TY - JOUR AU - Vanlinthout, L.E.H. AU - Mesfin, S.H. AU - Hens, N. AU - Vanacker, B.F. AU - Robertson, E.N. AU - Booij, L.H.D.J. PY - 2014 UR - https://hdl.handle.net/2066/135880 AB - We systematically reviewed factors associated with intubation conditions in randomised controlled trials of mivacurium, using random-effects meta-regression analysis. We included 29 studies of 1050 healthy participants. Four factors explained 72.9% of the variation in the probability of excellent intubation conditions: mivacurium dose, 24.4%; opioid use, 29.9%; time to intubation and age together, 18.6%. The odds ratio (95% CI) for excellent intubation was 3.14 (1.65-5.73) for doubling the mivacurium dose, 5.99 (2.14-15.18) for adding opioids to the intubation sequence, and 6.55 (6.01-7.74) for increasing the delay between mivacurium injection and airway insertion from 1 to 2 min in subjects aged 25 years and 2.17 (2.01-2.69) for subjects aged 70 years, p < 0.001 for all. We conclude that good conditions for tracheal intubation are more likely by delaying laryngoscopy after injecting a higher dose of mivacurium with an opioid, particularly in older people. TI - A systematic review and meta-regression analysis of mivacurium for tracheal intubation EP - 1387 SN - 0003-2409 IS - iss. 12 SP - 1377 JF - Anaesthesia VL - vol. 69 DO - http://dx.doi.org/10.1111/anae.12786 ER - TY - JOUR AU - Staals, L.M. AU - Boer, H.D. de AU - Egmond, J. van AU - Hope, F. AU - Pol, F.M. van de AU - Bom, A.H. AU - Driessen, J.J. AU - Booij, L.H.D.J. PY - 2011 UR - https://hdl.handle.net/2066/96292 AB - PURPOSE: Sugammadex is a selective relaxant binding agent designed to encapsulate the aminosteroidal neuromuscular blocking agent rocuronium, thereby reversing its effect. Both sugammadex and the sugammadex-rocuronium complex are eliminated by the kidneys. This study investigated the effect of sugammadex on recovery of rocuronium-induced neuromuscular block in cats with clamped renal pedicles, as a model for acute renal failure. METHODS: Twelve male cats were divided into two groups and anesthetized with medetomidine, ketamine, and alpha-chloralose. The cats were intubated and ventilated with a mixture of oxygen and air. Neuromuscular monitoring was performed by single twitch monitoring. Rocuronium 0.5 mg/kg i.v. was administered. After spontaneous recovery from neuromuscular block, both renal pedicles were ligated. A second dose of rocuronium 0.5 mg/kg i.v. was given. One minute after disappearance of the twitches, in Group 1 placebo (0.9% saline) and in Group 2 sugammadex 5.0 mg/kg i.v. was administered. Onset time, duration of neuromuscular block, and time to recovery to 25, 50, 75, and 90% were determined. Results : After renal pedicle ligation, sugammadex reversed rocuronium-induced neuromuscular block significantly faster than spontaneous recovery. Mean time (SEM) to 90% recovery of the twitch response was 4.7 (0.25) min (Group 2) versus 31.1 (5.0) min (Group 1) (p < 0.0001). No signs of recurrence of neuromuscular block were observed for 90 min after complete twitch restoration. Sugammadex caused no significant cardiovascular effects. CONCLUSION: Sugammadex rapidly and effectively reversed rocuronium-induced neuromuscular block in anesthetized cats, even when both renal pedicles were ligated and renal elimination of the drugs was no longer possible. TI - Reversal of rocuronium-induced neuromuscular block by sugammadex is independent of renal perfusion in anesthetized cats EP - 246 SN - 0913-8668 IS - iss. 2 SP - 241 JF - Journal of Anesthesia VL - vol. 25 DO - http://dx.doi.org/10.1007/s00540-010-1090-3 ER - TY - JOUR AU - Staals, L.M. AU - Egmond, J. van AU - Driessen, J.J. AU - Boer, H.D. de AU - Pol, F.M. van de AU - Bom, A.H. AU - Booij, L.H.D.J. PY - 2011 UR - https://hdl.handle.net/2066/97383 AB - BACKGROUND AND OBJECTIVE: 3-Desacetyl-vecuronium is an active metabolite of the neuromuscular blocking agent (NMBA) vecuronium, which might lead to residual paralysis after prolonged administration of vecuronium in critically ill patients with renal failure. This study investigated the ability of sugammadex to reverse 3-desacetyl-vecuronium-induced neuromuscular block (NMB) in the anaesthetised rhesus monkey. METHODS: Experiments were performed in anaesthetised female rhesus monkeys. After bolus intravenous injection of vecuronium (n = 8) or 3-desacetyl-vecuronium (n = 8) 10 mug kg(-1) (ED90), a continuous infusion of the same NMBA was started to maintain the first twitch of the train-of-four (TOF) at 10% of baseline value. The infusion was stopped and NMB recovered spontaneously. The procedure was repeated, but immediately after stopping the infusion, an intravenous bolus dose of sugammadex 0.5 or 1.0 mg kg(-1) was given. For each NMBA, four placebo experiments were performed, in which the second recovery from NMB was also spontaneous. For all experiments, time to recovery of the TOF ratio to 90% was retrieved. RESULTS: After administration of sugammadex for reversal of 3-desacetyl-vecuronium-induced NMB, recovery was significantly faster than spontaneous recovery. Mean time to recovery of TOF to 90% was 3.2 min (sugammadex 0.5 mg kg(-1)) and 2.6 min (1.0 mg kg(-1)), compared to spontaneous recovery (17.6 min). For vecuronium-induced NMB, mean time to recovery of TOF to 90% was 17.1 min (0.5 mg kg(-1)) and 4.6 min (1.0 mg kg(-1)), compared to spontaneous recovery (23.4 min). CONCLUSION: Sugammadex rapidly and effectively reversed 3-desacetyl-vecuronium-induced NMB in the rhesus monkey, at a lower dose than that needed to reverse vecuronium-induced NMB. TI - Sugammadex reverses neuromuscular block induced by 3-desacetyl-vecuronium, an active metabolite of vecuronium, in the anaesthetised rhesus monkey EP - 272 SN - 0265-0215 IS - iss. 4 SP - 265 JF - European Journal of Anaesthesiology VL - vol. 28 DO - https://doi.org/10.1097/EJA.0b013e328340894f ER - TY - BOOK AU - Booij, L.H.D.J. PY - 2011 SN - 9789090258850 UR - https://hdl.handle.net/2066/83212 PB - Nijmegen : [S.n.] TI - Achtentwintig jaar later. Verantwoording van een academische loopbaan N1 - Rede uitgesproken bij het afscheid als hoogleraar Anesthesiologie aan het Universitair Medisch Centrum St Radboud/ de Radboud Universiteit Nijmegen PS - 30 p. L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/83212/83212.pdf?sequence=1 ER - TY - JOUR AU - Boer, H.D. de AU - Egmond, J. van AU - Driessen, J.J. AU - Booij, L.H.D.J. PY - 2010 UR - https://hdl.handle.net/2066/87786 AB - A neuromuscular blocking drug (NMBD) induced neuromuscular blockade (NMB) in patients with myasthenia gravis usually dissipates either spontaneously or by administration of neostigmine. We administered sugammadex to a patient with myasthenia gravis to reverse a rocuronium-induced profound NMB. NMBDs predispose such patients to severe postoperative residual paralysis and respiratory complications. Sugammadex binds steroidal NMBDs and, therefore reverses a rocuronium or vecuronium-induced NMB, without interfering with cholinergic transmission. A rapid and complete recovery from profound NMB was achieved and no adverse events were observed. This case suggests that sugammadex is a safe and effective antagonist of a rocuronium induced NMB blockade in patients with myasthenia gravis. TI - A new approach to anesthesia management in myasthenia gravis: reversal of neuromuscular blockade by sugammadex. EP - 184 SN - 0034-9356 IS - iss. 3 SP - 181 JF - Revista Espanõla de Anestesiología y Reanimación VL - vol. 57 N1 - 1 maart 2010 ER - TY - JOUR AU - Boer, H.D. de AU - Egmond, J. van AU - Driessen, J.J. AU - Booij, L.H.D.J. PY - 2010 UR - https://hdl.handle.net/2066/89110 TI - Sugammadex in patients with myasthenia gravis. EP - 653 SN - 0003-2409 IS - iss. 6 SP - 653 JF - Anaesthesia VL - vol. 65 N1 - 1 juni 2010 DO - http://dx.doi.org/10.1111/j.1365-2044.2010.06360.x ER - TY - JOUR AU - Booij, L.H.D.J. AU - Scheffer, G.J. PY - 2010 UR - https://hdl.handle.net/2066/89152 TI - Succinylcholine should no longer be used in anaesthesia and intensive care. EP - 9 SN - 0921-8769 IS - iss. 5 SP - 9 JF - Nederlands Tijdschrift voor Anesthesiologie VL - vol. 22 ER - TY - JOUR AU - Vanlinthout, L.E.H. AU - Booij, L.H.D.J. AU - Egmond, J. van AU - Robertson, E.N. PY - 2010 UR - https://hdl.handle.net/2066/89883 AB - We measured acceleromyography and mechanomyography simultaneously with monitoring of rocuronium-induced neuromuscular block in four patients with myotonic dystrophy type 1. Furthermore, we compared neuromuscular block measures from these patients with those from normal controls from previous studies. In myotonic dystrophy type 1 patients, the dose-response curve obtained with acceleromyography was steeper and right-shifted compared with that obtained using mechanomyography. However, the effective doses to produce 95% neuromuscular block determined with both acceleromyography and mechanomyography were similar to each other and to values found in normal patients. In the three myotonic dystrophy type 1 patients with mild to moderate disease, times to recovery from block were similar to those observed in normal controls. In both patients and normal controls, neuromuscular block recovered faster with acceleromyography. However, in one patient with severe muscle wasting, recovery of neuromuscular block was prolonged. We conclude that mechanomyography and acceleromyography cannot be used interchangeably to monitor neuromuscular block in myotonic dystrophy type 1 patients. TI - Comparison of mechanomyography and acceleromyography for the assessment of rocuronium induced neuromuscular block in myotonic dystrophy type 1. EP - 607 SN - 0003-2409 IS - iss. 6 SP - 601 JF - Anaesthesia VL - vol. 65 N1 - 1 juni 2010 DO - http://dx.doi.org/10.1111/j.1365-2044.2010.06342.x ER - TY - JOUR AU - Haren, F.G. van AU - Driessen, J.J. AU - Kadic, L. AU - Egmond, J. van AU - Booij, L.H.D.J. AU - Scheffer, G.J. PY - 2010 UR - https://hdl.handle.net/2066/87755 AB - BACKGROUND AND OBJECTIVES: To evaluate the feasibility of determining the extent of sympathetic blockade by skin temperature measurement with infrared thermography and relate the cranial extent of the temperature increase to that of the sensory block after spinal anaesthesia. METHODS: Before and 5, 10 and 20 min after the administration of spinal anaesthesia, skin temperatures were measured with infrared thermography at the dermatomes T2-L3, in 12 male patients scheduled for lower limb surgery. The most cephalad dermatome at which sensory blockade occurred was related to the dermatome at which the largest temperature jump (corrected for baseline temperature) occurred. Results : The baseline temperatures showed considerable variation across the dermatomes, being lower below T12 than at the thoracic dermatomes. The mean difference between the level of the cephalad skin temperature elevation front (mean 1.03 degrees C, SD 0.8 degrees C) and cranial sensory block height was 0.10 dermatomes (SD 1.16), correlation coefficient (0.88, P<0.001). CONCLUSION: The varying baseline temperatures across the trunk, the limited sympathetic block-induced increase in skin temperature at the trunk and the difficult control of influences from the surroundings partly obscured the extent of the skin temperature increase and its correlation to sensory block height. These factors have to be controlled to improve the use of infrared cameras as an easy bedside tool for predicting the cranial extent of (sympathetic blockade during) spinal anaesthesia. TI - The relation between skin temperature increase and sensory block height in spinal anaesthesia using infrared thermography. EP - 1110 SN - 0001-5172 IS - iss. 9 SP - 1105 JF - Acta Anaesthesiologica Scandinavica VL - vol. 54 N1 - 1 oktober 2010 DO - http://dx.doi.org/10.1111/j.1399-6576.2010.02298.x ER - TY - JOUR AU - Booij, L.H.D.J. PY - 2009 UR - https://hdl.handle.net/2066/79529 AB - Residual paralysis, with its subsequent postoperative pulmonary sequelae, is one of the major complications of anaesthesia, and was recognised shortly after the introduction of neuromuscular blocking drugs into routine clinical practice. Although its incidence decreased with the introduction of intermediate duration drugs, and further diminished with routine neuromuscular monitoring and reversal with cholinesterase inhibitors, residual paralysis still remained a problem. In the search for alternatives to stop the effect of neuromuscular blocking drugs and to match their duration of action to clinical need, chelation of the non-depolarising neuromuscular blocking drugs was considered. It was recognised that cyclodextrins could encapsulate steroidal molecules and thereby inactivate the aminosteroidal neuromuscular blocking drugs. In order to improve the binding of rocuronium to the cyclodextrin and to increase the compound's water solubility, the molecule was modified. This led to the development of sugammadex (Org 25969), a modified gamma-cyclodextrin. The modification of the molecule and the initial in vitro studies that led to in vivo and later human studies of this conceptually new drug for anaesthesia are described. TI - Cyclodextrins and the emergence of sugammadex. EP - 37 SN - 0003-2409 IS - iss. suppl. 1 SP - 31 JF - Anaesthesia VL - vol. 64 Suppl 1 DO - http://dx.doi.org/10.1111/j.1365-2044.2008.05868.x ER - TY - JOUR AU - Booij, L.H.D.J. AU - Egmond, J. van AU - Driessen, J.J. AU - Boer, H.D. de PY - 2009 UR - https://hdl.handle.net/2066/80280 AB - A review is presented of animal studies of the selective steroidal neuromuscular blocking drug binding agent sugammadex. These studies demonstrate that sugammadex is faster in onset than the currently used acetylcholinesterase inhibitors, has no muscarinic effects, and is characterised by lack of adverse effects on other organs. These results offer support for the further development of sugammadex for clinical use in humans. TI - In vivo animal studies with sugammadex. EP - 44 SN - 0003-2409 IS - iss. suppl. 1 SP - 38 JF - Anaesthesia VL - vol. 64 Suppl 1 DO - http://dx.doi.org/10.1111/j.1365-2044.2008.05869.x ER - TY - JOUR AU - Boer, H.D. de AU - Egmond, J. van AU - Booij, L.H.D.J. AU - Driessen, J.J. PY - 2009 UR - https://hdl.handle.net/2066/81674 AB - A case is reported in which a child with Duchenne muscular dystrophy received a dose of sugammadex to reverse a rocuronium-induced profound neuromuscular block. Sugammadex is the first selective relaxant binding agent and reverses rocuronium- and vecuronium-induced neuromuscular block. A fast and efficient recovery from profound neuromuscular block was achieved, and no adverse events or other safety concerns were observed. TI - Reversal of rocuronium-induced profound neuromuscular block by sugammadex in Duchenne muscular dystrophy. EP - 1228 SN - 1155-5645 IS - iss. 12 SP - 1226 JF - Paediatric Anaesthesia VL - vol. 19 DO - http://dx.doi.org/10.1111/j.1460-9592.2009.03178.x ER - TY - JOUR AU - Bonthuis, D. AU - Morava, E. AU - Booij, L.H.D.J. AU - Driessen, J.J. PY - 2009 UR - https://hdl.handle.net/2066/81455 AB - Stuve Wiedemann syndrome (SWS) is an autosomal recessively inherited syndrome which is characterized by bowing of the long bones, camptodactyly, facial dysmorphism, hypotonia, feeding and swallowing difficulties, and respiratory distress. In most cases episodes of unexplained hyperthermia are present. Patients with SWS can develop hyperthermia in conjunction with anesthesia and surgery, and a relationship has been suggested between the syndrome and malignant hyperthermia. We describe a 3-year-old child diagnosed with SWS to whom we administered general anesthesia during the removal of a corneal ulcer and dilatation of the lacrimal duct. Our patient had received, uncomplicated, inhalational anesthesia five times previously for different operations. There were no anesthesia-related complications in the present or previous perioperative periods. On one occasion the patient developed mild postoperative hyperthermia. We believe that this hyperthermia is different from the specific disorder of malignant hyperthermia and that sevoflurane can be safely used in patients with SWS. We also describe symptomatically related syndromes and their theoretical risks for anesthesia. TI - Stuve Wiedemann syndrome and related syndromes: case report and possible anesthetic complications. EP - 217 SN - 1155-5645 IS - iss. 3 SP - 212 JF - Paediatric Anaesthesia VL - vol. 19 DO - http://dx.doi.org/10.1111/j.1460-9592.2008.02891.x ER - TY - JOUR AU - Sparr, H.J. AU - Booij, L.H.D.J. AU - Fuchs-Buder, T. PY - 2009 UR - https://hdl.handle.net/2066/79739 AB - Up to now only acetylcholine esterase inhibitors, such as neostigmine, were available as antagonists of residual neuromuscular blocks. Sugammadex is a modified gamma-cyclodextrin that binds rocuronium and chemically similar aminosteroidal muscle relaxants, such as vecuronium. The underlying mechanism of action is new and differs completely from that of acetylcholine esterase inhibitors. This review summarizes data published so far within the framework of the licensing procedure about the efficacy, safety and side-effects of sugammadex and presents potential new anesthesiological concepts using this compound. TI - [Sugammadex. New pharmacological concept for antagonizing rocuronium and vecuronium] J2 - [Sugammadex. New pharmacological concept for antagonizing rocuronium and vecuronium] EP - 80 SN - 0003-2417 IS - iss. 1 SP - 66 JF - Anaesthesist VL - vol. 58 DO - https://doi.org/10.1007/s00101-008-1455-2 ER - TY - JOUR AU - Sommers, M.G.J. AU - Egmond, J. van AU - Booij, L.H.D.J. AU - Heerschap, A. PY - 2009 UR - https://hdl.handle.net/2066/80056 AB - Isoflurane (ISO) can be a valuable alternative for alpha-chloralose (ACL) anesthesia in functional MRI (fMRI) studies. Therefore, we compared the efficacy of the blood oxygen level dependent (BOLD) effect in fMRI studies during ISO and ACL anesthesia sequentially in the same animals. After non-invasive instrumentation for ventilation and monitoring, series of T2* weighted MR images were acquired during forepaw stimulation, first under ISO, then followed by ACL anesthesia. The results demonstrated that ISO and ACL were both suitable to perform this fMRI experiment. The center of activation was at the same stereotactic position for both anesthetics and matched the primary somatosensory cortex (S1). Under the applied conditions, the BOLD response during ISO anesthesia declined in magnitude during the first stimulation period, as compared to ACL. From this study, we conclude that since ISO has several positive properties in comparison to ACL, including fast pharmacokinetics and suitability for repeated measurements, it is a valuable alternative for anesthesia in fMRI studies of rats. TI - Isoflurane anesthesia is a valuable alternative for alpha-chloralose anesthesia in the forepaw stimulation model in rats. EP - 418 SN - 0952-3480 IS - iss. 4 SP - 414 JF - NMR in Biomedicine VL - vol. 22 DO - https://doi.org/10.1002/nbm.1351 ER - TY - JOUR AU - Booij, L.H.D.J. AU - Leeuwen, E. van PY - 2008 UR - https://hdl.handle.net/2066/70868 AB - PURPOSE OF REVIEW: Anaesthetists are members of the operating team. Although the surgeons usually consider themselves to be the leaders of the team, all members, including the anaesthetist, have their own legal, ethical and professional responsibilities. RECENT FINDINGS: Good communication and sharing responsibility are characteristics of teamwork. Many factors can affect team functioning: training differences, social status, differences in responsibility, gender, age and culture, among others. An increasing number of individuals are involved in modern treatment due to limited working hours and increasing subspecialization, which complicates collaboration. Not all participants have the same perception of the team structure and its operation. Multidisciplinary, well designed training programmes are needed. SUMMARY: Anaesthetists have to be more aware of their position in the care team and pay more attention to their legal, ethical and professional responsibilities. TI - Teamwork and the legal and ethical responsibility of the anaesthetist. EP - 182 SN - 0952-7907 IS - iss. 2 SP - 178 JF - Current Opinion in Anesthesiology VL - vol. 21 DO - http://dx.doi.org/10.1097/ACO.0b013e3282f5ff87 ER - TY - JOUR AU - Boer, H.D. de AU - Egmond, J. van AU - Booij, L.H.D.J. AU - Driessen, J.J. PY - 2008 UR - https://hdl.handle.net/2066/70922 TI - Sugammadex, a new topic in neuromuscular management EP - 23 SN - 0921-8769 SP - 19 JF - Nederlands Tijdschrift voor Anesthesiologie VL - vol. 20 ER - TY - JOUR AU - Booij, L.H.D.J. PY - 2008 UR - https://hdl.handle.net/2066/71057 AB - PURPOSE OF REVIEW: Pharmacology is one of the corner stones of anesthesia. Outcome of anesthesia is related, in part, to both pharmacodynamics and pharmacokinetics of anesthetic drugs. Recent developments have indicated that among individuals, major differences exist in pharmacological effects. In this regard, sex, age, and genetic profile are increasingly considered to be of importance. RECENT FINDINGS: For a number of anesthetic drugs, it has been demonstrated that sex differences influence their effects and thus can alter the outcome of anesthesia. Also other genetically determined differences than sex are important. SUMMARY: In the future, it is expected that an individual's pharmacological needs will be based on age, sex, and genomics. TI - Sex, age, and genetics in anesthesia. EP - 466 SN - 0952-7907 IS - iss. 4 SP - 462 JF - Current Opinion in Anesthesiology VL - vol. 21 DO - http://dx.doi.org/10.1097/ACO.0b013e3283007ea3 ER - TY - JOUR AU - Boer, H.D. de AU - Driessen, J.J. AU - Egmond, J. van AU - Booij, L.H.D.J. PY - 2008 UR - https://hdl.handle.net/2066/71170 TI - Non-steroidal neuromuscular blocking agents to re-establish paralysis after reversal of rocuronium-induced neuromuscular block with sugammadex. EP - 6 SN - 0832-610X IS - iss. 2 SP - 124-5; author reply 125 JF - Canadian Journal of Anaesthesia VL - vol. 55 ER - TY - JOUR AU - Boer, H.D. de AU - Egmond, J. van AU - Driessen, J.J. AU - Booij, L.H.D.J. PY - 2007 UR - https://hdl.handle.net/2066/52422 TI - Update on the management of neuromuscular block-focus on sugammadex. EP - 6 SN - 1178-2021 IS - iss. 5 SP - 1 JF - Neuropsychiatric Disease and Treatment VL - vol. 3 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/52422/52422.pdf?sequence=1 ER - TY - JOUR AU - Mourisse, J.M.J. AU - Lerou, J.G.C. AU - Struys, M. AU - Zwarts, M.J. AU - Booij, L.H.D.J. PY - 2007 UR - https://hdl.handle.net/2066/53194 AB - BACKGROUND: The relative roles of forebrain and brainstem in producing adequate anaesthesia are unclear. METHODS: We simultaneously analysed the effects of sevoflurane (Group S; n = 18) or propofol (Group P; n = 29) on the bispectral index (BIS) and the first component of the blink reflex (R1). The dose of anaesthetic agent was increased until loss of blink reflex. After discontinuation and reappearance of blink reflex activity, the amount was increased again. The area under curve R1 (area-R1) of the electromyogram of the orbicularis oculi muscle after electrical stimulation of the supraorbital nerve was measured. Using a sigmoid E(max) model and a first-order rate constant k(e0), we characterized the dose-response relationships for BIS and area-R1. RESULTS: Concentration-dependent depression of BIS and area-R1 was adequately modelled. The concentration that causes an effect midway between minimum and maximum (EC50) for area-R1 was smaller than EC50 for BIS in both groups [0.34 (0.19) vs 1.29 (0.19) vol% and 1.78 (0.65) vs 2.69 (0.67) mug ml(-1); mean (sd)]. At doses of sevoflurane and propofol with equivalent depression of BIS, sevoflurane depressed area-R1 more than propofol. The k(e0) for area-R1 was about half that for BIS in both groups: 0.24 (0.19-0.29) vs 0.48 (0.38-0.60) min(-1) for Group S; 0.28 (0.23-0.34) vs 0.46 (0.40-0.54) min(-1) for Group P, geometric mean (95% CI). CONCLUSIONS: The blink reflex (brainstem function) is more sensitive to sevoflurane or propofol than BIS (forebrain function). Sevoflurane suppresses the blink reflex more than propofol. Different k(e0)s for blink reflex vs BIS indicate different effect sites. TI - Multi-level approach to anaesthetic effects produced by sevoflurane or propofol in humans: 1. BIS and blink reflex. EP - 745 SN - 0007-0912 IS - iss. 6 SP - 737 JF - British Journal of Anaesthesia VL - vol. 98 DO - https://doi.org/10.1093/bja/aem104 ER - TY - JOUR AU - Mourisse, J.M.J. AU - Lerou, J.G.C. AU - Struys, M. AU - Zwarts, M.J. AU - Booij, L.H.D.J. PY - 2007 UR - https://hdl.handle.net/2066/53290 AB - BACKGROUND: General anaesthesia could be assessed at two sites: cortical structures and the spinal cord. However, the practicalities of measurement at these two sites differ substantially. METHODS: We simultaneously analysed effects of sevoflurane (Group S; n = 16) or propofol (Group P; n = 17) on bispectral index (BIS) and the tetanic stimulus-induced withdrawal reflex (TIWR). TIWR was quantified by the area under the curve of the electromyogram of the biceps femoris muscle after electrical stimulation of the sural nerve. After loss of consciousness, TIWR was evoked once per minute. The anaesthetic was increased until TIWR disappeared. After discontinuation of the anaesthetic and reappearance of TIWR, the amount of anaesthetic was increased again. Using a sigmoid E(max) model and a first-order rate constant k(e0), we characterized the dose-response relationships for BIS and TIWR. RESULTS: Concentration-dependent depression of TIWR was reasonably well modelled for sevoflurane, but poorly for propofol. TIWR was completely suppressed by sevoflurane, but not propofol. Sevoflurane reduced TIWR to 5 mV ms (very weak movement) at 1.68 vol% end-expired concentration [approximately minimum alveolar concentration (MAC value)]. The k(e0)s for TIWR were smaller than those for BIS: 0.25 (0.16-0.39) vs 0.41 (0.33-0.51) min(-1) for Group S; 0.25 (0.22-0.30) vs 0.34 (0.29-0.40) min(-1) for Group P [geometric mean (95% CI)]. CONCLUSIONS: High concentrations of sevoflurane depress TIWR more than propofol. With propofol, we frequently observed a paradoxical behaviour of muscles of the lower leg. TIWR lags behind BIS, indicating different effect sites for two intended anaesthetic effects: unresponsiveness to noxious stimulation and unconsciousness. TI - Multi-level approach to anaesthetic effects produced by sevoflurane or propofol in humans: 2. BIS and tetanic stimulus-induced withdrawal reflex. EP - 755 SN - 0007-0912 IS - iss. 6 SP - 746 JF - British Journal of Anaesthesia VL - vol. 98 DO - https://doi.org/10.1093/bja/aem105 ER - TY - JOUR AU - Broek, P.L.C. van den AU - Rijn, C.M. van AU - Egmond, J. van AU - Coenen, A.M.L. AU - Booij, L.H.D.J. PY - 2006 UR - https://hdl.handle.net/2066/50614 AB - BACKGROUND AND OBJECTIVE: Anaesthesiologists need parameters that measure the depth of anaesthesia. In the context of this need, the present study investigated in rats how two variables from the electroencephalogram, the burst suppression ratio and effective correlation dimension correlated with a measure of anaesthetic depth as measured in the strength of a noxious withdrawal reflex. METHODS: Eight rats were exposed to different inspiratory concentrations of sevoflurane, each rat in two separate experiments. In the first experiment, spontaneously breathing animals could move freely and no painful stimuli were applied. In the second experiment, in mechanically ventilated restrained anaesthetized rats, the withdrawal reflex was measured every 80 s. In both experiments the electroencephalogram was continuously recorded. The concentration in the effector compartment was estimated using a first order two compartment model. Correlation dimension was computed following the Grassberger/Procaccia/Takens approach with optimized parameter settings to achieve maximum sensitivity to anaesthetic drug effects and enable real-time computation. The Hill, equation was fitted to the data, describing the effect as a function of sevoflurane concentration. RESULTS: Good correlations of Depth of Anaesthesia with correlation dimension as well as burst suppression ratio were established in both types of experiments. Arousal by noxious stimuli decreased burst suppression ratio and increased correlation dimension. The effective sevoflurane concentration associated with 50% of the maximum effect (C50) was higher in experiment II (stimulation) than in experiment I (no stimulation): i.e. for correlation dimension 2.18% vs. 0.60% and for burst suppression ratio 3.07% vs. 1.73%. The slope factors were: gammaCD = 4.15 vs. gammaCD = 1.73 and gammaBSR = 5.2 vs. gammaBSR = 5.4. Correlation dimension and burst suppression ratio both correlated with the strength of the withdrawal reflex with correlation coefficients of 0.46 and 0.66 respectively (P < 0.001). CONCLUSIONS: Both correlation dimension and burst suppression ratio are related to anaesthetic depth and are affected by noxious stimuli. The relationship between anaesthetic depth and burst suppression ratio is confirmed and the potential of correlation dimension is demonstrated. TI - An effective correlation dimension and burst suppression ratio of the EEG in rat. Correlation with sevoflurane induced anaesthetic depth. EP - 402 SN - 0265-0215 IS - iss. 5 SP - 391 JF - European Journal of Anaesthesiology VL - vol. 23 DO - http://dx.doi.org/10.1017/S0265021505001857 ER - TY - JOUR AU - Broek, P.L.C. van den AU - Rijn, C.M. van AU - Egmond, J. van AU - Coenen, A.M.L. AU - Booij, L.H.D.J. PY - 2006 UR - https://hdl.handle.net/2066/56943 AB - Although brain signals measured under the skull (electrocorticogram, ECoG) and signals measured on top of the scalp (electroencephalogram, EEG) stem from the same brain activity, they are different. We investigated how we can produce EEG when we know ECoG ("forward problem") and how we can produce ECoG when we know EEG ("inverse problem"). We modeled the head as three concentric spheres, representing the brain, skull and scalp. Brain activity is simulated by a dipole. The forward method links the ECoG potentials on the inner sphere to the EEG potentials on the outer sphere via a transfer matrix, based on the geometries and the conductivities of tissues involved. Results showed that the error between analytically computed EEG and EEG produced from analytically produced ECoG with the forward method, is smaller at electrodes close to the source, compared to electrodes far away from the source. The higher the resolution of an ECoG electrode grid, the better the forward model works. Another finding was that the forward model is more accurate or surface sources, compared to deep sources. This result is of practical importance, since most cognitive interesting sources stem from the cortex (the outermost layer of the brain). In the inverse model, the transfer matrix is inverted and additional regularization constraints are applied to compute ECoG from simulated EEG. We showed that the inverse model gives good results. The forward method is tested with data measured from an epileptic patient at the University of Freiburg. Results show that the forward model gives better results at the EEG electrode overlying the ECoG grid compared to the electrode posterior to the grid. Further research is needed to make errors smaller. TI - An effective correlation dimension and burst suppression ratio of the EEG in rat. Correlation with sevoflurane induced anaesthetic depth EP - 402 SN - 0265-0215 IS - iss. 5 SP - 391 JF - European Journal of Anaesthesiology VL - vol. 23 PS - 12 p. DO - http://dx.doi.org/10.1017/S0265021505001857 ER - TY - JOUR AU - Boer, H.D. de AU - Egmond, J. van AU - Pol, F. van de AU - Bom, A. AU - Booij, L.H.D.J. PY - 2006 UR - https://hdl.handle.net/2066/49508 AB - BACKGROUND: At present, reversal of neuromuscular block induced by steroidal neuromuscular blocking agents (NMBAs) is achieved by administration of cholinesterase inhibitors. Chemical encapsulation of steroidal NMBAs, such as rocuronium, by a cyclodextrin is a new concept in neuromuscular block reversal. The present study evaluates the capacity of nine synthetic cyclodextrin derivatives (Org 25288, Org 25289, Org 25467, Org 25168, Org 25169, Org 25555, Org 25166, Org 26142, and Org 25969) to reverse constant neuromuscular block of approximately 90%, induced by rocuronium infusion in the Rhesus monkey, using single twitch stimulation. The ability of these cyclodextrin derivatives to reverse neuromuscular block was compared with the reversal of the same neuromuscular block by the commonly used combination of neostigmine and atropine. METHODS: After a bolus injection of rocuronium, continuous infusion was started to reduce twitch contractions to approximately 10% of baseline values. After a steady state block of at least 10 min the infusion was stopped and the preparation was allowed to recover spontaneously. This process was repeated, but at the time the infusion was stopped, either one of the nine cyclodextrin derivatives or a combination of neostigmine and atropine was given. RESULTS: Recovery with cyclodextrin derivatives Org 26142 and Org 25969 was faster than after a combination of neostigmine and atropine (P<0.05). Injection of these cyclodextrin derivatives did not affect blood pressure or heart rate. Signs of residual block or recurarization were not observed in any of these experiments. In the experiments in which a combination of neostigmine and atropine was given, two animals showed signs of abdominal discomfort as frequently seen after the administration of neostigmine and significant changes in circulatory variables. CONCLUSIONS: Chemical encapsulation or chelation of rocuronium is a new concept in reversing neuromuscular block induced by rocuronium. TI - Chemical encapsulation of rocuronium by synthetic cyclodextrin derivatives: reversal of neuromuscular block in anaesthetized Rhesus monkeys. EP - 206 SN - 0007-0912 IS - iss. 2 SP - 201 JF - British Journal of Anaesthesia VL - vol. 96 DO - https://doi.org/10.1093/bja/aei306 ER - TY - JOUR AU - Boer, H.D. de AU - Egmond, J. van AU - Pol, F. van de AU - Bom, A. AU - Booij, L.H.D.J. PY - 2006 UR - https://hdl.handle.net/2066/50337 AB - BACKGROUND: Reversal of neuromuscular blockade can be accomplished by chemical encapsulation of rocuronium by sugammadex, a synthetic gamma-cyclodextrin derivative. The current study determined the feasibility of reversal of rocuronium-induced profound neuromuscular blockade with sugammadex in the anesthetized rhesus monkey using train-of-four stimulation. METHODS: Four female rhesus monkeys each underwent three experiments. In each experiment, first, a 100-microg/kg dose of rocuronium was injected and spontaneous recovery was monitored. After full recovery, a 500-microg/kg dose of rocuronium was injected. Up to this point, all three experiments in a single monkey were identical. One minute after this rocuronium injection, either one of the two tested dosages of sugammadex (1.0 or 2.5 mg/kg) was injected or saline was injected. RESULTS: Injection of 100 microg/kg rocuronium resulted in a mean neuromuscular blockade of 93.0% (SD = 4%), and profound blockade was achieved by injection of 500 microg/kg. In all experiments, a 100% neuromuscular blockade was achieved at this dose. After injection of the high rocuronium dose, the 90% recovery of the train-of-four ratio took 28 min (SD = 7 min) after saline, 26 min (SD = 9.5 min) after 1 mg/kg sugammadex, and 8 min (SD = 3.6 min) after 2.5 mg/kg sugammadex. Signs of residual blockade or recurarization were not observed. Injection of sugammadex had no significant effects on blood pressure or heart rate. CONCLUSIONS: Chemical encapsulation of rocuronium by sugammadex is a new therapeutic mechanism allowing effective and rapid reversal of profound neuromuscular blockade induced by rocuronium in anesthetized rhesus monkeys. TI - Reversal of profound rocuronium neuromuscular blockade by sugammadex in anesthetized rhesus monkeys. EP - 723 SN - 0003-3022 IS - iss. 4 SP - 718 JF - Anesthesiology VL - vol. 104 DO - https://doi.org/10.1097/00000542-200604000-00016 ER - TY - JOUR AU - Boer, H.D. de AU - Egmond, J. van AU - Pol, F. van de AU - Bom, A. AU - Booij, L.H.D.J. PY - 2006 UR - https://hdl.handle.net/2066/50461 AB - BACKGROUND: Binding of the steroidal molecule of rocuronium by a cyclodextrin is a new concept for reversal of neuromuscular block. The present study evaluated the ability of Sugammadex Org 25969, a synthetic gamma-cyclodextrin derivative, to reverse constant neuromuscular block of about 90% induced by rocuronium or the non-steroidal neuromuscular blocking drugs, mivacurium or atracurium, in the anaesthetized Rhesus monkey. METHODS: After a bolus injection of rocuronium, mivacurium or atracurium, a continuous infusion of these drugs was started to maintain the first twitch contraction of the train-of-four at approximately 10% of its baseline value. After a steady state block of at least 10 min the infusion was stopped and the preparation was allowed to recover spontaneously. This process was repeated, but at the time the infusion was stopped, either sugammadex 0.5 or 1.0 mg kg(-1) was given in the rocuronium-induced blockade and sugammadex 1.0 mg kg(-1) was given in the mivacurium- and atracurium-induced blockade. RESULTS: Sugammadex caused a rapid and complete reversal of rocuronium-induced neuromuscular block. The recovery time to train of four ratio=0.9 after spontaneous recovery was 14.4 min (sd=3.4 min; n=14). This was reduced significantly (P<0.001) to 3.7 min (sd=3.3 min; n=4) with sugammadex 0.5 mg kg(-1) and to 1.9 min (sd=1.0 min; n=4) with sugammadex 1.0 mg kg(-1). Signs of residual blockade or re-curarization were not observed. Reversal of mivacurium- or atracurium-induced neuromuscular block (n=2 in each experiment) by sugammadex (1.0 mg kg(-1)) was not effective. In all experiments, injection of sugammadex had no effects on blood pressure or heart rate. CONCLUSIONS: Sugammadex is effective in reversing rocuronium, but not mivacurium- or atracurium-induced neuromuscular block. TI - Sugammadex, a new reversal agent for neuromuscular block induced by rocuronium in the anaesthetized Rhesus monkey. EP - 479 SN - 0007-0912 IS - iss. 4 SP - 473 JF - British Journal of Anaesthesia VL - vol. 96 DO - https://doi.org/10.1093/bja/ael013 ER - TY - JOUR AU - Boer, H.D. de AU - Egmond, J. van AU - Pol, F. van de AU - Bom, A. AU - Driessen, J.J. AU - Booij, L.H.D.J. PY - 2006 UR - https://hdl.handle.net/2066/51063 AB - BACKGROUND: Reversal of neuromuscular block can be accomplished by chemical encapsulation of rocuronium by sugammadex (Org 25969), a synthetic gamma-cyclodextrin derivative. The present study determined the time course of the reversal action of sugammadex on rocuronium-induced block in the anaesthetized Rhesus monkey using train-of-four stimulation. METHODS: A bolus injection of rocuronium 100 microg kg(-1) (about 1xED(90)) was given to determine the degree of neuromuscular block reached by this dose. After complete spontaneous recovery, a rapid bolus injection of sugammadex, 1 mg kg(-1), was given and at different time intervals (15, 30 or 60 min, in three different experiments) the effect of another rocuronium bolus injection of 100 microg kg(-1) was determined. RESULTS: Injection of the first dose of rocuronium resulted in a mean neuromuscular block (depression of first twitch) of 93 (SEM=1.6)%. Fifteen minutes after injection of sugammadex the same rocuronium dose resulted in 17% (SEM=5.6) block. After 30 and 60 min these maximum blocks amounted to 49% (SEM=7.6) and 79% (SEM=4.2), respectively. The estimated half-life of sugammadex in Rhesus monkey is 30 (SEM=4.9) min. CONCLUSIONS: The half-life of sugammadex (Org 25969), a new fast and efficient reversal agent for rocuronium-induced block, is relatively short in the Rhesus monkey, implying the possibility to perform neuromuscular block by rocuronium shortly after reversal of a prior block. In translation to the human situation differences in rocuronium sensitivity and kinetics should be taken into account. TI - Time course of action of sugammadex (Org 25969) on rocuronium-induced block in the Rhesus monkey, using a simple model of equilibration of complex formation. EP - 686 SN - 0007-0912 IS - iss. 5 SP - 681 JF - British Journal of Anaesthesia VL - vol. 97 DO - https://doi.org/10.1093/bja/ael240 ER - TY - JOUR AU - Driessen, J.J. AU - Robertson, E.N. AU - Booij, L.H.D.J. PY - 2005 UR - https://hdl.handle.net/2066/48754 AB - BACKGROUND: We have evaluated the use of the TOF-Guard (TOF, train-of-four) acceleromyographic thumb responses to ulnar nerve stimulation in neonates and infants and the return of the responses after neuromuscular blockade. METHODS: Baseline acceleromyographic recording of thumb adduction to ulnar nerve stimulation during volatile anaesthesia was performed in 22 babies aged less than 30 weeks. At the start of stimulation the automatic set-up procedure of the TOF-Guard was used to see if a 100% control twitch height could be achieved. Irrespective of the ability to achieve a 100% control twitch height, TOF stimulation was used thereafter. When no automatic 100% control twitch could be reached, the transducer signal gain factor was set manually to obtain a 100% value. In 14 of the 22 children the recovery after neuromuscular blockade with rocuronium 0.3 mg kg(-1) was recorded. RESULTS: In nine of 22 patients a 100% baseline twitch height was obtained with the automatic set-up. In the other 13 babies the TOF-Guard display indicated that the transducer signal was too low. The mean time to recovery of control twitch to 75% of baseline after rocuronium 0.3 mg kg(-1) was 51 min (SD = 21) and the time to recovery of the TOF ratio to 70% was 49 min (SD = 19). The mean final twitch height and TOF after recovery from rocuronium blockade were 101% (SD = 15) and 92% (SD = 12), respectively. CONCLUSION: The recovery of the responses after neuromuscular blockade to near baseline values shows that acceleromyography can be used to measure neuromuscular block and recovery in neonates and infants. TI - Acceleromyography in neonates and small infants: baseline calibration and recovery of the responses after neuromuscular blockade with rocuronium. EP - 15 SN - 0265-0215 IS - iss. 1 SP - 11 JF - European Journal of Anaesthesiology VL - vol. 22 DO - http://dx.doi.org/10.1017/S0265021505000037 ER - TY - JOUR AU - Robertson, E.N. AU - Driessen, J.J. AU - Booij, L.H.D.J. PY - 2005 UR - https://hdl.handle.net/2066/49119 AB - BACKGROUND AND OBJECTIVE: This study clarifies the relationship between the neuromuscular blocking effects of rocuronium 0.6 mg kg(-1) and its pharmacokinetics in patients with renal failure. METHODS: Seventeen healthy patients and 17 patients with renal failure were studied under propofol anaesthesia in this prospective open label study. Rocuronium 0.6 mg kg(-1) was given after induction of anaesthesia. The train-of-four mechano-myographic response of the thumb to supramaximal stimulation of the ulnar nerve at 2 Hz every 12 s was measured. Venous blood samples (4 mL) were obtained at 0, 2, 4, 7, 10, 15, 20, 30, 60, 120, 180, 240 and 360 min after relaxant administration. Samples were centrifuged, separated and stored at -20 degrees C until plasma levels of rocuronium and its metabolites were measured. Two- and three-exponential equations were used to describe the pharmacokinetic data in each group and these were compared to each other using the Wilcoxon signed rank sum test as was the pharmacodynamic data. P < 0.05 was significant. RESULTS: Onset of block was similar in both groups. Clinical duration and the time to recovery of the train-of-four to 70% were prolonged in the renal failure group compared to control; 49 vs. 32 min (P < 0.004, 95% confidential, interval 17, difference 5-28) and 88 vs. 55 min (P < 0.001, 95% confidential interval 33, difference 17-50), respectively. Clearance of rocuronium was reduced by 39% in the renal failure patients compared to control, with an 84% increase in the mean residence time. The volume of distribution was unaffected by renal failure. CONCLUSIONS: The duration of action of a bolus dose of 0.6 mg kg(-1) rocuronium is increased significantly in patients with end-stage renal failure compared to healthy controls. This increase may be due to a decreased clearance of rocuronium, the disease process causing the renal failure and/or the medication which patients with renal failure need in their treatment. TI - Pharmacokinetics and pharmacodynamics of rocuronium in patients with and without renal failure. EP - 10 SN - 0265-0215 IS - iss. 1 SP - 4 JF - European Journal of Anaesthesiology VL - vol. 22 DO - http://dx.doi.org/10.1017/S0265021505000025 ER - TY - JOUR AU - Scheffer, G.J. AU - Lange, J.J. de AU - Klein, J. AU - Damen, J. AU - Booij, L.H.D.J. AU - Kleef, J.W. van PY - 2005 UR - https://hdl.handle.net/2066/48636 TI - Een omstreden uitspraak. EP - 99 SN - 0025-8245 IS - iss. 3 SP - 96 JF - Medisch Contact VL - vol. 60 ER - TY - JOUR AU - Broek, P.L.C. van den AU - Egmond, J. van AU - Rijn, C.M. van AU - Takens, F. AU - Coenen, A.M.L. AU - Booij, L.H.D.J. PY - 2005 UR - https://hdl.handle.net/2066/47849 TI - Feasibility of real-time calculation of correlation integral derived statistics applied to EGG time series EP - 208 SN - 0167-2789 IS - iss. 3-4 SP - 198 JF - Physica D-Nonlinear Phenomena VL - vol. 203 DO - https://doi.org/10.1016/j.physd.2005.03.012 ER - TY - JOUR AU - Broek, P.L.C. van den AU - Egmond, J. van AU - Rijn, C.M. van AU - Takens, F. AU - Coenen, A.M.L. AU - Booij, L.H.D.J. PY - 2005 UR - https://hdl.handle.net/2066/56948 AB - This study assessed the feasibility of online calculation of the correlation integral (C(r)) aiming to apply C(r)-derived statistics. For real-time application it is important to reduce calculation time. It is shown how our method works for EEG time series. Methods: To achieve online calculation of C(r) a non-randomly subset of inter vector distances was chosen and computer code was optimized. The effect of distance exclusion was investigated for both non-randomly and randomly chosen subsets. A C(r)-derived statistic was computed: an effective correlation dimension (CD) following the Grassberger-Procaccia-Takens approach. Results: By taking a subset of the maximum possible number of distances, C(r)-computation time could be easily 100 times reduced with marginal changes and minor variability in the C(r)-derived statistic CD. Applied to the EEG CD gives a good indication of the depth of anesthesia. Conclusions: If applied to the EEG, apparently a large number of distances can be omitted in the calculation of C(r) with minimal consequences. This outcome confirms Hoeffding's theory of U-statistics and hence it is expected to occur generally, also for non-EEG time series. TI - Feasibility of real-time calculation of correlation integral derived statistics applied to EEG time series EP - 208 SN - 0167-2789 IS - iss. 3 SP - 198 JF - Physica D-Nonlinear Phenomena VL - vol. 203 DO - https://doi.org/10.1016/j.physd.2005.03.012 ER - TY - JOUR AU - Robertson, E.N. AU - Driessen, J.J. AU - Booij, L.H.D.J. PY - 2004 UR - https://hdl.handle.net/2066/57166 AB - BACKGROUND AND AIM: Rocuronium may be given to patients for intubation and also after they have received suxamethonium for intubation. The neuromuscular profile of rocuronium given after recovery from suxamethonium may not be identical to that when rocuronium has been given alone. The neuromuscular effects of suxamethonium and rocuronium, and their effects on intraocular pressure (IOP), heart rate (HR) and arterial pressure were also recorded. METHODS: Thirty patients were randomly allocated to receive either 0.6mg kg(-1) rocuronium (n = 15) or 1 mg kg(-1) suxamethonium (n = 15) for intubation. Anaesthesia was first induced using propofol 2.5 mg kg(-1) and fentanyl 2 microg kg(-1) and maintained with propofol 6-12 mg kg(-1) h(-1). The response of the thumb to supramaximal train-of-four (TOF) ulnar nerve stimulation at the wrist was measured using a mechanomyograph. In the suxamethonium group, when the first twitch of the TOF had recovered to 90%, rocuronium 0.6 mg kg(-1) was administered. Before administration of relaxant, baseline readings of HR, arterial pressure and IOP were measured until stable, then the appropriate relaxant administered. Thereafter, all readings were repeated at 30, 90, 150, 210 and 270 s. Tracheal intubation was performed 300 s after the intubating dose and all recordings repeated 30 s later. Mechanomyographic monitoring was continued until 70% TOF recovery. RESULTS: Suxamethonium had a more rapid onset than rocuronium (49s vs. 74s, P < 0.0001). The onset time of rocuronium after suxamethonium was significantly reduced (56 s) and the time to recover to a TOF of 70% following rocuronium was increased by previous suxamethonium administration (47 vs. 58 min, P < 0.05). Suxamethonium caused a marked rise in IOP (>30%) and HR (>10%) while rocuronium had little effect on either. CONCLUSION: Previous suxamethonium administration decreases the onset time and increases the duration of action of rocuronium. Unlike suxamethonium, rocuronium has few cardiovascular effects and causes little change in IOP. TI - Suxamethonium administration prolongs the duration of action of subsequent rocuronium. EP - 737 SN - 0265-0215 IS - iss. 9 SP - 734 JF - European Journal of Anaesthesiology VL - vol. 21 DO - http://dx.doi.org/10.1017/S0265021504009111 ER - TY - JOUR AU - Bleeker, C.P. AU - Hendriks, I.M. AU - Booij, L.H.D.J. PY - 2004 UR - https://hdl.handle.net/2066/57094 AB - We describe a patient with an intracerebral haemorrhage following an accidental dural puncture during an attempted epidural for pain relief in labour. Anaesthetists need to include intracerebral haemorrhage in the differential diagnosis of post-dural puncture headache in the puerperium. TI - Postpartum post-dural puncture headache: is your differential diagnosis complete? EP - 464 SN - 0007-0912 IS - iss. 3 SP - 461 JF - British Journal of Anaesthesia VL - vol. 93 DO - http://dx.doi.org/10.1093/bja/aeh198 ER - TY - JOUR AU - Mourisse, J.M.J. AU - Lerou, J.G.C. AU - Zwarts, M.J. AU - Booij, L.H.D.J. PY - 2004 UR - https://hdl.handle.net/2066/58597 AB - BACKGROUND: General anaesthesia is characterized by loss of consciousness, amnesia and obtundation of reflex responses to noxious stimuli. Quantifying the blink reflex may reflect the depression of reflex arches induced by anaesthetics and thus being informative on the anaesthetic state. METHODS: The relation between the electrically evoked blink reflexes and the depth of sedation and anaesthesia induced with intravenous propofol was investigated. Twenty patients received propofol by target-controlled infusion to create a stepwise deepening of sedation and anaesthesia. Depth of anaesthesia was assessed using the observer's assessment of anaesthesia and sedation (OAAS) scale, and by bispectral EEG analysis (BIS). Probit analysis was used to estimate the predicted propofol effect site concentrations producing unconsciousness, no response to noxious stimulation, and loss of blink reflex components. RESULTS: Latency of the first (R1) and second (R2) blink component increased, whereas duration and area decreased with increasing depth of sedation and anaesthesia. A reasonably strong correlation between OAAS and the areas of R1 and R2 components was found (Spearman's rho = 0.92 and 0.89). The areas of R1 and R2 and the OAAS also correlated with BIS (Spearman's rho = 0.91, 0.88 and 0.90). EC(50) and EC(95) for loss of R1 were 2.8 (95% CI: 2.5-3.2) micro g/ml and 4.6 (95% CI: 4.1-5.5) micro g/ml, respectively. CONCLUSIONS: Our results suggest that the differential sensitivity of the components of the blink reflex could be useful in monitoring depth of sedation and light levels of anaesthesia during the administration of propofol. Both OAAS and BIS correlate similarly with the blink reflex components. TI - Electromyographic assessment of blink reflexes correlates with a clinical scale of depth of sedation/anaesthesia and BIS during propofol administration. EP - 1179 SN - 0001-5172 IS - iss. 9 SP - 1174 JF - Acta Anaesthesiologica Scandinavica VL - vol. 48 DO - https://doi.org/10.1111/j.1399-6576.2004.00485.x ER - TY - JOUR AU - Driessen, J.J. AU - Oort, A.M. van AU - Booij, L.H.D.J. PY - 2003 UR - https://hdl.handle.net/2066/141014 AB - Congenital supravalvular aortic stenosis is an uncommon type of aortic obstruction. When critical, it represents an extreme variant of outflow tract obstruction with increased risk of cardiovascular instability during exercise or anaesthesia. We present a case of severe myocardial ischaemia during induction of anaesthesia with sevoflurane in a 3-month baby with a presumed diagnosis of valvular aortic stenosis for which a percutaneous balloon dilatation of the aortic valve was scheduled. TI - Severe myocardial ischaemia during mask induction of anaesthesia in an infant with unknown critical supravalvular aortic stenosis. EP - 570 SN - 0003-2409 IS - iss. 6 SP - 568 JF - Anaesthesia VL - vol. 58 DO - http://dx.doi.org/10.1046/j.1365-2044.2003.03146.x ER - TY - JOUR AU - Mourisse, J.M.J. AU - Booij, L.H.D.J. PY - 2003 UR - https://hdl.handle.net/2066/155956 TI - Bispectral index detects period of cerebral hypoperfusion during cardiopulmonary bypass. EP - 78 SN - 1053-0770 IS - iss. 1 SP - 76 JF - Journal of Cardiothoracic and Vascular Anesthesia VL - vol. 17 DO - http://dx.doi.org/10.1053/jcan.2003.14 ER - TY - JOUR AU - Diagos, P. AU - Bos, J.A. AU - Verrips, A. AU - Booij, L.H.D.J. PY - 2003 UR - https://hdl.handle.net/2066/155978 TI - Giant axonal neuropathy and anaesthesia. EP - 724 SN - 0003-2409 IS - iss. 7 SP - 723 JF - Anaesthesia VL - vol. 58 DO - http://dx.doi.org/10.1046/j.1365-2044.2003.327915.x ER - TY - JOUR AU - Jongh, R.F.J. de AU - Vissers, K.C.P. AU - Meert, T.F. AU - Booij, L.H.D.J. AU - Deyne, C.S. AU - Heylen, R. PY - 2003 UR - https://hdl.handle.net/2066/156000 AB - IMPLICATIONS: That IL-6 is an interesting target in the study of pain is underscored by its biomolecular properties, its localization after experimental pain, and its modulating effect on pain after administration. TI - The role of interleukin-6 in nociception and pain. EP - 1103 SN - 0003-2999 IS - iss. 4 SP - 1096 JF - Anesthesia and Analgesia VL - vol. 96 DO - http://dx.doi.org/10.1213/01.ANE.0000055362.56604.78 ER - TY - JOUR AU - Jongh, R.F.J. de AU - Vissers, K.C.P. AU - Booij, L.H.D.J. AU - Jongh, K.L. de AU - Vincken, P. AU - Meert, T.F. PY - 2003 UR - https://hdl.handle.net/2066/155989 AB - Surgery is followed by an acute-phase response, including hypothalamo-pituitary-adrenal (HPA)-axis activation and fever. Considering its physiological properties and its behaviour in plasma after stress and surgery, the pro-inflammatory cytokine interleukin (IL)-6 is a putative candidate in eliciting these stress-related symptoms. However, evidence for this hypothesis is lacking. Rats subjected to individual psychological stress for 1h were injected intraperitoneally with saline or 3.33 microg per 100g rat neutralizing antibodies against rat IL-6. Thereafter, the single-housed rats were anaesthetized for 25 min, with or without undergoing a laparotomy. Intermittently, oesophageal temperatures were measured at defined time points. A parallel group of rats undergoing the same study protocol were decapitated, at time points when body temperatures differed, to obtain blood for measurement of plasma adrenocorticotropic hormone and corticosterone. Individual housing resulted in hyperthermia. Antibodies against IL-6 accelerated normalization of body temperature after individualizing stress, limited postoperative hyperthermia after laparotomy, but accentuated hyperthermia after anaesthesia alone. Antibody administration was not able to significantly influence the plasma hormone levels during any experiment. The present study indicates that IL-6 is a thermoregulatory factor during psychological, anaesthesiological and surgical stress, but the cytokine does not participate in HPA-axis activation until 6h after anaesthesia or surgery. A dose-finding study with antibodies against IL-6 ought to further identify the degree of contribution of IL-6 to perioperative thermoregulation. TI - Interleukin-6 and perioperative thermoregulation and HPA-axis activation. EP - 256 SN - 1043-4666 IS - iss. 5 SP - 248 JF - Cytokine VL - vol. 21 DO - https://doi.org/10.1016/S1043-4666(03)00093-0 ER - TY - JOUR AU - Mourisse, J.M.J. AU - Gerrits, W.B.J. AU - Lerou, J.G.C. AU - Egmond, J. van AU - Zwarts, M.J. AU - Booij, L.H.D.J. PY - 2003 UR - https://hdl.handle.net/2066/155967 AB - BACKGROUND: There are at least three components of the anesthetic state: loss of consciousness, amnesia and obtundation of reflex responses to noxious stimuli. To investigate the third component, we used a standard electrical stimulus to evoke a blink reflex, which was electromyographically recorded. These data may give information on the anesthetic state. METHODS: The relation between the electrically evoked blink and corneal reflexes and the depth of sedation and anesthesia induced with intravenous midazolam was investigated. Ten patients received i.v. increments of midazolam (1 mg, 2 mg, 3 mg, 3 mg, 3 mg, etc., until a 21-mg total dose) to create a step-wise deepening of sedation and anesthesia. Depth of anesthesia was assessed by the Observer's Assessment of Alertness/Sedation (OAAS) scale, ranging from 5 ( = awake and alert) to 0 ( = no motor response to tetanic stimulation). RESULTS: Latency of the first (R1) and second (R2) blink components and the corneal (C) reflex component increased, whereas duration and area decreased with increasing depth of sedation and anesthesia. R1 was last seen at an OAAS score [mean (SD)] of 1.8 (0.8), R2 at a score of 3.1 (1.1), C at a score of 3.8 (0.8), and R3 at 4.8 (0.5). These end-points were all statistically different from each other, except R2 vs. C. CONCLUSIONS: Our results suggest that the differential sensitivity of the components of the blink reflex could be useful to monitor depth of sedation and light levels of anesthesia during the administration of midazolam. TI - Electromyographic assessment of blink and corneal reflexes during midazolam administration: useful methods for assessing depth of anesthesia? EP - 600 SN - 0001-5172 IS - iss. 5 SP - 593 JF - Acta Anaesthesiologica Scandinavica VL - vol. 47 DO - https://doi.org/10.1034/j.1399-6576.2003.00100.x ER - TY - JOUR AU - Lerou, J.G.C. AU - Booij, L.H.D.J. PY - 2002 UR - https://hdl.handle.net/2066/155935 AB - BACKGROUND: We quantified the predictive performance of our computer model of the administration of inhalation anaesthesia from a Datex-Ohmeda Modulus CD circle-absorber system. METHODS: In 50 patients, desflurane anaesthesia was maintained with a fresh-gas flow (FGF) of 0.5 litres min(-1) of both nitrous oxide and oxygen, preceded by fast (n=14) or slow (n=36) induction: FGF greater than total ventilation, Group F; FGF equal to 1.0 litres min(-1), Group S. The two versions of the model studied differed in the size of their inter-tissue diffusion, as 0 (version 1) and 3% (version 2) of the cardiac output was shifted from the viscera to adipose tissue. Model performance was judged by comparing measured and predicted gas concentrations in terms of three variables for each gas concentration in each patient: root mean squared error (rmse=total error), bias (mean predicted - measured) (systematic error), and scatter (error around bias). These variables were then averaged over all patients. These measures were calculated overall, and separately for each group and each stage (1 = induction or 2 = maintenance). RESULTS: Model predictions were in reasonable to very good agreement with clinically obtained data. Version 2 performed better than version 1. Differences between groups were not demonstrated. The model performed better for stage 2, but only for desflurane. In group S, results (mean (SD); as percentages of the measured values for nitrous oxide, oxygen and desflurane) in the order rmse, bias, and scatter were for end-tidal concentrations of nitrous oxide: 8 (4), 8 (5), 2 (1)%; oxygen: 11 (4), -10 (6), 2 (1.1)%; nitrogen: 0.9 (0.6), -0.8 (0.6), 0.2 (0.1) vol%; carbon dioxide: 1.8 (0.6), 1.8 (0.6), 0.2 (0.1) vol%; desflurane, stage 2: 8 (4), 4 (7), 4 (2)%, vs 15 (6), -10 (8), 9 (4)% for stage 1. CONCLUSION: Administration of inhalation anaesthesia can be based on version 2 of this model, but must be guided by active monitoring. TI - Model-based administration of inhalation anaesthesia. 3. Validating the system model. EP - 37 SN - 0007-0912 IS - iss. 1 SP - 24 JF - British Journal of Anaesthesia VL - vol. 88 DO - http://dx.doi.org/10.1093/bja/88.1.24 ER - TY - JOUR AU - Lerou, J.G.C. AU - Verheijen, R. AU - Booij, L.H.D.J. PY - 2002 UR - https://hdl.handle.net/2066/155936 AB - BACKGROUND: We developed and tested a simple dosing strategy for rapid induction with isoflurane followed by maintenance under minimal-flow conditions, that is 0.5 litre min(-1) total fresh gas flow (FGF). An end-expired concentration was to be achieved within 5 min in a desired therapeutic window, that is 0.8-1.1 vol%, and to be maintained within it for at least 30 min. METHODS: With our new model we computed a three-stage regimen using one fixed vaporizer setting: 3 vol% isoflurane in a FGF of 3 and 1.5 litre min(-1), each for 3 min, and 0.5 litre min thereafter. The ratio of nitrous oxide:oxygen was, consecutively, 2:1, 2:1, and 2:3. We evaluated this scheme in 58 adult patients (body mass 74 (SD 13) kg), mostly during eye and ear, nose, and throat surgery. RESULTS: Measured oxygen (33-45 vol%) and nitrous oxide concentrations (66-50 vol%) evolved in accordance with those computed. In five patients with a median of body mass 92 kg (range 76-126 kg), inspired oxygen concentrations decreased to less than 30 vol%. End-expired isoflurane concentration entered the window after 2 min (range 1.0-5.67 min) and attained its maximum, that is 0.96 vol% (0.8-1.2 vol%), after 3.45 min (1.67-6.33 min). The mean end-expired concentration was in the desired window from 3-60 min and an average of 72% of individual measurements were within the window from 3-30 min. The scheme was adapted in six patients (excluded from analysis) because of hypotension. CONCLUSION: The regimen is easily remembered, reliable, and lends itself to alternative strategies, but must be guided by the monitoring of gas and vapour concentrations and haemodynamic variables. TI - Model-based administration of inhalation anaesthesia. 4. Applying the system model. EP - 183 SN - 0007-0912 IS - iss. 2 SP - 175 JF - British Journal of Anaesthesia VL - vol. 88 DO - http://dx.doi.org/10.1093/bja/88.2.175 ER - TY - JOUR AU - Booij, L.H.D.J. AU - Vree, T.B. PY - 2002 UR - https://hdl.handle.net/2066/155937 TI - Neuromusculaire overdracht en neurotoxines. EP - 140 SN - 0921-8769 SP - 128 JF - Nederlands Tijdschrift voor Anesthesiologie VL - vol. 15 ER - TY - JOUR AU - Booij, L.H.D.J. PY - 2002 UR - https://hdl.handle.net/2066/155938 TI - Perioperatieve antistolling met Fondaparinux en epidurale anesthesie. EP - 101 SN - 0921-8769 SP - 97 JF - Nederlands Tijdschrift voor Anesthesiologie VL - vol. 15 ER - TY - JOUR AU - Booij, L.H.D.J. AU - Vree, T.B. AU - Burm, A.G.L. PY - 2002 UR - https://hdl.handle.net/2066/155940 TI - Stereo-isomerie in de anesthesiologie. EP - 84 SN - 0921-8769 SP - 75 JF - Nederlands Tijdschrift voor Anesthesiologie VL - vol. 15 ER - TY - JOUR AU - Driessen, J.J. AU - Robertson, E.N. AU - Egmond, J. van AU - Booij, L.H.D.J. PY - 2002 UR - https://hdl.handle.net/2066/155941 AB - BACKGROUND: The time-course of the neuromuscular effects of rocuronium 0.3 mg.kg-1 during nitrous oxide-halothane anaesthesia in children with and without renal failure is unknown. This study compared the neuromuscular blocking effects in these groups. METHODS: The study was approved by the Hospital Ethical Committee. In the control group, 14 healthy children without renal disease were scheduled for various elective surgical procedures. Sixteen children with endstage renal failure, 14 of whom were already on renal dialysis, were scheduled for (re)placement of dialysis catheters (n=14) or for renal transplantation (n=2). Anaesthesia was induced and maintained with halothane and nitrous oxide in oxygen. Acceleromyographic thumb adduction after supramaximal ulnar nerve stimulation was recorded using train-of-four stimulation every 15 s. The onset time, the time to recovery of the first twitch to 25% or 75% and to recovery of a train-of-four ratio of 0.7 after rocuronium 0.3 mg.kg-1 were measured. Statistical analysis was performed with Student's t-test. P < 0.05 was considered statistically significant. RESULTS: The onset time was longer in children with renal failure (139 s, SD=71) than in control children (87 s, SD=43) (P=0.02). There were no significant differences in the duration of action of rocuronium between children without renal failure and in 15 out of 16 children with renal failure. CONCLUSIONS: In children with renal failure, aged over 1 year, a single bolus dose of rocuronium 0.3 mg.kg-1 does not cause a prolonged block, but has a slower onset than in healthy children. TI - Time-course of action of rocuronium 0.3 mg.kg-1 in children with and without endstage renal failure. EP - 510 SN - 1155-5645 IS - iss. 6 SP - 507 JF - Paediatric Anaesthesia VL - vol. 12 DO - http://dx.doi.org/10.1046/j.1460-9592.2002.00891.x ER - TY - JOUR AU - Booij, L.H.D.J. PY - 2002 UR - https://hdl.handle.net/2066/156011 TI - End-of-life decisions in The Netherlands. EP - 165 SN - 0265-0215 IS - iss. 3 SP - 161 JF - European Journal of Anaesthesiology VL - vol. 19 ER - TY - JOUR AU - Booij, L.H.D.J. PY - 2002 UR - https://hdl.handle.net/2066/156013 AB - In its attempt to liberate the hostages in Moscow, the government used a gas or vapour. Classical war gases are not appropriate for such a task because they cause irreparable damage, while inhalation anaesthetics are inappropriate because they take too long to take effect, and because hundreds of litres would have been required for a sufficient effect. Following the liberation of the hostages, it was reported that a fentanyl derivative had been used, most likely carfentanyl. From the way that the hostages, in Moscow were liberated, it is clear that terrorist attacks in which chemicals are used may also take place in the future in the Netherlands. In order to be able to react adequately to such situations, additional training for physicians and other health-care personnel is urgently necessary and the hospitals must also be better prepared for this task, especially for the artificial respiration of large numbers of patients and for the administration of large amounts of antidote in easy-to-use dosage units. From now on, on-site treatment and stabilisation will not be reserved only for trauma cases. TI - Het bij beëndiging van de schouwburggijzeling in Moskou gebruikte middel en de ontoereikende voorbereiding van Nederland op een terroristische chemische calamiteit. EP - 2401 SN - 0028-2162 IS - iss. 50 SP - 2396 JF - Nederlands Tijdschrift voor Geneeskunde VL - vol. 146 ER - TY - JOUR AU - Simon, M.A.M. AU - Vree, T.B. AU - Gielen, M.J.M. AU - Booij, L.H.D.J. AU - Lagerwerf, A.J. PY - 2002 UR - https://hdl.handle.net/2066/155939 TI - Similar motor block effects and disposition kinetics between lidocaine and (+/-) mepivacaine in patients undergoing axillary brachial plexus block during day case surgery. EP - 1311 SN - 1537-744X SP - 1298 JF - Scientific World Journal VL - vol. 2 DO - https://doi.org/10.1100/tsw.2002.180 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/155939/155939.pdf?sequence=1 ER - TY - JOUR AU - Booij, L.H.D.J. AU - Vree, T.B. PY - 2001 UR - https://hdl.handle.net/2066/155942 TI - De ethische verantwoordelijkheid van de anesthesioloog in de gezondheidszorg EP - 65 SN - 0921-8769 SP - 59 JF - Nederlands Tijdschrift voor Anesthesiologie VL - vol. 14 ER - TY - JOUR AU - Booij, L.H.D.J. PY - 2001 UR - https://hdl.handle.net/2066/155943 AB - Muscle relaxants in intensive care unit (ICU) patients are predominantly administered to facilitate intubation. The adverse effect profile of succinylcholine is such that its use in the ICU must be considered obsolete. Suitable alternatives are the intermediately long-acting nondepolarizing relaxants, of which rocuronium is probably preferable. TI - Is succinylcholine appropriate or obsolete in the intensive care unit? EP - 6 SN - 0090-3493 IS - iss. 5 SP - 245- JF - Critical Care Medicine VL - vol. 5 DO - http://dx.doi.org/10.1097/00003246-197709000-00008 ER - TY - JOUR AU - Lerou, J.G.C. AU - Booij, L.H.D.J. PY - 2001 UR - https://hdl.handle.net/2066/155944 AB - This paper is the first of a series of reports on a system model for the administration of inhalation anaesthesia. We present the development and basic testing of the model. It is a multiple-gas model; it covers fresh-gas flow rates from basal to more than total ventilation and includes an actual, not an idealized, circle-absorber breathing system featuring a standing bellows ventilator. Kinetics of nitrogen, oxygen, carbon dioxide, nitrous oxide, inhaled anaesthetic agents and helium are described. Their partial pressures sum to the total pressure. Ventilation and cardiac output are treated as continuous, not cyclical. The model of the breathing system was empirically matched to the chosen one (a GMS absorber and 7850 ventilator (Datex-Ohmeda)). Predictions for the wash-in of isoflurane and the uptake of desflurane and isoflurane agree well with observed data. The results obtained by continuously checking total gas pressures, calculating mass balances and simulating the measurement of alveolar space by the closed-circuit helium dilution method support the mathematical credibility of the model. It thus merits further exploration. TI - Model-based administration of inhalation anaesthesia. 1. Developing a system model. EP - 28 SN - 0007-0912 IS - iss. 1 SP - 12-2 JF - British Journal of Anaesthesia VL - vol. 86 DO - http://dx.doi.org/10.1093/bja/86.1.12 ER - TY - JOUR AU - Lerou, J.G.C. AU - Booij, L.H.D.J. PY - 2001 UR - https://hdl.handle.net/2066/155946 AB - We explored our model by displaying its new capabilities, testing its sensitivity to variations in input data and illustrating its use. Its multiple-gas character allows simulation of the mechanisms governing concentration and second gas effects. Simulating the volume of a standing bellows makes it possible to test algorithms for automated closed-circuit anaesthesia. Using desflurane, the model's sensitivity to changes in blood/gas partition coefficient (range 0.42-0.576), cardiac output and minute ventilation was analysed. The model was very sensitive to changes in blood solubility; other results agreed with those reported previously. An alveolar isoflurane tension of 1% atm was rapidly attained and maintained, even using 0.5 litres min(-1) of fresh gas, when isoflurane was 'co-administered' through a vaporizer set to 3.5 vol% and a single aliquot (1.25 ml liquid) injected into the expiratory limb. As a result of its credibility and capabilities, the model is to be tested in the clinical setting. TI - Model-based administration of inhalation anaesthesia. 2. Exploring the system model. EP - 37 SN - 0007-0912 IS - iss. 1 SP - 29-3 JF - British Journal of Anaesthesia VL - vol. 86 DO - http://dx.doi.org/10.1093/bja/86.1.29 ER - TY - JOUR AU - Booij, L.H.D.J. PY - 2001 UR - https://hdl.handle.net/2066/155948 TI - The future of anaesthesiology. EP - 6 SN - 0265-0215 IS - iss. 3 SP - 131- JF - European Journal of Anaesthesiology VL - vol. 18 DO - http://dx.doi.org/10.1097/00003643-200103000-00001 ER - TY - JOUR AU - Booij, L.H.D.J. AU - Houweling, P.J. PY - 2001 UR - https://hdl.handle.net/2066/155947 TI - Rocuronium: high risk for anaphylaxis? EP - 6 SN - 0007-0912 IS - iss. 5 SP - 805- JF - British Journal of Anaesthesia VL - vol. 87 ER - TY - JOUR AU - Lee Kong, P. AU - Vree, T.B. AU - Booij, L.H.D.J. PY - 2001 UR - https://hdl.handle.net/2066/155949 TI - Vermindert pre-operatief toegediende morfine met gereguleerde afgifte (Kapanol) de post-operatieve pijn op de verkoeverkamer? EP - 65 SN - 0921-8769 SP - 59 JF - Nederlands Tijdschrift voor Anesthesiologie VL - vol. 14 ER - TY - CONF AU - Broek, P.L.C. van den AU - Egmond, J. van AU - Rijn, C.M. van AU - Dirksen, R. AU - Coenen, A.M.L. AU - Booij, L.H.D.J. PY - 2000 UR - http://repository.ubn.ru.nl/handle/2066/126744 AB - To find a new measure from the EEG that quantifies the effects of anesthetics during surgery, the correlation dimension (CD) of the EEG of eight rats was estimated. To get informed about the anesthetic state, the noxious induced withdrawal reflex (NIWR) was measured, i.e. the force elicited by transcutaneous electrical stimulation of the hind paw. The algorithm of Grassberger and Procaccia (1983) to compute the CD was slightly modified and labeled as "dimensional complexity" (DC). The DC was estimated by applying a fit procedure to find the scaling region in the correlation integral. Experiments were performed under propofol infusion (30 à 40 mg.kg-1.h-1), with repeated bolus injections (3 mg) to induce periods of more profound anesthesia. The DC was compared to the Spectral Edge Frequency (SEF), a linear measure extracted from the power spectrum. The DC and SEF were correlated with the NIWR responses. The DC showed higher and more consistent correlations with the NIWR than the SEF. Correlation coefficients of NIWR and DC mainly varied between 0.6 and 0.8. Conclusion: New parameters from the field of non-linear dynamics can be an aiding tool in detecting effectual changes induced by anesthetics. PB - Singapore : World Scientific TI - The application of a non-linear analysis technique to the monitoring of anesthetic effects in the rat EP - 262 SP - 259 CT - Lehnertz, K.; Elger, C.E.; Arnhold, J. (ed.), Chaos in the brain. Proceedings of the 1999 Workshop ER - TY - JOUR AU - Booij, L.H.D.J. AU - Vree, T.B. AU - Driessen, J.J. PY - 2000 UR - https://hdl.handle.net/2066/155950 TI - De farmacologie van het bijkomen uit anesthesie EP - 101 SN - 0921-8769 SP - 96 JF - Nederlands Tijdschrift voor Anesthesiologie VL - vol. 13 ER - TY - JOUR AU - Booij, L.H.D.J. AU - Vree, T.B. PY - 2000 UR - https://hdl.handle.net/2066/155951 TI - Ethical responsibilities of the anaesthesiologist in patient care EP - 28 SN - 1027-9148 IS - iss. 1 SP - 24 JF - South African Journal of Anaesthesiology and Analgesia VL - vol. 6 ER - TY - JOUR AU - Booij, L.H.D.J. AU - Vree, T.B. PY - 2000 UR - https://hdl.handle.net/2066/155954 TI - Skeletal muscle relaxants: pharmacodynamics and pharmacokinetics in different patient groups EP - 534 SN - 1368-5031 IS - iss. 8 SP - 526 JF - International Journal of Clinical Practice VL - vol. 54 ER - TY - JOUR AU - Booij, L.H.D.J. PY - 2000 UR - https://hdl.handle.net/2066/155955 TI - The history of neuromuscular blocking agents EP - 33 SN - 0953-7112 SP - 27 JF - Current Anaesthesia and Critical Care VL - vol. 11 ER - TY - JOUR AU - Driessen, J.J. AU - Robertson, E.N. AU - Egmond, J. van AU - Booij, L.H.D.J. PY - 2000 UR - https://hdl.handle.net/2066/155957 TI - The time-course of action and recovery of rocuronium 0.3 mg x kg(-1) in infants and children during halothane anaesthesia measured with acceleromyography EP - 497 SN - 1155-5645 IS - iss. 5 SP - 493 JF - Paediatric Anaesthesia VL - vol. 10 DO - http://dx.doi.org/10.1046/j.1460-9592.2000.00543.x ER - TY - JOUR AU - Driessen, J.J. AU - Robertson, E.N. AU - Booij, L.H.D.J. PY - 2000 UR - https://hdl.handle.net/2066/155958 TI - Which is better in children: edrophonium or neostigmine? [letter] EP - 294 SN - 0007-0912 IS - iss. 2 SP - 293 JF - British Journal of Anaesthesia VL - vol. 84 ER - TY - JOUR AU - Booij, L.H.D.J. AU - Broek, L.A.G.M. van der AU - Caulfield, W. AU - Dommerholt-Caris, B.M.G. AU - Clark, J.K. AU - Egmond, J. van AU - McGuire, R. AU - Muir, A.W. AU - Ottenheijm, H.C.J. AU - Rees, D.C. PY - 2000 UR - https://hdl.handle.net/2066/155953 TI - Non-depolarizing neuromuscular blocking activity of bisquaternary amino di- and tripeptide derivatives EP - 4833 SN - 0022-2623 IS - iss. 25 SP - 4822 JF - Journal of Medicinal Chemistry VL - vol. 43 DO - https://doi.org/10.1021/jm0010062 ER - TY - JOUR AU - Cozanitis, D.A. AU - Booij, L.H.D.J. PY - 2000 UR - https://hdl.handle.net/2066/155952 TI - Muscle relaxants and renal failure [letter] EP - 1714 SN - 1079-2082 SP - 1713 JF - American Journal of Health-System Pharmacy VL - vol. 57 ER - TY - JOUR AU - Booij, L.H.D.J. PY - 1999 UR - https://hdl.handle.net/2066/155959 TI - Anaesthesia and organ transplantation (editorial). EP - 285 SN - 0953-7112 SP - 285 JF - Current Anaesthesia and Critical Care VL - vol. 10 ER - TY - JOUR AU - Booij, L.H.D.J. AU - Vree, T.B. PY - 1999 UR - https://hdl.handle.net/2066/155960 TI - Anaesthesia in patients with neuromuscular diseases EP - 32 SN - 1027-9148 IS - iss. 4 SP - 24 JF - South African Journal of Anaesthesiology and Analgesia VL - vol. 5 ER - TY - JOUR AU - Booij, L.H.D.J. PY - 1999 UR - https://hdl.handle.net/2066/155961 TI - Brain death and care of the brain death patient. EP - 318 SN - 0953-7112 SP - 312 JF - Current Anaesthesia and Critical Care VL - vol. 10 ER - TY - JOUR AU - Booij, L.H.D.J. AU - Vree, T.B. PY - 1999 UR - https://hdl.handle.net/2066/155962 TI - De rol van de anesthesioloog bij de beheersing van de luchtweg in de spoedeisende geneeskunde. EP - 85 SN - 0921-8769 SP - 81 JF - Nederlands Tijdschrift voor Anesthesiologie VL - vol. 12 ER - TY - JOUR AU - Booij, L.H.D.J. AU - Driessen, J.J. AU - Vree, T.B. PY - 1999 UR - https://hdl.handle.net/2066/155966 TI - Spierrelaxatie voor de kleintjes. EP - 26 SN - 0921-8769 SP - 21 JF - Nederlands Tijdschrift voor Anesthesiologie VL - vol. 12 ER - TY - JOUR AU - Booij, L.H.D.J. PY - 1999 UR - https://hdl.handle.net/2066/155968 TI - The best way to defend our profession, intra murally and beyond. EP - 27 SN - 0001-5164 IS - iss. 1 SP - 19 JF - Acta Anaesthesiologica Belgica VL - vol. 50 ER - TY - JOUR AU - Booij, L.H.D.J. AU - Vree, T.B. AU - Koppers-Hoyset, H. AU - Lagerwerf, A.J. PY - 1999 UR - https://hdl.handle.net/2066/155964 TI - Explorative pharmacokinetic study of preoperative administration of morphine 50 mg sustained-release capsules (Kapanol) to surgical patients. EP - 132 SN - 1173-2563 SP - 125 JF - Clinical Drug Investigation VL - vol. 18 DO - https://doi.org/10.2165/00044011-199918020-00005 ER - TY - JOUR AU - Simon, M.A.M. AU - Vree, T.B. AU - Gielen, M.J.M. AU - Booij, L.H.D.J. AU - Lagerwerf, A.J. PY - 1999 UR - https://hdl.handle.net/2066/155965 TI - Similar motor block effects with different disposition kinetics between lidocaine and (±) articaine in patients undergoing axillary brachial plexus block during day case surgery. EP - 607 SN - 0946-1965 IS - iss. 12 SP - 598 JF - International Journal of Clinical Pharmacology and Therapeutics VL - vol. 37 ER - TY - JOUR AU - Driessen, J.J. AU - Harbers, J.B.M. AU - Egmond, J. van AU - Booij, L.H.D.J. PY - 1999 UR - https://hdl.handle.net/2066/155963 TI - Evaluation of the electroencephalographic bispectral index during fentanyl-midazolam anaesthesia for cardiac surgery. Does it predict haemodynamic responses during endotracheal intubation and sternotomy? EP - 627 SN - 0265-0215 SP - 622 JF - European Journal of Anaesthesiology VL - vol. 16 DO - https://doi.org/10.1046/j.1365-2346.1999.00551.x ER - TY - JOUR AU - Bleeker, C.P. AU - Vree, T.B. AU - Grood, P.M.R.M. de AU - Booij, L.H.D.J. PY - 1999 UR - https://hdl.handle.net/2066/155969 TI - Vanuit welke context gezien is het van belang om de lange halfwaardetijd van propofol en zijn glucuronide metabolieten te kennen? EP - 122 SN - 0921-8769 SP - 116 JF - Nederlands Tijdschrift voor Anesthesiologie VL - vol. 12 ER - TY - JOUR AU - Driessen, J.J. AU - Robertson, E.N. AU - Booij, L.H.D.J. AU - Vree, T.B. PY - 1998 UR - https://hdl.handle.net/2066/155970 TI - Accelerated recovery and disposition from rocuronium in an end-stage renal failure patient on chronic anticonvulsant therapy with sodium valproate and primidone EP - 388 SN - 0007-0912 SP - 386 JF - British Journal of Anaesthesia VL - vol. 80 PS - 3 p. ER - TY - JOUR AU - Booij, L.H.D.J. AU - Vree, T.B. PY - 1998 UR - https://hdl.handle.net/2066/155971 TI - Clinical pharmacology research, from design to publication and patient care EP - 123 SN - 0921-8769 SP - 117 JF - Nederlands Tijdschrift voor Anesthesiologie VL - vol. 11 PS - 7 p. ER - TY - JOUR AU - Simon, M.A.M. AU - Vree, T.B. AU - Gielen, M.J.M. AU - Booij, L.H.D.J. PY - 1998 UR - https://hdl.handle.net/2066/155973 TI - Comparison of the effects and disposition kinetics of articaine and lidocaine in 20 patients undergoing intravenous regional anaesthesia during day case surgery EP - 92 SN - 0928-1231 SP - 88 JF - Pharmacy World and Science VL - vol. 20 PS - 5 p. DO - http://dx.doi.org/10.1023/A:1008622018161 ER - TY - JOUR AU - Simon, M.A.M. AU - Gielen, M.J.M. AU - Vree, T.B. AU - Booij, L.H.D.J. PY - 1998 UR - https://hdl.handle.net/2066/155974 TI - Disposition of lignocaine for intravenous regional anaesthesia during day-case surgery EP - 37 SN - 0265-0215 SP - 32 JF - European Journal of Anaesthesiology VL - vol. 15 PS - 6 p. DO - http://dx.doi.org/10.1097/00003643-199801000-00007 ER - TY - JOUR AU - Diejen, D. van AU - Kaldeway, P. AU - Egmond, J. van AU - Booij, L.H.D.J. PY - 1998 UR - https://hdl.handle.net/2066/155976 TI - Perioperatieve normafwijkingen en gebeurtenissen EP - 12 SN - 0921-8769 SP - 6 JF - Nederlands Tijdschrift voor Anesthesiologie VL - vol. 11 PS - 7 p. ER - TY - JOUR AU - Simon, M.A.M. AU - Vree, T.B. AU - Gielen, M.J.M. AU - Booij, L.H.D.J. AU - Lagerwerf, A.J. PY - 1998 UR - https://hdl.handle.net/2066/155972 TI - Comparison of the dispositon kinetics of lidocaine (lignocaine) in patients undergoing intravenous regional anaesthesia versus axillary brachial plexus block during day case surgery EP - 27 SN - 1027-9148 IS - iss. 1 SP - 20 JF - South African Journal of Anaesthesiology and Analgesia VL - vol. 4 PS - 8 p. ER - TY - JOUR AU - Vanlinthout, L.E.H. AU - Bartels, C.F. AU - Lockridge, O. AU - Callens, K. AU - Booij, L.H.D.J. PY - 1998 UR - https://hdl.handle.net/2066/155977 TI - Prolonged paralysis after a test dose of mivacurium in a patient with atypical serum cholinesterase EP - 1202 SN - 0003-2999 SP - 1199 JF - Anesthesia and Analgesia VL - vol. 87 PS - 4 p. ER - TY - JOUR AU - Muir, A.W. AU - Sleigh, T. AU - Marshall, R.J. AU - Pow, E. AU - Anderson, K. AU - Booij, L.H.D.J. AU - Hill, D.R. PY - 1998 UR - https://hdl.handle.net/2066/155975 AB - This study was undertaken to investigate the neuromuscular blocking profile and cardiovascular effects of Org 9487, a new aminosteroidal, non-depolarizing, neuromuscular blocking agent structurally related to vecuronium, in anaesthetized animals and in isolated muscle preparations. In in vitro functional assays of neuromuscular blocking activity, Org 9487 was between eight and 15 times less potent than vecuronium. In cats and monkeys the potency of Org 9487 was approximately one-seventh and one-twentieth, respectively, that of vecuronium. In both species, Org 9487 induced rapidly developing (onset times between 1.5 min and 1.9 min) neuromuscular paralysis, which was shorter-lasting than that of vecuronium and similar in time course to suxamethonium. The vagal: neuromuscular blocking dose ratio for Org 9487 was 3 and ganglion block was seen only at approximately 20 times the neuromuscular blocking dose. There was no evidence in the rat that Org 9487, administered at doses up to 3 mg kg−1, inhibited noradrenaline reuptake. In anaesthetized dogs, Org 9487 (3 × 90% blocking dose) induced only relatively small and transient haemodynamic effects. The administration of clinically relevant doses of neostigmine or pyridostigmine shortened the time-course profile of Org 9487, even when administered during profound neuromuscular block. In animals, Org 9487 is a low potency, nondepolarizing neuromuscular blocking agent with a time course profile similar to that of suxamethonium. Although Org 9487 is less selective than vecuronium for the neuromuscular junction, it is unlikely to produce prohibitive cardiovascular side effects in man. TI - Neuromuscular blocking and cardiovascular effects of Org 9487, a new short-acting aminosteroidal blocking agent, in anaesthetized animals and in isolated muscle preparations EP - 479 SN - 0265-0215 SP - 467 JF - European Journal of Anaesthesiology VL - vol. 15 PS - 13 p. DO - https://doi.org/10.1097/00003643-199807000-00014 ER - TY - JOUR AU - Slappendel, R. AU - Crul, B.J.P. AU - Braak, G.J.J. AU - Geurts, J.W.M. AU - Booij, L.H.D.J. AU - Voerman, V.F. AU - Boo, T.M. de PY - 1997 UR - https://hdl.handle.net/2066/25035 TI - The efficacy of radiofrequency lesioning of the cervical spinal dorsal root ganglion in a double blinded randomized study: no difference between 40°C and 67°C treatments EP - 163 SN - 0304-3959 SP - 159 JF - Pain VL - vol. 73 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/25035/25035___.PDF?sequence=1 ER - TY - JOUR AU - Snoeck, M.M.J. AU - Gielen, M.J.M. AU - Sengers, R.C.A. AU - Padberg, G.W.A.M. AU - Iles, D.E.W. AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/24356 TI - Maligne hyperthermie als complicatie van anesthesie: aanleg is erfelijk EP - 619 SN - 0028-2162 IS - iss. 13 SP - 616 JF - Nederlands Tijdschrift voor Geneeskunde VL - vol. 141 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/24356/24356___.PDF?sequence=1 ER - TY - JOUR AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/24505 TI - Neuromuscular transmission and its pharmacological blockade : Part 4: Use of relaxants in paediatric and elderly patients, in obstetrics, and in the intensive care unit EP - 52 SN - 0928-1231 IS - iss. 1 SP - 45 JF - Pharmacy World and Science VL - vol. 19 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/24505/24505___.PDF?sequence=1 ER - TY - JOUR AU - Booij, L.H.D.J. AU - Leeuwen, S.J. van PY - 1997 UR - https://hdl.handle.net/2066/25797 TI - Ethics in anaesthesia and intensive care. EP - 153 SN - 0952-7907 SP - 147 JF - Current Opinion in Anesthesiology VL - vol. 10 ER - TY - JOUR AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/28947 PB - Kluwer academic publ TI - Neuromuscular transmission and its pharmacological blockade .3. Continuous infusion of relaxants and reversal and monitoring of relaxation EP - 44 SN - 0928-1231 IS - iss. 1 SP - 35 JF - Pharmacy World and Science VL - vol. 19 ER - TY - JOUR AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/28949 PB - Kluwer academic publ TI - Neuromuscular transmission and its pharmacological blockade .4. Use of relaxants in paediatric and elderly patients, in obstetrics, and in the intensive care unit EP - 52 SN - 0928-1231 IS - iss. 1 SP - 45 JF - Pharmacy World and Science VL - vol. 19 ER - TY - JOUR AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/28945 PB - Kluwer academic publ TI - Neuromuscular transmission and its pharmacological blockade .1. Neuromuscular transmission and general aspects of its blockade EP - 12 SN - 0928-1231 IS - iss. 1 SP - 1 JF - Pharmacy World and Science VL - vol. 19 ER - TY - JOUR AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/28946 PB - Kluwer academic publ TI - Neuromuscular transmission and its pharmacological blockade .2. Pharmacology of neuromuscular blocking agents EP - 34 SN - 0928-1231 IS - iss. 1 SP - 13 JF - Pharmacy World and Science VL - vol. 19 ER - TY - GEN AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/25255 TI - What is the most ideal analgesic for induction and maintenance of anesthesia? ER - TY - JOUR AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/25095 TI - The use of muscle relaxants in the intensive care unit EP - 44 SN - 0001-5164 IS - iss. 1 SP - 35 JF - Acta Anaesthesiologica Belgica VL - vol. 48 ER - TY - JOUR AU - Simon, M.A.M. AU - Vree, T.B. AU - Gielen, M.J.M. AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/25490 TI - Comparison of the disposition kinetics of lidocaine and (±)prilocaine in 20 patients undergoing intravenous regional anaesthesia during day case surgery EP - 146 SN - 0269-4727 IS - iss. 2 SP - 141 JF - Journal of Clinical Pharmacy and Therapeutics VL - vol. 22 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/25490/25490___.PDF?sequence=1 ER - TY - JOUR AU - Bunschoten, P. AU - Robertson, E.N. AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/25056 TI - Antagoneren van spierrelaxatie door vecuronium met behulp van neostigmine. EP - 66 SN - 0921-8769 SP - 66 JF - Nederlands Tijdschrift voor Anesthesiologie VL - vol. 10 ER - TY - JOUR AU - Whitford, A.M. AU - Godschalkx, A. AU - Robertson, E.N. AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/25452 TI - A clinical comparison of some cardiovascular and intraocular effects of ORG9487, vecuronium and succinylcholine EP - A848 SN - 0003-3022 IS - iss. 3A SP - A848 JF - Anesthesiology VL - vol. 87 ER - TY - JOUR AU - Diejen, D. van AU - Kaldeway, P. AU - Egmond, J. van AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/25717 TI - Een patiënten-enquete als middel voor het bepalen van de kwaliteit van de anesthesiologische zorg. EP - 142 SN - 0921-8769 SP - 137 JF - Nederlands Tijdschrift voor Anesthesiologie VL - vol. 10 ER - TY - JOUR AU - Bunschoten, P. AU - Robertson, E.N. AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/25045 TI - Antagoneren van spierrelaxatie door vecuronium met behulp van neostigmine EP - 1460 SN - 0028-2162 IS - iss. 29 SP - 1459 JF - Nederlands Tijdschrift voor Geneeskunde VL - vol. 141 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/25045/25045___.PDF?sequence=1 ER - TY - JOUR AU - Vree, T.B. AU - Oss, G.E.C.J.M. van AU - Gielen, M.J.M. AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/25785 TI - Epidural metabolism of articaine to its metabolite articainic acid in five patients after epidural administration of 600 mg Articaine EP - 163 SN - 0022-3573 IS - iss. 2 SP - 158 JF - Journal of Pharmacy and Pharmacology VL - vol. 49 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/25785/25785___.PDF?sequence=1 ER - TY - JOUR AU - Vree, T.B. AU - Grood, P.M.R.M. de AU - Beem, H.B.H. van AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/25660 TI - Disposition and renal clearance of propofol and its glucuronide metabolites after a short intravenous infusion of propofol EP - 151 SN - 1173-2563 IS - iss. 3 SP - 145 JF - Clinical Drug Investigation VL - vol. 13 ER - TY - JOUR AU - Groot, E. de AU - Driessen, J.J. AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/24796 TI - Remifentanil bij kortdurende operaties, een multicentre studie EP - 67 SN - 0921-8769 IS - iss. 2 SP - 67 JF - Nederlands Tijdschrift voor Anesthesiologie VL - vol. 10 ER - TY - JOUR AU - Vree, T.B. AU - Simon, M.A.M. AU - Gielen, M.J.M. AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/24780 TI - Regional metabolism of articaine in 10 patients undergoing intravenous regional anaesthesia during day case surgery. EP - 34 SN - 0306-5251 SP - 29 JF - British Journal of Clinical Pharmacology VL - vol. 44 ER - TY - JOUR AU - Vermeulen, P.M. AU - Lerou, J.G.C. AU - Dirksen, R. AU - Booij, L.H.D.J. AU - Borm, G.F. PY - 1997 UR - https://hdl.handle.net/2066/24802 TI - Repeated enflurane anaesthetics and model predictions: a study of the variability in the predictive performance measures EP - 496 SN - 0007-0912 IS - iss. 4 SP - 488 JF - British Journal of Anaesthesia VL - vol. 79 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/24802/24802___.PDF?sequence=1 ER - TY - JOUR AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/24503 TI - Neuromuscular transmission and its pharmacological blockade : Part 2: Pharmacology of neuromuscular blocking agents EP - 34 SN - 0928-1231 IS - iss. 1 SP - 13 JF - Pharmacy World and Science VL - vol. 19 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/24503/24503___.PDF?sequence=1 ER - TY - JOUR AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/24502 TI - Neuromuscular transmission and its pharmacological blockade : Part 1: Neuromuscular transmission and general aspects of its blockade EP - 12 SN - 0928-1231 IS - iss. 1 SP - 1 JF - Pharmacy World and Science VL - vol. 19 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/24502/24502___.PDF?sequence=1 ER - TY - JOUR AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/24504 TI - Neuromuscular transmission and its pharmacological blockade : Part 3: Continuous infusion of relaxants and reversal and monitoring of relaxation EP - 44 SN - 0928-1231 IS - iss. 1 SP - 35 JF - Pharmacy World and Science VL - vol. 19 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/24504/24504___.PDF?sequence=1 ER - TY - JOUR AU - Snoeck, M.M.J. AU - Gielen, M.J.M. AU - Sengers, R.C.A. AU - Padberg, G.W.A.M. AU - Iles, D.E.W. AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/24358 TI - Maligne Hyperthermie als complicatie van anesthesie: aanleg is erfelijk EP - 619 SN - 0028-2162 SP - 616 JF - Nederlands Tijdschrift voor Geneeskunde VL - vol. 141 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/24358/24358___.PDF?sequence=1 ER - TY - JOUR AU - Simon, M.A.M. AU - Vree, T.B. AU - Gielen, M.J.M. AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/155979 TI - Comparison of the disposition kinetics of lidocaine and ±prilocaine in 20 patients undergoing intravenous regional anaesthesia during day case surgery. EP - 146 SN - 0269-4727 SP - 141 JF - Journal of Clinical Pharmacy and Therapeutics VL - vol. 22 DO - http://dx.doi.org/10.1111/j.1365-2710.1997.tb00008.x ER - TY - JOUR AU - Diejen, D. van AU - Kaldeway, P. AU - Egmond, J. van AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/155981 TI - Een patiënten-enquete als middel voor het bepalen van de kwaliteit van de anesthesiologische zorg. EP - 142 SN - 0921-8769 SP - 137 JF - Nederlands Tijdschrift voor Anesthesiologie VL - vol. 10 ER - TY - JOUR AU - Vree, T.B. AU - Oss, G.E.C.J.M. van AU - Gielen, M.J.M. AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/155982 TI - Epidural metabolism of articaine to its metabolite articainic acid in five patients after epidural administration of 600 mg Articaine. EP - 163 SN - 0022-3573 SP - 158 JF - Journal of Pharmacy and Pharmacology VL - vol. 49 DO - http://dx.doi.org/10.1111/j.2042-7158.1997.tb06772.x ER - TY - JOUR AU - Booij, L.H.D.J. AU - Leeuwen, S.J. van PY - 1997 UR - https://hdl.handle.net/2066/155983 TI - Ethics in anaesthesia and intensive care. EP - 153 SN - 0952-7907 SP - 147 JF - Current Opinion in Anesthesiology VL - vol. 10 ER - TY - JOUR AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/155986 TI - Neuromuscular transmission and its pharmacological blockade. Part 1: Neuromuscular transmission and general aspects of its blockade. EP - 12 SN - 0928-1231 IS - iss. 1 SP - 1 JF - Pharmacy World and Science VL - vol. 19 DO - http://dx.doi.org/10.1023/A:1008694726564 ER - TY - JOUR AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/155987 TI - Neuromuscular transmission and its pharmacological blockade. Part 2: Pharmacology of neuromuscular blocking agents. EP - 34 SN - 0928-1231 IS - iss. 1 SP - 13 JF - Pharmacy World and Science VL - vol. 19 DO - http://dx.doi.org/10.1023/A:1008641427473 ER - TY - JOUR AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/155988 TI - Neuromuscular transmission and its pharmacological blockade. Part 3: Continuous infusion of relaxants and reversal and monitoring of relaxation. EP - 44 SN - 0928-1231 IS - iss. 1 SP - 35 JF - Pharmacy World and Science VL - vol. 19 DO - http://dx.doi.org/10.1023/A:1008645511543 ER - TY - JOUR AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/155990 TI - Neuromuscular transmission and its pharmacological blockade. Part 4: Use of relaxants in paediatric and elderly patients, in obstetrics, and in the intensive care unit. EP - 52 SN - 0928-1231 IS - iss. 1 SP - 45 JF - Pharmacy World and Science VL - vol. 19 DO - http://dx.doi.org/10.1023/A:1008697628382 ER - TY - JOUR AU - Vree, T.B. AU - Simon, M.A.M. AU - Gielen, M.J.M. AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/155991 TI - Regional metabolism of articaine in 10 patients undergoing intravenous regional anaesthesia during day case surgery. EP - 34 SN - 0306-5251 SP - 29 JF - British Journal of Clinical Pharmacology VL - vol. 44 DO - http://dx.doi.org/10.1046/j.1365-2125.1997.00621.x ER - TY - JOUR AU - Vermeulen, P.M. AU - Lerou, J.G.C. AU - Dirksen, R. AU - Booij, L.H.D.J. AU - Borm, G.F. PY - 1997 UR - https://hdl.handle.net/2066/155992 TI - Repeated enflurane anaesthetics and model predictions: a study of the variability in the predictive performance measures EP - 496 SN - 0007-0912 IS - iss. 4 SP - 488 JF - British Journal of Anaesthesia VL - vol. 79 DO - http://dx.doi.org/10.1093/bja/79.4.488 ER - TY - JOUR AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/155994 TI - The use of muscle relaxants in the intensive care unit EP - 44 SN - 0001-5164 SP - 35 JF - Acta Anaesthesiologica Belgica VL - vol. 48 ER - TY - JOUR AU - Snoeck, M.M.J. AU - Gielen, M.J.M. AU - Sengers, R.C.A. AU - Padberg, G.W.A.M. AU - Iles, D.E.W. AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/155984 TI - Malignant hyperthermia as a complication of anesthesia: predisposition is hereditary EP - 619 SN - 0028-2162 IS - iss. 13 SP - 616 JF - Nederlands Tijdschrift voor Geneeskunde VL - vol. 141 ER - TY - JOUR AU - Snoeck, M.M.J. AU - Gielen, M.J.M. AU - Sengers, R.C.A. AU - Padberg, G.W.A.M. AU - Iles, D.E.W. AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/155985 TI - Maligne Hyperthermie als complicatie van anesthesie: aanleg is erfelijk EP - 619 SN - 0028-2162 SP - 616 JF - Nederlands Tijdschrift voor Geneeskunde VL - vol. 141 PS - 4 p. ER - TY - JOUR AU - Vree, T.B. AU - Grood, P.M.R.M. de AU - Beem, H.B.H. van AU - Booij, L.H.D.J. PY - 1997 UR - https://hdl.handle.net/2066/155980 TI - Disposition and renal clearance of propofol and its glucuronide metabolites after a short intravenous infusion of propofol. EP - 151 SN - 1173-2563 IS - iss. 3 SP - 145 JF - Clinical Drug Investigation VL - vol. 13 DO - https://doi.org/10.2165/00044011-199713030-00004 ER - TY - JOUR AU - Slappendel, R. AU - Crul, B.J.P. AU - Braak, G.J.J. AU - Geurts, J.W.M. AU - Booij, L.H.D.J. AU - Voerman, V.F. AU - Boo, T.M. de PY - 1997 UR - https://hdl.handle.net/2066/155993 TI - The efficacy of radiofrequency lesioning of the cervical spinal dorsal root ganglion in a double blinded randomized study: no difference between 40°C and 67°C treatments EP - 163 SN - 0304-3959 SP - 159 JF - Pain VL - vol. 73 DO - https://doi.org/10.1016/S0304-3959(97)00094-8 ER - TY - JOUR AU - Vanlinthout, L.E.H. AU - Booij, L.H.D.J. AU - Egmond, J. van AU - Robertson, E.N. PY - 1996 UR - https://hdl.handle.net/2066/28622 PB - Lippincott-raven publ TI - The effect of aging on gender related differences in magnitude and onset of mivacurium induced neuromuscular block EP - A819 SN - 0003-3022 IS - Iss. 3A SP - A819 JF - Anesthesiology VL - Vol. 85 ER - TY - JOUR AU - Booij, L.H.D.J. PY - 1996 UR - https://hdl.handle.net/2066/22785 TI - Anaesthetic management of the trauma patient in the operating theatre. EP - 138 SN - 0953-7112 SP - 125 JF - Current Anaesthesia and Critical Care VL - vol. 7 ER - TY - JOUR AU - Vanlinthout, L.E.H. AU - Booij, L.H.D.J. AU - Egmond, J. van AU - Robertson, E.N. PY - 1996 UR - https://hdl.handle.net/2066/23117 TI - The effect of aging on gender related differences in magnitude and onset of mivacurium induced neuromuscular blockade EP - A819 SN - 0587-3096 SP - A819 JF - Abstracts of Scientific Papers, Annual Meeting - American Society of Anesthesiologists VL - vol. 85 ER - TY - JOUR AU - Booij, L.H.D.J. PY - 1996 UR - https://hdl.handle.net/2066/22979 TI - Sevoflurane for the maintenance of anaesthesia. EP - 9 SN - 1027-9148 IS - iss. 3 SP - 4 JF - South African Journal of Anaesthesiology and Analgesia VL - vol. 2 ER - TY - JOUR AU - Booij, L.H.D.J. PY - 1996 UR - https://hdl.handle.net/2066/23259 TI - Trauma anaesthesia. EP - 114 SN - 0953-7112 SP - 113 JF - Current Anaesthesia and Critical Care VL - vol. 7 ER - TY - JOUR AU - Booij, L.H.D.J. PY - 1996 UR - https://hdl.handle.net/2066/23929 TI - Future developments of non-depolarizing relaxants. EP - 334 SN - 0952-7907 SP - 331 JF - Current Opinion in Anesthesiology VL - vol. 9 ER - TY - JOUR AU - Vanlinthout, L.E.H. AU - Boo, T.M. de AU - Booij, L.H.D.J. 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PY - 1996 UR - https://hdl.handle.net/2066/23773 TI - Effect of isoflurane and sevoflurane on the magnitude and time course of neuromuscular block produced by vecuronium, pancuronium and atracurium EP - 395 SN - 0007-0912 IS - iss. 3 SP - 389 JF - British Journal of Anaesthesia VL - vol. 76 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/23773/23773___.PDF?sequence=1 ER - TY - JOUR AU - Brink, H.S. AU - Leeuwen, S.J. van AU - Booij, L.H.D.J. PY - 1996 UR - https://hdl.handle.net/2066/23065 TI - Suxamethonium riskant op de intensive care EP - 1295 SN - 0028-2162 IS - iss. 25 SP - 1293 JF - Nederlands Tijdschrift voor Geneeskunde VL - vol. 140 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/23065/23065___.PDF?sequence=1 ER - TY - JOUR AU - Booij, L.H.D.J. PY - 1996 UR - https://hdl.handle.net/2066/155995 TI - De rol van esterasen in de anesthesie. Een hernieuwd farmacotherapeutisch concept. 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