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In Vitro Synthesis and RNA Structure Probing of CUG Triplet Repeat RNA

Cruchten, R.T.P. van ; Wansink, D.G.

2020, Article / Letter to editor (Methods in Molecular Biology, vol. 2056, (2020), pp. 187-202)
248th ENMC International Workshop: Myotonic dystrophies: Molecular approaches for clinical purposes, framing a European molecular research network, Hoofddorp, the Netherlands, 11-13 October 2019

Wansink, D.G. ; Gourdon, Genevieve; Engelen, B.G.M. van ; Schoser, B.

2020, Article / Letter to editor (Neuromuscular Disorders, vol. 30, iss. 6, (2020), pp. 521-531)
Advanced Fluorescence Imaging to Distinguish Between Intracellular Fractions of Antisense Oligonucleotides

Bent, M.L. van der ; Wansink, D.G. ; Brock, R.E.

2020, Article / Letter to editor (Methods in Molecular Biology, vol. 2063, (2020), pp. 119-138)
Intrinsic Myogenic Potential of Skeletal Muscle-Derived Pericytes from Patients with Myotonic Dystrophy Type 1

Ausems, C.R.M. ; Raaijmakers, R.H.L. ; Broek, W.J.A.A. van den ; Willemse, M.P. ; Engelen, B.G.M. van ; Wansink, D.G. ; Bokhoven, H. van

2019, Article / Letter to editor (Molecular Therapy. Methods & Clinical Development, vol. 15, (2019), pp. 120-132)
CRISPR/Cas Applications in Myotonic Dystrophy: Expanding Opportunities

Raaijmakers, R.H.L. ; Ripken, L.S. ; Ausems, C.R.M. ; Wansink, D.G.

2019, Article / Letter to editor (International Journal of Molecular Sciences, vol. 20, iss. 15, (2019), article 3689)
The nuclear concentration required for antisense oligonucleotide activity in myotonic dystrophy cells

Bent, M.L. van der ; Silva Filho, O.P. da; Willemse, M.P. ; Hallbrink, M.; Wansink, D.G. ; Brock, R.E.

2019, Article / Letter to editor (The Faseb Journal, vol. 33, iss. 10, (2019), pp. 11314-11325)
(CTG)n repeat-mediated dysregulation of MBNL1 and MBNL2 expression during myogenesis in DM1 occurs already at the myoblast stage

Andre, L.M. ; Cruchten, R.T.P. van ; Willemse, M.P. ; Wansink, D.G.

2019, Article / Letter to editor (PLoS One, vol. 14, iss. 5, (2019), article e0217317)
Recovery in the Myogenic Program of Congenital Myotonic Dystrophy Myoblasts after Excision of the Expanded (CTG)n Repeat

Andre, L.M. ; Cruchten, R.T. van ; Willemse, Marieke ; Bezstarosti, Karel; Demmers, J.; Agtmaal, E.L. van; Wansink, D.G. ; Wieringa, B.

2019, Article / Letter to editor (International Journal of Molecular Sciences, vol. 20, iss. 22, (2019), article 5685)
Expanded CUG repeats in DMPK transcripts adopt diverse hairpin conformations without influencing the structure of the flanking sequences

Cruchten, R.T.P. van ; Wieringa, B. ; Wansink, D.G.

2019, Article / Letter to editor (Rna : a Publication of the Rna Society, vol. 25, iss. 4, (2019), pp. 481-495)
Assisted delivery of antisense therapeutics in animal models of heritable neurodegenerative and neuromuscular disorders: a systematic review and meta-analysis

Bent, M.L. van der ; Paulino da Silva Filho, O. ; Luijk, J. van ; Brock, R.E. ; Wansink, D.G.

2018, Article / Letter to editor (Scientific Reports, vol. 8, (2018), article 4181)
Abnormalities in Skeletal Muscle Myogenesis, Growth, and Regeneration in Myotonic Dystrophy

Andre, L.M. ; Ausems, C.R.M. ; Wansink, D.G. ; Wieringa, B.

2018, Article / Letter to editor (Frontiers in Neurology, vol. 9, (2018), article 368)
CRISPR/Cas9-Induced (CTGCAG)n Repeat Instability in the Myotonic Dystrophy Type 1 Locus: Implications for Therapeutic Genome Editing

Agtmaal, E.L. van; Andre, L.M. ; Willemse, M.P. ; Cumming, S.A.; Kessel, I.D.G. van; Broek, W.J.A.A. van den ; Gourdon, G.; Furling, D.; Mouly, V.; Monckton, D.G.; Wansink, D.G. ; Wieringa, B. et al. sine al.

2017, Article / Letter to editor (Molecular Therapy, vol. 25, iss. 1, (2017), pp. 24-43)
Trinucleotide-repeat expanded and normal DMPK transcripts contain unusually long poly(A) tails despite differential nuclear residence

Gudde, A.E.E.G.; Kessel, I.D.G. van; Andre, L.M. ; Wieringa, B. ; Wansink, D.G.

2017, Article / Letter to editor (Biochimica et Biophysica Acta, Gene Regulatory Mechanisms, vol. 1860, iss. 6, (2017), pp. 740-749)
Intracellular Distribution and Nuclear Activity of Antisense Oligonucleotides After Unassisted Uptake in Myoblasts and Differentiated Myotubes In Vitro

Gonzalez, A.M. ; Nillessen, B.; Kranzen, J.; Kessel, I.D.G. van; Croes, H.J.E. ; Aguilera, B.; Visser, P.C. de; Datson, N.A.; Mulders, S.A.; Deutekom, J.C. van; Wieringa, B. ; Wansink, D.G. et al. sine al.

2017, Article / Letter to editor (Nucleic Acid Therapeutics, vol. 27, iss. 3, (2017), pp. 144-158)
Antisense transcription of the myotonic dystrophy locus yields low-abundant rnas with and without (cag)n repeat

Gudde, A.E.E.G.; Heeringen, S.J. van ; Oude, A.I. de; Kessel, I.D.G. van; Estabrook, J.; Wang, E.T.; Wieringa, B. ; Wansink, D.G.

2017, Article / Letter to editor (Rna Biology, vol. 14, iss. 10, (2017), pp. 1374-1388)
A low absolute number of expanded transcripts is involved in myotonic dystrophy type 1 manifestation in muscle

Gudde, A.E.; Gonzalez-Barriga, A.; Broek, W.J. van den ; Wieringa, B. ; Wansink, D.G.

2016, Article / Letter to editor (Human Molecular Genetics, vol. 25, iss. 8, (2016), pp. 1648-1662)
Cell membrane integrity in myotonic dystrophy type 1: implications for therapy

Gonzalez, A.M.M. ; Kranzen, J.; Croes, H.J.E. ; Bijl, S.; Broek, W.J.A.A. van den ; Kessel, I.D.G. van; Engelen, B.G.M. van ; Deutekom, J.C. van; Wieringa, B. ; Mulders, S.A.; Wansink, D.G. et al. sine al.

2015, Article / Letter to editor (PLoS One, vol. 10, iss. 3, (2015), article e0121556)
Design and analysis of effects of triplet repeat oligonucleotides in cell models for myotonic dystrophy

Gonzalez-Barriga, A.; Mulders, S.A.M. ; Giessen, J. van der; Hooijer, J.D.; Bijl, S.; Kessel, I.D.G. van; Beers, J. van; Deutekom, J.C. van; Fransen, J.A.M. ; Wieringa, B. ; Wansink, D.G. et al. sine al.

2013, Article / Letter to editor (Molecular Therapy - Nucleic Acids, vol. 2, (2013), pp. e81)
Guidelines for the use and interpretation of assays for monitoring autophagy.

Klionsky, D.J.; Wansink, D.G. ; Netea, M.G. ; et al.

2012, Article / Letter to editor (Autophagy, vol. 8, iss. 4, (2012), pp. 445-544)
Phosphorylation target site specificity for AGC kinases DMPK E and Lats2.

Gerrits, L. ; Venselaar, H. ; Wieringa, B. ; Wansink, D.G. ; Hendriks, W.J.A.J.

2012, Article / Letter to editor (Journal of Cellular Biochemistry, vol. 113, iss. 6, (2012), pp. 2126-2135)
Gene duplication and conversion events shaped three homologous, differentially expressed myosin regulatory light chain (MLC2) genes.

Gerrits, L. ; Overheul, G.J. ; Derks, R.C.; Wieringa, B. ; Hendriks, W.J.A.J. ; Wansink, D.G.

2012, Article / Letter to editor (European Journal of Cell Biology, vol. 91, iss. 8, (2012), pp. 629-639)
Human male meiotic sex chromosome inactivation.

Vries, M. de ; Vosters, S.; Merkx, G.F.M.; Hauwers, K.W.M. d' ; Wansink, D.G. ; Ramos, L. ; Boer, P. de

2012, Article / Letter to editor (PLoS One, vol. 7, iss. 2, (2012), article e31485)
Abnormal actomyosin assembly in proliferating and differentiating myoblasts upon expression of a cytosolic DMPK isoform

Mulders, S.A.M. ; Horssen, R. van ; Gerrits, L. ; Bennink, M.B. ; Pluk, W.L.L.P. ; Boer-van Huizen, R.T. de ; Croes, H.J.E. ; Wijers, M.J.P. ; Loo, F.A. van de ; Fransen, J. ; Wieringa, B. ; Wansink, D.G. et al. sine al.

2011, Article / Letter to editor (Biochimica et Biophysica Acta. Molecular Cell Research, vol. 1813, iss. 5, (2011), pp. 867-877)
Myotonic dystrophy type 2 (DM2) and related disorders report of the 180th ENMC workshop including guidelines on diagnostics and management 3-5 December 2010, Naarden, The Netherlands.

Udd, B.; Meola, G.; Krahe, R.; Wansink, D.G. ; Bassez, G.; Kress, W.; Schoser, B.; Moxley, R.

2011, Article / Letter to editor (Neuromuscular Disorders, vol. 21, iss. 6, (2011), pp. 443-450)
The mouse mismatch repair protein, MSH3, is a nucleoplasmic protein that aggregates into denser nuclear bodies under conditions of stress.

Holt, I.J. ; Thanh Lam, L.; Tome, S.; Wansink, D.G. ; Riele, H. te; Gourdon, G.; Morris, G.E.

2011, Article / Letter to editor (Journal of Cellular Biochemistry, vol. 112, iss. 6, (2011), pp. 1612-1621)
Molecular therapy in myotonic dystrophy: focus on RNA gain-of-function.

Mulders, S.A.M. ; Engelen, B.G.M. van ; Wieringa, B. ; Wansink, D.G.

2010, Article / Letter to editor (Human Molecular Genetics, vol. 19, iss. R1, (2010), pp. R90-7)
DMPK protein isoforms are differentially expressed in myogenic and neural cell lineages.

Oude Ophuis, R.J.A. ; Mulders, S.A.M. ; Herpen, R.E.M.A. van ; Vorstenbosch, R.A. van de ; Wieringa, B. ; Wansink, D.G.

2009, Article / Letter to editor (Muscle and Nerve, vol. 40, iss. 4, (2009), pp. 545-555)
A tail-anchored myotonic dystrophy protein kinase isoform induces perinuclear clustering of mitochondria, autophagy, and apoptosis

Oude Ophuis, R.J.A. ; Wijers-Rouw, M.J.P. ; Bennink, M.B. ; Loo, F.A.J. van de ; Fransen, J. ; Wieringa, B. ; Wansink, D.G.

2009, Article / Letter to editor (PLoS One, vol. 4, iss. 11, (2009), article e8024)
Triplet-repeat oligonucleotide-mediated reversal of RNA toxicity in myotonic dystrophy.

Mulders, S.A.M. ; Broek, W.J.A.A. van den ; Wheeler, T.M.; Croes, H.J.E. ; Kuik-Romeijn, P. van; Kimpe, S.J. de; Furling, D.; Platenburg, G.J.; Gourdon, G.; Thornton, C.A.; Wieringa, B. ; Wansink, D.G. et al. sine al.

2009, Article / Letter to editor (Proceedings of the National Academy of Sciences USA, vol. 106, iss. 33, (2009), pp. 13915-13920)
Somatic CTG*CAG repeat instability in a mouse model for myotonic dystrophy type 1 is associated with changes in cell nuclearity and DNA ploidy.

Broek, W.J.A.A. van den ; Wansink, D.G. ; Wieringa, B.

2007, Article / Letter to editor (BMC Molecular Biology, vol. 8, (2007), pp. 61-1-61)
Chromosome-wide nucleosome replacement and H3.3 incorporation during mammalian meiotic sex chromosome inactivation.

Heijden, G.W. van der ; Derijck, A.H.A. ; Posfai, E.; Giele, M.M. ; Pelczar, P.; Ramos, L. ; Wansink, D.G. ; Vlag, J. van der ; Peters, A.H.; Boer, P. de

2007, Article / Letter to editor (Nature Genetics, vol. 39, iss. 2, (2007), pp. 251-258)
Coiled-coil interactions modulate multimerization, mitochondrial binding and kinase activity of myotonic dystrophy protein kinase splice isoforms.

Herpen, R.E.M.A. van ; Tjeertes, J.V.; Mulders, S.A.M. ; Oude Ophuis, R.J.A. ; Wieringa, B. ; Wansink, D.G.

2006, Article / Letter to editor (FEBS Journal, vol. 273, iss. 6, (2006), pp. 1124-1136)
Fen1 does not control somatic hypermutability of the (CTG)(n)*(CAG)(n) repeat in a knock-in mouse model for DM1.

Broek, W.J.A.A. van den ; Nelen, M.R. ; Heijden, G.W. van der ; Wansink, D.G. ; Wieringa, B.

2006, Article / Letter to editor (FEBS Letters, vol. 580, iss. 22, (2006), pp. 5208-5214)
Divergent mitochondrial and endoplasmic reticulum association of DMPK splice isoforms depends on unique sequence arrangements in tail anchors.

Herpen, R.E.M.A. van ; Oude Ophuis, R.J.A. ; Wijers-Rouw, M.J.P. ; Bennink, M.B. ; Loo, F.A.J. van de ; Fransen, J. ; Wieringa, B. ; Wansink, D.G.

2005, Article / Letter to editor (Molecular and Cellular Biology, vol. 25, iss. 4, (2005), pp. 1402-1414)
Mild impairment of motor nerve repair in mice lacking PTP-BL tyrosine phosphatase activity.

Wansink, D.G. ; Peters, W.J.M ; Schaafsma, I.; Sutmuller, R.P.M.; Oerlemans, F.T.J.J. ; Adema, G.J. ; Wieringa, B. ; Zee, C.E.E.M. van der ; Hendriks, W.J.A.J.

2004, Article / Letter to editor (Physiological Genomics, vol. 19, iss. 1, (2004), pp. 50-60)
Transgenic overexpression of human DMPK accumulates into hypertrophic cardiomyopathy, myotonic myopathy and hypotension traits of myotonic dystrophy.

O'Cochlain, D.F.; Perez-Terzic, C.; Reyes, S.; Kane, G.C.; Behfar, A.; Hodgson, D.M.; Strommen, J.A.; Liu, X.K.; Broek, W.J.A.A. van den ; Wansink, D.G. ; Wieringa, B. ; Terzic, A. et al. sine al.

2004, Article / Letter to editor (Human Molecular Genetics, vol. 13, iss. 20, (2004), pp. 2505-2518)
Alternative splicing controls myotonic dystrophy protein kinase structure, enzymatic activity, and subcellular localization.

Wansink, D.G. ; Herpen, R.E.M.A. van ; Coerwinkel, M.M.; Groenen, P.J.T.A. ; Hemmings, B.A.; Wieringa, B.

2003, Article / Letter to editor (Molecular and Cellular Biology, vol. 23, iss. 16, (2003), pp. 5489-5501)
Somatic expansion behaviour of the (CTG)n repeat in myotonic dystrophy knock-in mice is differentially affected by Msh3 and Msh6 mismatch-repair proteins.

Broek, W.J.A.A. van den ; Nelen, M.R. ; Wansink, D.G. ; Coerwinkel, M.M.; Riele, H. te; Groenen, P.J.T.A. ; Wieringa, B.

2002, Article / Letter to editor (Human Molecular Genetics, vol. 11, iss. 2, (2002), pp. 191-198)
Constitutive and regulated modes of splicing produce six major myotonic dystrophy protein kinase (DMPK) isoforms with distinct properties

Groenen, P.J.T.A. ; Wansink, D.G. ; Coerwinkel, M.M.; Broek, W.J.A.A. van den ; Jansen, G.; Wieringa, B.

2000, Article / Letter to editor (Human Molecular Genetics, vol. 9, iss. 4, (2000), pp. 605-616)
The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL

Cuppen, E.P.J.G. ; Ham, M.A.P.C. van ; Wansink, D.G. ; Leeuw, A. de; Wieringa, B. ; Hendriks, W.J.A.J.

2000, Article / Letter to editor (European Journal of Cell Biology, vol. 79, (2000), pp. 283-293)

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