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A practical approach to critical care ultrasound

Blans, M.J. ; Bosch, F.H. ; Hoeven, J.G. van der

2019, Article / Letter to editor (Journal of Critical Care, vol. 51, (2019), pp. 156-164)
Treatment With Acetylsalicylic Acid Reverses Endotoxin Tolerance in Humans In Vivo: A Randomized Placebo-Controlled Study

Leijte, G.P. ; Kiers, D. ; Heijden, W.A. van der ; Jansen, A. ; Gerretsen, J.; Boerrigter, V.; Netea, M.G. ; Kox, M. ; Pickkers, P.

2019, Article / Letter to editor (Critical Care Medicine, vol. 47, iss. 4, (2019), pp. 508-516)
Macrolide prescription in Dutch children: compliance with guidelines

Bandell, Rosa A.M.; Dekkers, T.; Semmekrot, Bernardus A.; Wildt, S.N. de ; Fleuren, Hanneke W.H.A.; Warle-van Herwaarden, Margaretha F.; Gerrits, G.P. ; Kramers, C.

2019, Article / Letter to editor (European Journal of Clinical Microbiology and Infectious Diseases, vol. 38, iss. 4, (2019), pp. 675-681)
Oscillometric and intra-arterial blood pressure in children post-kidney transplantation: Is invasive blood pressure measurement always needed?

Marouane, A. ; Cornelissen, E.A.M. ; Nusmeier, A. ; Bootsma-Robroeks, C.M.H.H.T.

2019, Article / Letter to editor (Pediatric Transplantation, vol. 23, iss. 1, (2019), article e13309)
The Safety, Tolerability, and Effects on the Systemic Inflammatory Response and Renal Function of the Human Chorionic Gonadotropin Hormone-Derivative EA-230 Following On-Pump Cardiac Surgery (The EASI Study): Protocol for a Randomized, Double-Blind, Placebo-Controlled Phase 2 Study

Groenendael, R. van ; Beunders, R. ; Hofland, J. ; Morshuis, W.J. ; Kox, M. ; Eijk, L.T.G.J. van ; Pickkers, P.

2019, Article / Letter to editor (JMIR Research Protocols, vol. 8, iss. 2, (2019), pp. 56-68, article e11441)
The value of the neutrophil-lymphocyte count ratio in the diagnosis of sepsis in patients admitted to the Intensive Care Unit: A retrospective cohort study

Westerdijk, K; Simons, K.S.; Zegers, M.J. ; Wever, P.C.; Pickkers, P. ; Jager, Cornelis P. C. de

2019, Article / Letter to editor (PLoS One, vol. 14, iss. 2, (2019), article e0212861)
Influenza virus and factors that are associated with ICU admission, pulmonary co-infections and ICU mortality

Beumer, M.C.; Koch, R.M. ; Beuningen, D. van; Oude Lashof, A.M.L. ; Veerdonk, F.L. van de ; Kolwijck, E. ; Hoeven, J.G. van der ; Bergmans, D.C.; Hoedemaekers, C.W.E.

2019, Article / Letter to editor (Journal of Critical Care, vol. 50, (2019), pp. 59-65)
Non-inferiority double-blind randomised controlled trial comparing gabapentin versus tramadol for the treatment of chronic neuropathic or mixed pain in children and adolescents: the GABA-1 trial-a study protocol

Kaguelidou, F.; Roux, E. Le; Mangiarini, L.; Lundin, R.; Leeuw, T.G. de; Pasqua, O. Della; Felisi, M.; Bonifazi, D.; Tibboel, D.; Ceci, A.; Wildt, S.N. de ; Alberti, C. et al. sine al.

2019, Article / Letter to editor (BMJ Open, vol. 9, iss. 2, (2019), pp. e023296)
Pharmacotherapeutic management of paediatric heart failure and ACE-I use patterns: a European survey

Diez, C. Castro; Khalil, F.; Schwender, H.; Dalinghaus, M.; Jovanovic, I.; Makowski, N.; Male, C.; Bajcetic, M.; Meulen, M. van der; Wildt, S.N. de ; Ablonczy, L.; Szatmari, A.; Klingmann, I.; Walsh, J.; Laer, S. et al. sine al.

2019, Article / Letter to editor (BMJ Paediatrics Open, vol. 3, iss. 1, (2019), pp. e000365)
The Ontogeny of UDP-glucuronosyltransferase Enzymes, Recommendations for Future Profiling Studies and Application Through Physiologically Based Pharmacokinetic Modelling

Badee, J.; Fowler, S.; Wildt, S.N. de ; Collier, A.C.; Schmidt, S.; Parrott, N.

2019, Article / Letter to editor (Clinical Pharmacokinetics, vol. 58, iss. 2, (2019), pp. 189-211)
Coronary Angiography after Cardiac Arrest without ST-Segment Elevation

Lemkes, Jorrit S.; Janssens, Gladys N.; Hoeven, Nina W. van der; Jewbali, Lucia S.D.; Dubois, Eric A.; Meuwissen, Martijn; Stoel, M.A.; Camaro, C. ; Hoeven, H. van der ; Oudemans-van Straaten, Heleen M.; Royen, N. van et al. sine al.

2019, Article / Letter to editor (The New England Journal of Medicine, vol. 380, iss. 15, (2019), pp. 1397-1407)
Recently Registered Midazolam Doses for Preterm Neonates Do Not Lead to Equal Exposure: A Population Pharmacokinetic Model

Voller, Swantje; Flint, R.B. ; Beggah, Fouzi; Reiss, Irwin K.M.; Andriessen, Peter; Zimmermann, L.J.; Liem, K.D. ; Wildt, S.N. de ; Knibbe, Catherijne A.J.; Simons, Sinno H.P.

2019, Article / Letter to editor (Journal of Clinical Pharmacology and Journal of New Drugs, vol. 59, iss. 10, (2019), pp. 1300-1308)
Risk stratification to improve Pediatric Early Warning Systems: it is all about the context

Teheux, L. ; Verlaat, C.W. ; Lemson, J. ; Draaisma, J.M.T. ; Fuijkschot, J.

2019, Article / Letter to editor (European Journal of Pediatrics, vol. 178, iss. 10, (2019), pp. 1589-1596)
Pharmacotherapy in paediatric heart failure: a Delphi process

Diez, Cristina C.; Khalil, F.; Makowski, N.; Schwender, Holger; Jovanovic, I.; Dalinghaus, M.; Wildt, S.N. de ; Laeer, S.

2019, Article / Letter to editor (Cardiology in the Young, vol. 29, iss. 7, (2019), pp. 869-876, article PII S104795111900066)
Diagnosis and outcome of acute respiratory failure in immunocompromised patients after bronchoscopy

Bauer, P.R.; Chevret, S.; Yadav, Hemang; Mehta, Sangeeta; Pickkers, P. ; Bukan, R.B.; Shah, S.; Hemelaar, P. ; Moralez, Guilliana M.; Vinatier, Isabelle

2019, Article / Letter to editor (European Respiratory Journal, vol. 54, iss. 1, (2019), article 1802442)
Incorporating Ontogeny in Physiologically Based Pharmacokinetic Modeling to Improve Pediatric Drug Development: What We Know About Developmental Changes in Membrane Transporters

Cheung, Kit Wun Kathy; Groen, Bianca D. van; Burckart, Gilbert J.; Zhang, L.; Wildt, S.N. de ; Huang, Shiew-Mei

2019, Article / Letter to editor (Journal of Clinical Pharmacology and Journal of New Drugs, vol. 59, (2019), pp. S56-S69)
Frontline Science: Endotoxin-induced immunotolerance is associated with loss of monocyte metabolic plasticity and reduction of oxidative burst

Grondman, I. ; Arts, R.J.W.; Koch, R.M. ; Leijte, G.P. ; Gerretsen, J.; Bruse, N. ; Kempkes, R.W.M.; Horst, R. ter ; Kox, M. ; Pickkers, P. ; Netea, M.G. ; Gresnigt, M.S. et al. sine al.

2019, Article / Letter to editor (Journal of Leukocyte Biology, vol. 106, iss. 1, (2019), pp. 11-25)
Hypoxia attenuates inflammation-induced hepcidin synthesis during experimental human endotoxemia

Kiers, D. ; Eijk, L.T.G.J. van ; Hoeven, J.G. van der ; Swinkels, D.W. ; Pickkers, P. ; Kox, M.

2019, Article / Letter to editor (Haematologica, vol. 104, iss. 6, (2019), pp. 230-232)
External Validation of Two Models to Predict Delirium in Critically Ill Adults Using Either the Confusion Assessment Method-ICU or the Intensive Care Delirium Screening Checklist for Delirium Assessment

Wassenaar, A. ; Schoonhoven, L. ; Devlin, J.W.; Haren, F.M. van; Slooter, A.J.; Jorens, P.G.; Jagt, M. van der; Simons, K.S.; Egerod, I.; Burry, L.D.; Beishuizen, A.; Matos, J.; Donders, A.R.T. ; Pickkers, P. ; Boogaard, M. van den et al. sine al.

2019, Article / Letter to editor (Critical Care Medicine, vol. 47, iss. 10, (2019), pp. e827-e835)
A double-blind, placebo-controlled, randomised, multicentre, proof-of-concept and dose-finding phase II clinical trial to investigate the safety, tolerability and efficacy of adrecizumab in patients with septic shock and elevated adrenomedullin concentration (AdrenOSS-2)

Geven, C.B.C.A.G. ; Blet, A.; Kox, M. ; Hartmann, O.; Scigalla, P.; Zimmermann, J.; Marx, G.; Laterre, P.F.; Mebazaa, A.; Pickkers, P.

2019, Article / Letter to editor (BMJ Open, vol. 9, iss. 2, (2019), article e024475)
Sepsis Management with a Blood Purification Membrane: European Experience

Pickkers, P. ; Vassiliou, Timon; Liguts, Valdis; Prato, Federico; Tissieres, Pierre; Kloesel, Stephan; Goldstein, Jacques; Harenski, Kai

2019, Article / Letter to editor (Blood Purification, vol. 47, (2019), pp. 36-44)
Identification of regulatory variants associated with genetic susceptibility to meningococcal disease

Borghini, L.; Png, E.; Binder, A.; Wright, V.J.; Pinnock, E.; Groot, R. de ; Hazelzet, J.; Emonts, M.; Flier, M. van der ; Philipsen, H.L.A. ; Schlapbach, L.J.; Anderson, S.; Secka, F.; Salas, A.; Fink, C.; Carrol, E.D.; Pollard, A.J.; Coin, L.J.; Kuijpers, T.W.; Martinon-Torres, F.; Zenz, W.; Levin, M.; Hibberd, M.L.; Davila, S.; Neeleman, C. ; Deuren, M. van ; Kunze, W.; Schermann, P. et al. sine al.

2019, Article / Letter to editor (Scientific Reports, vol. 9, (2019), article 6966)
Ensuring Antibiotic Development, Equitable Availability, and Responsible Use of Effective Antibiotics: Recommendations for Multisectoral Action

Monnier, A.A. ; Schouten, J.A. ; Tebano, G.; Zanichelli, V.; Huttner, B.D.; Pulcini, C.; Hulscher, M.E. ; Gyssens, I.C.J.

2019, Article / Letter to editor (Clinical Infectious Diseases, vol. 68, iss. 11, (2019), pp. 1952-1959)
Adrecizumab, a non-neutralizing anti-adrenomedullin antibody, improves haemodynamics and attenuates myocardial oxidative stress in septic rats

Blet, A.; Deniau, Benjamin; Geven, C.B.C.A.G. ; Sadoune, M.; Caillard, Anais; Kounde, Paul-Robert; Pickkers, P. ; Samuel, Jane-Lise; Mebazaa, Alexandre

2019, Article / Letter to editor (Intensive Care Medicine Experimental, vol. 7, (2019), article 25)
Development and daily use of a numeric rating score to assess sleep quality in ICU patients

Rood, P.J.T. ; Frenzel, T. ; Verhage, R.; Bonn, M.; Hoeven, H. van der ; Pickkers, P. ; Boogaard, M. van den

2019, Article / Letter to editor (Journal of Critical Care, vol. 52, (2019), pp. 68-74)
Electroencephalographic reactivity as predictor of neurological outcome in postanoxic coma: A multicenter prospective cohort study

Admiraal, Marjolein M.; Rootselaar, A.F. van; Hofmeijer, J.; Hoedemaekers, C.W.E. ; Kaam, C.R. van ; Keijzer, H.M. ; Schultz, Marcus J.; Horn, Janneke

2019, Article / Letter to editor (Annals of Neurology, vol. 86, iss. 1, (2019), pp. 17-27)
Glottic patency during noninvasive ventilation in patients with chronic obstructive pulmonary disease

Oppersma, Eline; Doorduin, J. ; Gooskens, Petra J.; Roesthuis, L.H. ; Heijden, E. van der ; Hoeven, J.G. van der ; Veltink, Peter H.; Heunks, L.M.A.

2019, Article / Letter to editor (Respiratory Physiology & Neurobiology, vol. 259, (2019), pp. 53-57)
Combining Brain Microdialysis and Translational Pharmacokinetic Modeling to Predict Drug Concentrations in Pediatric Severe Traumatic Brain Injury: The Next Step Toward Evidence-Based Pharmacotherapy?

Ketharanathan, N.; Yamamoto, Y.; Rohlwink, U.K.; Wildschut, E.D.; Mathot, R.A.A.; Lange, E.C.M. de; Wildt, S.N. de ; Argent, A.C.; Tibboel, D.; Figaji, A.A.

2019, Article / Letter to editor (Journal of Neurotrauma, vol. 36, iss. 1, (2019), pp. 111-117)
Gabapentin as add-on to morphine for severe neuropathic or mixed pain in children from age 3 months to 18 years - evaluation of the safety, pharmacokinetics, and efficacy of a new gabapentin liquid formulation: study protocol for a randomized controlled trial

Leeuw, T.G. de; Mangiarini, L.; Lundin, R.; Kaguelidou, F.; Zanden, T. van der; Pasqua, O.D.; Tibboel, D.; Ceci, A.; Wildt, S.N. de

2019, Article / Letter to editor (Trials, vol. 20, (2019), article 49)
Oxygen and platelets. Translational studies on therapeutic targets for immunomodulation

Kiers, H.D.

2019, Dissertation
Cerebral hemodynamics. After cardiac arrest, in sepsis and in the human endotoxemia model

Brule, J.M.D. van den

2019, Dissertation
Differential pathogen-host interactions

Koch, R.M.

2019, Dissertation
Comparison of antimicrobial stewardship programmes in acute-care hospitals in four European countries: A cross-sectional survey

Kallen, M.C.; Binda, F.; Oever, J. ten ; Tebano, G.; Pulcini, C.; Murri, R.; Hulscher, M.E.J.L. ; Schouten, J.A.

2019, Article / Letter to editor (International Journal of Antimicrobial Agents, vol. 54, iss. 3, (2019), pp. 338-345)
Effect of Hydrocortisone Therapy Initiated 7 to 14 Days After Birth on Mortality or Bronchopulmonary Dysplasia Among Very Preterm Infants Receiving Mechanical Ventilation A Randomized Clinical Trial

Onland, Wes; Cools, Filip; Kroon, Andre; Rademaker, Karin; Merkus, Maruschka P.; Dijk, Peter H.; Heijst, A.F.J. van ; Matthijsse, R. ; Boode, W.P. de ; Baal, Caroline van; Wildt, S.N. de et al. sine al.

2019, Article / Letter to editor (Jama : Journal of the American Medical Association, vol. 321, iss. 4, (2019), pp. 354-363)
Targeting adrenomedullin in sepsis

Geven, C.B.C.A.G.

2019, Dissertation
The potential impact of hematocrit correction on evaluation of tacrolimus target exposure in pediatric kidney transplant patients

Schijvens, A.M. ; Hesteren, Fransje H.S. van; Cornelissen, E.A.M. ; Bootsma-Robroeks, Charlotte M.H.H.T.; Bruggemann, R.J.M. ; Burger, D.M. ; Wildt, S.N. de ; Schreuder, M.F. ; Heine, R. ter

2019, Article / Letter to editor (Pediatric Nephrology, vol. 34, iss. 3, (2019), pp. 507-515)
The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity

Dominguez Andres, J. ; Novakovic, B.; Li, Yang; Scicluna, B.P.; Gresnigt, M.S.; Arts, R.J.; Oosting, M. ; Moorlag, S.J.C.F.M. ; Groh, L.A. ; Zwaag, J. ; Koch, R.M. ; Horst, R. ter ; Joosten, L.A.B. ; Kox, M. ; Pickkers, P. ; Kumar, V. ; Stunnenberg, H.G. ; Netea, M.G. et al. sine al.

2019, Article / Letter to editor (Cell Metabolism, vol. 29, iss. 1, (2019), pp. 211-220)
The KHENERGY Study: Safety and Efficacy of KH176 in Mitochondrial m.3243A>G Spectrum Disorders

Janssen, M.C.H. ; Koene, S. ; Laat, P. de ; Hemelaar, P. ; Pickkers, P. ; Spaans, Edwin; Beukema, R.J. ; Beyrath, J.D. ; Groothuis, J.T. ; Verhaak, C.M. ; Smeitink, J. et al. sine al.

2019, Article / Letter to editor (Clinical Pharmacology and Therapeutics, vol. 105, iss. 1, (2019), pp. 101-111)
Comparison of different lots of endotoxin and evaluation of in vivo potency over time in the experimental human endotoxemia model

Kiers, D. ; Leijte, G.P. ; Gerretsen, J.; Zwaag, J. ; Kox, M. ; Pickkers, P.

2019, Article / Letter to editor (Innate Immunity, vol. 25, iss. 1, (2019), pp. 34-45)
Delirium detection using relative delta power based on 1-minute single-channel EEG: a multicentre study

Numan, T.; Boogaard, M. van den ; Kamper, A.M.; Rood, P.J.T. ; Schoon, Y. ; Peelen, L.M.; Slooter, A.J.

2019, Article / Letter to editor (British Journal of Anaesthesia, vol. 122, iss. 1, (2019), pp. 60-68)
Pharmacology and pharmacogenetics of prednisone and prednisolone in patients with nephrotic syndrome

Schijvens, A.M. ; Heine, R. ter ; Wildt, S.N. de ; Schreuder, M.F.

2019, Article / Letter to editor (Pediatric Nephrology, vol. 34, iss. 3, (2019), pp. 389-403)
Preclinical safety evaluation of the adrenomedullin-binding antibody Adrecizumab in rodents, dogs and non-human primates

Geven, C.B.C.A.G. ; Kox, M. ; Blet, A.; Mebazaa, Alexandre; Schroedter, Mathias; Struck, Joachim; Bergmann, A.; Pickkers, P.

2019, Article / Letter to editor (Toxicology and Applied Pharmacology, vol. 369, (2019), pp. 1-16)
Current gaps in sepsis immunology: new opportunities for translational research

Rubio, I.; Osuchowski, M.F.; Shankar-Hari, M.; Skirecki, T.; Winkler, M.S.; Lachmann, G.; Rosee, P. La; Monneret, G.; Venet, F.; Bauer, M; Brunkhorst, F.M.; Kox, M. ; Cavaillon, J.M.; Uhle, F.; Weigand, M.A.; Flohe, S.B.; Wiersinga, W.J.; Martin-Fernandez, M.; Almansa, R.; Martin-Loeches, I.; Torres, A. Cedillo; Giamarellos-Bourboulis, E.J.; Girardis, M.; Cossarizza, A.; Netea, M.G. ; Poll, T. van der; Scherag, A.; Meisel, C.; Schefold, J.C.; Bermejo-Martin, J.F. et al. sine al.

2019, Article / Letter to editor (Lancet Infectious Diseases, vol. 19, iss. 12, (2019), pp. e422-e436)
Enteral Acetaminophen Bioavailability in Pediatric Intensive Care Patients Determined With an Oral Microtracer and Pharmacokinetic Modeling to Optimize Dosing

Kleiber, N.; Calvier, E.; Mooij, M.G.; Krekels, E.H.J.; Vaes, W.H.; Tibboel, D.; Knibbe, C.A.J.; Wildt, S.N. de

2019, Article / Letter to editor (Critical Care Medicine, vol. 47, iss. 12, (2019), pp. e975-e983)
The Implementation of a Multidisciplinary Approach for Potential Organ Donors in the Emergency Department

Witjes, M. ; Kotsopoulos, A.M.M. ; Otterspoor, L.; Herold, I.H.F.; Simons, K.S.; Woittiez, K.; Eijkenboom, J.J.; Hoeven, J.G. van der ; Jansen, N.E.; Abdo, W.F.

2019, Article / Letter to editor (Transplantation, vol. 103, iss. 11, (2019), pp. 2359-2365)
The use of an external ultrasound fixator (Probefix) on intensive care patients: a feasibility study

Blans, M.J. ; Bosch, F.H. ; Hoeven, J.G. van der

2019, Article / Letter to editor (The Ultrasound Journal, vol. 11, iss. 1, (2019), pp. 26)
beta-Blockade attenuates renal blood flow in experimental endotoxic shock by reducing perfusion pressure

Loon, L.M. van; Rongen, G.A.P.J.M. ; Hoeven, J.G. van der ; Veltink, P.H.; Lemson, J.

2019, Article / Letter to editor (Physiological Reports, vol. 7, iss. 23, (2019), pp. e14301)
An add-on training program involving breathing exercises, cold exposure, and meditation attenuates inflammation and disease activity in axial spondyloarthritis - A proof of concept trial

Buijze, G.A.; Jong, H.M.Y. De; Kox, M. ; Sande, M.G. van de; Schaardenburg, D. van; Vugt, R.M. Van; Popa, C. ; Pickkers, P. ; Baeten, D.L.

2019, Article / Letter to editor (PLoS One, vol. 14, iss. 12, (2019), article e0225749)
Effects of patient safety auditing in hospital care: results of a mixed-method evaluation (part 1)

Hanskamp-Sebregts, M.E. ; Zegers, M. ; Westert, G.P. ; Boeijen, W.M.J. ; Teerenstra, S. ; Gurp, P.J.M. van ; Wollersheim, H.C.

2019, Article / Letter to editor (International Journal for Quality in Health Care, vol. 31, iss. 7, (2019), pp. 8-15)
Nonpharmacologic Interventions to Prevent or Mitigate Adverse Long-Term Outcomes Among ICU Survivors: A Systematic Review and Meta-Analysis

Geense, W.W. ; Boogaard, M. van den ; Hoeven, J.G. van der ; Vermeulen, H. ; Hannink, G.J. ; Zegers, M.

2019, Article / Letter to editor (Critical Care Medicine, vol. 47, iss. 11, (2019), pp. 1607-1618)

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