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Stimulation of cholesterol biosynthesis in mitochondrial complex I-deficiency lowers reductive stress and improves motor function and survival in mice

Schirris, T.J.J.; Rossell, S.L.; Haas, R. de ; Frambach, S.J.C.M. ; Hoogstraten, C.A. ; Renkema, G.H. ; Beyrath, J.D. ; Willems, P.H.G.M. ; Huynen, M.A. ; Smeitink, J.A.M. ; Russel, F.G.M. ; Notebaart, R.A. et al. sine al.

2021, Article / Letter to editor (Biochimica et biophysica acta. Molecular basis of disease, vol. 1867, iss. 4, (2021), article 166062)
Rifampicin Transport by OATP1B1 Variants

Litjens, C.H.C. ; Heuvel, J.M.W. van den ; Russel, F.G.M. ; Aarnoutse, R.E. ; Brake, L.H.M. te ; Koenderink, J.B.

2020, Article / Letter to editor (Antimicrobial Agents and Chemotherapy, vol. 64, iss. 10, (2020), article e00955-20)
Developmental patterns in human blood-brain barrier and blood-cerebrospinal fluid barrier ABC drug transporter expression

Verscheijden, L.F.M.; Hattem, A.C. van; Pertijs, J.C.L.M. ; Jongh, C.A. de; Verdijk, R.M.; Smeets, B. ; Koenderink, J.B. ; Russel, F.G.M. ; Wildt, S.N. de

2020, Article / Letter to editor (Histochemistry and Cell Biology, vol. 154, iss. 3, (2020), pp. 265-273)
Completing the Enalaprilat Excretion Pathway-Renal Handling by the Proximal Tubule

Smeets, N.J.L. ; Litjens, C.H.C. ; Heuvel, J.M.W. van den ; Hove, H.; Broek, P.H.H. van den ; Russel, F.G.M. ; Koenderink, J.B. ; Wildt, S.N. de

2020, Article / Letter to editor (Pharmaceutics, vol. 12, iss. 10, (2020), article E935)
Assessment of Placental Disposition of Infliximab and Etanercept in Women With Autoimmune Diseases and in the Ex Vivo Perfused Placenta

Eliesen, G.A.M.; Drongelen, J. van ; Hove, H.; Kooijman, N.I.; Broek, P.H. van den ; Vries, A. De; Roeleveld, N. ; Russel, F.G.M. ; Greupink, R.

2020, Article / Letter to editor (Clinical Pharmacology and Therapeutics, vol. 108, iss. 1, (2020), pp. 99-106)
Transfer of daclatasvir and sofosbuvir's main metabolite, GS-331007, across the human placenta ex vivo

Freriksen, J.J.M. ; Meijerhof, M.; Drongelen, J. van ; Drenth, J.P.H. ; Burger, D.M. ; Russel, F.G.M. ; Colbers, A. ; Greupink, R.

2020, Article / Letter to editor (American Journal of Obstetrics and Gynecology, vol. 223, iss. 6, (2020), pp. 941-943)
A Randomized Trial of Distal Diuretics versus Dietary Sodium Restriction for Hypertension in Chronic Kidney Disease

Bovee, Dominique M.; Visser, Wesley J.; Middel, Igor; Mik-van Egmond, Anneke De; Greupink, R.; Masereeuw, R. ; Russel, F.G. ; Zietse, Robert; Hoorn, Ewout J.

2020, Article / Letter to editor (Journal of the American Society of Nephrology, vol. 31, iss. 3, (2020), pp. 650-662)
Assessment of Maternal and Fetal Dolutegravir Exposure by Integrating Ex Vivo Placental Perfusion Data and Physiologically-Based Pharmacokinetic Modeling

Freriksen, J.J.M. ; Schalkwijk, S.J.; Colbers, A.P. ; Abduljalil, K.; Russel, F.G.M. ; Burger, D.M. ; Greupink, R.

2020, Article / Letter to editor (Clinical Pharmacology and Therapeutics, vol. 107, iss. 6, (2020), pp. 1352-1361)
Chloroquine Dosing Recommendations for Pediatric COVID-19 Supported by Modeling and Simulation

Verscheijden, L.F.M.; Zanden, T.M. van der; Bussel, L.P.M. van; Hoop-Sommen, M. de; Russel, F.G.M. ; Johnson, T.N.; Wildt, S.N. de

2020, Article / Letter to editor (Clinical Pharmacology and Therapeutics, vol. 108, iss. 2, (2020), pp. 248-252)
Oxidative degradation of cyclophosphamide using thermal plasma activation and UV/H2O2 treatment in tap water

Graumans, M.H.F. ; Hoeben, W.; Russel, F.G.M. ; Scheepers, P.T.J.

2020, Article / Letter to editor (Environmental Research, vol. 182, (2020), article 109046)
Brothers in Arms: ABCA1- and ABCG1-Mediated Cholesterol Efflux as Promising Targets in Cardiovascular Disease Treatment.

Frambach, S.J.C.M. ; Haas, R. de ; Smeitink, J.A.M. ; Rongen, G.A.P.J.M. ; Russel, F.G.M. ; Schirris, T.J.J.

2020, Article / Letter to editor (Pharmacological Reviews, vol. 72, iss. 1, (2020), pp. 152-190)
Physiologically-based pharmacokinetic models for children: Starting to reach maturation?

Verscheijden, L.F.M.; Koenderink, J.B. ; Johnson, T.N.; Wildt, S.N. de ; Russel, F.G.M.

2020, Article / Letter to editor (Pharmacology and Therapeutics. Part A: Chemotherapy, Toxicology and Metabolic Inhibitors, vol. 211, (2020), article 107541)
Organic anion transporters 1 and 3 influence cellular energy metabolism in renal proximal tubule cells

Vriend, J.; Hoogstraten, C.A. ; Venrooij, K.R.; Berge, B.T. van den ; Govers, L.P.; Rooij, A.J.M. van ; Huigen, M.C.D.G. ; Schirris, T.J.J.; Russel, F.G.M. ; Masereeuw (UU), R. ; Wilmer, M.J.G. et al. sine al.

2019, Article / Letter to editor (Biological Chemistry, vol. 400, iss. 10, (2019), pp. 1347-1358)
Review article: direct-acting antivirals for the treatment of HCV during pregnancy and lactation - implications for maternal dosing, foetal exposure, and safety for mother and child

Freriksen, J.J.M. ; Seyen, M. van ; Judd, A.; Gibb, D.M.; Collins, I.J.; Greupink, R.; Russel, F.G.M. ; Drenth, J.P.H. ; Colbers, A. ; Burger, D.M.

2019, Article / Letter to editor (Alimentary Pharmacology & Therapeutics, vol. 50, iss. 7, (2019), pp. 738-750)
Toxicokinetics of a urinary metabolite of tebuconazole following controlled oral and dermal administration in human volunteers

Oerlemans, A. ; Verscheijden, L.F.M.; Mol, J.G.J.; Vermeulen, R.C.H.; Westerhout, J.; Roeleveld, N. ; Russel, F.G.M. ; Scheepers, P.T.J.

2019, Article / Letter to editor (Archives of Toxicology, vol. 93, iss. 9, (2019), pp. 2545-2553)
Evaluating darunavir/ritonavir dosing regimens for HIV-positive pregnant women using semi-mechanistic pharmacokinetic modelling

Schalkwijk, S.J.; Heine, R. ter ; Colbers, A.P. ; Capparelli, Edmund; Best, Brookie M.; Cressey, Tim R.; Greupink, R.; Russel, F.G. ; Karlsson, Mats O.; Burger, D.M.

2019, Article / Letter to editor (Journal of Antimicrobial Chemotherapy, vol. 74, iss. 5, (2019), pp. 1348-1356)
Development of a physiologically-based pharmacokinetic pediatric brain model for prediction of cerebrospinal fluid drug concentrations and the influence of meningitis

Verscheijden, L.F.M.; Koenderink, J.B. ; Wildt, S.N. de ; Russel, F.G.M.

2019, Article / Letter to editor (Plos Computational Biology, vol. 15, iss. 6, (2019), pp. e1007117)
To be or not to be pink(1): contradictory findings in an animal model for Parkinson's disease

Haas, R. de ; Heltzel, L.C.M.W. ; Tax, D.; Broek, P.H. van den ; Steenbreker, H.; Verheij, M.M.M. ; Russel, F.G.M. ; Orr, A.L.; Nakamura, K.; Smeitink, J.A.M.

2019, Article / Letter to editor (Brain Communications, vol. 1, iss. 1, (2019), pp. fcz016)
Differential effects of psychoactive substances on human wildtype and polymorphic T356M dopamine transporters (DAT)

Zwartsen, A.; Litjens, C.H.C. ; Hondebrink, L.; Heuvel, J van den; Greupink, R.; Russel, F.G.M. ; Lange, D.W. de; Legler, J.; Koenderink, J.B. ; Westerink, R.H.

2019, Article / Letter to editor (Toxicology, vol. 422, (2019), pp. 69-75)
Uremic solutes modulate hepatic bile acid handling and induce mitochondrial toxicity

Weigand, K.M. ; Schirris, T.J.J.; Houweling, Megan; Heuvel, J.M.W. van den ; Koenderink, J.B. ; Dankers, A.C.A. ; Russel, F.G. ; Greupink, R.

2019, Article / Letter to editor (Toxicology in Vitro, vol. 56, (2019), pp. 52-61)
Disease-Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium

Evers, R.; Piquette-Miller, M.; Polli, J.W.; Russel, F.G.M. ; Sprowl, J.A.; Tohyama, K.; Ware, J.A.; Wildt, S.N. de ; Xie, W; Brouwer, K.L.R.

2018, Article / Letter to editor (Clinical Pharmacology and Therapeutics, vol. 104, iss. 5, (2018), pp. 900-915)
The Role of Efflux Pumps in Tuberculosis Treatment and Their Promise as a Target in Drug Development: Unraveling the Black Box

Brake, L.H.M. te ; Knegt, G.J. de; Steenwinkel, J.E. de; Dam, T.J.P. van; Burger, D.M. ; Russel, F.G.M. ; Crevel, R. van ; Koenderink, J.B. ; Aarnoutse, R.

2018, Article / Letter to editor (Annual review of pharmacology and toxicology, vol. 58, (2018), pp. 271-291)
Parenteral bilirubin in healthy volunteers: a reintroduction in translational research

Dekker, Douwe ; Dorresteijn, M.J. ; Welzen, M.E.B. ; Timman, S.T. ; Pickkers, P. ; Burger, D.M. ; Smits, P. ; Wagener, F.A.D.T.G. ; Russel, F.G.M.

2018, Article / Letter to editor (British Journal of Clinical Pharmacology, vol. 84, iss. 2, (2018), pp. 268-279)
Development of a mechanistic biokinetic model for hepatic bile acid handling to predict possible cholestatic effects of drugs

Notenboom, Sylvia; Weigand, K.M. ; Proost, Johannes H.; Lipzig, Marola M.H. van; Steeg, E. Van de; Broek, P.H.H. van den ; Greupink, R.; Russel, F.G. ; Groothuis, G.M.

2018, Article / Letter to editor (European Journal of Pharmaceutical Sciences, vol. 115, (2018), pp. 175-184)
Expression of Organic Anion Transporter 1 or 3 in Human Kidney Proximal Tubule Cells Reduces Cisplatin Sensitivity

Nieskens, T.T.G.; Peters, J.G.P. ; Dabaghie, D.; Korte, D.; Jansen, K.; Asbeck, A.H. van ; Tavraz, N.N.; Friedrich, T.; Russel, F.G.M. ; Masereeuw, R. ; Wilmer, M.J.G. et al. sine al.

2018, Article / Letter to editor (Drug Metabolism and Disposition, vol. 46, iss. 5, (2018), pp. 592-599)
Placental disposition of the immunosuppressive drug tacrolimus in renal transplant recipients and in ex vivo perfused placental tissue

Freriksen, J.J.M. ; Feyaerts, D. ; Broek, P.H.H. van den ; Heijden, O.W.H. van der ; Drongelen, J. van ; Hamersvelt, H.W. van ; Russel, F.G. ; Molen, R.G. van der ; Greupink, R.

2018, Article / Letter to editor (European Journal of Pharmaceutical Sciences, vol. 119, (2018), pp. 244-248)
Prediction of Fetal Darunavir Exposure by Integrating Human Ex-Vivo Placental Transfer and Physiologically Based Pharmacokinetic Modeling

Schalkwijk, S.J.; Buaben, A.O.; Freriksen, J.J.M. ; Colbers, A.P. ; Burger, D.M. ; Greupink, R.; Russel, F.G.M.

2018, Article / Letter to editor (Clinical Pharmacokinetics, vol. 57, iss. 6, (2018), pp. 705-716)
Statins Affect Skeletal Muscle Performance: Evidence for Disturbances in Energy Metabolism

Allard, N.A.E.; Schirris, T.J.J.; Verheggen, R.J. ; Russel, F.G.M. ; Rodenburg, R.J.T. ; Smeitink, J.A.M. ; Hopman, M.T.E. ; Timmers, S.

2018, Article / Letter to editor (Journal of Clinical Endocrinology and Metabolism, vol. 103, iss. 1, (2018), pp. 75-84)
Screening of Drug-Transporter Interactions in a 3D Microfluidic Renal Proximal Tubule on a Chip

Vriend, J.; Nieskens, T.T.G.; Vormann, Marianne K.; Berge, Bartholomeus T. van den; Heuvel, Angelique van den; Russel, F.G.M. ; Masereeuw, R. ; Wilmer, M.J.G.

2018, Article / Letter to editor (Aaps Journal, vol. 20, iss. 5, (2018), article UNSP 87)
A Mechanism-Based Population Pharmacokinetic Analysis Assessing the Feasibility of Efavirenz Dose Reduction to 400 mg in Pregnant Women

Schalkwijk, S.J.; Heine, R. ter ; Colbers, A. ; Huitema, Alwin D.R.; Denti, Paolo; Dooley, Kelly E.; Greupink, R.; Russel, F.G.M. ; Mirochnick, Mark; Burger, D.M.

2018, Article / Letter to editor (Clinical Pharmacokinetics, vol. 57, iss. 11, (2018), pp. 1421-1433)
Urine collection methods for non-toilet-trained children in biological monitoring studies: Validation of a disposable diaper for characterization of tebuconazole exposure

Oerlemans, A. ; Dael, M.F.P. van ; Vermeulen, R.C.H.; Russel, F.G. ; Scheepers, P.T.J.

2018, Article / Letter to editor (Toxicology Letters, vol. 298, (2018), pp. 201-206)
Experimental study of diclofenac and its biliary metabolites on anastomotic healing

Yauw, S.T.K.; Lomme, R.M.L.M. ; Broek, P.H.H. van den ; Greupink, R.; Russel, F.G.M. ; Goor, H. van

2018, Article / Letter to editor (BJS Open, vol. 2, iss. 4, (2018), pp. 220-228)
Proguanil and cycloguanil are organic cation transporter and multidrug and toxin extrusion substrates

Velden, M van der; Bilos, A. ; Heuvel, J.M. van den ; Rijpma, S.R. ; Hurkmans, E.G.E. ; Sauerwein, R.W. ; Russel, F.G.M. ; Koenderink, J.B.

2017, Article / Letter to editor (Malaria Journal, vol. 16, iss. 1, (2017), article 422)
Heterogeneous transport of digitalis-like compounds by P-glycoprotein in vesicular and cellular assays

Gozalpour, E.; Wilmer, M.J.G. ; Bilos, A. ; Masereeuw, R. ; Russel, F.G. ; Koenderink, J.B.

2016, Article / Letter to editor (Toxicology in Vitro, vol. 32, (2016), pp. 138-145)
Physiologically Based Modelling of Darunavir/Ritonavir Pharmacokinetics During Pregnancy

Colbers, A. ; Greupink, R.; Litjens, C.; Burger, D.M. ; Russel, F.G.M.

2016, Article / Letter to editor (Clinical Pharmacokinetics, vol. 55, iss. 3, (2016), pp. 381-396)
Placental transfer of the HIV integrase inhibitor dolutegravir in an ex vivo human cotyledon perfusion model

Schalkwijk, S.J.; Greupink, R.; Colbers, A.P. ; Wouterse, A.C. ; Verweij, V.G.M. ; Drongelen, J. van ; Teulen, M.J.A. ; Oetelaar, D. van den; Burger, D.M. ; Russel, F.G.

2016, Article / Letter to editor (Journal of Antimicrobial Chemotherapy, vol. 71, iss. 2, (2016), pp. 480-483)
Substantially lowered dolutegravir exposure in a treatment-experienced perinatally HIV-1-infected pregnant woman

Schalkwijk, S.J.; Feiterna-Sperling, C.; Weizsacker, K.; Colbers, A. ; Buhrer, C.; Greupink, R.; Russel, F.G.M. ; Burger, D.M.

2016, Article / Letter to editor (Aids, vol. 30, iss. 12, (2016), pp. 1999-2001)
First reported use of elvitegravir and cobicistat during pregnancy

Schalkwijk, S.J.; Colbers, A. ; Konopnicki, D.; Greupink, R.; Russel, F.G. ; Burger, D.M.

2016, Article / Letter to editor (Aids, vol. 30, iss. 5, (2016), pp. 807-808)
Uremic Solutes in Chronic Kidney Disease and Their Role in Progression

Brand, J.A. van den; Mutsaers, H.A.; Zuilen, A.D. van; Blankestijn, P.J.; Broek, P.H.H. van den ; Russel, F.G.M. ; Masereeuw, R. ; Wetzels, J.F.M.

2016, Article / Letter to editor (PLoS One, vol. 11, iss. 12, (2016), article e0168117)
The effect of dipyridamole on the pharmacokinetics of metformin: a randomized crossover study in healthy volunteers

El Messaoudi, S. ; Russel, F.G. ; Colbers, A. ; Bandell, C.C.; Broek, P.H.H. van den ; Burger, D.M. ; Rongen, G.A. ; Riksen, N.P.

2016, Article / Letter to editor (European Journal of Clinical Pharmacology, vol. 72, iss. 6, (2016), pp. 725-730)
Cathepsin L is crucial for the development of early experimental diabetic nephropathy

Garsen, M.; Rops, L.W.M.M. ; Dijkman, H.B. ; Willemsen, B.K.; Kuppevelt, T.H. van ; Russel, F.G.M. ; Rabelink, T.J.; Berden, J.H. ; Reinheckel, T.; Vlag, J. van der

2016, Article / Letter to editor (Kidney International. Supplement, vol. 90, iss. 5, (2016), pp. 1012-1022)
Vital and dispensable roles of Plasmodium multidrug resistance transporters during blood- and mosquito-stage development

Rijpma, S.R. ; Velden, M. van der; Annoura, T.; Matz, J.M.; Kenthirapalan, S.; Kooij, T.W. ; Matuschewski, K.; Gemert, G.J.A. van ; Vegte-Bolmer, M.G. van de ; Siebelink-Stoter, R. ; Graumans, W. ; Ramesar, J.; Klop, O.; Russel, F.G. ; Sauerwein, R.W. ; Janse, C.J.; Franke-Fayard, B.M.; Koenderink, J.B. et al. sine al.

2016, Article / Letter to editor (Molecular Microbiology, vol. 101, iss. 1, (2016), pp. 78-91)
Multidrug ATP-binding cassette transporters are essential for hepatic development of Plasmodium sporozoites

Rijpma, S.R. ; Velden, M. van der; Gonzalez-Pons, M.; Annoura, T.; Schaijk, B.C.L. van ; Gemert, G.J.A. van ; Heuvel, J.M.W. van den ; Ramesar, J.; Chevalley-Maurel, S.; Ploemen, I.H.; Khan, S.M.; Franetich, J.F.; Mazier, D.; Wilt, J.H.W. de ; Serrano, A.E.; Russel, F.G. ; Janse, C.J.; Sauerwein, R.W. ; Koenderink, J.B. ; Franke-Fayard, B.M. et al. sine al.

2016, Article / Letter to editor (Cellular Microbiology, vol. 18, iss. 3, (2016), pp. 369-383)
Protective Efficacy Induced by Genetically Attenuated Mid-to-Late Liver-Stage Arresting Plasmodium berghei Deltamrp2 Parasites

Velden, M van der; Rijpma, S.R. ; Verweij, V.; Gemert, G.J.A. van ; Chevalley-Maurel, S.; Vegte-Bolmer, M. van de ; Franke-Fayard, B.M.; Russel, F.G.M. ; Janse, C.J.; Sauerwein, R.W. ; Koenderink, J.B. et al. sine al.

2016, Article / Letter to editor (American Journal of Tropical Medicine and Hygiene, vol. 95, iss. 2, (2016), pp. 378-382)
MRP1 mediates folate transport and antifolate sensitivity in Plasmodium falciparum

Rijpma, S.R. ; Velden, M. van der; Bilos, A. ; Jansen, R.S.; Mahakena, S.; Russel, F.G. ; Sauerwein, R.W. ; Wetering, K. van de; Koenderink, J.B.

2016, Article / Letter to editor (FEBS Letters, vol. 590, iss. 4, (2016), pp. 482-492)
Gait analysis in a mouse model resembling Leigh disease

Haas, R. de ; Russel, F.G. ; Smeitink, J.A.

2016, Article / Letter to editor (Behavioural Brain Research, vol. 296, (2016), pp. 191-198)
Inhibitory potential of tuberculosis drugs on ATP-binding cassette drug transporters

Brake, L.H. te ; Russel, F.G. ; Heuvel, J.J.T.M. ; Knegt, G.J. de; Steenwinkel, J.E. de; Burger, D.M. ; Aarnoutse, R.E. ; Koenderink, J.B.

2016, Article / Letter to editor (Tuberculosis, vol. 96, (2016), pp. 150-157)
Moxifloxacin Is a Potent In Vitro Inhibitor of OCT- and MATE-Mediated Transport of Metformin and Ethambutol

Brake, L.H.M. te ; Heuvel, J.M.W. van den ; Buaben, A.O.; Crevel, R. van ; Bilos, A. ; Russel, F.G. ; Aarnoutse, R.E. ; Koenderink, J.B.

2016, Article / Letter to editor (Antimicrobial Agents and Chemotherapy, vol. 60, iss. 12, (2016), pp. 7105-7114)
Inhibitory Potential of Antifungal Drugs on ATP-Binding Cassette Transporters P-Glycoprotein, MRP1 to MRP5, BCRP, and BSEP

Lempers, V.J. ; Heuvel, J.J.M.W. van den ; Russel, F.G. ; Aarnoutse, R.E. ; Burger, D.M. ; Bruggemann, R.J. ; Koenderink, J.B.

2016, Article / Letter to editor (Antimicrobial Agents and Chemotherapy, vol. 60, iss. 6, (2016), pp. 3372-3379)
Statin Lactonization by Uridine 5'-Diphospho-glucuronosyltransferases (UGTs)

Schirris, T.J.J.; Ritschel, T.; Bilos, A. ; Smeitink, J. ; Russel, F.G.M.

2015, Article / Letter to editor (Molecular Pharmaceutics, vol. 12, iss. 11, (2015), pp. 4048-4055)

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