TY  - JOUR
AU  - Evertz, R.
AU  - Bennekom, S. van
AU  - Dirksen, M.T.
AU  - Verheugt, F.W.A.
PY  - 2009
UR  - https://hdl.handle.net/2066/80464
TI  - Hotline sessions of the 31st European Congress of Cardiology.
EP  - 2565
SN  - 0195-668X
IS  - iss. 21
SP  - 2562
JF  - European Heart Journal
VL  - vol. 30
ER  - 
TY  - JOUR
AU  - Hirsch, A.
AU  - Windhausen, F.
AU  - Tijssen, J.G.P.
AU  - Oude Ophuis, A.J.M.
AU  - Giessen, W.J. van der
AU  - Zee, P.M. van der
AU  - Cornel, J.H.
AU  - Verheugt, F.W.A.
AU  - Winter, R.J. de
PY  - 2009
UR  - https://hdl.handle.net/2066/80830
AB  - AIMS: In several observational studies, revascularization is associated with substantial reduction in mortality in patients with non-ST-segment elevation acute coronary syndrome (nSTE-ACS). This has strengthened the belief that routine early angiography would lead to a reduction in mortality. We investigated the association between actual in-hospital revascularization and long-term outcome in patients with nSTE-ACS included in the ICTUS trial. METHODS AND RESULTS: The study population of the present analysis consists of ICTUS participants who were discharged alive after initial hospitalization. The ICTUS trial was a randomized, controlled trial in which 1200 patients were randomized to an early invasive or selective invasive strategy. The endpoints were death from hospital discharge until 4 year follow-up and death or spontaneous myocardial infarction (MI) until 3 years. Among 1189 patients discharged alive, 691 (58%) underwent revascularization during initial hospitalization. In multivariable Cox regression analyses, in-hospital revascularization was independently associated with a reduction in 4 year mortality and 3 year event rate of death or spontaneous MI: hazard ratio (HR) 0.59 [95% confidence interval (CI) 0.37-0.96] and 0.46 (95% CI 0.31-0.68). However, when intention-to-treat analysis was performed, no differences in cumulative event rates were observed between the early invasive and selective invasive strategies: HR 1.10 (95% CI 0.70-1.74) for death and 1.27 (95% CI 0.88-1.85) for death or spontaneous MI. CONCLUSION: The ICTUS trial did not show that an early invasive strategy resulted in a better outcome than a selective invasive strategy in patients with nSTE-ACS. However, similar to retrospective analyses from observational studies, actual revascularization was associated with lower mortality and fewer MI. Whether an early invasive strategy leads to a better outcome than a selective invasive strategy cannot be inferred from the observation that revascularized patients have a better prognosis in non-randomized studies.
TI  - Diverging associations of an intended early invasive strategy compared with actual revascularization, and outcome in patients with non-ST-segment elevation acute coronary syndrome: the problem of treatment selection bias.
EP  - 654
SN  - 0195-668X
IS  - iss. 6
SP  - 645
JF  - European Heart Journal
VL  - vol. 30
ER  - 
TY  - JOUR
AU  - Werf, F. van de
AU  - Ardissino, D.
AU  - Betriu, A.
AU  - Cokkinos, D.V.
AU  - Falk, E.
AU  - Fox, K.A.
AU  - Julian, D.
AU  - Lengyel, M.
AU  - Kastrati, A.
AU  - Ruzyllo, W.
AU  - Thygesen, K.
AU  - Underwood, S.R.
AU  - Vahanian, A.
AU  - Verheugt, F.W.A.
AU  - Wijns, W.
PY  - 2008
UR  - https://hdl.handle.net/2066/69128
TI  - Management of acute myocardial infarction in patients presenting with ST-elevation.
EP  - 2945
SN  - 0195-668X
IS  - iss. 23
SP  - 2909
JF  - European Heart Journal
VL  - vol. 29
DO  - https://doi.org/10.1093/eurheartj/ehn416
ER  - 
TY  - JOUR
AU  - Clappers, N.
AU  - Brouwer, M.A.
AU  - Verheugt, F.W.A.
PY  - 2008
UR  - https://hdl.handle.net/2066/69957
TI  - How to react to high platelet reactivity?
EP  - 2
SN  - 0195-668X
IS  - iss. 11
SP  - 1471; author reply 1471
JF  - European Heart Journal
VL  - vol. 29
ER  - 
TY  - JOUR
AU  - Bergman, H.
AU  - Rolink, A.M.
AU  - Verheugt, F.W.A.
PY  - 2008
UR  - https://hdl.handle.net/2066/69983
TI  - Hotline sessions of the 30th European Congress of Cardiology.
EP  - 3064
SN  - 0195-668X
IS  - iss. 24
SP  - 3061
JF  - European Heart Journal
VL  - vol. 29
DO  - https://doi.org/10.1093/eurheartj/ehn522
ER  - 
TY  - JOUR
AU  - Yap, S.C.
AU  - Roos-Hesselink, J.W.
AU  - Hoendermis, E.S.
AU  - Budts, W.
AU  - Vliegen, H.W.
AU  - Mulder, B.J.M.
AU  - Dijk, A.P.J. van
AU  - Schalij, M.J.
AU  - Drenthen, W.
PY  - 2007
UR  - https://hdl.handle.net/2066/51420
AB  - AIMS: To investigate outcome and complications of implantable cardioverter defibrillators (ICDs) in adults with congenital heart disease (CHD) and to identify predictors of (in-) appropriate shocks. METHODS AND RESULTS: Sixty-four CHD patients >/= 18 years at first ICD implantation [63% tetralogy of Fallot (TOF) and age at implantation 37 +/- 13 years] were identified using the Dutch adult CHD registry and a Belgian tertiary care centre database. Median follow-up duration was 3.7 years. Early complications included pocket haematoma (n = 3), lead failure (n = 2), and pneumothorax (n = 2). Late complications occurred in 11 (17%) patients, including lead failure (n = 6) and and electrical storm (n = 3). Overall, 30 device-related re-interventions were performed in 20 patients (31%), including four premature generator changes and seven lead replacements. Half of the patients received one or more shocks, and 46 shocks in 15 patients (23%) were classified as appropriate. One hundred and sixty shocks in 26 patients (41%) were classified as inappropriate. No predictors of (in-)appropriate shocks were identified, except TOF being associated with less appropriate shocks than patients with other CHD (HR 0.29, P = 0.02). CONCLUSION: The ICD provided effective therapy in a quarter of adults with CHD with low complication rates. The incidence of inappropriate shocks, however, appeared to be excessive and warrants further attention.
TI  - Outcome of implantable cardioverter defibrillators in adults with congenital heart disease: a multi-centre study.
EP  - 1861
SN  - 0195-668X
IS  - iss. 15
SP  - 1854
JF  - European Heart Journal
VL  - vol. 28
DO  - https://doi.org/10.1093/eurheartj/ehl306
ER  - 
TY  - JOUR
AU  - Caterina, R. de
AU  - Husted, S.
AU  - Wallentin, L.
AU  - Agnelli, G.
AU  - Bachmann, F.
AU  - Baigent, C.
AU  - Jespersen, J.
AU  - Kristensen, S.D.
AU  - Montalescot, G.
AU  - Siegbahn, A.
AU  - Verheugt, F.W.A.
AU  - Weitz, J.
PY  - 2007
UR  - https://hdl.handle.net/2066/52834
TI  - Anticoagulants in heart disease: current status and perspectives.
EP  - 913
SN  - 0195-668X
IS  - iss. 7
SP  - 880
JF  - European Heart Journal
VL  - vol. 28
ER  - 
TY  - JOUR
AU  - Zegers, E.S.
AU  - Verheugt, F.W.A.
PY  - 2007
UR  - https://hdl.handle.net/2066/52301
TI  - Hotline sessions of the 29th European congress of cardiology.
EP  - 2802
SN  - 0195-668X
IS  - iss. 22
SP  - 2799
JF  - European Heart Journal
VL  - vol. 28
ER  - 
TY  - JOUR
AU  - Verheugt, F.W.A.
AU  - Gersh, B.J.
AU  - Armstrong, P.W.
PY  - 2006
UR  - https://hdl.handle.net/2066/50046
AB  - Reperfusion therapy for ST-elevation acute coronary syndromes aims at early and complete recanalization of the infarct-related artery in order to salvage myocardium and improve both early and late clinical outcomes. Myocardial necrosis is usually confirmed and quantified by myocardial enzyme release in plasma. However, over 10% of patients treated with reperfusion therapy fail to develop an enzyme rise, but do exhibit transient ECG changes, which are consistent with an aborted myocardial infarction. The earlier the reperfusion therapy is instituted, the higher the incidence of aborted infarction. Treatment within an hour after symptom onset may result in 25% of aborted infarction and is in combination with complete (70%) ST-segment resolution associated with better survival. This endpoint is easy to define and occurs promptly in time. The faster that effective treatment is initiated, the more likely aborted infarction will occur. Given that mortality, re-infarction, and stroke are declining in incidence, we suggest the introduction of aborted infarction as an endpoint in clinical trials of ST-elevation acute coronary syndromes.
TI  - Aborted myocardial infarction: a new target for reperfusion therapy.
EP  - 904
SN  - 0195-668X
IS  - iss. 8
SP  - 901
JF  - European Heart Journal
VL  - vol. 27
ER  - 
TY  - JOUR
AU  - Daly, C.A.
AU  - Clemens, F.
AU  - Lopez-Sendon, J.L.
AU  - Tavazzi, L.
AU  - Boersma, E.
AU  - Danchin, N.
AU  - Delahaye, F.
AU  - Gitt, A.
AU  - Julian, D.
AU  - Mulcahy, D.
AU  - Ruzyllo, W.
AU  - Thygesen, K.
AU  - Verheugt, F.W.A.
AU  - Fox, K.M.
PY  - 2006
UR  - https://hdl.handle.net/2066/51013
AB  - AIMS: The European Society of Cardiology published guidelines for the management of stable angina in 1997, with the objective of promoting an evidence-based approach to the condition. This study focuses on the impact of guideline compliant medical treatment on clinical outcome in patients with stable angina. METHODS AND RESULTS: The Euro Heart Survey of Stable Angina is a multicentre prospective observational study conducted between 2002 and 2003. Patients with a clinical diagnosis of stable angina by a cardiologist were enrolled and follow-up was conducted at 1 year. The primary outcome of interest was death or myocardial infarction (MI). The increasing intensity of guideline compliant medical therapy was quantified by means of a simple treatment score based on the use of guideline advocated therapies: antiplatelets, statins, and beta-blockers. A total of 3779 patients were included in the initial survey. Increasing intensity of guideline compliant therapy at initial assessment was associated with a reduction in death and MI during follow-up in patients with angina and confirmed coronary disease (HR 0.68; 95% CI 0.49-0.95 per unit increase in treatment score). All cardiovascular events were also significantly reduced in this subgroup (HR 0.82; 95% CI 0.69-0.97). The benefits of guideline compliant therapy were only observed in patients with objective evidence of coronary disease. CONCLUSION: Guideline compliant medical therapy improves clinical outcome in patients with stable angina and objective evidence of coronary disease.
TI  - The impact of guideline compliant medical therapy on clinical outcome in patients with stable angina: findings from the Euro Heart Survey of stable angina.
EP  - 1304
SN  - 0195-668X
IS  - iss. 11
SP  - 1298
JF  - European Heart Journal
VL  - vol. 27
DO  - https://doi.org/10.1093/eurheartj/ehl005
ER  - 
TY  - JOUR
AU  - Oosterhof, T.
AU  - Meijboom, F.J.
AU  - Vliegen, H.W.
AU  - Hazekamp, M.G.
AU  - Zwinderman, A.H.
AU  - Bouma, B.J.
AU  - Dijk, A.P.J. van
AU  - Mulder, B.J.M.
PY  - 2006
UR  - https://hdl.handle.net/2066/50692
AB  - AIMS: To analyse the long-term outcomes after pulmonary valve replacement (PVR) in patients with a previous correction for tetralogy of Fallot. METHODS AND RESULTS: In a retrospective study, 158 adult patients with a diagnosis of tetralogy of Fallot, who had undergone a PVR after initial total correction in childhood, were identified from the CONCOR (CONgenital CORvitia) registry. All patients underwent 175 PVRs between June 1986 and June 2005. To analyse the predictors for homograft dysfunction and adverse events (death, reoperations, balloon angioplasty), Cox-regression analysis was performed. Overall freedom from significant homograft dysfunction was 66% after 5 years and 47% after 10 years. We could not identify predictors for combined homograft dysfunction. Event-free survival was 78% at 10 years and 68% at 15 years after PVR. Both early significant pulmonary regurgitation (PR) (HR 6.8, P = 0.017) and pulmonary stenosis (PS) (HR 4.0, P = 0.037) after surgery were associated with adverse events. When analysing direct post-operative PR or PS, we observed that in patients with severe, pre-operative PR, right ventricular aneurysm/patch resection resulted in a lower post-operative PR (mean difference grade 0.38 +/- 0.14, P = 0.01). Less significant post-operative PS was associated with a higher diameter of the homograft (HR 0.37, P = 0.006). CONCLUSION: While 47% of the patients in our study were free from homograft dysfunction at 10 years after PVR, event-free survival after PVR remained fairly good (78%). Significant residual lesions directly after surgery influenced event-free survival. A smaller diameter of the pulmonary homograft and severe pre-surgical PR were related to early homograft dysfunction after surgery.
TI  - Long-term follow-up of homograft function after pulmonary valve replacement in patients with tetralogy of Fallot.
EP  - 1484
SN  - 0195-668X
IS  - iss. 12
SP  - 1478
JF  - European Heart Journal
VL  - vol. 27
DO  - https://doi.org/10.1093/eurheartj/ehl033
ER  - 
TY  - JOUR
AU  - Panhuyzen-Goedkoop, N.M.
AU  - Verheugt, F.W.A.
PY  - 2006
UR  - https://hdl.handle.net/2066/50460
TI  - Sudden cardiac death due to hypertrophic cardiomyopathy can be reduced by pre-participation cardiovascular screening in young athletes.
EP  - 2153
SN  - 0195-668X
IS  - iss. 18
SP  - 2152
JF  - European Heart Journal
VL  - vol. 27
DO  - https://doi.org/10.1093/eurheartj/ehl171
ER  - 
TY  - JOUR
AU  - Clappers, N.
AU  - Verheugt, F.W.A.
PY  - 2006
UR  - https://hdl.handle.net/2066/50304
TI  - Hotline sessions of the 28th European Congress of Cardiology/World Congress of Cardiology 2006.
EP  - 2899
SN  - 0195-668X
IS  - iss. 23
SP  - 2896
JF  - European Heart Journal
VL  - vol. 27
DO  - https://doi.org/10.1093/eurheartj/ehl368
ER  - 
TY  - JOUR
AU  - Wezenberg, E.
AU  - Dartel, M.M.C. van
AU  - Kuilenburg, J.T. van
AU  - Plesiewicz, I.
AU  - Leeuw, F.E. de
AU  - Pop, G.A.M.
AU  - Pop-Purceleanu, M.
AU  - Hulstijn, W.
PY  - 2006
UR  - https://hdl.handle.net/2066/55487
TI  - The relationship between atrial fibrillation, neurocognitive deficits and depression
EP  - 36
SN  - 0195-668X
IS  - iss. S1
SP  - 36
JF  - European Heart Journal
VL  - vol. 27
PS  - 1 p.
ER  - 
TY  - JOUR
AU  - Dieker, H.J.
AU  - Brouwer, M.A.
AU  - Verheugt, F.W.A.
PY  - 2005
UR  - https://hdl.handle.net/2066/48756
TI  - ESC guidelines for percutaneous coronary interventions.
EP  - 2477
SN  - 0195-668X
IS  - iss. 22
SP  - 2475
JF  - European Heart Journal
VL  - vol. 26
DO  - http://dx.doi.org/10.1093/eurheartj/ehi562
ER  - 
TY  - JOUR
AU  - Huber, K.
AU  - Caterina, R. de
AU  - Kristensen, S.D.
AU  - Verheugt, F.W.A.
AU  - Montalescot, G.
AU  - Maestro, L.B.
AU  - Werf, F. van de
PY  - 2005
UR  - https://hdl.handle.net/2066/49206
TI  - Pre-hospital reperfusion therapy: a strategy to improve therapeutic outcome in patients with ST-elevation myocardial infarction.
EP  - 2074
SN  - 0195-668X
IS  - iss. 19
SP  - 2063
JF  - European Heart Journal
VL  - vol. 26
DO  - https://doi.org/10.1093/eurheartj/ehi413
ER  - 
TY  - JOUR
AU  - Daly, C.A.
AU  - Clemens, F.
AU  - Lopez-Sendon, J.
AU  - Tavazzi, L.
AU  - Boersma, E.
AU  - Danchin, N.
AU  - Delahaye, F.
AU  - Gitt, A.
AU  - Julian, D.
AU  - Mulcahy, D.
AU  - Ruzyllo, W.
AU  - Thygesen, K.
AU  - Verheugt, F.W.A.
AU  - Fox, K.M.
PY  - 2005
UR  - https://hdl.handle.net/2066/48550
AB  - AIMS: In order to assess adherence to guidelines and international variability in management, the Euro Heart Survey of Newly Presenting Angina prospectively studied medical therapy, percutaneous coronary intervention (PCI), and surgery in patients with new-onset stable angina in Europe. METHODS AND RESULTS: Consecutive patients, 3779 in total, with a clinical diagnosis of stable angina by a cardiologist were enrolled. After initial assessment by a cardiologist, 78% were treated with aspirin, 48% with a statin, and 67% with a beta-blocker. ACE-inhibitors were prescribed by the cardiologist in 37% overall. Revascularization rates were low, with only 501 (13%) patients having PCI or coronary bypass surgery performed or planned. However, when restricted to patients with coronary disease documented within 4 weeks of assessment, over 50% had revascularization performed or planned. Among other factors, the national rate of angiography and availability of invasive facilities significantly predicted the likelihood of revascularization, OR 2.4 and 2.0, respectively. CONCLUSION: This survey shows a shortfall between guidelines and practice with regard to the use of evidence-based drug therapy and evidence that revascularization rates are strongly influenced by non-clinical, in addition to clinical, factors.
TI  - The initial management of stable angina in Europe, from the Euro Heart Survey: a description of pharmacological management and revascularization strategies initiated within the first month of presentation to a cardiologist in the Euro Heart Survey of Stable Angina.
EP  - 1022
SN  - 0195-668X
IS  - iss. 10
SP  - 1011
JF  - European Heart Journal
VL  - vol. 26
DO  - https://doi.org/10.1093/eurheartj/ehi109
ER  - 
TY  - JOUR
AU  - Meijboom, L.J.
AU  - Vos, F.E.
AU  - Timmermans, J.
AU  - Boers, G.H.J.
AU  - Zwinderman, A.H.
AU  - Mulder, B.J.M.
PY  - 2005
UR  - https://hdl.handle.net/2066/47547
AB  - AIMS: In women with Marfan syndrome pregnancy presents an increased risk of dilatation, dissection, and rupture of the aorta. The aim of this study was to investigate the influence of pregnancy on growth of the aortic root. METHODS AND RESULTS: Between 1993 and 2004 127 women with Marfan syndrome were prospectively followed; 61 women had one or more children; in 23 women, 33 pregnancies could be followed prospectively for aortic dimensions. Only one woman had suffered an aortic complication, a type A dissection (limited to the ascending aorta), before pregnancy. Out of 66 childless women a comparison group of 22 women was selected and individually matched. Mean initial aortic root diameter just before pregnancy was 37+/-5 mm (range 25-45). Before, during, and after pregnancy the overall individual aortic root diameter change (in 31 pregnancies) was not significant (P=0.77). Only the woman with a previous type A dissection developed an aortic complication (type B dissection) during her second pregnancy. No cardiac complications occurred in the other 22 women during their pregnancies. During a median follow-up of 6.4 years, no significant difference in growth of the aortic root was observed between the pregnancy group and the matched childless group (0.28 vs. 0.19 mm/year, P=0.08, respectively). CONCLUSION: Pregnancy in women with Marfan syndrome seems to be relatively safe up to an aortic root diameter of 45 mm, at least as far as our observed diameter range of 25-45 mm is concerned.
TI  - Pregnancy and aortic root growth in the Marfan syndrome: a prospective study.
EP  - 920
SN  - 0195-668X
IS  - iss. 9
SP  - 914
JF  - European Heart Journal
VL  - vol. 26
DO  - https://doi.org/10.1093/eurheartj/ehi103
ER  - 
TY  - JOUR
AU  - Daly, C.A.
AU  - Clemens, F.
AU  - Lopez-Sendon, J.
AU  - Tavazzi, L.
AU  - Boersma, E.
AU  - Danchin, N.
AU  - Delahaye, F.
AU  - Gitt, A.
AU  - Julian, D.
AU  - Mulcahy, D.
AU  - Ruzyllo, W.
AU  - Thygesen, K.
AU  - Verheugt, F.W.A.
AU  - Fox, K.M.
PY  - 2005
UR  - https://hdl.handle.net/2066/48196
AB  - AIMS: The Euro Heart Survey of Stable Angina set out to prospectively study the presentation and management of patients with stable angina as first seen by a cardiologist in Europe, with particular reference to adherence to existing guidelines and regional variability in patient presentation and initial assessment. METHODS AND RESULTS: Consecutive outpatients with a clinical diagnosis by a cardiologist of stable angina were enrolled in the study and 3779 patients were included in the analysis. The average age was 61 years and 58% were male. The majority of patients (88%) had mild to moderate angina, CCS class I or II. Despite a high prevalence of recognized risk factors, 27% did not have cholesterol and 33% did not have glucose measured within 4 weeks of assessment. The resting ECG was abnormal in 41% of patients. An exercise ECG was performed or planned as part of initial investigation in 76% of patients and 18% had a stress imaging test such as perfusion scanning or stress echo. A coronary angiogram was performed or planned in 41%, and 64% had an echo. The time from assessment to investigation varied widely, particularly for angiography. One in 10 patients had neither any form of stress test nor angiography, with marked regional variation. Availability of invasive facilities increased the likelihood of both non-invasive and invasive investigations. Those with more severe symptoms or longer duration of symptoms or a positive non-invasive test were more likely to have angiography. In multivariable analysis, a positive stress test was the strongest predictor of the use of angiography, associated with a six-fold increase in the likelihood of invasive investigation. However, gender and availability of facilities were also predictive. CONCLUSION: Considerable variation in features at presentation and use of investigations has been identified in the stable angina population in Europe. The evaluation of biochemical cardiovascular risk factors was suboptimal. Overall rates of non-invasive investigation for angina and the clinical appropriateness of factors predictive of the use of invasive investigation were broadly in line with guidelines. However, the influence of access to facilities, and marked international variation in rates and timing of investigation suggest that factors unrelated to clinical need are also influential in the management of patients with stable angina.
TI  - The clinical characteristics and investigations planned in patients with stable angina presenting to cardiologists in Europe: from the Euro Heart Survey of Stable Angina.
EP  - 1010
SN  - 0195-668X
IS  - iss. 10
SP  - 996
JF  - European Heart Journal
VL  - vol. 26
DO  - https://doi.org/10.1093/eurheartj/ehi171
ER  - 
TY  - JOUR
AU  - Keuper, W.
AU  - Verheugt, F.W.A.
PY  - 2005
UR  - https://hdl.handle.net/2066/47730
TI  - Hotline sessions of the 27th European congress of cardiology.
EP  - 2599
SN  - 0195-668X
IS  - iss. 23
SP  - 2596
JF  - European Heart Journal
VL  - vol. 26
ER  - 
TY  - JOUR
AU  - Schellekens, S.A.
AU  - Verheugt, F.W.A.
PY  - 2004
UR  - https://hdl.handle.net/2066/58269
TI  - Hotline sessions of the 26th European Congress of Cardiology.
EP  - 2166
SN  - 0195-668X
IS  - iss. 23
SP  - 2164
JF  - European Heart Journal
VL  - vol. 25
ER  - 
TY  - JOUR
AU  - Patrono, C.
AU  - Bachmann, F.
AU  - Baigent, C.
AU  - Bode, C.
AU  - Caterina, R. de
AU  - Charbonnier, B.
AU  - Fitzgerald, D.
AU  - Hirsh, J.
AU  - Husted, S.
AU  - Kvasnicka, J.
AU  - Montalescot, G.
AU  - Garcia Rodriguez, L.A.
AU  - Verheugt, F.W.A.
AU  - Vermylen, J.
AU  - Wallentin, L.
AU  - Priori, S.G.
AU  - Alonso Garcia, M.A.
AU  - Blanc, J.J.
AU  - Budaj, A.
AU  - Cowie, M.
AU  - Dean, V.
AU  - Deckers, J.A.
AU  - Fernandez Bugos, E.
AU  - Lekakis, J.
AU  - Lindahl, B.
AU  - Mazzotta, G.
AU  - Steg, P.G.
AU  - Teixeira, F.
AU  - Wilcox, R.
PY  - 2004
UR  - https://hdl.handle.net/2066/58492
TI  - Expert consensus document on the use of antiplatelet agents. The task force on the use of antiplatelet agents in patients with atherosclerotic cardiovascular disease of the European society of cardiology.
EP  - 181
SN  - 0195-668X
IS  - iss. 2
SP  - 166
JF  - European Heart Journal
VL  - vol. 25
DO  - http://dx.doi.org/10.1016/j.ehj.2003.10.013
ER  - 
TY  - JOUR
AU  - Barbato, E.
AU  - Aarnoudse, W.
AU  - Aengevaeren, W.R.M.
AU  - Werner, G.
AU  - Klauss, V.
AU  - Bojara, W.
AU  - Herzfeld, I.
AU  - Oldroyd, K.G.
AU  - Pijls, N.H.
AU  - Bruyne, B. de
PY  - 2004
UR  - https://hdl.handle.net/2066/59099
AB  - BACKGROUND: Coronary flow reserve (CFR) and fractional flow reserve (FFR) provide complementary information on the coronary circulation. Using a pressure wire, it is possible to calculate CFR by thermodilution (CFR(thermo)), so that FFR and CFR can be measured with a single guide wire. The present multicentric study was performed to compare the feasibility of CFR(thermo)obtained with an improved algorithm and a standardized injection technique and its agreement with Doppler-derived CFR (CFR(Doppler)). METHODS AND RESULTS: In 86 patients with coronary artery disease recruited during 1 week in eight centres FFR, CFR(thermo)and CFR(Doppler)were measured. FFR could be obtained in all patients (100%). An optimal CFR(Doppler)could be obtained in 69% of the patients. CFR(thermo)could be obtained in 97% of the patients. A significant correlation was found between CFR(Doppler)and CFR(thermo)(r=0.79, P<0.0001) but CFR(thermo)tended to be higher than CFR(Doppler). CONCLUSIONS: In a setting close to 'real world' practice, this multicentric study confirms the feasibility and reliability of thermodilution-derived CFR. In addition, the safety and the swiftness of assessing FFR and CFR with one single guide wire makes the latter a unique clinical tool for the evaluation of the coronary circulation.
TI  - Validation of coronary flow reserve measurements by thermodilution in clinical practice.
EP  - 223
SN  - 0195-668X
IS  - iss. 3
SP  - 219
JF  - European Heart Journal
VL  - vol. 25
ER  - 
TY  - JOUR
AU  - Schiks, I.E.J.M.
AU  - Nogarede-Hoekstra, J.
AU  - Aengevaeren, W.R.M.
AU  - Verheugt, F.W.A.
AU  - Achterberg, T. van
PY  - 2004
UR  - https://hdl.handle.net/2066/58745
TI  - Controlled comparison of early versus late ambulation after femoral sheath removal in coronary angioplasty.
EP  - 24
SN  - 0195-668X
IS  - iss. (suppl)
SP  - 24
JF  - European Heart Journal
VL  - vol. 25
ER  - 
TY  - JOUR
AU  - Dieker, H.J.
AU  - Verheugt, F.W.A.
PY  - 2003
UR  - https://hdl.handle.net/2066/175879
TI  - Hotline sessions of the 25th European Congress of Cardiology.
EP  - 2158
SN  - 0195-668X
IS  - iss. 23
SP  - 2156
JF  - European Heart Journal
VL  - vol. 24
ER  - 
TY  - JOUR
AU  - Werf, F. van de
AU  - Ardissino, D.
AU  - Betriu, A.
AU  - Cokkinos, D.V.
AU  - Falk, E.
AU  - Fox, K.
AU  - Julian, D.
AU  - Lengyel, M.
AU  - Neumann, F.J.
AU  - Ruzyllo, W.
AU  - Thygesen, C.
AU  - Underwood, S.R.
AU  - Vahanian, A.
AU  - Verheugt, F.W.A.
AU  - Wijns, W.
PY  - 2003
UR  - https://hdl.handle.net/2066/185091
TI  - Management of acute myocardial infarction in patients presenting with ST-segment elevation. The Task Force on the Management of Acute Myocardial Infarction of the European Society of Cardiology.
EP  - 66
SN  - 0195-668X
IS  - iss. 1
SP  - 28
JF  - European Heart Journal
VL  - vol. 24
ER  - 
TY  - JOUR
AU  - Werf, F. van de
AU  - Barron, H.V.
AU  - Armstrong, P.W.
AU  - Granger, C.
AU  - Berioli, S.
AU  - Barbash, G.
AU  - Pehrsson, K.
AU  - Verheugt, F.W.A.
AU  - Meyer, J.
AU  - Betriu, A.
AU  - Califf, R.M.
AU  - Li, X.
AU  - Fox, N.L.
PY  - 2001
UR  - https://hdl.handle.net/2066/186834
AB  - BACKGROUND: Fibrinolytic therapy increases the risk of bleeding events. TNK-tPA (tenecteplase) is a variant of rt-PA with greater fibrin specificity and reduced plasma clearance that can be given as a single bolus. We compared the incidence and predictors of bleeding events after treatment with TNK-tPA and rt-PA. METHODS AND RESULTS: In the Assessment of the Safety and Efficacy of a New Thrombolytic (ASSENT)-2 trial, 16 949 patients with acute myocardial infarction were randomly assigned a single weight-adjusted bolus of TNK-tPA or a 90-min infusion of rt-PA. A total of 4.66% of patients in the TNK-tPA group experienced major non-cerebral bleeding, in comparison with 5.94% in the rt-PA group (P=0.0002). This lower rate was associated with a significant reduction in the need for blood transfusion (4.25% vs 5.49%, P=0.0003) and was consistent across subgroups. Independent risk factors for major bleeding were older age, female gender, lower body weight, enrolment in the U.S.A. and a diastolic blood pressure <70 mmHg. Females at high risk (age >75 years and body weight <67 kg) were less likely to have major bleeding when treated with TNK-tPA even after other risk factors were taken into account. A total of 0.93% of patients in the TNK-tPA and 0.94% of patients in the rt-PA group experienced an intracranial haemorrhage. Female patients >75 years of age who weighed <67 kg tended to have lower rates of intracranial haemorrhage when treated with TNK-tPA (3/264, 1.14% vs 8/265, 3.02%). CONCLUSIONS: The increased fibrin specificity and single bolus administration of TNK-tPA do not increase the risk of intracranial haemorrhage but are associated with less non-cerebral bleeding, especially amongst high-risk patients.
TI  - Incidence and predictors of bleeding events after fibrinolytic therapy with fibrin-specific agents: a comparison of TNK-tPA and rt-PA.
EP  - 2261
SN  - 0195-668X
IS  - iss. 24
SP  - 2253
JF  - European Heart Journal
VL  - vol. 22
DO  - https://doi.org/10.1053/euhj.2001.2686
ER  - 
TY  - JOUR
AU  - Remmen, J.J.
AU  - Verheugt, F.W.A.
PY  - 2001
UR  - https://hdl.handle.net/2066/223947
TI  - The hotline sessions of the 23rd European congress of cardiology.
EP  - 2037
SN  - 0195-668X
IS  - iss. 22
SP  - 2033
JF  - European Heart Journal
VL  - vol. 22
DO  - https://doi.org/10.1053/euhj.2001.3010
ER  - 
TY  - JOUR
AU  - Berg, J.M. ten
AU  - Gerritsen, W.B.M.
AU  - Haas, F.J.L.M.
AU  - Verheugt, F.W.A.
AU  - Plokker, H.W.M.
PY  - 2000
UR  - https://hdl.handle.net/2066/173897
TI  - An additional bolus of aspirin does not guarantee complete platelet inhibition during PTCA.
EP  - 382
SN  - 0195-668X
SP  - 382
JF  - European Heart Journal
VL  - vol. 23
ER  -