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Death after awakening from post-anoxic coma: the "Best CPC" project

Taccone, Fabio Silvio; Horn, Janneke; Storm, C.; Cariou, A.; Sandroni, C.; Friberg, H.; Hoedemaekers, C. ; Oddo, M.

2019, Article / Letter to editor (Critical Care, vol. 23, (2019), article 107)
Less Is More?-A Feasibility Study of Fluid Strategy in Critically Ill Children With Acute Respiratory Tract Infection

Ingelse, S.A.; Geukers, Vincent G.; Dijsselhof, Monique E.; Lemson, J. ; Bem, R.A.; Woensel, J.B. van

2019, Article / Letter to editor (Frontiers in Pediatrics, vol. 7, (2019), article 496)
Organization and training at national level of antimicrobial stewardship and infection control activities in Europe: an ESCMID cross-sectional survey

Maraolo, Alberto Enrico; Ong, D.S.Y.; Cimen, Cansu; Howard, Philip; Kofteridis, Diamantis P.; Schouten, J.A. ; Pulcini, Celine; Harxhi, Arjan

2019, Article / Letter to editor (European Journal of Clinical Microbiology and Infectious Diseases, vol. 38, iss. 11, (2019), pp. 2061-2068)
EBV-Related Hodgkin Lymphoma in an ICF2 Patient: Is EBV Susceptibility a Hallmark of This ICF Subtype?

Licciardi, F.; Boogaard, M. van den ; Piane, M. Delle; Tovo, P.A.; Montin, D.

2019, Article / Letter to editor (Journal of Clinical Immunology, vol. 39, iss. 3, (2019), pp. 234-236)
Differential pathogen-host interactions

Koch, R.M.

2019, Dissertation
Comparison of antimicrobial stewardship programmes in acute-care hospitals in four European countries: A cross-sectional survey

Kallen, M.C.; Binda, F.; Oever, J. ten ; Tebano, G.; Pulcini, C.; Murri, R.; Hulscher, M.E.J.L. ; Schouten, J.A.

2019, Article / Letter to editor (International Journal of Antimicrobial Agents, vol. 54, iss. 3, (2019), pp. 338-345)
Multicentric experience with interferon gamma therapy in sepsis induced immunosuppression. A case series

Payen, Didier; Faivre, Valerie; Miatello, Jordi; Leentjens, J. ; Brumpt, Caren; Tissieres, Pierre; Pickkers, P. ; Lukaszewicz, Anne Claire

2019, Article / Letter to editor (BMC Infectious Diseases, vol. 19, iss. 1, (2019), article 931)
Development of quality indicators for the management of Staphylococcus aureus bacteraemia

Oever, J. ten ; Jansen, Joell L.; Vaart, Thomas W. van der; Schouten, J.A. ; Hulscher, M.E.J.L. ; Verbon, Annelies

2019, Article / Letter to editor (Journal of Antimicrobial Chemotherapy, vol. 74, iss. 11, (2019), pp. 3344-3351)
Process evaluation of the effects of patient safety auditing in hospital care (part 2)

Hanskamp-Sebregts, M.E.C. ; Zegers, M. ; Boeijen, W.M.J. ; Wollersheim, H.C. ; Gurp, P.J. van ; Westert, G.P.

2019, Article / Letter to editor (International Journal for Quality in Health Care, vol. 31, iss. 6, (2019), pp. 433-441)
Sustainability of clinical pathway guided care in cardiac surgery ICU patients; 9-years experience in over 7500 patients

Kolk, B.M. van der ; Boogaard, M. van den ; Hoeven, J.G. van der ; Noyez, L. ; Pickkers, P.

2019, Article / Letter to editor (International Journal for Quality in Health Care, vol. 31, iss. 6, (2019), pp. 456-463)
Risk Factors for Mortality in Pediatric Postsurgical versus Medical Severe Sepsis

Thakkar, R.K.; Weiss, S.L.; Fitzgerald, J.C.; Keele, L.; Thomas, N.J.; Nadkarni, V.M.; Neeleman, C. ; Lemson, J. ; Sherring, C.; Bushell, T.

2019, Article / Letter to editor (Journal of Surgical Research, vol. 242, (2019), pp. 100-110)
Routine lung ultrasound to detect postoperative pulmonary complications following major abdominal surgery: a prospective observational feasibility study

Touw, H.R.W. ; Schuitemaker, A.E.; Daams, F.; Peet, D.L. van der; Bronkhorst, E.M. ; Schober, P.; Boer, C.; Tuinman, P.R.

2019, Article / Letter to editor (The Ultrasound Journal, vol. 11, iss. 1, (2019), pp. 20)
The Human Chorionic Gonadotropin Derivate EA-230 Modulates the Immune Response and Exerts Renal Protective Properties: Therapeutic Potential in Humans

Groenendael, R. van ; Beunders, R. ; Kox, M. ; Eijk, L.T.G.J. van ; Pickkers, P.

2019, Article / Letter to editor (Seminars in Nephrology, vol. 39, iss. 5, (2019), pp. 496-504)
Cardiac output-guided hemodynamic therapy for adult living donor kidney transplantation in children under 20 kg: A pilot study

Voet, M. ; Nusmeier, A. ; Lerou, J.G. ; Luijten, J.; Cornelissen, M. ; Lemson, J.

2019, Article / Letter to editor (Paediatric Anaesthesia, vol. 29, iss. 9, (2019), pp. 950-958)
Effects of levosimendan on respiratory muscle function in patients weaning from mechanical ventilation

Roesthuis, L.H. ; Hoeven, H. van der ; Sinderby, C.; Frenzel, T. ; Ottenheijm, C.; Brochard, L.; Doorduin, J. ; Heunks, L.

2019, Article / Letter to editor (Intensive Care Medicine, vol. 45, iss. 10, (2019), pp. 1372-1381)
Fever in Sepsis: Still a Hot Topic

Leijte, G.P. ; Kox, M. ; Pickkers, P.

2019, Article / Letter to editor (American Journal of Respiratory and Critical Care Medicine, vol. 200, iss. 2, (2019), pp. 263-264)
Fish scale crystals: an under-recognised cause of intestinal necrosis

Bogaerts, J.M.A.; Hoeven, J.G. van der ; Arts, E.E.A.; Kolk, B.M. van der ; Brosens, L.A.A.

2019, Article / Letter to editor (Journal of Clinical Pathology : the Journal of the Association of Clinical Pathologists, vol. 72, iss. 8, (2019), pp. 567)
Impact of Early Acute Kidney Injury on Management and Outcome in Patients With Acute Respiratory Distress Syndrome: A Secondary Analysis of a Multicenter Observational Study

McNicholas, B.A.; Rezoagli, E.; Pham, T.; Madotto, F.; Guiard, E.; Fanelli, V.; Bellani, G.; Griffin, M.D.; Schouten, J.A. ; Ranieri, M.; Laffey, J.G. et al. sine al.

2019, Article / Letter to editor (Critical Care Medicine, vol. 47, iss. 9, (2019), pp. 1216-1225)
Innovative Drugs to Target Renal Inflammation in Sepsis: Alkaline Phosphatase

Hummeke-Oppers, F.; Hemelaar, P. ; Pickkers, P.

2019, Article / Letter to editor (Frontiers in Pharmacology, vol. 10, (2019), article 919)
Physician Experiences with Communicating Organ Donation with the Relatives: A Dutch Nationwide Evaluation on Factors that Influence Consent Rates

Witjes, M. ; Kruijff, P.E.V.; Haase-Kromwijk, B.; Hoeven, J.G. van der ; Jansen, N.E.; Abdo, W.F.

2019, Article / Letter to editor (Neurocritical Care, vol. 31, iss. 2, (2019), pp. 357-364)
Dose-linearity of the pharmacokinetics of an intravenous [(14) C]midazolam microdose in children

Groen, B.D.; Vaes, W.H.; Park, B.K.; Krekels, E.H.J.; Duijn, E. van; Korgvee, L.T.; Maruszak, W.; Grynkiewicz, G.; Garner, R.C.; Knibbe, Catherijne A.J.; Tibboel, D.; Wildt, S.N. de ; Turner, M.A. et al. sine al.

2019, Article / Letter to editor (British Journal of Clinical Pharmacology, vol. 85, iss. 10, (2019), pp. 2332-2340)
A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization

Cheung, K.W.K.; Groen, B.D.; Spaans, E.; Borselen, M.D. van; Bruijn, A. de; Simons-Oosterhuis, Y.; Tibboel, D.; Samsom, J.N.; Verdijk, R.M.; Smeets, B. ; Zhang, L.; Huang, S.M.; Giacomini, K.M.; Wildt, S.N. de et al. sine al.

2019, Article / Letter to editor (Clinical Pharmacology and Therapeutics, vol. 106, iss. 5, (2019), pp. 1083-1092)
Emergency Department to ICU Time Is Associated With Hospital Mortality: A Registry Analysis of 14,788 Patients From Six University Hospitals in The Netherlands*

Groenland, Carline N.; Termorshuizen, Fabian; Rietdijk, Wim J.R.; Brule, J.M. van den ; Dongelmans, Dave A.; Jonge, Evert de; Boersma, Eric; Uil, Corstiaan A. den

2019, Article / Letter to editor (Critical Care Medicine, vol. 47, iss. 11, (2019), pp. 1564-1571)
Epidemiology and Outcome of Critically Ill Pediatric Cancer and Hematopoietic Stem Cell Transplant Patients Requiring Continuous Renal Replacement Therapy: A Retrospective Nationwide Cohort Study

Raymakers-Janssen, Paulien A.M.A.; Lilien, Marc R.; Tibboel, Dick; Kneyber, Martin C.J.; Dijkstra, Sandra; Woensel, J.B. van; Lemson, J. ; Waardenburg, D. van; Roeleveld, P.P.

2019, Article / Letter to editor (Critical Care Medicine, vol. 47, iss. 11, (2019), pp. E893-E901)
Targeting adrenomedullin in sepsis

Geven, C.B.C.A.G.

2019, Dissertation
The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity

Dominguez Andres, J. ; Novakovic, B.; Li, Yang; Scicluna, B.P.; Gresnigt, M.S.; Arts, R.J.; Oosting, M. ; Moorlag, S.J.C.F.M. ; Groh, L.A. ; Zwaag, J. ; Koch, R.M. ; Horst, R. ter ; Joosten, L.A.B. ; Kox, M. ; Pickkers, P. ; Kumar, V. ; Stunnenberg, H.G. ; Netea, M.G. et al. sine al.

2019, Article / Letter to editor (Cell Metabolism, vol. 29, iss. 1, (2019), pp. 211-220)
The KHENERGY Study: Safety and Efficacy of KH176 in Mitochondrial m.3243A>G Spectrum Disorders

Janssen, M.C.H. ; Koene, S. ; Laat, P. de ; Hemelaar, P. ; Pickkers, P. ; Spaans, Edwin; Beukema, R.J. ; Beyrath, J.D. ; Groothuis, J.T. ; Verhaak, C.M. ; Smeitink, J. et al. sine al.

2019, Article / Letter to editor (Clinical Pharmacology and Therapeutics, vol. 105, iss. 1, (2019), pp. 101-111)
The potential impact of hematocrit correction on evaluation of tacrolimus target exposure in pediatric kidney transplant patients

Schijvens, A.M. ; Hesteren, Fransje H.S. van; Cornelissen, E.A.M. ; Bootsma-Robroeks, Charlotte M.H.H.T.; Bruggemann, R.J.M. ; Burger, D.M. ; Wildt, S.N. de ; Schreuder, M.F. ; Heine, R. ter

2019, Article / Letter to editor (Pediatric Nephrology, vol. 34, iss. 3, (2019), pp. 507-515)
Oxygen and platelets. Translational studies on therapeutic targets for immunomodulation

Kiers, H.D.

2019, Dissertation
Cerebral hemodynamics. After cardiac arrest, in sepsis and in the human endotoxemia model

Brule, J.M.D. van den

2019, Dissertation
Pharmacology and pharmacogenetics of prednisone and prednisolone in patients with nephrotic syndrome

Schijvens, A.M. ; Heine, R. ter ; Wildt, S.N. de ; Schreuder, M.F.

2019, Article / Letter to editor (Pediatric Nephrology, vol. 34, iss. 3, (2019), pp. 389-403)
Preclinical safety evaluation of the adrenomedullin-binding antibody Adrecizumab in rodents, dogs and non-human primates

Geven, C.B.C.A.G. ; Kox, M. ; Blet, A.; Mebazaa, Alexandre; Schroedter, Mathias; Struck, Joachim; Bergmann, A.; Pickkers, P.

2019, Article / Letter to editor (Toxicology and Applied Pharmacology, vol. 369, (2019), pp. 1-16)
Comparison of different lots of endotoxin and evaluation of in vivo potency over time in the experimental human endotoxemia model

Kiers, D. ; Leijte, G.P. ; Gerretsen, J.; Zwaag, J. ; Kox, M. ; Pickkers, P.

2019, Article / Letter to editor (Innate Immunity, vol. 25, iss. 1, (2019), pp. 34-45)
How to measure quantitative antibiotic use in order to support antimicrobial stewardship in acute care hospitals: a retrospective observational study

Kallen, M.C.; Natsch, S.S. ; Opmeer, B.C.; Hulscher, M. ; Schouten, J.A. ; Prins, J.M.; Linden, P. van der

2019, Article / Letter to editor (European Journal of Clinical Microbiology and Infectious Diseases, vol. 38, iss. 2, (2019), pp. 347-355)
Effect of Hydrocortisone Therapy Initiated 7 to 14 Days After Birth on Mortality or Bronchopulmonary Dysplasia Among Very Preterm Infants Receiving Mechanical Ventilation A Randomized Clinical Trial

Onland, Wes; Cools, Filip; Kroon, Andre; Rademaker, Karin; Merkus, Maruschka P.; Dijk, Peter H.; Heijst, A.F.J. van ; Matthijsse, R. ; Boode, W.P. de ; Baal, Caroline van; Wildt, S.N. de et al. sine al.

2019, Article / Letter to editor (Jama : Journal of the American Medical Association, vol. 321, iss. 4, (2019), pp. 354-363)
The Safety, Tolerability, and Effects on the Systemic Inflammatory Response and Renal Function of the Human Chorionic Gonadotropin Hormone-Derivative EA-230 Following On-Pump Cardiac Surgery (The EASI Study): Protocol for a Randomized, Double-Blind, Placebo-Controlled Phase 2 Study

Groenendael, R. van ; Beunders, R. ; Hofland, J. ; Morshuis, W.J. ; Kox, M. ; Eijk, L.T.G.J. van ; Pickkers, P.

2019, Article / Letter to editor (JMIR Research Protocols, vol. 8, iss. 2, (2019), pp. 56-68, article e11441)
The value of the neutrophil-lymphocyte count ratio in the diagnosis of sepsis in patients admitted to the Intensive Care Unit: A retrospective cohort study

Westerdijk, K; Simons, K.S.; Zegers, M.J. ; Wever, P.C.; Pickkers, P. ; Jager, Cornelis P. C. de

2019, Article / Letter to editor (PLoS One, vol. 14, iss. 2, (2019), article e0212861)
Differences in 90-day mortality of delirium subtypes in the intensive care unit: A retrospective cohort study

Rood, P.J.T. ; Schoor, F.R. van de ; Tertholen, K. van; Pickkers, P. ; Boogaard, M. van den

2019, Article / Letter to editor (Journal of Critical Care, vol. 53, (2019), pp. 120-124)
Organ donation in the Netherlands; how to improve donor identification and family consent

Witjes, M.

2019, Dissertation
Monitoring patient-ventilator breath contribution in the critically ill during neurally adjusted ventilatory assist: reliability and improved algorithms for bedside use

Jonkman, Annemijn H.; Jansen, D. ; Gadgil, Suvarna; Keijzer, Christiaan; Girbes, Armand R.J.; Scheffer, G.J. ; Hoeven, J.G. van der ; Sinderby, Christer S.; Heunks, L.M.A.

2019, Article / Letter to editor (Journal of Applied Physiology, vol. 127, iss. 1, (2019), pp. 264-271)
Prophylactic Haloperidol Effects on Long-term Quality of Life in Critically Ill Patients at High Risk for Delirium Results of the REDUCE Study

Rood, P.J.T. ; Zegers, M. ; Slooter, A.J.; Beishuizen, Albertus; Simons, K.S.; Voort, P.H. van der; Hoeven, J.G. van der ; Pickkers, P. ; Boogaard, M.H.W.A. van den

2019, Article / Letter to editor (Anesthesiology, vol. 131, iss. 2, (2019), pp. 328-335)
Remote ischaemic preconditioning does not modulate the systemic inflammatory response or renal tubular stress biomarkers after endotoxaemia in healthy human volunteers: a single-centre, mechanistic, randomised controlled trial

Zwaag, J. ; Beunders, R. ; Warle, M.C.; Kellum, J.A.; Riksen, N.P. ; Pickkers, P. ; Kox, M.

2019, Article / Letter to editor (British Journal of Anaesthesia, vol. 123, iss. 2, (2019), pp. 177-185)
Retrospective cohort study on factors associated with mortality in high-risk pediatric critical care patients in the Netherlands

Verlaat, C.W.M. ; Wubben, N. ; Visser, I.H.; Hazelzet, J.A.; Waardenburg, D. van; Dam, Nicolette A. van; Hoeven, J.G. van der ; Lemson, J. ; Boogaard, M. van den

2019, Article / Letter to editor (BMC Pediatrics, vol. 19, iss. 1, (2019), article 274)
Ensuring Antibiotic Development, Equitable Availability, and Responsible Use of Effective Antibiotics: Recommendations for Multisectoral Action

Monnier, A.A. ; Schouten, J.A. ; Tebano, G.; Zanichelli, V.; Huttner, B.D.; Pulcini, C.; Hulscher, M.E. ; Gyssens, I.C.J.

2019, Article / Letter to editor (Clinical Infectious Diseases, vol. 68, iss. 11, (2019), pp. 1952-1959)
Diagnosis and outcome of acute respiratory failure in immunocompromised patients after bronchoscopy

Bauer, P.R.; Chevret, S.; Yadav, Hemang; Mehta, Sangeeta; Pickkers, P. ; Bukan, R.B.; Shah, S.; Hemelaar, P. ; Moralez, Guilliana M.; Vinatier, Isabelle

2019, Article / Letter to editor (European Respiratory Journal, vol. 54, iss. 1, (2019), article 1802442)
Incorporating Ontogeny in Physiologically Based Pharmacokinetic Modeling to Improve Pediatric Drug Development: What We Know About Developmental Changes in Membrane Transporters

Cheung, Kit Wun Kathy; Groen, Bianca D. van; Burckart, Gilbert J.; Zhang, L.; Wildt, S.N. de ; Huang, Shiew-Mei

2019, Article / Letter to editor (Journal of Clinical Pharmacology and Journal of New Drugs, vol. 59, (2019), pp. S56-S69)
Pharmacotherapy in paediatric heart failure: a Delphi process

Diez, Cristina C.; Khalil, F.; Makowski, N.; Schwender, Holger; Jovanovic, I.; Dalinghaus, M.; Wildt, S.N. de ; Laeer, S.

2019, Article / Letter to editor (Cardiology in the Young, vol. 29, iss. 7, (2019), pp. 869-876, article PII S104795111900066)
Recently Registered Midazolam Doses for Preterm Neonates Do Not Lead to Equal Exposure: A Population Pharmacokinetic Model

Voller, Swantje; Flint, R.B. ; Beggah, Fouzi; Reiss, Irwin K.M.; Andriessen, Peter; Zimmermann, L.J.; Liem, K.D. ; Wildt, S.N. de ; Knibbe, Catherijne A.J.; Simons, Sinno H.P.

2019, Article / Letter to editor (Journal of Clinical Pharmacology and Journal of New Drugs, vol. 59, iss. 10, (2019), pp. 1300-1308)
Risk stratification to improve Pediatric Early Warning Systems: it is all about the context

Teheux, L. ; Verlaat, C.W. ; Lemson, J. ; Draaisma, J.M.T. ; Fuijkschot, J.

2019, Article / Letter to editor (European Journal of Pediatrics, vol. 178, iss. 10, (2019), pp. 1589-1596)
Adrecizumab, a non-neutralizing anti-adrenomedullin antibody, improves haemodynamics and attenuates myocardial oxidative stress in septic rats

Blet, A.; Deniau, Benjamin; Geven, C.B.C.A.G. ; Sadoune, M.; Caillard, Anais; Kounde, Paul-Robert; Pickkers, P. ; Samuel, Jane-Lise; Mebazaa, Alexandre

2019, Article / Letter to editor (Intensive Care Medicine Experimental, vol. 7, (2019), article 25)

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