 2019 UR - https://hdl.handle.net/2066/202707 TI - Treatment strategies and outcomes in patients with non-ST-elevation acute coronary syndrome in the Netherlands EP - 63 SN - 1568-5888 IS - iss. 2 SP - 61 JF - Netherlands Heart Journal VL - vol. 27 DO - https://doi.org/10.1007/s12471-018-1218-x L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/202707/202707.pdf?sequence=1 ER - TY - JOUR AU - Badings, E.A. AU - Hermanides, R.S. AU - Sluis, A. van der AU - Dambrink, J.H. AU - Gosselink, A.T.M. AU - Kedhi, E. AU - Ottervanger, J.P. AU - Roolvink, V. AU - Remkes, W.S. AU - Riet, E. van 't AU - Suryapranata, H. AU - Hof, A.W.J. van ’t PY - 2019 UR - https://hdl.handle.net/2066/202710 AB - BACKGROUND: An early invasive strategy (EIS) is recommended in high-risk patients with non-ST-elevation acute coronary syndrome (NSTE-ACS), defined as coronary angiography (CAG), within 24h of admission. The aim of the present study is to investigate guideline adherence, patient characteristics associated with timing of the intervention and clinical outcome. METHODS: In a prospective registry, the use and timing of CAG and the characteristics and clinical outcome associated with timing were evaluated in high-risk ACS patients. The outcome of early versus delayed invasive strategy (DIS) was compared. RESULTS: Between 2006 and 2014, 2,299 high-risk NSTE-ACS patients were included. The use of CAG increased from 77% in 2006 to 90% in 2014 (p trend <0.001) together with a decrease of median time to CAG from 23.3 to 14.5h (p trend <0.001) and an increase of patients undergoing EIS from 50 to 60% (p trend= 0.002). Patient factors independently related to DIS were higher GRACE risk score, higher age and the presence of comorbidities. No difference was found in incidence of mortality, reinfarction or bleeding at 30-day follow-up. All-cause mortality at 1year follow-up was 4.1% vs 7.0% in EIS and DIS respectively (hazard ratio 1.67, 95% confidence interval 1.12-2.49) but was comparable after adjustment for confounding factors. CONCLUSION: The percentage of high-risk NSTE-ACS patients undergoing CAG and EIS has increased in the last decade. In contrast to the guidelines, patients with a higher risk profile are less likely to undergo EIS. However, no difference in outcome after 30 days and 1 year was found after multivariate adjustment for this higher risk. TI - Use, timing and outcome of coronary angiography in patients with high-risk non-ST-segment elevation acute coronary syndrome in daily clinical practice: insights from a 'real world' prospective registry EP - 80 SN - 1568-5888 IS - iss. 2 SP - 73 JF - Netherlands Heart Journal VL - vol. 27 DO - https://doi.org/10.1007/s12471-018-1212-3 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/202710/202710.pdf?sequence=1 ER - TY - JOUR AU - Pisters, R. AU - Elvan, A. AU - Crijns, H.J.G.M. AU - Hemels, M.E.W. PY - 2018 UR - https://hdl.handle.net/2066/191924 TI - Optimal long-term antithrombotic management of atrial fibrillation: life cycle management EP - 320 SN - 1568-5888 IS - iss. 6 SP - 311 JF - Netherlands Heart Journal VL - vol. 26 DO - https://doi.org/10.1007/s12471-018-1118-0 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/191924/191924.pdf?sequence=1 ER - TY - JOUR AU - Joustra, R. AU - Dijk, A.P.J. van AU - Meijburg, H.W. AU - Boulaksil, M. PY - 2018 UR - https://hdl.handle.net/2066/200446 TI - A freaky artery EP - 578 SN - 1568-5888 IS - iss. 11 SP - 577 JF - Netherlands Heart Journal VL - vol. 26 DO - https://doi.org/10.1007/s12471-018-1189-y L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/200446/200446.pdf?sequence=1 ER - TY - JOUR AU - Nguyen, U.C. AU - Cluitmans, M.J.M. AU - Prinzen, F.W. AU - Mihl, C. AU - Vernooy, K. PY - 2018 UR - https://hdl.handle.net/2066/200366 TI - Reply to the letter from Bhagirath et al.: Imaging for cardiac resynchronisation therapy requires cardiac magnetic resonance EP - 642 SN - 1568-5888 IS - iss. 12 SP - 641 JF - Netherlands Heart Journal VL - vol. 26 DO - https://doi.org/10.1007/s12471-018-1196-z L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/200366/200366.pdf?sequence=1 ER - TY - JOUR AU - Cate, T.J.F. ten AU - Dijk, A.P.J. van PY - 2018 UR - https://hdl.handle.net/2066/200248 TI - Mind the gap: closure of right to left shunts for rare indications EP - 534 SN - 1568-5888 IS - iss. 11 SP - 533 JF - Netherlands Heart Journal VL - vol. 26 DO - https://doi.org/10.1007/s12471-018-1164-7 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/200248/200248.pdf?sequence=1 ER - TY - JOUR AU - Vlastra, W. AU - Piek, M. AU - Lavieren, M.A. van AU - Hassell, M.E.C.J. AU - Claessen, B.E. AU - Wijntjens, G.W. AU - Hoef, T.P. van de AU - Sjauw, K.D. AU - Beijk, M.A. AU - Delewi, R. AU - Piek, J.J. PY - 2018 UR - https://hdl.handle.net/2066/190517 AB - BACKGROUND: Coronary artery spasm may be the underlying mechanism in up to 10% of cases of acute coronary syndrome (ACS) and sudden cardiac death. Asian individuals exhibit a 3-times greater incidence of spasm than Caucasians; this is likely due to different types of mechanisms. Consequently, solid data is limited about the long-term prognosis in Caucasian patients presenting with ACS and/or out-of-hospital cardiac arrest (OHCA) caused by coronary spasm. METHODS: Between 2002 and 2015, thirty Caucasian patients with coronary artery spasm presenting with ACS (N = 29) and/or OHCA (N = 11) were enrolled in this prospective registry. Follow-up, consisting of regular outpatient visits, was conducted with a mean follow-up period of 7.5 +/- 3.3 years. Outcomes included presence of stable angina pectoris, recurrence of ACS, occurrence of implantable cardioverter defibrillator (ICD) shocks and death. RESULTS: The majority of patients (60%) remained asymptomatic during the entire follow-up period. At the end of the follow-up period only 3 patients still experienced stable angina (10%). Only 2 patients (7%) had a recurrent cardiac event, in which the ICD provided appropriate shock therapy. Half of the patients treated with stenting (N = 6), required re-interventions. CONCLUSION: Coronary spasm with ACS and/or OHCA in a Caucasian patient cohort has a relatively benign prognosis in the majority of patients in long-term follow-up, if treated appropriately with medical therapy. Both the role of ICD in OHCA secondary to coronary spasm, and the efficacy of stenting to treat vasospastic angina, warrant further study in large-sized prospective clinical trials. TI - Long-term outcomes of a Caucasian cohort presenting with acute coronary syndrome and/or out-of-hospital cardiac arrest caused by coronary spasm EP - 33 SN - 1568-5888 IS - iss. 1 SP - 26 JF - Netherlands Heart Journal VL - vol. 26 DO - https://doi.org/10.1007/s12471-017-1065-1 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/190517/190517.pdf?sequence=1 ER - TY - JOUR AU - Yokota, S. AU - Ottervanger, J.P. AU - Mouden, M. AU - Boer, M.J. de AU - Jager, P.L. De AU - Timmer, J.R. PY - 2018 UR - https://hdl.handle.net/2066/190527 AB - PURPOSE: Normal myocardial perfusion imaging (MPI) is associated with excellent prognosis. However, in patients with persisting symptoms, it may be difficult to determine the patients in whom invasive angiography is justified to rule out false negative MPI. We evaluated predictors for severe stenosis at invasive angiography in patients with persisting symptoms after normal MPI. METHODS: 229 consecutive patients with normal MPI, without previous bypass surgery, underwent invasive angiography within 6 months. Older age was defined as >65 years. Multivariable analyses were performed to adjust for differences in baseline variables. RESULTS: Mean age was 62+/- 11 years, 48% were women. Severe stenosis was observed in 34%, and of these patients 60% had single-vessel disease (not left main coronary artery disease). After adjusting for several variables, including diabetes, smoking status, hypertension and hypercholesterolaemia, predictors of severe stenosis were male gender, odds ratio (OR) 2.7 (95% confidence interval (CI) 1.5-4.9), older age, OR 1.9 (95% CI 1.02-3.54) previous PCI, OR 2.0 (95% CI 1.0-4.3) and typical angina, OR 2.5 (95% CI 1.4-4.6). CONCLUSIONS: Increasing age, male gender, previous PCI and typical symptoms are predictors of severe stenosis at invasive coronary angiography in patients with normal MPI. The majority of these patients have single-vessel disease. TI - Predictors of severe stenosis at invasive coronary angiography in patients with normal myocardial perfusion imaging EP - 202 SN - 1568-5888 IS - iss. 4 SP - 192 JF - Netherlands Heart Journal VL - vol. 26 DO - https://doi.org/10.1007/s12471-018-1091-7 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/190527/190527.pdf?sequence=1 ER - TY - JOUR AU - Boulaksil, M. AU - Liem, S.S. AU - Akarkach, M. AU - Timmermans, J. PY - 2018 UR - https://hdl.handle.net/2066/190534 TI - Residual flow in false lumen of chronic descending aortic dissection EP - 51 SN - 1568-5888 IS - iss. 1 SP - 50 JF - Netherlands Heart Journal VL - vol. 26 DO - https://doi.org/10.1007/s12471-017-1052-6 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/190534/190534.pdf?sequence=1 ER - TY - JOUR AU - Sengkerij, P. AU - Hemels, M.E.W. PY - 2018 UR - https://hdl.handle.net/2066/190542 TI - What the elite athlete does not want to know EP - 112 SN - 1568-5888 IS - iss. 3 SP - 111 JF - Netherlands Heart Journal VL - vol. 26 DO - https://doi.org/10.1007/s12471-018-1082-8 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/190542/190542.pdf?sequence=1 ER - TY - JOUR AU - Parbhudayal, R.Y. AU - Allaart, C.P. AU - Loon, R.B. van AU - Meijboom, L.J. AU - Rossum, A.C. van AU - Nijveldt, R. PY - 2018 UR - https://hdl.handle.net/2066/190547 TI - Don't judge the myocardium by its cover : The incremental value of cardiac magnetic resonance imaging in left ventricular hypertrophy EP - 168 SN - 1568-5888 IS - iss. 3 SP - 167 JF - Netherlands Heart Journal VL - vol. 26 DO - https://doi.org/10.1007/s12471-017-1069-x L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/190547/190547.pdf?sequence=1 ER - TY - JOUR AU - Panhuyzen-Goedkoop, N.M. AU - Wellens, H.J. AU - Piek, J.J. PY - 2018 UR - https://hdl.handle.net/2066/189819 TI - Early recognition of sudden cardiac arrest in athletes during sports activity EP - 25 SN - 1568-5888 IS - iss. 1 SP - 21 JF - Netherlands Heart Journal VL - vol. 26 DO - https://doi.org/10.1007/s12471-017-1061-5 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/189819/189819.pdf?sequence=1 ER - TY - JOUR AU - Panhuyzen-Goedkoop, N.M. AU - Wellens, H.J. AU - Piek, J.J. PY - 2018 UR - https://hdl.handle.net/2066/190462 TI - Reply to the letter from A. Zorzi and D. Corrado. Rhythm analysis with an AED in an unconscious athlete EP - 228 SN - 1568-5888 IS - iss. 4 SP - 228 JF - Netherlands Heart Journal VL - vol. 26 DO - https://doi.org/10.1007/s12471-018-1100-x L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/190462/190462.pdf?sequence=1 ER - TY - JOUR AU - Panhuyzen-Goedkoop, N.M. AU - Jorstad, H.T. AU - Smeets, J.L.R.M. PY - 2018 UR - https://hdl.handle.net/2066/190474 AB - Sudden cardiac arrest or death (SCA/SCD) in athletes has a low event rate. Pre-participation or eligibility screening is a widely accepted method of primary prevention of SCA/SCD in athletes. Most European countries and international sports governing bodies perform ECG-inclusive screening. However, implementation of a resting 12-lead ECG in pre-participation or eligibility cardiac screening is still a topic of debate. Recently, the 'International recommendations for electrocardiographic interpretation in athletes' was published in three leading international medical journals. These international ECG criteria are based on studies with detailed information on resting 12-lead ECG of Caucasian and Afro-Caribbean athletes or on consensus in case evidence was lacking. Normal, borderline and abnormal ECG findings in young athletes (age 12-35 years) are clearly described and illustrated to assist the screening physician in interpreting ECGs of athletes correctly.In this 'point of view paper' we will discuss whether these new ECG criteria actually help prevent SCA/SCD in athletes. TI - A new consensus document on electrocardiographic interpretation in athletes: does it help to prevent sudden cardiac death in athletes? EP - 132 SN - 1568-5888 IS - iss. 3 SP - 127 JF - Netherlands Heart Journal VL - vol. 26 DO - https://doi.org/10.1007/s12471-018-1076-6 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/190474/190474.pdf?sequence=1 ER - TY - JOUR AU - Panhuyzen-Goedkoop, N.M. AU - Wilde, A.A. PY - 2018 UR - https://hdl.handle.net/2066/190356 AB - The European and Bethesda recommendations roughly state that any athlete with channelopathy is not eligible to participate in sports on a presumed risk of potentially life-threatening ventricular tachycardia or fibrillation. However, eligibility decision-making on a presumed risk of ventricular tachycardia or fibrillation is debatable. Channelopathies are primary electrical cardiac disorders and are usually transmitted as an autosomal dominant trait. Some of the channelopathies are potentially fatal in relation to exercise and predispose to life-threatening cardiac arrhythmias including ventricular tachycardia or fibrillation. Exercise, swimming, body heating and electrolyte depletion can all act as a trigger of ventricular tachycardia or fibrillation in channelopathy. However, new research mentioned a very low incidence of ventricular tachycardia or fibrillation in athletes with channelopathy challenging the decision of disqualification. Recently, the American recommendations for sports participation in athletes with a cardiovascular disorder have updated their eligibility decision-making.In this manuscript we describe the signature features of the electrocardiogram changes in channelopathies and we argue that new research data should allow for the introduction of more liberal eligibility decision-making for sports participation in athletes with channelopathy, not only in the United States but also in European countries. TI - Athletes with channelopathy may be eligible to play EP - 153 SN - 1568-5888 IS - iss. 3 SP - 146 JF - Netherlands Heart Journal VL - vol. 26 DO - https://doi.org/10.1007/s12471-018-1077-5 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/190356/190356.pdf?sequence=1 ER - TY - JOUR AU - Kikkert, W.J. AU - Damman, P. PY - 2018 UR - https://hdl.handle.net/2066/193247 AB - The optimal duration of dual antiplatelet therapy (DAPT) for stable coronary artery disease and acute coronary syndrome is a complex decision. We review current literature on standard duration DAPT versus short duration DAPT (6 months or shorter) or extended duration DAPT (>12 months) after percutaneous coronary intervention with drug-eluting stent placement, and prolonged treatment after 12 months in acute coronary syndrome. Current guideline recommendations are summarised, including the use of risk scores for ischaemic and bleeding risk assessment. Because of the limitations of current risk scores, we propose multiple patient-related and procedure-related factors for the ischaemic and bleeding risk assessment aiding in personalised DAPT duration. TI - Optimal duration of dual antiplatelet therapy for coronary artery disease EP - 333 SN - 1568-5888 IS - iss. 6 SP - 321 JF - Netherlands Heart Journal VL - vol. 26 DO - https://doi.org/10.1007/s12471-018-1113-5 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/193247/193247.pdf?sequence=1 ER - TY - JOUR AU - Panhuyzen-Goedkoop, N.M. AU - Piek, J.J. PY - 2018 UR - https://hdl.handle.net/2066/193259 TI - Resuscitation on the pitch with cardiac massage and on-site AED SN - 1568-5888 IS - iss. 5 SP - 286 JF - Netherlands Heart Journal VL - vol. 26 DO - https://doi.org/10.1007/s12471-018-1109-1 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/193259/193259.pdf?sequence=1 ER - TY - JOUR AU - Arslan, F. AU - Bongartz, L.G. AU - Berg, J.M. ten AU - Jukema, J.W. AU - Appelman, Y. AU - Liem, A.H. AU - Hof, A.W.J. van ’t AU - Damman, P. PY - 2018 UR - https://hdl.handle.net/2066/195247 TI - 2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: comments from the Dutch ACS working group EP - 421 SN - 1568-5888 IS - iss. 9 SP - 417 JF - Netherlands Heart Journal VL - vol. 26 DO - https://doi.org/10.1007/s12471-018-1134-0 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/195247/195247.pdf?sequence=1 ER - TY - JOUR AU - IJsselmuiden, A.J.J. AU - Zwaan, E.M. AU - Oemrawsingh, R.M. AU - Bom, M.J. AU - Dankers, F.J.W.M. AU - Boer, M.J. de AU - Camaro, C. AU - Geuns, R.J.M. van AU - Daemen, J. AU - Heijden, D.J. van der AU - Jukema, J.W. AU - Kraaijeveld, A.O. AU - Meuwissen, M. AU - Scholzel, B.E. AU - Pundziute, G. AU - Harst, P. van der AU - Ramshorst, J. van AU - Dirksen, M.T. AU - Zivelonghi, C. AU - Agostoni, P. AU - Heyden, J.A.S. Van der AU - Wykrzykowska, J.J. AU - Scholte, M.J. AU - Nef, H.M. AU - Kofflard, M.J.M. AU - Royen, N. van AU - Alings, M. AU - Kedhi, E. PY - 2018 UR - https://hdl.handle.net/2066/196083 AB - INTRODUCTION: Optical coherence tomography (OCT) enables detailed imaging of the coronary wall, lumen and intracoronary implanted devices. Responding to the lack of specific appropriate use criteria (AUC) for this technique, we conducted a literature review and a procedure for appropriate use criteria. METHODS: Twenty-one of all 184 members of the Dutch Working Group on Interventional Cardiology agreed to evaluate 49 pre-specified cases. During a meeting, factual indications were established whereupon members individually rated indications on a 9-point scale, with the opportunity to substantiate their scoring. RESULTS: Twenty-six indications were rated 'Appropriate', eighteen indications 'May be appropriate', and five 'Rarely appropriate'. Use of OCT was unanimously considered 'Appropriate' in stent thrombosis, and 'Appropriate' for guidance in PCI, especially in distal left main coronary artery and proximal left anterior descending coronary artery, unexplained angiographic abnormalities, and use of bioresorbable vascular scaffold (BVS). OCT was considered 'Rarely Appropriate' on top of fractional flow reserve (FFR) for treatment indication, assessment of strut coverage, bypass anastomoses or assessment of proximal left main coronary artery. CONCLUSIONS: The use of OCT in stent thrombosis is unanimously considered 'Appropriate' by these experts. Varying degrees of consensus exists on the appropriate use of OCT in other settings. TI - Appropriate use criteria for optical coherence tomography guidance in percutaneous coronary interventions : Recommendations of the working group of interventional cardiology of the Netherlands Society of Cardiology EP - 483 SN - 1568-5888 IS - iss. 10 SP - 473 JF - Netherlands Heart Journal VL - vol. 26 PS - 11 p. DO - https://doi.org/10.1007/s12471-018-1143-z L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/196083/196083.pdf?sequence=1 ER - TY - JOUR AU - Hofmeijer, J. AU - Hemels, M.E.W. PY - 2018 UR - https://hdl.handle.net/2066/196259 TI - Recovery after cardiac arrest: the brain is the heart of the matter EP - 485 SN - 1568-5888 IS - iss. 10 SP - 484 JF - Netherlands Heart Journal VL - vol. 26 DO - https://doi.org/10.1007/s12471-018-1156-7 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/196259/196259.pdf?sequence=1 ER - TY - JOUR AU - Nguyen, U.C. AU - Cluitmans, M.J.M. AU - Luermans, J.G.L.M. AU - Strik, M. AU - Vos, C.B. de AU - Kietselaer, B.L.J.H. AU - Mihl, C. AU - Vernooy, K. PY - 2018 UR - https://hdl.handle.net/2066/196192 TI - Visualisation of coronary venous anatomy by computed tomography angiography prior to cardiac resynchronisation therapy implantation EP - 440 SN - 1568-5888 IS - iss. 9 SP - 433 JF - Netherlands Heart Journal VL - vol. 26 DO - https://doi.org/10.1007/s12471-018-1132-2 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/196192/196192.pdf?sequence=1 ER - TY - JOUR AU - Nas, J. AU - Thannhauser, J. AU - Herrmann, J.J. AU - Wulp, K. van der AU - Grunsven, P.M. van AU - Royen, N. van AU - Boer, M.J. de AU - Bonnes, J.L. AU - Brouwer, M.A. PY - 2018 UR - https://hdl.handle.net/2066/199441 TI - Changes in automated external defibrillator use and survival after out-of-hospital cardiac arrest in the Nijmegen area EP - 605 SN - 1568-5888 IS - iss. 12 SP - 600 JF - Netherlands Heart Journal VL - vol. 26 DO - https://doi.org/10.1007/s12471-018-1162-9 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/199441/199441.pdf?sequence=1 ER - TY - JOUR AU - Maass, A.H. AU - Hemels, M.E.W. AU - Allaart, C.P. PY - 2018 UR - https://hdl.handle.net/2066/199487 TI - Magnetic resonance imaging in patients with cardiac implantable electronic devices EP - 590 SN - 1568-5888 IS - iss. 12 SP - 584 JF - Netherlands Heart Journal VL - vol. 26 DO - https://doi.org/10.1007/s12471-018-1192-3 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/199487/199487.pdf?sequence=1 ER - TY - JOUR AU - Boulaksil, M. AU - Gevers, R.M. PY - 2017 UR - https://hdl.handle.net/2066/169657 TI - Enlarged jugular veins EP - 281 SN - 1568-5888 IS - iss. 4 SP - 280 JF - Netherlands Heart Journal VL - vol. 25 DO - https://doi.org/10.1007/s12471-016-0940-5 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/169657/169657.pdf?sequence=1 ER - TY - JOUR AU - Hemels, M.E.W. PY - 2017 UR - https://hdl.handle.net/2066/169693 TI - How to get a smoker addicted to quitting EP - 15 SN - 1568-5888 IS - iss. 1 SP - 14 JF - Netherlands Heart Journal VL - vol. 25 DO - https://doi.org/10.1007/s12471-016-0920-9 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/169693/169693.pdf?sequence=1 ER - TY - JOUR AU - Pisters, R. AU - Vugt, S.P.G. van AU - Brouwer, M.A. AU - Elvan, A. AU - Holt, W.L. ten AU - Zwart, P.A.G. AU - Crijns, H.J.G.M. AU - Hemels, M.E.W. PY - 2017 UR - https://hdl.handle.net/2066/179607 TI - Real-life use of Rivaroxaban in the Netherlands: data from the Xarelto for Prevention of Stroke in Patients with Atrial Fibrillation (XANTUS) registry EP - 558 SN - 1568-5888 IS - iss. 10 SP - 551 JF - Netherlands Heart Journal VL - vol. 25 DO - https://doi.org/10.1007/s12471-017-1009-9 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/179607/179607.pdf?sequence=1 ER - TY - JOUR AU - Everaert, B. AU - Wykrzykowska, J.J. AU - Koolen, J. AU - Harst, P. van der AU - Heijer, P. AU - Henriques, J.P. AU - Schaaf, R. AU - Smet, B. de AU - Hofma, S.H. AU - Diletti, R. AU - Weevers, A. AU - Hoorntje, J. AU - Smits, P. AU - Geuns, R.J.M. van PY - 2017 UR - https://hdl.handle.net/2066/182904 AB - BACKGROUND: To eliminate some of the potential late limitations of permanent metallic stents, the bioresorbable coronary stents or 'bioresorbable vascular scaffolds' (BVS) have been developed. METHODS: We reviewed all currently available clinical data on BVS implantation. RESULTS: Since the 2015 position statement on the appropriateness of BVS in percutaneous coronary interventions, several large randomised trials have been presented. These have demonstrated that achieving adequate 1 and 2 year outcomes with these first-generation BVS is not straightforward. These first adequately powered studies in non-complex lesions showed worse results if standard implantation techniques were used for these relatively thick scaffolds. Post-hoc analyses hypothesise that outcomes similar to current drug-eluting stents are still possible if aggressive lesion preparation, adequate sizing and high-pressure postdilatation are implemented rigorously. As long as this has not been confirmed in prospective studies the usage should be restricted to experienced centres with continuous outcome monitoring. For more complex lesions, results are even more disappointing and usage should be discouraged. When developed, newer generation scaffolds with thinner struts or faster resorption rates are expected to improve outcomes. In the meantime prolonged dual antiplatelet therapy (DAPT, beyond one year) is recommended in an individualised approach for patients treated with current generation BVS. CONCLUSION: The new 2017 recommendations downgrade and limit the use of the current BVS to experienced centres within dedicated registries using the updated implantation protocol and advise the prolonged usage of DAPT. In line with these recommendations the manufacturer does not supply devices to the hospitals without such registries in place. TI - Recommendations for the use of bioresorbable vascular scaffolds in percutaneous coronary interventions : 2017 revision EP - 428 SN - 1568-5888 IS - iss. 7-8 SP - 419 JF - Netherlands Heart Journal VL - vol. 25 DO - https://doi.org/10.1007/s12471-017-1014-z L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/182904/182904.pdf?sequence=1 ER - TY - JOUR AU - Panhuyzen-Goedkoop, N.M. AU - Piek, J.J. PY - 2017 UR - https://hdl.handle.net/2066/182908 TI - Resuscitation on the pitch EP - 604 SN - 1568-5888 IS - iss. 11 SP - 603 JF - Netherlands Heart Journal VL - vol. 25 DO - https://doi.org/10.1007/s12471-017-1043-7 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/182908/182908.pdf?sequence=1 ER - TY - JOUR AU - Waard, G.A. de AU - Royen, N. van PY - 2017 UR - https://hdl.handle.net/2066/182922 TI - Statins; the panacea of cardiovascular disease EP - 230 SN - 1568-5888 IS - iss. 4 SP - 229 JF - Netherlands Heart Journal VL - vol. 25 DO - https://doi.org/10.1007/s12471-017-0967-2 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/182922/182922.pdf?sequence=1 ER - TY - JOUR AU - Rahhab, Z. AU - Kortlandt, F.A. AU - Velu, J.F. AU - Schurer, R.A.J. AU - Delgado, V. AU - Tonino, P. AU - Boven, A.J. van AU - Branden, B.J.L. Van den AU - Kraaijeveld, A.O. AU - Voskuil, M. AU - Hoorntje, J. AU - Wely, M.H. van AU - Houwelingen, K. van AU - Bleeker, G.B. AU - Rensing, B. AU - Kardys, I. AU - Baan, J., Jr. AU - Heyden, J.A.S. Van der AU - Mieghem, N.M. van PY - 2017 UR - https://hdl.handle.net/2066/182726 AB - PURPOSE: Data on MitraClip procedural safety and efficacy in the Netherlands are scarce. We aim to provide an overview of the Dutch MitraClip experience. METHODS: We pooled anonymised demographic and procedural data of 1151 consecutive MitraClip patients, from 13 Dutch hospitals. Data was collected by product specialists in collaboration with local operators. Effect on mitral regurgitation was intra-procedurally assessed by transoesophageal echocardiography. Technical success and device success were defined according to modified definitions of the Mitral Valve Academic Research Consortium (MVARC). RESULTS: Median age was 76 (interquartile range 69-82) years and 59% were males. Patients presented with >/=moderate mitral regurgitation and a predominance of functional mitral regurgitation (72%). Overall, 611 (53%) patients were treated with one Clip, 486 (42%) with >/=2 Clips and 54 (5%) received no Clip. The number of patients with >/=2 Clips increased from 22% in 2009 to 52% in 2016. Device success and technical success were 91 and 95%, respectively, and were consistent over the years. Significant reduction of mitral regurgitation by MitraClip was achieved in 94% of patients and was observed more often in patients with functional mitral regurgitation (95% vs. 91%, p = 0.025). Device time declined from 145 min in 2009 to 55 min in 2016. CONCLUSION: MitraClip experience in the Netherlands is growing with excellent technical success and device success. Over the years, device time decreased and more patients were treated with >/=2 Clips. TI - Current MitraClip experience, safety and feasibility in the Netherlands EP - 400 SN - 1568-5888 IS - iss. 6 SP - 394 JF - Netherlands Heart Journal VL - vol. 25 DO - https://doi.org/10.1007/s12471-017-0992-1 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/182726/182726.pdf?sequence=1 ER - TY - JOUR AU - Verheugt, F.W.A. PY - 2017 UR - https://hdl.handle.net/2066/176877 TI - Antiplatelet therapy with CABG: chaos in the Netherlands EP - 481 SN - 1568-5888 IS - iss. 9 SP - 481 JF - Netherlands Heart Journal VL - vol. 25 DO - https://doi.org/10.1007/s12471-017-1031-y L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/176877/176877.pdf?sequence=1 ER - TY - JOUR AU - Joustra, R. AU - Boulaksil, M. AU - Meijburg, H.W. AU - Smeets, J.L. PY - 2017 UR - https://hdl.handle.net/2066/176992 TI - Dizziness and slow heart rate during exercise EP - 466 SN - 1568-5888 IS - iss. 7-8 SP - 465 JF - Netherlands Heart Journal VL - vol. 25 DO - https://doi.org/10.1007/s12471-017-0985-0 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/176992/176992.pdf?sequence=1 ER - TY - JOUR AU - Amier, R.P. AU - Loon, R.B. van AU - Meijboom, L.J. AU - Nijveldt, R. PY - 2017 UR - https://hdl.handle.net/2066/177038 TI - I spy with my MRI: Cause of complete heart block in a young patient revealed EP - 404 SN - 1568-5888 IS - iss. 6 SP - 403 JF - Netherlands Heart Journal VL - vol. 25 DO - https://doi.org/10.1007/s12471-017-0997-9 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/177038/177038.pdf?sequence=1 ER - TY - JOUR AU - Schellings, D.A.A.M. AU - Hof, A.W. van 't AU - Berg, J.M. van den AU - Elvan, A. AU - Giannitsis, E. AU - Hamm, C. AU - Suryapranata, H. AU - Adiyaman, A. PY - 2017 UR - https://hdl.handle.net/2066/169760 AB - BACKGROUND: The Zwolle Risk Score (ZRS) identifies primary percutaneous coronary intervention (PPCI) patients at low mortality risk, eligible for early discharge. Recently, this score was improved by adding baseline NT-proBNP. However, the optimal timepoint for NT-proBNP measurement is unknown. METHODS: PPCI patients in the On-Time 2 study were candidates. The ZRS and NT-proBNP levels on admission, at 18-24 h, at 72-96 h, and the change in NT-proBNP from baseline to 18-24 h (delta NT-proBNP) were determined. We investigated whether addition of the different NT-proBNP measurements to the ZRS improves the prediction of 30-day mortality. Based on cut-off values reflecting zero mortality at 30 d, patients who potentially could be discharged early were identified and occurrence of major adverse cardiac events (MACE) and major bleeding until 10 d was registered. RESULTS: 845 patients were included. On multivariate analyses, NT-proBNP at baseline (HR 2.09, 95% CI 1.59-2.74, p < 0.001), at 18-24 h (HR 6.83, 95% CI 2.94-15.84), and at 72-96 h (HR 3.32, 95% CI 1.22-9.06) independently predicted death at 30 d. Addition of NT-proBNP to the ZRS improved prediction of mortality, particularly at 18-24 h (net reclassification index 29%, p < 0.0001, integrated discrimination improvement 17%, p < 0.0001). Based on ZRS (<2) or NT-proBNP at 18-24 h (<2500 pg/ml) 75% of patients could be targeted for early discharge at 48 h, with expected re-admission rates of 1.2% due to MACE and/or major bleeding. CONCLUSIONS: NT-proBNP at different timepoints improves prognostication of the ZRS. Particularly at 18-24 h post PPCI, the largest group of patients that potentially could be discharged early was identified. TI - NT-proBNP during and after primary PCI for improved scheduling of early hospital discharge EP - 249 SN - 1568-5888 IS - iss. 4 SP - 243 JF - Netherlands Heart Journal VL - vol. 25 DO - https://doi.org/10.1007/s12471-016-0935-2 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/169760/169760.pdf?sequence=1 ER - TY - JOUR AU - Berndt, N. AU - Vries, H. de AU - Lechner, L. AU - Acker, F. Van AU - Froelicher, E.S. AU - Verheugt, F.W. AU - Mudde, A. AU - Bolman, C. PY - 2017 UR - https://hdl.handle.net/2066/169686 AB - BACKGROUND: Without assistance, smokers being admitted to the hospital for coronary heart disease often return to regular smoking within a year. OBJECTIVE: This study assessed the 12-month effectiveness of a telephone and a face-to-face counselling intervention on smoking abstinence among cardiac patients. Differential effects for subgroups varying in their socioeconomic status and intention to quit smoking were also studied. METHODS: A randomised controlled trial was used. During hospital stay, smokers hospitalised for coronary heart disease were assigned to usual care (n = 245), telephone counselling (n = 223) or face-to-face counselling (n = 157). Eligible patients were allocated to an intervention counselling group and received nicotine patches. After 12 months, self-reported continued abstinence was assessed and biochemically verified in quitters. Effects on smoking abstinence were tested using multilevel logistic regression analyses applying the intention-to-treat approach. RESULTS: Compared with usual care, differential effects of telephone and face-to-face counselling on continued abstinence were found in patients with a low socioeconomic status and in patients with a low quit intention. For these patients, telephone counselling increased the likelihood of abstinence threefold (OR = 3.10, 95 % CI 1.32-7.31, p = 0.01), whereas face-to-face counselling increased this likelihood fivefold (OR = 5.30, 95 % CI 2.13-13.17, p < 0.001). Considering the total sample, the interventions did not result in stronger effects than usual care. CONCLUSION: Post-discharge telephone and face-to-face counselling interventions increased smoking abstinence rates at 12 months compared with usual care among cardiac patients of low socioeconomic status and low quit intentions. The present study indicates that patients of high socioeconomic status and high quit motivation require different cessation approaches. TI - High intensity smoking cessation interventions: Cardiac patients of low socioeconomic status and low intention to quit profit most EP - 32 SN - 1568-5888 IS - iss. 1 SP - 24 JF - Netherlands Heart Journal VL - vol. 25 DO - https://doi.org/10.1007/s12471-016-0906-7 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/169686/169686.pdf?sequence=1 ER - TY - JOUR AU - Boulaksil, M. AU - Meuwese, C.L. AU - Evertz, R. AU - Kolff-Kamphuis, M.G.M. PY - 2017 UR - https://hdl.handle.net/2066/182256 TI - Broad complex rhythm with a salty taste EP - 351 SN - 1568-5888 IS - iss. 5 SP - 350 JF - Netherlands Heart Journal VL - vol. 25 DO - https://doi.org/10.1007/s12471-017-0951-x L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/182256/182256.pdf?sequence=1 ER - TY - JOUR AU - Joustra, R. AU - Polderman, F.N. AU - Smeets, J.L. AU - Daniels, M.C. AU - Boulaksil, M. PY - 2017 UR - https://hdl.handle.net/2066/169867 TI - Typical ECG findings in an unconscious patient EP - 222 SN - 1568-5888 IS - iss. 3 SP - 221 JF - Netherlands Heart Journal VL - vol. 25 DO - https://doi.org/10.1007/s12471-016-0910-y L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/169867/169867.pdf?sequence=1 ER - TY - JOUR AU - Riel, A.C. van AU - Schuuring, M.J. AU - Hessen, I.D. van AU - Dijk, A.P.J. van AU - Hoendermis, E.S. AU - Yip, J.W. AU - Mulder, B.J. AU - Bouma, B.J. PY - 2016 UR - https://hdl.handle.net/2066/171851 AB - BACKGROUND: Advanced treatment of pulmonary arterial hypertension (PAH) in congenital heart disease (CHD) is increasingly applied worldwide following the-mainly Western world based-international PAH-CHD guidelines. However, studies comparing clinical presentation and outcome after the initiation of PAH-specific treatment are lacking. We aimed to analyse this in a Singaporean and Dutch cohort of PAH-CHD patients. METHODS: Adult CHD patients starting PAH-specific therapy, enrolled in two nationwide registries, were analysed. Patients received phosphodiesterase-type-5 inhibitors, endothelin receptor antagonists, or a combination. Change in six-minute walk test (6MWT) during follow-up was analysed using linear mixed model analysis. Determinants for mortality were assessed using Cox proportional hazard analyses. RESULTS: A total of 74 patients, 45 Dutch (mean age 47 +/- 14 years) and 29 Singaporean (mean age 41 +/- 14 years) were analysed. Despite a lower 6MWT (312 versus 395 metres, p = 0.01) and peak VO2 (35 versus 49 % of predicted, p = 0.01) at baseline in Singaporean patients, the treatment effect was similar in the two populations. Age at initiation of therapy (per 5 year lower age, beta = + 4.5, p = 0.017) was the strongest predictor of improvement in exercise capacity, corrected for ethnicity, baseline 6MWT, sex and CHD defect. CONCLUSIONS: Patients from Singapore had a worse clinical performance at baseline compared with the PAH-CHD patients from the Netherlands. No relation between ethnicity and improvement in 6MWT after PAH-specific therapy was found. Age at initiation of PAH-specific therapy was the strongest predictor of treatment efficacy and mortality, emphasising the need for early initiation of treatment in these patients. TI - Treatment of pulmonary arterial hypertension in congenital heart disease in Singapore versus the Netherlands: age exceeds ethnicity in influencing clinical outcome EP - 416 SN - 1568-5888 IS - iss. 6 SP - 410 JF - Netherlands Heart Journal VL - vol. 24 DO - https://doi.org/10.1007/s12471-016-0820-z L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/171851/171851.pdf?sequence=1 ER - TY - JOUR AU - Post, M.C. AU - Dijk, A.P.J. van AU - Hoendermis, E.S. AU - Bogaard, H.J. AU - Empel, V. Van AU - Boomars, K.A. PY - 2016 UR - https://hdl.handle.net/2066/171308 TI - PulmoCor: national registry for pulmonary hypertension EP - 430 SN - 1568-5888 IS - iss. 6 SP - 425 JF - Netherlands Heart Journal VL - vol. 24 DO - https://doi.org/10.1007/s12471-016-0830-x L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/171308/171308.pdf?sequence=1 ER - TY - JOUR AU - Hartog, A.W. den AU - Franken, R. AU - Berg, M.P. AU - Zwinderman, A.H. AU - Timmermans, J. AU - Scholte, A.J. AU - Waard, V. de AU - Spijkerboer, A.M. AU - Pals, G. AU - Mulder, B.J. AU - Groenink, M. PY - 2016 UR - https://hdl.handle.net/2066/171721 AB - BACKGROUND: Mild biventricular dysfunction is often present in patients with Marfan syndrome. Losartan has been shown to reduce aortic dilatation in patients with Marfan syndrome. This study assesses the effect of losartan on ventricular volume and function in genetically classified subgroups of asymptomatic Marfan patients without significant valvular regurgitation. METHODS: In this predefined substudy of the COMPARE study, Marfan patients were classified based on the effect of their FBN1 mutation on fibrillin-1 protein, categorised as haploinsufficient or dominant negative. Patients were randomised to a daily dose of losartan 100 mg or no additional treatment. Ventricular volumes and function were measured by magnetic resonance imaging at baseline and after 3 years of follow-up. RESULTS: Changes in biventricular dimensions were assessed in 163 Marfan patients (48 % female; mean age 38 +/- 13 years). In patients with a haploinsufficient FBN1 mutation (n = 43), losartan therapy (n = 19) increased both biventricular end diastolic volume (EDV) and stroke volume (SV) when compared with no additional losartan (n = 24): left ventricular EDV: 9 +/- 26 ml vs. -8 +/- 24 ml, p = 0.035 and right ventricular EDV 12 +/- 23 ml vs. -18 +/- 24 ml; p < 0.001 and for left ventricle SV: 6 +/- 16 ml vs. -8 +/- 17 ml; p = 0.009 and right ventricle SV: 8 +/- 16 ml vs. -7 +/- 19 ml; p = 0.009, respectively. No effect was observed in patients with a dominant negative FBN1 mutation (n = 92), or without an FBN1 mutation (n = 28). CONCLUSION: Losartan therapy in haploinsufficient Marfan patients increases biventricular end diastolic volume and stroke volume, furthermore, losartan also appears to ameliorate biventricular filling properties. TI - The effect of losartan therapy on ventricular function in Marfan patients with haploinsufficient or dominant negative FBN1 mutations EP - 681 SN - 1568-5888 IS - iss. 11 SP - 675 JF - Netherlands Heart Journal VL - vol. 24 DO - https://doi.org/10.1007/s12471-016-0905-8 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/171721/171721.pdf?sequence=1 ER - TY - JOUR AU - Oosterwerff, E.F. AU - Fagel, N.D. AU - Slagboom, T. AU - Tijssen, J.G. AU - Herrman, J.P. AU - Smits, P.C. AU - Suttorp, M.J. AU - Ronner, E. AU - Laarman, G.J. AU - Patterson, M.S. AU - Amoroso, G. AU - Vink, M.A. AU - Schaaf, R.J. van der AU - Verheugt, F.W. AU - Riezebos, R.K. PY - 2016 UR - https://hdl.handle.net/2066/172759 AB - BACKGROUND: The OPTIMA trial was a randomised multicentre trial exploring the influence of the timing of percutaneous coronary intervention (PCI) on patient outcomes in an intermediate to high risk non-ST-elevation acute coronary syndrome (NSTE-ACS) population. In order to decide the best treatment strategy for patients presenting with NSTE-ACS, long-term outcomes are essential. METHODS: Five-year follow-up data from 133 of the 142 patients could be retrieved (94 %). The primary endpoint was a composite of death and spontaneous myocardial infarction (MI). Spontaneous MI was defined as MI occurring more than 30 days after randomisation. Secondary endpoints were the individual outcomes of death, spontaneous MI or re-PCI. RESULTS: No significant difference with respect to the primary endpoint was observed (17.8 vs. 10.1 %; HR 1.55, 95 % CI: 0.73-4.22, p = 0.21). There was no significant difference in mortality rate. However, spontaneous MI was significantly more common in the group receiving immediate PCI (11.0 vs. 1.4 %; HR 4.46, 95 % CI: 1.21-16.50, p = 0.02). We did not find a significant difference between the groups with respect to re-PCI rate. CONCLUSION: There was no difference in the composite of death and spontaneous MI. The trial suggests an increased long-term risk of spontaneous MI for patients treated with immediate PCI. TI - Impact of percutaneous coronary intervention timing on 5-year outcome in patients with non-ST-segment elevation acute coronary syndromes. The 'wait a day' approach might be safer EP - 180 SN - 1568-5888 IS - iss. 3 SP - 173 JF - Netherlands Heart Journal VL - vol. 24 DO - https://doi.org/10.1007/s12471-016-0803-0 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/172759/172759.pdf?sequence=1 ER - TY - JOUR AU - Schoonbeek, R.C. AU - Pieper, P.G. AU - Slooten, Y.J. van AU - Freling, H.G. AU - Sieswerda, G.T. AU - Dijk, A.P.J. van AU - Jongbloed, M.R. AU - Post, M.C. AU - Bouma, B.J. AU - Berger, R.M. AU - Ebels, T. AU - Melle, J.P. van PY - 2016 UR - https://hdl.handle.net/2066/171019 AB - OBJECTIVES: N-terminal Btype natriuretic peptide (NT-proBNP) is an important biomarker for the detection of heart failure. Adults with congenital heart disease (ACHD) and a prosthetic heart valve are at risk for heart failure. This study aimed to determine the value of NT-proBNP in ACHD patients with a prosthetic valve and investigate its relationship with cardiac function and exercise capacity. METHODS: In this multi-centre cross-sectional observational study, data regarding medical history, echocardiography, exercise testing (VO2peak) and laboratory blood evaluation (including NT-proBNP) were collected in ACHD patients with a single prosthetic valve (either homografts, heterografts or mechanical valves). RESULTS: A total of 306 ACHD patients with pulmonary valve replacement (PVR, n = 139), aortic valve replacement (n = 141), mitral valve replacement (n = 21) or tricuspid valve replacement (n = 5) were investigated. The majority of patients (77 %) were in NYHA class I or II. Elevated NT-proBNP levels (cut-off >/=125 pg/ml) were found in 50 % of the patients, with the highest levels in patients with mitral valve replacements. In this study population, NT-proBNP levels were associated with gender (p = 0.029) and VO2max (p < 0.001). In PVR patients, NT-proBNP levels were associated with lower VO2peak, also after adjustment for age, gender and age at valve replacement in a multivariate model (p = 0.015). CONCLUSIONS: In patients with ACHD and a prosthetic valve, elevated NT-proBNP levels are frequently observed despite preserved NYHA class. In PVR patients, a higher NT-proBNP level was associated with a lower VO2peak. These results may be of importance in the ongoing discussion about the timing of valve replacement in patients with CHD. TI - NT-proBNP and exercise capacity in adult patients with congenital heart disease and a prosthetic valve: a multicentre PROSTAVA study EP - 665 SN - 1568-5888 IS - iss. 11 SP - 653 JF - Netherlands Heart Journal VL - vol. 24 DO - https://doi.org/10.1007/s12471-016-0896-5 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/171019/171019.pdf?sequence=1 ER - TY - JOUR AU - Baggen, V.J. AU - Driessen, M.M.P. AU - Post, M.C. AU - Dijk, A.P.J. van AU - Roos-Hesselink, J.W. AU - Bosch, A.E. van den AU - Takkenberg, J.J. AU - Sieswerda, G.T. PY - 2016 UR - https://hdl.handle.net/2066/172394 AB - BACKGROUND: Identification of patients at risk of deterioration is essential to guide clinical management in pulmonary arterial hypertension (PAH). This study aims to provide a comprehensive overview of well-investigated echocardiographic findings that are associated with clinical deterioration in PAH. METHODS: MEDLINE and EMBASE databases were systematically searched for longitudinal studies published by April 2015 that reported associations between echocardiographic findings and mortality, transplant or clinical worsening. Meta-analysis using random effect models was performed for echocardiographic findings investigated by four or more studies. In case of statistical heterogeneity a sensitivity analysis was conducted. RESULTS: Thirty-seven papers investigating 51 echocardiographic findings were included. Meta-analysis of univariable hazard ratios (HRs) and sensitivity analysis showed that presence of pericardial effusion (pooled HR 1.70; 95 % CI 1.44-1.99), right atrial area (pooled HR 1.71; 95 % CI 1.38-2.13) and tricuspid annular plane systolic excursion (TAPSE; pooled HR 1.72; 95 % CI 1.34-2.20) were the most well-investigated and robust predictors of mortality or transplant. CONCLUSIONS: This meta-analysis substantiates the clinical yield of specific echocardiographic findings in the prognostication of PAH patients in day-to-day practice. In particular, pericardial effusion, right atrial area and TAPSE are of prognostic value. TI - Echocardiographic findings associated with mortality ortransplant in patients with pulmonary arterial hypertension:A systematic review and meta-analysis EP - 389 SN - 1568-5888 IS - iss. 6 SP - 374 JF - Netherlands Heart Journal VL - vol. 24 DO - https://doi.org/10.1007/s12471-016-0845-3 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/172394/172394.pdf?sequence=1 ER - TY - JOUR AU - Gommans, D.H.F. AU - Bakker, J. AU - Cramer, G.E. AU - Verheugt, F.W.A. AU - Brouwer, M.A. AU - Kofflard, M.J.M. PY - 2016 UR - https://hdl.handle.net/2066/172762 AB - PURPOSE: The use of cardiac magnetic resonance (CMR) analysis has increased in patients with hypertrophic cardiomyopathy (HCM). Quantification of left ventricular (LV) measures will be affected by the inclusion or exclusion of the papillary muscles as part of the LV mass, but the magnitude of effect and potential consequences are unknown. METHODS: We performed Cine-CMR in (1) clinical HCM patients (n = 55) and (2) subclinical HCM mutation carriers without hypertrophy (n = 14). Absolute and relative differences in LV ejection fraction (EF) and mass were assessed between algorithms with and without inclusion of the papillary muscles. RESULTS: Papillary muscle mass in group 1 was 6.6 +/- 2.5 g/m(2) and inclusion of the papillary muscles resulted in significant relative increases in LVEF of 4.5 +/- 1.8 % and in LV mass of 8.7 +/- 2.6 %. For group 2 these figures were 4.0 +/- 0.9 g/m(2), 3.8 +/- 1.0 % and 9.5 +/- 1.8 %, respectively. With a coefficient of variation of 4 %, this 9 % difference in LV mass during CMR follow-up will be considered a change, while in fact the exact same mass may have been assessed according to two different algorithms. CONCLUSIONS: In clinical HCM patients, CMR quantification of important LV measures is significantly affected by inclusion or exclusion of the papillary muscles. In relative terms, the difference was similar in subjects without hypertrophy. This underscores a general need for a uniform approach in CMR image analysis. TI - Impact of the papillary muscles on cardiac magnetic resonance image analysis of important left ventricular parameters in hypertrophic cardiomyopathy EP - 331 SN - 1568-5888 IS - iss. 5 SP - 326 JF - Netherlands Heart Journal VL - vol. 24 DO - https://doi.org/10.1007/s12471-016-0805-y L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/172762/172762.pdf?sequence=1 ER - TY - JOUR AU - Joustra, R. AU - Boulaksil, M. AU - Meijburg, H.W. AU - Daniels, M.C. PY - 2016 UR - https://hdl.handle.net/2066/170870 TI - Left bundle branch block in serious hyperkalaemia: rate-dependency? EP - 560 SN - 1568-5888 IS - iss. 9 SP - 559 JF - Netherlands Heart Journal VL - vol. 24 DO - https://doi.org/10.1007/s12471-016-0865-z L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/170870/170870.pdf?sequence=1 ER - TY - JOUR AU - Joustra, R. AU - Kievit, P.C. AU - Verkroost, M.W. AU - Gehlmann, H.R. AU - Boer, M.J. de PY - 2016 UR - https://hdl.handle.net/2066/171682 TI - Ascending aorta perforation with cardiac tamponade 19 days after transcatheter aortic valve implantation EP - 622 SN - 1568-5888 IS - iss. 10 SP - 621 JF - Netherlands Heart Journal VL - vol. 24 DO - https://doi.org/10.1007/s12471-016-0867-x L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/171682/171682.pdf?sequence=1 ER - TY - JOUR AU - Teuwen, C.P. AU - Taverne, Y.J.H.J. AU - Houck, C. AU - Gotte, M. AU - Brundel, B.J. AU - Evertz, R. AU - Witsenburg, M. AU - Roos-Hesselink, J.W. AU - Bogers, A.J AU - Groot, N.M. de PY - 2016 UR - https://hdl.handle.net/2066/171611 AB - The prevalence of patients with congenital heart disease (CHD) has increased over the last century. As a result, the number of CHD patients presenting with late, postoperative tachyarrhythmias has increased as well. The aim of this review is to discuss the present knowledge on the mechanisms underlying both atrial and ventricular tachyarrhythmia in patients with CHD and the advantages and disadvantages of the currently available invasive treatment modalities. TI - Tachyarrhythmia in patients with congenital heart disease: inevitable destiny? EP - 170 SN - 1568-5888 IS - iss. 3 SP - 161 JF - Netherlands Heart Journal VL - vol. 24 DO - https://doi.org/10.1007/s12471-015-0797-z L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/171611/171611.pdf?sequence=1 ER - TY - JOUR AU - Blok, I.M. AU - Riel, A.C. van AU - Schuuring, M.J. AU - Duffels, M.G. AU - Vis, J.C. AU - Dijk, A.P.J. van AU - Hoendermis, E.S. AU - Mulder, B.J. AU - Bouma, B.J. PY - 2015 UR - https://hdl.handle.net/2066/154944 AB - BACKGROUND: Decrease in quality of life (QoL) in left-sided heart failure precedes poor survival, which can be reversed with exercise training. We investigated whether QoL is associated with mortality in pulmonary arterial hypertension due to congenital heart disease (PAH-CHD) patients. METHODS: In this observational study, PAH-CHD adults referred for PAH-specific therapy were included. QoL surveys (SF36) were recorded during 2 years of therapy. Based on shift in SF36 scores during this period, patients had either decreased or non-decreased QoL. Subsequently, the patients were followed for mortality. RESULTS: Thirty-nine PAH-CHD patients (mean age 42, 44 % male, 49 % Down's syndrome) were analysed. Following PAH-specific therapy, SF36 physical component summary (PCS) decreased in 13 (35-31 points, p = 0.001) and showed no decrease in 26 patients (34-43 points, mean values, p < 0.001). Post-initiation phase, median follow-up was 4.5 years, during which 12 deaths occurred (31 %), 10 (56 %) in the decreased and 2 (10 %) in the non-decreased group (p = 0.002). Cox regression showed a decrease in SF36 PCS predicted mortality (HR 3.4, 95 % CI 1.03-11, p = 0.045). CONCLUSIONS: In PAH-CHD patients, decrease in SF36 PCS following initiation of PAH-specific therapy is a determinant of mortality. TI - Decrease in quality of life predicts mortality in adult patients with pulmonary arterial hypertension due to congenital heart disease EP - 284 SN - 1568-5888 IS - iss. 5 SP - 278 JF - Netherlands Heart Journal VL - vol. 23 DO - https://doi.org/10.1007/s12471-015-0666-9 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/154944/154944.pdf?sequence=1 ER - TY - JOUR AU - Laar, C. van AU - Kievit, P.C. AU - Noyez, L. PY - 2015 UR - https://hdl.handle.net/2066/154036 TI - Surgical aortic valve replacement in patients older than 75 years: is there really a quality of life benefit? EP - 179 SN - 1568-5888 IS - iss. 3 SP - 174 JF - Netherlands Heart Journal VL - vol. 23 DO - https://doi.org/10.1007/s12471-015-0660-2 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/154036/154036.pdf?sequence=1 ER - TY - JOUR AU - Verheugt, F.W.A. PY - 2015 UR - https://hdl.handle.net/2066/154411 TI - Anticoagulation in patients with mechanical heart valves: follow the guidelines! EP - 110 SN - 1568-5888 IS - iss. 2 SP - 109 JF - Netherlands Heart Journal VL - vol. 23 DO - https://doi.org/10.1007/s12471-014-0642-9 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/154411/154411.pdf?sequence=1 ER - TY - JOUR AU - Zijlstra, F. AU - Boer, M.J. de PY - 2015 UR - https://hdl.handle.net/2066/153455 TI - Acute myocardial infarction in the elderly EP - 476 SN - 1568-5888 IS - iss. 10 SP - 475 JF - Netherlands Heart Journal VL - vol. 23 DO - https://doi.org/10.1007/s12471-015-0751-0 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/153455/153455.pdf?sequence=1 ER - TY - JOUR AU - Camaro, C. AU - Boer, M.J. de PY - 2015 UR - https://hdl.handle.net/2066/153915 AB - Acute coronary syndromes are usually classified on the basis of the presence or absence of ST elevation on the ECG: ST-elevation myocardial infarction or non-ST-elevation myocardial infarction (NSTEMI)patients with acute myocardial infarction (AMI) need immediate therapy, without unnecessary delay and primary percutaneous coronary intervention (PPCI) should preferably be performed within 90 min after first medical contact. However, in AMI patients without ST-segment elevation (pre) hospital triage for immediate transfer to the catheterisation laboratory may be difficult. Moreover, initial diagnosis and risk stratification take place at busy emergency departments and chest pain units with additional risk of 'PPCI delay'. Optimal timing of angiography and revascularisation remains a challenge. We describe a patient with NSTEMI who was scheduled for early coronary angiography within 24 h but retrospectively should have been sent to the cath lab immediately because he had a significant amount of myocardium at risk, undetected by non-invasive parameters. TI - STEMI or non-STEMI: that is the question EP - 244 SN - 1568-5888 IS - iss. 4 SP - 243 JF - Netherlands Heart Journal VL - vol. 23 DO - https://doi.org/10.1007/s12471-015-0665-x L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/153915/153915.pdf?sequence=1 ER - TY - JOUR AU - Boer, M.J. de AU - Zijlstra, F. PY - 2015 UR - https://hdl.handle.net/2066/153916 AB - STEMI time delays have been introduced as a performance indicator or marker of quality of care. As they are only one part of a very complex medical process, one should be aware of concomitant issues that may be overlooked or even be more important with regard to clinical outcome of STEMI patients. In this overview we try to summarise the most important ones. TI - STEMI time delays: a clinical perspective : Editorial comment on the article by Verweij et al EP - 419 SN - 1568-5888 IS - iss. 9 SP - 415 JF - Netherlands Heart Journal VL - vol. 23 DO - https://doi.org/10.1007/s12471-015-0728-z L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/153916/153916.pdf?sequence=1 ER - TY - JOUR AU - Pans, S.J. AU - Kimmenade, R.R. van AU - Ruurda, J.P. AU - Meijboom, F.J. AU - Sieswerda, G.T. AU - Zaane, B. van PY - 2015 UR - https://hdl.handle.net/2066/155393 AB - Laparoscopic surgery in patients with Fontan circulation is a haemodynamic challenge; venous return may be compromised by insufflation of carbon dioxide into the abdomen (increasing intra-abdominal pressure), the use of reverse Trendelenburg position and positive pressure ventilation. Combined with an increase in pulmonary vascular resistance due to hypercarbia, cardiac output may be reduced. However, for non-haemodynamic reasons, laparoscopic surgery has advantages over open surgery: less postoperative pain, shorter hospital stay, a reduction in postoperative wound infections and a reduction of respiratory complications. In this case report, we present a patient with Fontan circulation who underwent uneventful laparoscopic cholecystectomy. TI - Haemodynamics in a patient with Fontan physiology undergoing laparoscopic cholecystectomy EP - 385 SN - 1568-5888 IS - iss. 7-8 SP - 383 JF - Netherlands Heart Journal VL - vol. 23 DO - https://doi.org/10.1007/s12471-015-0704-7 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/155393/155393.pdf?sequence=1 ER - TY - JOUR AU - Drost, J.T. AU - Grutters, J.P.C. AU - Wilt, G.J. van der AU - Schouw, Y.T. van der AU - Maas, A.H.E.M. PY - 2015 UR - https://hdl.handle.net/2066/152947 AB - BACKGROUND: Women with a history of preeclampsia are at increased risk for future hypertension and cardiovascular disease (CVD); until now it is not clear whether preventive measures are needed. METHODS: A decision-analytic Markov model was constructed to evaluate healthcare costs and effects of screening and treatment (100 % compliance) for hypertension post preeclampsia based on the available literature. Cardiovascular events and CVD mortality were defined as health states. Outcomes were measured in absolute costs, events, life-years and quality-adjusted life-years (QALYs). Sensitivity and threshold analyses were performed to address uncertainty. RESULTS: Over a 20-year time horizon, events occurred in 7.2 % of the population after screening, and in 8.5 % of the population without screening. QALYs increased from 16.37 (no screening strategy) to 16.40 (screening strategy), an increment of 0.03 (95 % CI 0.01;0.05) QALYs. Total expected costs were euro 8016 in the screening strategy, and euro 9087 in the none screening strategy (expected saving of euro 1071 (95 % CI - 3146;-87) per person). CONCLUSION: Annual hypertension screening and treatment in women with a history of preeclampsia may save costs, for at least a similar quality of life and survival due to prevented CVD compared with standard care. TI - Yearly hypertension screening in women with a history of pre-eclampsia: a cost-effectiveness analysis EP - 591 SN - 1568-5888 IS - iss. 12 SP - 585 JF - Netherlands Heart Journal VL - vol. 23 PS - 7 p. DO - https://doi.org/10.1007/s12471-015-0760-z L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/152947/152947.pdf?sequence=1 ER - TY - JOUR AU - Cate, T.J.F. ten AU - Wely, M.H. van AU - Gehlmann, H.R. AU - Mauti, M. AU - Camaro, C. AU - Reifart, N. AU - Suryapranata, H. AU - Boer, M.J. de PY - 2015 UR - https://hdl.handle.net/2066/152546 AB - AIMS: The consequences of high radiation dose for patient and staff demand constant improvements in X-ray dose reduction technology. This study assessed non-inferiority of image quality and quantified patient dose reduction in interventional cardiology for an anatomy-specific optimised cine acquisition chain combined with advanced real-time image noise reduction algorithms referred to as 'study cine', compared with conventional angiography. METHODS: Fifty patients underwent two coronary angiographic acquisitions: one with advanced image processing and optimised exposure system settings to enable dose reduction (study cine) and one with standard image processing and exposure settings (reference cine). The image sets of 39 patients (18 females, 21 males) were rated by six experienced independent reviewers, blinded to the patient and image characteristics. The image pairs were randomly presented. Overall 85 % of the study cine images were rated as better or equal quality compared with the reference cine (95 % CI 0.81-0.90). The median dose area product per frame decreased from 55 to 26 mGy.cm(2)/frame (53 % reduction, p < 0.001). CONCLUSION: This study demonstrates that the novel X-ray imaging technology provides non-inferior image quality compared with conventional angiographic systems for interventional cardiology with a 53 % patient dose reduction. TI - Novel X-ray image noise reduction technology reduces patient radiation dose while maintaining image quality in coronary angiography EP - 530 SN - 1568-5888 IS - iss. 11 SP - 525 JF - Netherlands Heart Journal VL - vol. 23 DO - https://doi.org/10.1007/s12471-015-0742-1 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/152546/152546.pdf?sequence=1 ER - TY - JOUR AU - Verheugt, F.W.A. PY - 2014 UR - https://hdl.handle.net/2066/133910 TI - Trials, registries and guidelines for non-ST-elevation acute coronary syndromes EP - 54 SN - 1568-5888 IS - iss. 2 SP - 52 JF - Netherlands Heart Journal VL - vol. 22 DO - https://doi.org/10.1007/s12471-013-0495-7 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/133910/133910.pdf?sequence=1 ER - TY - JOUR AU - Postma, S. AU - Dambrink, J.H. AU - Boer, M.J. de AU - Gosselink, A.T.M. AU - Ottervanger, J.P. AU - Koopmans, P.C. AU - Berg, J.M. van den AU - Suryapranata, H. AU - Hof, A.W. van 't PY - 2014 UR - https://hdl.handle.net/2066/136116 AB - AIMS: To evaluate the relation between residential distance and total ischaemic time in patients with acute ST-elevation myocardial infarction (STEMI). METHODS: STEMI patients were transported to the Isala Hospital Zwolle with the intention to perform primary percutaneous coronary intervention PCI (pPCI) from 2004 until 2010 (n = 4149). Of these, 1424 patients (34 %) were referred via a non-PCI 'spoke' centre ('spoke' patients) and 2725 patients (66 %) were referred via field triage in the ambulance (ambulance patients). RESULTS: A longer residential distance increased median total ischaemic time in 'spoke' patients (0-30 km: 228 min, >30-60 km: 235 min, >60-90 km: 264 min, p < 0.001), however not in ambulance patients (0-30 km: 179 min, >30-60 km: 175 min, >60-90 km: 186 min, p = 0.225). After multivariable linear regression analysis, in 'spoke' patients residential distance of >30-60 km compared with 0-30 km was not independently associated with ischaemic time; however, a residential distance of >60-90 km (exp (B) = 1.11, 95 % CI 1.01-1.12) compared with 0-30 km was independently related with ischaemic time. In ambulance patients, residential distance of >30-60 and >60-90 km compared with 0-30 km was not independently associated with ischaemic time. CONCLUSION: A longer distance from the patient's residence to a PCI centre was associated with a small but significant increase in time to treatment in 'spoke' patients, however not in ambulance patients. Therefore, referral via field triage in the ambulance did not lead to a significant increase in time to treatment, especially at long distances (up to 90 km). TI - The influence of residential distance on time to treatment in ST-elevation myocardial infarction patients EP - 519 SN - 1568-5888 IS - iss. 11 SP - 513 JF - Netherlands Heart Journal VL - vol. 22 DO - https://doi.org/10.1007/s12471-014-0599-8 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/136116/136116.pdf?sequence=1 ER - TY - JOUR AU - Jaspers Focks, J. AU - Tielemans, M.M. AU - Rossum, L.G.M. van AU - Eikendal, T. AU - Brouwer, M.A. AU - Jansen, J.B.M.J. AU - Laheij, R.J.F. AU - Verheugt, F.W.A. AU - Oijen, M.G.H. van PY - 2014 UR - http://repository.ubn.ru.nl/handle/2066/127588 AB - BACKGROUND: Aspirin is associated with gastrointestinal side effects such as gastric ulcers, gastric bleeding and dyspepsia. High-dose effervescent calcium carbasalate (ECC), a buffered formulation of aspirin, is associated with reduced gastric toxicity compared with plain aspirin in healthy volunteers, but at lower cardiovascular doses no beneficial effects were observed. AIM: To compare the prevalence of self-reported gastrointestinal symptoms between low-dose plain aspirin and ECC. METHODS: A total of 51,869 questionnaires were sent to a representative sample of the Dutch adult general population in December 2008. Questions about demographics, gastrointestinal symptoms in general and specific symptoms, comorbidity, and medication use including bioequivalent doses of ECC (100 mg) and plain aspirin (80 mg) were stated. We investigated the prevalence of self-reported gastrointestinal symptoms on ECC compared with plain aspirin using univariate and multivariate logistic regression analyses. RESULTS: A total of 16,715 questionnaires (32 %) were returned and eligible for analysis. Of these, 911 (5 %) respondents reported the use of plain aspirin, 633 (4 %) ECC and 15,171 reported using neither form of aspirin (91 %). The prevalence of self-reported gastrointestinal symptoms in general was higher in respondents using ECC (27.5 %) compared with plain aspirin (26.3 %), but did not differ significantly with either univariate (OR 1.06, 95 %CI 0.84-1.33), or multivariate analysis (aOR 1.08, 95 %CI 0.83-1.41). Also, none of the specific types of symptoms differed between the two aspirin formulations. CONCLUSIONS: In this large cohort representative of the general Dutch population, low-dose ECC is not associated with a reduction in self-reported gastrointestinal symptoms compared with plain aspirin. TI - Gastrointestinal symptoms in low-dose aspirin users: a comparison between plain and buffered aspirin EP - 112 SN - 1568-5888 IS - iss. 3 SP - 107 JF - Netherlands Heart Journal VL - vol. 22 DO - https://doi.org/10.1007/s12471-014-0522-3 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/127588/127588.pdf?sequence=1 ER - TY - JOUR AU - Jaspers Focks, J. AU - Brouwer, M.A. PY - 2014 UR - https://hdl.handle.net/2066/133844 TI - Novel oral anticoagulants: the translation of 'de Leidraad' into daily clinical practice EP - 296 SN - 1568-5888 IS - iss. 6 SP - 295 JF - Netherlands Heart Journal VL - vol. 22 DO - https://doi.org/10.1007/s12471-014-0557-5 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/133844/133844.pdf?sequence=1 ER - TY - JOUR AU - Boer, M.J. de AU - Wall, E.E. van der PY - 2013 UR - https://hdl.handle.net/2066/119239 TI - Choosing wisely or beyond the guidelines EP - 2 SN - 1568-5888 IS - iss. 1 SP - 1 JF - Netherlands Heart Journal VL - vol. 21 DO - https://doi.org/10.1007/s12471-012-0352-0 ER - TY - JOUR AU - Boer, M.J. de PY - 2013 UR - https://hdl.handle.net/2066/125260 TI - Atrial fibrillation: A kiss of death? EP - 498 SN - 1568-5888 IS - iss. 11 SP - 497 JF - Netherlands Heart Journal VL - vol. 21 DO - https://doi.org/10.1007/s12471-013-0475-y L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/125260/125260.pdf?sequence=1 ER - TY - JOUR AU - Verheugt, F.W.A. PY - 2013 UR - https://hdl.handle.net/2066/126143 AB - In patients with nonvalvular atrial fibrillation, oral anticoagulation with the vitamin K antagonists acenocoumarol, phenprocoumon and warfarin reduces the risk of stroke by more than 60 %, whereas single or double antiplatelet therapy is much less effective and sometimes associated with a similar bleeding risk as vitamin K antagonists. Besides bleeding, and intracranial haemorrhage in particular, INR monitoring remains the largest drawback of vitamin K antagonists. In the last decade oral agents have been developed that directly block the activity of thrombin (factor IIa), as well as drugs that directly inhibit activated factor X (Xa), which is the first compound in the final common pathway to the activation of thrombin. These agents have been approved for stroke prevention in atrial fibrillation and are now reimbursed under a national guideline for their safe use. They have advantages in that they do not need monitoring and have a fast onset and offset of action, but lack an established specific antidote. This survey addresses the role of modern anticoagulation for stroke prevention in atrial fibrillation. TI - The new oral anticoagulants in atrial fibrillation: an update EP - 484 SN - 1568-5888 IS - iss. 11 SP - 480 JF - Netherlands Heart Journal VL - vol. 21 DO - https://doi.org/10.1007/s12471-013-0473-0 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/126143/126143.pdf?sequence=1 ER - TY - JOUR AU - Evertz, R. AU - Arbelo, E. AU - Mont, L. PY - 2013 UR - https://hdl.handle.net/2066/125832 TI - Rapid palpitations: three of a kind? SN - 1568-5888 IS - iss. 10 SP - 472 JF - Netherlands Heart Journal VL - vol. 21 DO - https://doi.org/10.1007/s12471-013-0451-6 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/125832/125832.pdf?sequence=1 ER - TY - JOUR AU - Evertz, R. AU - Brugada, J. PY - 2013 UR - https://hdl.handle.net/2066/126138 TI - The kiss of the girl from Ipanema EP - 376 SN - 1568-5888 IS - iss. 7-8 SP - 374 JF - Netherlands Heart Journal VL - vol. 21 DO - https://doi.org/10.1007/s12471-013-0434-7 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/126138/126138.pdf?sequence=1 ER - TY - JOUR AU - Boulaksil, M. AU - Robbers-Visser, D. AU - Westra, S. AU - Smeets, J.L.R.M. PY - 2013 UR - https://hdl.handle.net/2066/119183 TI - Recurrent syncope: a slow heart rate? SN - 1568-5888 IS - iss. 9 SP - 423 JF - Netherlands Heart Journal VL - vol. 21 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/119183/119183.pdf?sequence=1 ER - TY - JOUR AU - Verheugt, F.W.A. PY - 2012 UR - https://hdl.handle.net/2066/109569 AB - Patients with congestive heart failure have a significant risk of stroke due to thromboembolism from the dilated left ventricle. Two relatively small trials suggest that oral anticoagulation with vitamin-K antagonists may reduce this risk when compared with placebo, aspirin or clopidogrel. However, more studies are eagerly awaited. So far, physicians seeing patients with heart failure should decide who needs antithrombotic prophylaxis on a case-by-case basis, especially since most heart failure patients have significant comorbidity precluding the use of oral anticoagulant. TI - Antithrombotic therapy in heart failure. EP - 178 SN - 1568-5888 IS - iss. 4 SP - 176 JF - Netherlands Heart Journal VL - vol. 20 N1 - 1 april 2012 DO - http://dx.doi.org/10.1007/s12471-012-0250-5 ER - TY - JOUR AU - Kievit, P.C. PY - 2012 UR - https://hdl.handle.net/2066/109656 TI - Symptomatic severe aortic stenosis in the TAVI era: heart team assessment for all EP - 486 SN - 1568-5888 IS - iss. 12 SP - 485 JF - Netherlands Heart Journal VL - vol. 20 DO - http://dx.doi.org/10.1007/s12471-012-0334-2 ER - TY - JOUR AU - Freling, H.G. AU - van Slooten, Y.J. AU - Melle, J.P. van AU - Mulder, B.J. AU - Dijk, A.P. van AU - Hillege, H.L. AU - Post, M.C. AU - Sieswerda, G.T. AU - Jongbloed, M.R. AU - Willems, T.P. AU - Pieper, P.G. PY - 2012 UR - https://hdl.handle.net/2066/109213 AB - BACKGROUND: Data on long-term complications in adult patients with congenital heart disease (ACHD) and a prosthetic valve are scarce. Moreover, the influence of prosthetic valves on quality of life (QoL) and functional outcome in ACHD patients with prosthetic valves has not been studied. OBJECTIVES: The primary objective of the PROSTAVA study is to investigate the relation between prosthetic valve characteristics (type, size and location) and functional outcome as well as QoL in ACHD patients. The secondary objectives are to investigate the prevalence and predictors of prosthesis-related complications including prosthesis-patient mismatch. METHODS: The PROSTAVA study, a multicentre cross-sectional observational study, will include approximately 550 ACHD patients with prosthetic valves. Primary outcome measures are maximum oxygen uptake during cardiopulmonary exercise testing and QoL. Secondary outcomes are the prevalence and incidence of valve-related complications including prosthesis-patient mismatch. Other evaluations are medical history, physical examination, echocardiography, MRI, rhythm monitoring and laboratory evaluation (including NT-proBNP). IMPLICATIONS: Identification of the relation between prosthetic valve characteristics in ACHD patients on one hand and functional outcome, QoL, the prevalence and predictors of prosthesis-related complications on the other hand may influence the choice of valve prosthesis, the indication for more extensive surgery and the indication for re-operation. TI - Prosthetic valves in adult patients with congenital heart disease: Rationale and design of the Dutch PROSTAVA study EP - 424 SN - 1568-5888 IS - iss. 10 SP - 419 JF - Netherlands Heart Journal VL - vol. 20 DO - https://doi.org/10.1007/s12471-012-0308-4 ER - TY - JOUR AU - Noyez, L. AU - Kievit, P.C. AU - Swieten, H.A. van AU - Boer, M.J. de PY - 2012 UR - https://hdl.handle.net/2066/110487 AB - BACKGROUND: The EuroSCORE, worldwide used as a model for prediction of mortality after cardiac surgery, has recently been renewed. Since October 2011, the EuroSCORE II calculator is available at the EuroSCORE website and recommended for clinical use. The intention of this paper is to compare the use of the initial EuroSCORE and EuroSCORE II as a risk evaluation tool. METHODS: 100 consecutive patients who underwent combined mitral valve and coronary bypass surgery (MVR + CABG) and 100 consecutive patients undergoing combined aortic valve surgery and coronary bypass surgery (AVR + CABG) at the Radboud University Nijmegen Medical Center before 10 October 2011 were included. For both groups the initial EuroSCORE and the EuroSCORE II model were used for risk calculation and based on the calculated risks, cumulative sum charts (CUSUM) were constructed to evaluate the impact on performance monitoring. RESULTS: For the MVR + CABG group the calculated risk using the initial logistic EuroSCORE was 9.95 +/- 8.47 (1.51-45.37) versus 5.08 +/- 4.03 (0.67-19.76) for the EuroSCORE II. For the AVR + CABG group 9.50 +/- 8.6 (1.51-69.5) versus 4.77 +/- 6.6 (0.96-64.24), respectively. For both groups the calculated risk by the EuroSCORE II was statistically lower compared with the initial EuroSCORE (p < 0.001). This lower expected risk has influence on performance monitoring, using risk-adjusted CUSUM analysis. CONCLUSION: The EuroSCORE II, based on a recently updated database, reduces the overestimation of the calculated risk by the initial EuroSCORE. This difference is statistically significant and the EuroSCORE II may also reflect better current surgical performance. TI - Cardiac operative risk evaluation: The EuroSCORE II, does it make a real difference? EP - 498 SN - 1568-5888 IS - iss. 12 SP - 494 JF - Netherlands Heart Journal VL - vol. 20 DO - https://doi.org/10.1007/s12471-012-0327-1 ER - TY - JOUR AU - Wirianta, J. AU - Mouden, M. AU - Ottervanger, J.P. AU - Timmer, J.R. AU - Juwana, Y.B. AU - Boer, M.J. de AU - Suryapranata, H. PY - 2012 UR - https://hdl.handle.net/2066/109145 AB - BACKGROUND: Multislice computed tomography (MSCT) can be used to detect myocardial bridging (MB) of coronary arteries. However, most published studies included small cohorts and did not collect data about predictors. We investigated prevalence and predictors of MB in an Indonesian population. METHODS: All patients who had MSCT at Cinere Hospital, Jakarta, Indonesia between 2006 and 2009 were included in a prospective registry. MB was defined when at least half of the coronary artery was imbedded within the myocardium with a normal epicardial course of the proximal and distal portion. RESULTS: Of the 934 patients (mean age 53 years, 37.8 % female), MB could be observed in 152 patients (16.3 %). Patients with MB were younger compared with those without MB. Coronary risk factors were not different between the two groups. Coronary calcifications and moderate to severe coronary stenoses were less prevalent in patients with MB, also after adjusting for differences in age. At the time of diagnosis, only a few patients with MB were treated with beta-blockers (35 %) or calcium channel blockers (13 %). CONCLUSIONS: Prevalence of myocardial bridging as detected by MSCT is relatively high. Patients with MB were younger and had a lower prevalence of coronary sclerosis. MB could be the cause of their unexplained symptoms. Follow-up studies are necessary to assess the symptoms of these patients, their response to treatment and the incidence of (coronary) events. MSCT can be used to identify patients for potential new treatment strategies. TI - Prevalence and predictors of bridging of coronary arteries in a large Indonesian population, as detected by 64-slice computed tomography scan EP - 401 SN - 1568-5888 IS - iss. 10 SP - 396 JF - Netherlands Heart Journal VL - vol. 20 DO - https://doi.org/10.1007/s12471-012-0296-4 ER - TY - JOUR AU - Beukema, R.J. AU - Elvan, A. AU - Ottervanger, J.P. AU - Boer, M.J. de AU - Hoorntje, J.C.A. AU - Suryapranata, H. AU - Dambrink, J.H. AU - Gosselink, A.T.M. AU - Hof, A.W. van 't PY - 2012 UR - https://hdl.handle.net/2066/110192 AB - AIM: In patients with ST-segment elevation myocardial infarction (STEMI), it is uncertain whether atrial fibrillation has prognostic implications. There may be a difference between atrial fibrillation before and after reperfusion therapy. METHODS AND RESULTS: In patients with STEMI treated with primary percutaneous coronary intervention (PCI), ECGs were analysed before and after primary PCI. Of the 1623 patients with electrocardiographic data before primary PCI, 53 patients (3.3%) had atrial fibrillation. Patients with atrial fibrillation were older, were more often female, and less often had anterior MI location. Of the 1728 patients with electrocardiographic data after primary PCI, 52 patients (3.0%) had atrial fibrillation. Atrial fibrillation was more common in older patients and in those with Killip class >1. Also patients with occlusion of the right coronary artery or TIMI flow 0 before primary PCI more commonly had AF after the procedure. Not successful reperfusion was also associated with a higher incidence of AF after primary PCI. Although both atrial fibrillation before and after primary PCI were associated with increased mortality, multivariable analyses, adjusting for differences in age, gender and Killip class on admission, revealed that atrial fibrillation after PCI (OR 3.69, 95% CI 1.87-7.29) but not before PCI (OR 1.86, 95% CI 0.89-3.90) was independent and statistically significantly associated with long-term mortality. CONCLUSION: In patients with STEMI, atrial fibrillation after but not before primary PCI has independent prognostic implications. Possibly, atrial fibrillation after the PCI is a symptom of failed reperfusion and a sign of heart failure. TI - Atrial fibrillation after but not before primary angioplasty for ST-segment elevation myocardial infarction of prognostic importance. EP - 160 SN - 1568-5888 IS - iss. 4 SP - 155 JF - Netherlands Heart Journal VL - vol. 20 N1 - 1 april 2012 DO - https://doi.org/10.1007/s12471-012-0242-5 ER - TY - JOUR AU - Boer, M.J. de AU - Suryapranata, H. PY - 2012 UR - https://hdl.handle.net/2066/108457 TI - It's a small world after all. EP - 253 SN - 1568-5888 IS - iss. 6 SP - 252 JF - Netherlands Heart Journal VL - vol. 20 N1 - 1 juni 2012 DO - https://doi.org/10.1007/s12471-012-0291-9 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/108457/108457.pdf?sequence=1 ER - TY - JOUR AU - Soedamah-Muthu, S.S. AU - Geleijnse, J.M. AU - Giltay, E.J. AU - Goede, J. de AU - Oude Griep, L.M. AU - Waterham, E. AU - Tetsma-Jansen, A.M. AU - Mulder, B.J. AU - Boer, M.J. de AU - Deckers, J.W. AU - Zock, P.L. AU - Kromhout, D. AU - et al. PY - 2012 UR - https://hdl.handle.net/2066/108511 TI - Levels and trends in cardiovascular risk factors and drug treatment in 4837 elderly Dutch myocardial infarction patients between 2002 and 2006 EP - 109 SN - 1568-5888 SP - 102 JF - Netherlands Heart Journal VL - vol. 20 DO - https://doi.org/10.1007/s12471-012-0248-z L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/108511/108511.pdf?sequence=1 ER - TY - JOUR AU - Bonnes, J.L. AU - Brouwer, M.A. PY - 2012 UR - https://hdl.handle.net/2066/110556 TI - Clinical Trial Update On Optimal Antithrombotic Therapy In Non-Valvular AF. EP - 11 SN - 1568-5888 IS - iss. Suppl 1 SP - 9 JF - Netherlands Heart Journal VL - vol. 20 ER - TY - JOUR AU - Schellings, D.A.A.M. AU - Symersky, T. AU - Ottervanger, J.P. AU - Ramdat Misier, A.R. AU - Boer, M.J. de PY - 2012 UR - https://hdl.handle.net/2066/110562 AB - BACKGROUND: Although patient care in cardiology departments may be of high quality, patients with cardiac disease in other departments tend to receive less attention from cardiologists. Driven by the shorter duration of admission nowadays and the fact that consultations are often performed in between the daily work schedules, the amount of cardiac disease as well as the impact on the daily workload can be underestimated. We determined characteristics, prevalence of cardiac disease and in-hospital mortality of patients in whom cardiology consultation was requested. METHOD: In this prospective, observational study, individual data of all consecutive patients admitted to non-cardiology departments in whom cardiology consultation was requested were registered. RESULTS: During the study period, 264 patients were included. Mean age was 70 years. Most patients were admitted to the internal medicine ward (37 %), followed by the surgical ward (30 %). The most common reasons for cardiology consultation were: suspected heart failure (20 %), suspected infective endocarditis (15 %), suspected rhythm abnormalities (14 %) and suspected acute coronary syndrome (13 %). In 29 % of all consultations a cardiac diagnosis was found. Hospital mortality was 9.0 %. CONCLUSION: Patients who are admitted to a non-cardiology department and who need cardiology consultation are particularly elderly people with a high prevalence of cardiac disease and high in-hospital mortality. For these reasons cardiology consultation is an important part of clinical cardiology deserving a structured approach. TI - Clinical cardiology consultation at non-cardiology departments: stepchild of patient care? EP - 263 SN - 1568-5888 IS - iss. 6 SP - 260 JF - Netherlands Heart Journal VL - vol. 20 N1 - 1 juni 2012 DO - https://doi.org/10.1007/s12471-012-0273-y ER - TY - JOUR AU - Dinh, T. AU - Baur, L.H. AU - Pisters, R. AU - Kamp, O. AU - Verheugt, F.W.A. AU - Smeets, J.L.R.M. AU - Cheriex, E.C. AU - Tieleman, R.G. AU - Prins, M.H. AU - Crijns, H.J.G.M. PY - 2011 UR - https://hdl.handle.net/2066/97916 AB - BACKGROUND: Antithrombotic management in atrial fibrillation (AF) is currently based on clinical characteristics, despite evidence of potential fine-tuning with transoesophageal echocardiography (TEE). This open, randomised, multicentre study addresses the hypothesis that a comprehensive strategy of TEE-based aspirin treatment in AF patients is feasible and safe. METHODS: Between 2005 and 2009, ten large hospitals in the Netherlands enrolled AF patients with a moderate risk of stroke. Patients without thrombogenic TEE characteristics were randomised to aspirin or vitamin K antagonists (VKA). The primary objective is to show that TEE-based aspirin treatment is safe compared with VKA therapy. The secondary objective tests feasibility of TEE as a tool to detect echocardiographic features of high stroke risk. This report compares randomised to non-randomised patients and describes the feasibility of a TEE-based approach. RESULTS: In total, 310 patients were included. Sixty-nine patients were not randomised because of non-visualisation (n = 6) or TEE risk factors (n = 63). Compared with non-randomised patients, randomised patients (n = 241) were younger (65 +/- 11 vs. 69 +/- 9 years, p = 0.004), had less coronary artery disease (9 vs. 20%, p = 0.018), previous TIA (1.7 vs. 7.2%, p = 0.029), AF during TEE (25 vs. 54%, p < 0.001), mitral incompetence (55 vs. 70%, p = 0.038), VKA use (69 vs. 82%, p = 0.032), had a lower mean CHADS(2) score (1.2 +/- 0.6 vs. 1.6 +/- 1.0, p = 0.004), and left ventricular ejection fraction (59 +/- 8 vs. 56 +/- 8%, p = 0.016). CONCLUSIONS: This study shows that a TEE-based approach for fine-tuning stroke risk in AF patients with a moderate risk for stroke is feasible. Follow-up data will address the safety of this TEE-based approach. TI - Feasibility of TEE-guided stroke risk assessment in atrial fibrillation-background, aims, design and baseline data of the TIARA pilot study EP - 222 SN - 1568-5888 IS - iss. 5 SP - 214 JF - Netherlands Heart Journal VL - vol. 19 DO - https://doi.org/10.1007/s12471-011-0095-3 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/97916/97916.pdf?sequence=1 ER - TY - JOUR AU - Wall, E.E. van der AU - Boer, M.J. de AU - Doevendans, P.A. AU - Wilde, A.A.M. AU - Zijlstra, F. PY - 2011 UR - https://hdl.handle.net/2066/97069 TI - Journal metrics for the Netherlands Heart Journal EP - 161 SN - 1568-5888 IS - iss. 4 SP - 159 JF - Netherlands Heart Journal VL - vol. 19 DO - https://doi.org/10.1007/s12471-011-0099-z L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/97069/97069.pdf?sequence=1 ER - TY - JOUR AU - Erol-Yilmaz, A. AU - Westra, S.W. AU - Smeets, J.L.R.M. PY - 2011 UR - https://hdl.handle.net/2066/97319 TI - Rhythm Puzzle: A Patient with Dizziness EP - 95 SN - 1568-5888 IS - iss. 2 SP - 95 JF - Netherlands Heart Journal VL - vol. 19 DO - https://doi.org/10.1007/s12471-010-0068-y L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/97319/97319.pdf?sequence=1 ER - TY - JOUR AU - Noyez, L. AU - Kievit, P.C. AU - Verkroost, M.W.A. AU - Wetten, H.B. van AU - Verhagen, A.F.T.M. AU - Swieten, H.A. van PY - 2010 UR - https://hdl.handle.net/2066/88645 AB - Over the last years, measurements of quality of care have become more and more a public product, used by providers, purchasers and consumers, and patients. This information serves as an important guide for improvement, as well as a decision support tool for everybody taking part in medical treatment. This evolution can be compared with advertising and as in commercials it is important to use the right information. In this report we focus on the quality of adult cardiac surgery. Honest information is of course essential, but in this article attention is asked for the variables used to evaluate the quality of cardiac surgery. (Neth Heart J 2010;18:365-9.). TI - Evaluation of quality in adult cardiac surgery: let us speak the same language. EP - 369 SN - 1568-5888 IS - iss. 7-8 SP - 365 JF - Netherlands Heart Journal VL - vol. 18 N1 - 1 augustus 2010 ER - TY - JOUR AU - Verheugt, F.W.A. PY - 2010 UR - https://hdl.handle.net/2066/89324 TI - Safety of dual antiplatelet therapy in daily cardiology practice. EP - 229 SN - 1568-5888 IS - iss. 5 SP - 228 JF - Netherlands Heart Journal VL - vol. 18 N1 - 1 mei 2010 ER - TY - JOUR AU - Verheugt, F.W.A. PY - 2010 UR - https://hdl.handle.net/2066/87773 AB - In patients with nonvalvular atrial fibrillation oral anticoagulation with the vitamin K antagonists acenocoumarol, phenprocoumon and warfarin reduces the risk of stroke by more than 60%, whereas single or double antiplatelet therapy is much less effective and sometimes associated with a similar bleeding risk as vitamin K antagonists. Besides bleeding, INR monitoring and high interindividual variability remain the largest drawbacks of vitamin K antagonists. In the last decade oral agents have been developed that directly block the activity of thrombin (factor IIa), as well as drugs that directly inhibit activated factor X (Xa), which is the first protein in the final common pathway to the activation of thrombin. These agents have huge advantages in that they do not need monitoring and have a fast onset and offset of action. This survey addresses the role of classical and modern anticoagulation in stroke prevention in atrial fibrillation. (Neth Heart J 2010;18:314-8.). TI - The new oral anticoagulants. EP - 318 SN - 1568-5888 IS - iss. 6 SP - 314 JF - Netherlands Heart Journal VL - vol. 18 N1 - 1 juni 2010 ER - TY - JOUR AU - Dewilde, W. AU - Verheugt, F.W.A. AU - Breet, N. AU - Koolen, J.J. AU - Berg, J.M. ten PY - 2010 UR - https://hdl.handle.net/2066/89856 AB - Chronic oral anticoagulant treatment is obligatory in patients (class I) with mechanical heart valves and in patients with atrial fibrillation with CHADS2 score >1. When these patients undergo percutaneous coronary intervention with placement of a stent, there is also an indication for treatment with aspirin and clopidogrel. Unfortunately, triple therapy is known to increase the bleeding risk. For this group of patients, the bottom line is to find the ideal therapy in patients with indications for both chronic anticoagulation therapy and percutaneous intervention to prevent thromboembolic complications such as stent thrombosis without increasing the risk of bleeding. (Neth Heart J 2010;18:444-50.). TI - 'Ins' and 'outs' of triple therapy: Optimal antiplatelet therapy in patients on chronic oral anticoagulation who need coronary stenting. EP - 450 SN - 1568-5888 IS - iss. 9 SP - 444 JF - Netherlands Heart Journal VL - vol. 18 N1 - 1 september 2010 ER - TY - JOUR AU - Heestermans, A.A. AU - Hermanides, R.S. AU - Gosselink, A.T.M. AU - Boer, M.J. de AU - Hoorntje, J.C.A. AU - Suryapranata, H. AU - Ottervanger, J.P. AU - Dambrink, J.H. AU - Kolkman, E.G.W. AU - Berg, J.M. ten AU - Zijlstra, F. AU - Hof, A.W. van 't PY - 2010 UR - https://hdl.handle.net/2066/89388 TI - A comparison between upfront high-dose tirofiban versus provisional use in the real-world of the non-selected STEMI patients undergoing primary PCI. EP - 597 SN - 1568-5888 IS - iss. 12 SP - 592 JF - Netherlands Heart Journal VL - vol. 18 DO - https://doi.org/10.1007/s12471-010-0840-z ER - TY - JOUR AU - Meissner, A. AU - Trappe, H.J. AU - Boer, M.J. de AU - Gorgels, A.P. AU - Wellens, H.L.L. PY - 2010 UR - https://hdl.handle.net/2066/87695 AB - Background/Objectives. Rapid risk stratification of the patient with acute chest pain is essential to select the best management. We investigated the value of the ECG at first medical contact to determine size of the ischaemic myocardial area and thereby severity of risk.Methods. In 386 patients with acute chest pain, ECG findings were correlated with the coronary angiogram. Using ST-segment deviation patterns the location of the coronary culprit lesion was predicted and thereby size of the area at risk. Four groups of patients were present. Those with a narrow QRS and a total 12-lead ST-segment deviation score of >/=5 mm (group 1) or /=120 ms (group 3), and patients with previous coronary bypass grafting (CABG) or percutaneous coronary intervention (PCI) (group 4).Results. Correct coronary culprit lesion localisation was possible in 84% of the 185 patients in group 1, 40% of the total cohort. Accurate prediction was not possible in most patients in groups 2, 3 and 4, in spite of extensive coronary artery disease in group 3 and 4. Conclusions. Using the 12-lead ECG the size of the myocardial area at risk can be accurately predicted when the total ST-segment deviation score is >/=5 mm, allowing identification of those in need of a PCI. In most patients with bundle branch block, previous CABG or PCI, the ECG can not localise the culprit lesion. This approach simplifies and accelerates decision-making at first medical contact. (Neth Heart J 2010;18:301-6.). TI - The value of the ECG for decision-making at first medical contact in the patient with acute chest pain. EP - 306 SN - 1568-5888 IS - iss. 6 SP - 301 JF - Netherlands Heart Journal VL - vol. 18 N1 - 1 juni 2010 ER - TY - JOUR AU - Boer, M.J. de PY - 2010 UR - https://hdl.handle.net/2066/88888 TI - Discrimination of the elderly: how guilty are you? EP - 227 SN - 1568-5888 IS - iss. 5 SP - 227 JF - Netherlands Heart Journal VL - vol. 18 N1 - 1 mei 2010 ER - TY - JOUR AU - Schellings, D.A.A.M. AU - Dambrink, J.H. AU - Hoorntje, J.C.A. AU - Boer, M.J. de AU - Hof, A.W. van 't AU - Suryapranata, H. PY - 2010 UR - https://hdl.handle.net/2066/87279 AB - Background. In patients with unstable angina or non-ST-elevation acute coronary syndrome (NSTE-ACS) who are eligible for PCI, routine stenting is the recommended treatment strategy, based on the opinion of experts. Provisional stenting may provide a viable alternative by retaining the early benefits of stenting without its potential late hazards.Method. Patients with NSTE-ACS were randomised to provisional or routine stenting after coronary angiography. Patients were followed for up to ten years. The occurrence of major adverse cardiac events (MACE) was recorded.Results. 237 consecutive patients with NSTE-ACS were randomly assigned to routine stenting (n=116) or provisional stenting (n=121). No difference in the incidence of MACE at 30 days was observed. At six months, angiographic restenosis was lower in the routine stenting group (41 vs. 20%, p=0.02), paralleled by more MACE in the provisional stenting group at one year (40.5 vs. 27.6%, p=0.036). At complete follow-up the difference in MACE was not significant (61.2 vs. 50%, p=0.084) because of relatively more target lesion revascularisations in the routine stent group. There was no difference in the incidence of very late stent thrombosis (1.7 vs. 3.4%, p=0.439). The only independent predictor of MACE was beta-blocker use (RR 0.62 [0.431; 0.892] p=0.010).Conclusion. In selective patients with NSTE-ACS, routine stenting was more beneficial than provisional stenting for a period of up to five years, driven by a reduction in repeat revascularisation procedures. After this period, the benefit was no longer significant. Beta-blocker use was the only independent predictor of MACE throughout the complete follow-up period. (Neth Heart J 2010;18:307-13.). TI - Long-term comparison of balloon angioplasty with provisional stenting versus routine stenting in patients with non-ST-elevation acute coronary syndrome. EP - 313 SN - 1568-5888 IS - iss. 6 SP - 307 JF - Netherlands Heart Journal VL - vol. 18 N1 - 1 juni 2010 ER -