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Noradrenaline drives immunosuppression in sepsis: clinical consequences

Stolk, R.F. ; Kox, M. ; Pickkers, P.

2020, Article / Letter to editor (Intensive Care Medicine, vol. 46, iss. 6, (2020), pp. 1246-1248)
Suboptimal Dosing of Fluconazole in Critically Ill Patients: Time To Rethink Dosing

Muilwijk, E.W. ; Lange, D.W. de; Schouten, J.A. ; Wasmann, R.E. ; Heine, R. ter ; Burger, D.M. ; Colbers, A. ; Haas, P.J.; Verweij, P.E. ; Pickkers, P. ; Brüggemann, R.J.M. et al. sine al.

2020, Article / Letter to editor (Antimicrobial Agents and Chemotherapy, vol. 64, iss. 10, (2020), article e00984-20)
Nangibotide in patients with septic shock: a Phase 2a randomized controlled clinical trial

François, B.; Wittebole, X.; Ferrer, R.; Mira, J.P.; Dugernier, T.; Gibot, S.; Derive, M.; Olivier, A.; Cuvier, V.; Witte, S.; Pickkers, P. ; Vandenhende, F.; Garaud, J.J.; Sánchez, M.; Salcedo-Magguilli, M.; Laterre, P.F. et al. sine al.

2020, Article / Letter to editor (Intensive Care Medicine, vol. 46, iss. 7, (2020), pp. 1425-1437)
Effect of anakinra in COVID-19

Kooistra, E.J.; Waalders, N.J.B.; Kox, M. ; Pickkers, P.

2020, Article / Letter to editor (The Lancet. Rheumatology, vol. 2, iss. 9, (2020), pp. e523-e524)
Proenkephalin Compared to Conventional Methods to Assess Kidney Function in Critically Ill Sepsis Patients

Beunders, R. ; Groenendael, R. van ; Leijte, G.P. ; Kox, M. ; Pickkers, P.

2020, Article / Letter to editor (Shock, vol. 54, iss. 3, (2020), pp. 308-314)
Influence of sedation on delirium recognition in critically ill patients: A multinational cohort study

Boogaard, M.H.W.A. van den ; Wassenaar, A. ; Haren, Frank M.P. van ; Slooter, A.J.; Jorens, Philippe G.; Jagt, M. van der; Pickkers, P. ; Devlin, John W.

2020, Article / Letter to editor (Australian Critical Care, vol. 33, iss. 5, (2020), pp. 420-425)
Reply to Chapman et al

Beunders, R. ; Bongers, C.C.W.G.; Pickkers, P.

2020, Article / Letter to editor (Journal of Applied Physiology, vol. 129, iss. 1, (2020), article 162)
The effects of physical exercise on the assessment of kidney function

Beunders, R. ; Bongers, C.C.W.G.; Pickkers, P.

2020, Article / Letter to editor (Journal of Applied Physiology, vol. 128, iss. 5, (2020), pp. 1459-1460)
Targeting the Heme-Heme Oxygenase System to Prevent Severe Complications Following COVID-19 Infections

Wagener, F.A.D.T.G. ; Pickkers, P. ; Peterson, S.J.; Immenschuh, S.; Abraham, N.G.

2020, Article / Letter to editor (Antioxidants, vol. 9, iss. 6, (2020), article E540)
Added value of serial bio-adrenomedullin measurement in addition to lactate for the prognosis of septic patients admitted to ICU

Blet, A.; Roquetaillade, C. de; Hartmann, O.; Struck, J.; Pickkers, P. ; Mebazaa, A.; Chousterman, B.G.

2020, Article / Letter to editor (Critical Care, vol. 24, iss. 1, (2020), article 69)
Synergistic Signaling of TLR and IFN alpha/beta Facilitates Escape of IL-18 Expression from Endotoxin Tolerance

Verweyen, Emely; Holzinger, Dirk; Weinhage, Toni; Hinze, Claas; Wittkowski, Helmut; Pickkers, P. ; Foell, Dirk; Kessel, Christoph

2020, Article / Letter to editor (American Journal of Respiratory and Critical Care Medicine, vol. 201, iss. 5, (2020), pp. 526-539)
Dysregulated activities of proline-specific enzymes in septic shock patients (sepsis-2)

Vliegen, Gwendolyn; Kehoe, Kaat; Bracke, An; Hert, Emilie De; Verkerk, Robert; Fransen, Erik; Peters, E. ; Pickkers, P. ; Jorens, Philippe G.; Meester, Ingrid De

2020, Article / Letter to editor (PLoS One, vol. 15, iss. 4, (2020), article e0231555)
Monocytic HLA-DR expression kinetics in septic shock patients with different pathogens, sites of infection and adverse outcomes

Leijte, G.P. ; Rimmele, Thomas; Kox, M. ; Bruse, N. ; Monard, Celine; Gossez, Morgane; Pickkers, P. ; Venet, F.

2020, Article / Letter to editor (Critical Care, vol. 24, iss. 1, (2020), article 110)
The clinical relevance of oliguria in the critically ill patient: analysis of a large observational database

Vincent, J.L.; Ferguson, A.; Pickkers, P. ; Jakob, S.M.; Jaschinski, Ulrich; Almekhlafi, Ghaleb A.; Bauer, P.R.; Sakr, Y.

2020, Article / Letter to editor (Critical Care, vol. 24, iss. 1, (2020), article 171)
Involvement of Lactate and Pyruvate in the Anti-Inflammatory Effects Exerted by Voluntary Activation of the Sympathetic Nervous System

Zwaag, J. ; Horst, R. ter ; Blazenovic, Ivana; Stoessel, Daniel; Ratter, Jacqueline; Worseck, Josephine M.; Stienstra, R. ; Netea, M.G. ; Pickkers, P. ; Kox, M.

2020, Article / Letter to editor (Metabolites, vol. 10, iss. 4, (2020), article 148)
Characterization of the phenotype of human eosinophils and their progenitors in the bone marrow of healthy individuals

Hassani, M.; Staveren, S. van; Grinsven, E. van; Bartels, M.; Tesselaar, K.; Leijte, G.P. ; Kox, M. ; Pickkers, P. ; Vrisekoop, N.; Koenderman, L.

2020, Article / Letter to editor (Haematologica, vol. 105, iss. 2, (2020), pp. e52-e56)
Anakinra treatment in critically ill COVID-19 patients: a prospective cohort study

Kooistra, E.J.; Waalders, N.J.B.; Grondman, I. ; Janssen, N.A.F. ; Nooijer, A.H. de ; Netea, M.G. ; Veerdonk, F.L. van de ; Hoeven, J.G. van der ; Kox, M. ; Pickkers, P.

2020, Article / Letter to editor (Critical Care, vol. 24, iss. 1, (2020), article 688)
Association between incident delirium and 28-and 90-day mortality in critically ill adults: a secondary analysis

Duprey, Matthew S.; Boogaard, M.H.W.A. van den ; Hoeven, J.G. van der ; Pickkers, P. ; Briesacher, Becky A.; Saczynski, Jane S.; Griffith, John L.; Devlin, John W.

2020, Article / Letter to editor (Critical Care, vol. 24, iss. 1, (2020), article 161)
COVID-19 patients exhibit less pronounced immune suppression compared with bacterial septic shock patients

Kox, M. ; Frenzel, T. ; Schouten, J.A. ; Veerdonk, F.L. van de ; Hemelaar, P. ; Beunders, R. ; Hoeven, J.G. van der ; Gerretsen, J.J.F. ; Netea, M.G. ; Joosten, L.A.B. ; Janssen, N.A.F. ; Grondman, I. ; Nooijer, A.H. de ; Mast, Q. de ; Jaeger, M. ; Kouijzer, I.J.E. ; Lemmers, H.L.M. ; Crevel, R. van ; Maat, J.S. van de ; Moorlag, S.J.C.F.M. ; Taks, E.J.M. ; Debisarun, A. ; Wertheim, H.F.L. ; Hopman, J. ; Rahamat-Langendoen, J.C. ; Bleeker-Rovers, C.P. ; Fasse, E. ; Rijssen, E. van ; Cranenbroek, B. van ; Smeets, R.L. ; Joosten, I. ; Koenen, H.J. ; Pickkers, P. et al. sine al.

2020, Article / Letter to editor (Critical Care, vol. 24, iss. 1, (2020), article 263)
Effect of Vasopressors on the Macro- and Microcirculation During Systemic Inflammation in Humans In Vivo

Loon, L.M. van; Stolk, R.F. ; Hoeven, J.G. van der ; Veltink, P.H.; Pickkers, P. ; Lemson, J. ; Kox, M.

2020, Article / Letter to editor (Shock, vol. 53, iss. 2, (2020), pp. 171-174)
COVID-19: 10 things I wished I'd known some months ago

Pickkers, P. ; Hoeven, H. van der ; Citerio, G.

2020, Article / Letter to editor (Intensive Care Medicine, vol. 46, iss. 7, (2020), pp. 1449-1452)
Norepinephrine Dysregulates the Immune Response and Compromises Host Defense during Sepsis

Stolk, R.F. ; Pasch, E. van der; Naumann, F.V. ; Schouwstra, J.; Bressers, S.; Herwaarden, A.E. van ; Gerretsen, J.J.F. ; Schambergen, R.; Ruth, M.M. ; Hoeven, J.G. van der ; Leeuwen, H. van; Pickkers, P. ; Kox, M. et al. sine al.

2020, Article / Letter to editor (American Journal of Respiratory and Critical Care Medicine, vol. 202, iss. 6, (2020), pp. 830-842)
Elective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans

Nepogodiev, D.; Omar, Omar; Glasbey, J.C.; Li, E.; Simoes, J.F.F.; Abbott, T.; Pickkers, P. ; Venn, M.L.; Bhangu, A.

2020, Article / Letter to editor (British Journal of Surgery, vol. 107, iss. 11, (2020), pp. 1440-1449)
Recommendations on Acute Kidney Injury Biomarkers From the Acute Disease Quality Initiative Consensus Conference A Consensus Statement

Ostermann, M.; Zarbock, A.; Goldstein, Stuart; Kashani, K.; Macedo, E.; Murugan, Raghavan; Pickkers, P. ; Kellum, J.A.; Ronco, C.

2020, Article / Letter to editor (JAMA Network Open, vol. 3, iss. 10, (2020), article e2019209)
Acute respiratory failure in immunocompromised patients: outcome and clinical features according to neutropenia status

Mokart, D.; Darmon, M.; Schellongowski, P.; Pickkers, P. ; Soares, M.; Rello, J.; Bisbal, Magali; Azoulay, E.

2020, Article / Letter to editor (Annals of Intensive Care, vol. 10, iss. 1, (2020), article 146)
Etiologies and Outcomes of Acute Respiratory Failure in Solid Organ Transplant Recipients: Insight Into the EFRAIM Multicenter Cohort

Messika, Jonathan; Darmon, M.; Mal, Herve; Pickkers, P. ; Soares, M.; Canet, Emmanuel; Zafrani, Lara; Azoulay, E.

2020, Article / Letter to editor (Transplantation Proceedings, vol. 52, iss. 10, (2020), pp. 2980-2987)
Proenkephalin: A New Biomarker for Glomerular Filtration Rate and Acute Kidney Injury

Khorashadi, Mina; Beunders, R. ; Pickkers, P. ; Legrand, M.

2020, Article / Letter to editor (Nephron, vol. 144, iss. 12, (2020), pp. 655-661)
Endotoxemia-Induced Release of Pro-inflammatory Mediators Are Associated With Increased Glomerular Filtration Rate in Humans in vivo

Beunders, R. ; Schuetz, Maren J.; Groenendael, R. van ; Leijte, G.P. ; Kox, M. ; Eijk, L.T. ; Pickkers, P.

2020, Article / Letter to editor (Frontiers in Medicine, vol. 7, (2020), article 559671)
Proenkephalin as a new biomarker for pediatric acute kidney injury - reference values and performance in children under one year of age

Hartman, S.J.F. ; Zwiers, Alexandra J.M.; Water, Nadies E.C. van de; Rosmalen, Joost van; Struck, Joachim; Schulte, Janin; Pickkers, P. ; Beunders, R. ; Schreuder, M.F. ; Wildt, S.N. de

2020, Article / Letter to editor (Clinical Chemistry and Laboratory Medicine, vol. 58, iss. 11, (2020), pp. 1911-1919)
Aminoglycosides in Immunocompromised Critically Ill Patients With Bacterial Pneumonia and Septic Shock: A Post-Hoc Analysis of a Prospective Multicenter Multinational Cohort

Lopez, Rene; Rello, J.; Taccone, F.S.; Salem, Omar Ben Hadj; Bauer, P.R.; Seguin, Amelie; Pickkers, P. ; Azoulay, E.; Darmon, M.

2020, Article / Letter to editor (Shock, vol. 54, iss. 6, (2020), pp. 731-737)
Breath-synchronized electrical stimulation of the expiratory muscles in mechanically ventilated patients: a randomized controlled feasibility study and pooled analysis

Jonkman, Annemijn H.; Frenzel, T. ; McCaughey, Euan J.; McLachlan, Angus J.; Boswell-Ruys, Claire L.; Collins, David W.; Kox, M. ; Pickkers, P. ; Roesthuis, L.H. ; Schouten, J.A. ; Butler, Jane E.; Heunks, L.M.A. et al. sine al.

2020, Article / Letter to editor (Critical Care, vol. 24, iss. 1, (2020), article 628)
Higher Dosage of Ciprofloxacin Necessary in Critically Ill Patients: A New Dosing Algorithm Based on Renal Function and Pathogen Susceptibility

Gieling, E.M.; Wallenburg, E. ; Frenzel, T. ; Lange, D.W. de; Schouten, J.A. ; Oever, J. ten ; Kolwijck, E. ; Burger, D.M. ; Pickkers, P. ; Heine, R. ter ; Brüggemann, R.J.M. et al. sine al.

2020, Article / Letter to editor (Clinical Pharmacology and Therapeutics, vol. 108, iss. 4, (2020), pp. 770-774)
Increased Plasma Heparanase Activity in COVID-19 Patients

Buijsers, B. ; Yanginlar, C. ; Nooijer, A.H. de ; Grondman, I. ; Maciej-Hulme, M.L.; Jonkman, W.I. ; Janssen, N.A.F. ; Rother, N ; Graaf, M.J.J. de ; Pickkers, P. ; Kox, M. ; Joosten, L.A.B. ; Nijenhuis, T. ; Netea, M.G. ; Hilbrands, L.B. ; Veerdonk, F.L. van de ; Duivenvoorden, R. ; Mast, Q. de ; Vlag, J. van der et al. sine al.

2020, Article / Letter to editor (Frontiers in Immunology, vol. 11, (2020), article 575047)
Prophylactic Haloperidol Effects on Long-term Quality of Life in Critically Ill Patients at High Risk for Delirium Results of the REDUCE Study

Rood, P.J.T. ; Zegers, M. ; Slooter, A.J.; Beishuizen, Albertus; Simons, K.S.; Voort, P.H. van der; Hoeven, J.G. van der ; Pickkers, P. ; Boogaard, M.H.W.A. van den

2019, Article / Letter to editor (Anesthesiology, vol. 131, iss. 2, (2019), pp. 328-335)
Remote ischaemic preconditioning does not modulate the systemic inflammatory response or renal tubular stress biomarkers after endotoxaemia in healthy human volunteers: a single-centre, mechanistic, randomised controlled trial

Zwaag, J. ; Beunders, R. ; Warle, M.C.; Kellum, J.A.; Riksen, N.P. ; Pickkers, P. ; Kox, M.

2019, Article / Letter to editor (British Journal of Anaesthesia, vol. 123, iss. 2, (2019), pp. 177-185)
A randomized double-blind, placebo-controlled clinical phase IIa trial on safety, immunomodulatory effects and pharmacokinetics of EA-230 during experimental human endotoxaemia

Groenendael, R. van ; Kox, M. ; Leijte, G.P. ; Koeneman, B.; Gerretsen, J.; Eijk, L.T. ; Pickkers, P.

2019, Article / Letter to editor (British Journal of Clinical Pharmacology, vol. 85, iss. 7, (2019), pp. 1559-1571)
What's new in immunostimulating strategies in the ICU

Pickkers, P. ; Poll, T. van der

2019, Article / Letter to editor (Intensive Care Medicine, vol. 45, iss. 1, (2019), pp. 110-112)
Adrenomedullin in heart failure: pathophysiology and therapeutic application

Voors, A.A.; Kremer, D.; Geven, C.B.C.A.G. ; Maaten, J.M.A.A. van der; Struck, J.; Bergmann, A.; Pickkers, P. ; Metra, M.; Mebazaa, A.; Dungen, H.D.; Butler, J. et al. sine al.

2019, Article / Letter to editor (European Journal of Heart Failure, vol. 21, iss. 2, (2019), pp. 163-171)
Experimental human endotoxemia as a model of systemic inflammation

Lier, D.; Geven, C.B.C.A.G. ; Leijte, G.P. ; Pickkers, P.

2019, Article / Letter to editor (Biochimie, vol. 159, (2019), pp. 99-106)
Differences in 90-day mortality of delirium subtypes in the intensive care unit: A retrospective cohort study

Rood, P.J.T. ; Schoor, F.R. van de ; Tertholen, K. van; Pickkers, P. ; Boogaard, M. van den

2019, Article / Letter to editor (Journal of Critical Care, vol. 53, (2019), pp. 120-124)
Influenza and associated co-infections in critically ill immunosuppressed patients

Martin-Loeches, I.; Lemiale, V.; Geoghegan, P.; McMahon, M.A.; Pickkers, P. ; Soares, M.; Perner, A.; Meyhoff, T.S.; Bukan, R.B.; Rello, J.; Bauer, P.R.; Louw, A. van de; Taccone, F.S.; Salluh, J.; Hemelaar, P. ; Schellongowski, P.; Rusinova, K.; Terzi, N.; Mehta, S.; Antonelli, M.; Kouatchet, A.; Klepstad, P.; Valkonen, M.; Landburg, P.P.; Barratt-Due, A.; Bruneel, F.; Pene, F.; Metaxa, V.; Moreau, A.S.; Souppart, V.; Burghi, G.; Girault, C.; Silva, U.V.A.; Montini, L.; Barbier, F.; Nielsen, L.B.; Gaborit, B.; Mokart, D.; Chevret, S.; Azoulay, E. et al. sine al.

2019, Article / Letter to editor (Critical Care, vol. 23, iss. 1, (2019), pp. 152)
Long-Term Effects of Experimental Human Endotoxemia on Immune Cell Function: Similarities and Differences With Sepsis.

Rodriguez Rosales, Y.A. ; Kox, M. ; Rijssen, E. van ; Cranenbroek, B. van ; Welie, M. van; Pickkers, P. ; Joosten, I. ; Koenen, H.J.P.M.

2019, Article / Letter to editor (Shock, vol. 51, iss. 6, (2019), pp. 678-689)
Mitochondrial DNA: Innocent in Plasma, but Guilty in Urine?

Leijte, G.P. ; Pickkers, P. ; Kox, M.

2019, Article / Letter to editor (Shock, vol. 51, iss. 2, (2019), pp. 266)
New frontiers in precision medicine for sepsis-induced immunoparalysis

Bruse, N. ; Leijte, G.P. ; Pickkers, P. ; Kox, M.

2019, Article / Letter to editor (Expert Review of Clinical Immunology, vol. 15, iss. 3, (2019), pp. 251-263)
Obesity in the critically ill: a narrative review

Schetz, M.; Jong, A. de; Deane, A.M.; Druml, W.; Hemelaar, P. ; Pelosi, P.; Pickkers, P. ; Reintam-Blaser, A.; Roberts, J.; Sakr, Y.; Jaber, S. et al. sine al.

2019, Article / Letter to editor (Intensive Care Medicine, vol. 45, iss. 6, (2019), pp. 757-769)
Quality Improvement Goals for Acute Kidney Injury

Kashani, K.; Rosner, M.H.; Haase, M.; Lewington, A.J.P.; O'Donoghue, D.J.; Wilson, F.P.; Nadim, M.K.; Silver, S.A.; Zarbock, A.; Ostermann, M.; Mehta, R.L.; Kane-Gill, S.L.; Ding, X.; Pickkers, P. ; Bihorac, A.; Siew, E.D.; Barreto, E.F.; Macedo, E.; Kellum, J.A.; Palevsky, P.M.; Tolwani, A.J.; Ronco, C.; Juncos, L.A.; Rewa, O.G.; Bagshaw, S.M.; Mottes, T.A.; Koyner, J.L.; Liu, K.D.; Forni, L.G.; Heung, M.; Wu, V.C. et al. sine al.

2019, Article / Letter to editor (Clinical Journal of the American Society of Nephrology, vol. 14, iss. 6, (2019), pp. 941-953)
Treatment with a polymyxin B filter to capture endotoxin in sepsis patients: is there a signal for therapeutic efficacy?

Pickkers, P. ; Russell, J.A.

2019, Article / Letter to editor (Intensive Care Medicine, vol. 45, iss. 2, (2019), pp. 282-283)
Treatment With Acetylsalicylic Acid Reverses Endotoxin Tolerance in Humans In Vivo: A Randomized Placebo-Controlled Study

Leijte, G.P. ; Kiers, D. ; Heijden, W.A. van der ; Jansen, A. ; Gerretsen, J.; Boerrigter, V.; Netea, M.G. ; Kox, M. ; Pickkers, P.

2019, Article / Letter to editor (Critical Care Medicine, vol. 47, iss. 4, (2019), pp. 508-516)
The Safety, Tolerability, and Effects on the Systemic Inflammatory Response and Renal Function of the Human Chorionic Gonadotropin Hormone-Derivative EA-230 Following On-Pump Cardiac Surgery (The EASI Study): Protocol for a Randomized, Double-Blind, Placebo-Controlled Phase 2 Study

Groenendael, R. van ; Beunders, R. ; Hofland, J. ; Morshuis, W.J. ; Kox, M. ; Eijk, L.T.G.J. van ; Pickkers, P.

2019, Article / Letter to editor (JMIR Research Protocols, vol. 8, iss. 2, (2019), pp. 56-68, article e11441)
The value of the neutrophil-lymphocyte count ratio in the diagnosis of sepsis in patients admitted to the Intensive Care Unit: A retrospective cohort study

Westerdijk, K; Simons, K.S.; Zegers, M.J. ; Wever, P.C.; Pickkers, P. ; Jager, Cornelis P. C. de

2019, Article / Letter to editor (PLoS One, vol. 14, iss. 2, (2019), article e0212861)

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