Browsing by Author "Dinarello, C.A."

Now showing items 1-50 of 273

Human recombinant interleukin-38 suppresses inflammation in mouse models of local and systemic disease
Graaf, D.M. de ; Maas, R.J.A. ; Smeekens, S.P. ; Eisenmesser, E.Z.; Redzic, Jasmina S.; Helsen, M.M.A. ; Joosten, L.A.B. ; Dinarello, C.A. ; Veerdonk, F.L. van de
2021, Article / Letter to editor (Cytokine, vol. 137, (2021), article 155334)
IL-37 exerts therapeutic effects in experimental autoimmune encephalomyelitis through the receptor complex IL-1R5/IL-1R8
Sanchez-Fernandez, Alba; Zandee, Stephanie; Amo-Aparicio, Jesus; Charabati, Marc; Prat, Alexandre; Garlanda, Cecilia; Dinarello, C.A. ; Lopez-Vales, R.
2021, Article / Letter to editor (Theranostics, vol. 11, iss. 1, (2021), pp. 1-13)
Extracellular and nuclear roles of IL-37 after spinal cord injury
Amo-Aparicio, Jesus; Sanchez-Fernandez, Alba; Li, Suzhao; Eisenmesser, E.Z.; Garlanda, Cecilia; Dinarello, C.A. ; Lopez-Vales, R.
2021, Article / Letter to editor (Brain, Behavior, and Immunity, vol. 91, (2021), pp. 194-201)
IL-18 and infections: Is there a role for targeted therapies?
Vecchié, A.; Bonaventura, A.; Toldo, S.; Dagna, L.; Dinarello, C.A. ; Abbate, A.
2021, Article / Letter to editor (Journal of Cellular Physiology, vol. 236, iss. 3, (2021), pp. 1638-1657)
Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease
Abbate, A.; Toldo, S.; Marchetti, C.; Kron, J.; Tassell, B.W. Van; Dinarello, C.A.
2020, Article / Letter to editor (Circulation Research, vol. 126, iss. 9, (2020), pp. 1260-1280)
The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease
Lonnemann, N.; Hosseini, S.; Marchetti, C.; Skouras, D.B.; Stefanoni, D.; d'Alessandro, A.; Dinarello, C.A. ; Korte, M.
2020, Article / Letter to editor (Proceedings of the National Academy of Sciences USA, vol. 117, iss. 50, (2020), pp. 32145-32154)
IL-37 Expression Is Downregulated in Lesional Psoriasis Skin
Rønholt, K.; Nielsen, A.L.; Johansen, C.; Vestergaard, C.; Fauerbye, A.; López-Vales, R.; Dinarello, C.A. ; Iversen, L.
2020, Article / Letter to editor (ImmunoHorizons, vol. 4, iss. 11, (2020), pp. 754-761)
Inflammasome Sensor NLRP1 Confers Acquired Drug Resistance to Temozolomide in Human Melanoma
Zhai, Z.; Samson, J.M.; Yamauchi, T.; Vaddi, P.K.; Matsumoto, Y.; Dinarello, C.A. ; Menon, D.; Fujita, M.
2020, Article / Letter to editor (Cancers, vol. 12, iss. 9, (2020), article 2518)
Early IL-1 receptor blockade in severe inflammatory respiratory failure complicating COVID-19
Cauchois, R.; Koubi, M.; Delarbre, D.; Manet, C.; Carvelli, J.; Blasco, V.B.; Jean, R.; Fouche, L.; Bornet, C.; Pauly, V.; Mazodier, K.; Pestre, V.; Jarrot, P.A.; Dinarello, C.A. ; Kaplanski, G. et al. sine al.
2020, Article / Letter to editor (Proceedings of the National Academy of Sciences USA, vol. 117, iss. 32, (2020), pp. 18951-18953)
Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis
Hernandez, G.; Mills, T.S.; Rabe, J.L.; Chavez, J.S.; Kuldanek, S.; Kirkpatrick, G.; Noetzli, L.; Jubair, W.K.; Zanche, M.; Myers, J.R.; Stevens, B.M.; Fleenor, C.J.; Adane, B.; Dinarello, C.A. ; Ashton, J.; Jordan, C.T.; Paola, J. Di; Hagman, J.R.; Holers, V.Michael; Kuhn, K.A.; Pietras, E.M. et al. sine al.
2020, Article / Letter to editor (Haematologica, vol. 105, iss. 3, (2020), pp. 585-597)
PASylation of IL-1 receptor antagonist (IL-1Ra) retains IL-1 blockade and extends its duration in mouse urate crystal-induced peritonitis
Powers, Nicholas E.; Swartzwelter, Benjamin; Marchetti, C.; Graaf, D.M. de ; Lerchner, Alexandra; Schlapschy, Martin; Skerra, Arne; Dinarello, Charles A.
2020, Article / Letter to editor (Journal of Biological Chemistry, vol. 295, iss. 3, (2020), pp. 868-882)
Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout
Kluck, V. ; Deuren, R.C. van ; Cavalli, G.; Shaukat, A.; Arts, P.; Cleophas, M.C.P. ; Crisan, T. O.; Tausche, A.K.; Riches, P.; Dalbeth, N.; Stamp, L.K.; Hindmarsh, J.H.; Jansen, T.; Janssen, M. ; Steehouwer, M. ; Lelieveld, S.H.; Vorst, M. van de ; Gilissen, C. ; Dagna, L.; Veerdonk, F.L. van de ; Eisenmesser, E.Z.; Kim, S.; Merriman, T.R.; Hoischen, A. ; Netea, M.G. ; Dinarello, C.A. ; Joosten, L.A.B. et al. sine al.
2020, Article / Letter to editor (Annals of the Rheumatic Diseases, vol. 79, iss. 4, (2020), pp. 536-544)
Dapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: an open-label, dose-adaptive, proof-of-concept, phase 2a trial
Kluck, V. ; Jansen, Tim L.Th A.; Janssen, M; Comarniceanu, Antoaneta; Efde, M.N.; Tengesdal, I.W. ; Schraa, K. ; Cleophas, M.C.P. ; Dinarello, C.A. ; Joosten, L.A.B.
2020, Article / Letter to editor (The Lancet. Rheumatology, vol. 2, iss. 5, (2020), pp. E270-E280)
OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis
Sanchez-Fernandez, Alba; Skouras, Damaris B.; Dinarello, C.A. ; Lopez-Vales, R.
2019, Article / Letter to editor (Frontiers in Immunology, vol. 10, (2019), article 2578)
The IL-1 family of cytokines and receptors in rheumatic diseases
Dinarello, C.A.
2019, Article / Letter to editor (Nature Reviews. Rheumatology, vol. 15, iss. 10, (2019), pp. 612-632)
The Significance of IL-36 Hyperactivation and IL-36R Targeting in Psoriasis
Madonna, S.; Girolomoni, G.; Dinarello, C.A. ; Albanesi, C.
2019, Article / Letter to editor (International Journal of Molecular Sciences, vol. 20, iss. 13, (2019), article 3318)
Blocking IL-1 beta reverses the immunosuppression in mouse breast cancer and synergizes with anti-PD-1 for tumor abrogation
Kaplanov, Irena; Carmi, Yaron; Kornetsky, Rachel; Shemesh, Avishai; Shurin, Galina V.; Shurin, Michael R.; Dinarello, C.A. ; Voronov, E.; Apte, R.N.
2019, Article / Letter to editor (Proceedings of the National Academy of Sciences USA, vol. 116, iss. 4, (2019), pp. 1361-1369)
Efficacy of canakinumab as first-line biologic agent in adult-onset Still's disease
Cavalli, G.C. ; Tomelleri, A.; Luca, G. De; Campochiaro, C.; Dinarello, C.A. ; Baldissera, E.; Dagna, L.
2019, Article / Letter to editor (Arthritis Research & Therapy, vol. 21, iss. 1, (2019), pp. 54)
Role for nuclear interleukin-37 in the suppression of innate immunity
Li, Suzhao; Amo-Aparicio, Jesus; Neff, C.P.; Tengesdal, I.W. ; Azam, T.; Palmer, B.E.; Bufler, P.; Dinarello, C.A.
2019, Article / Letter to editor (Proceedings of the National Academy of Sciences USA, vol. 116, iss. 10, (2019), pp. 4456-4461)
Romidepsin suppresses monosodium urate crystal-induced cytokine production through upregulation of suppressor of cytokine signaling 1 expression
Cleophas, M.C.P. ; Crisan, T. O.; Kluck, V. ; Hoogerbrugge, N. ; Netea-Maier, R.T. ; Dinarello, C.A. ; Netea, M.G. ; Joosten, L.A.B.
2019, Article / Letter to editor (Arthritis Research & Therapy, vol. 21, (2019), article 50)
IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease
Hojen, J.F.; Kristensen, Marie Louise Vindvad; McKee, Amy S.; Wade, Megan Taylor; Azam, T.; Lunding, Lars P.; Graaf, D.M. de ; Fischer, S.; Dinarello, C.A.
2019, Article / Letter to editor (Nature Immunology, vol. 20, iss. 9, (2019), pp. 1138-+)
Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity
Mantovani, A.; Dinarello, C.A. ; Molgora, M.; Garlanda, C.
2019, Article / Letter to editor (Immunity, vol. 50, iss. 4, (2019), pp. 778-795)
Interleukin-37 monomer is the active form for reducing innate immunity
Eisenmesser, E.Z.; Gottschlich, Adrian; Redzic, Jasmina S.; Paukovich, Natasia; Nix, Jay C.; Azam, T.; Meng, Xianzhong; Dinarello, C.A.
2019, Article / Letter to editor (Proceedings of the National Academy of Sciences USA, vol. 116, iss. 12, (2019), pp. 5514-5522)
Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism
Jeong, Mark Y.; Lin, Ying H.; Wennersten, Sara A.; Demos-Davies, Kimberly M.; Cavasin, Maria A.; Mahaffey, Jennifer H.; Dinarello, C.A. ; McKinsey, T.A.
2018, Article / Letter to editor (Science Translational Medicine, vol. 10, iss. 427, (2018), article eaao0144)
Anakinra Therapy for Non-cancer Inflammatory Diseases
Cavalli, G.; Dinarello, C.A.
2018, Article / Letter to editor (Frontiers in Pharmacology, vol. 9, (2018), article 1157)
IL-37 Expression Reduces Lean Body Mass in Mice by Reducing Food Intake
Kuipers, E.N.; Dam, A.D. van; Ballak, D.B.; Wit, E.A. de; Dinarello, C.A. ; Stienstra, R. ; Diepen, J.A. van ; Rensen, P.C.; Boon, M.R.
2018, Article / Letter to editor (International Journal of Molecular Sciences, vol. 19, iss. 8, (2018), article 2264)
Interleukin-1alpha as an intracellular alarmin in cancer biology
Voronov, E.; Dinarello, C.A. ; Apte, R.N.
2018, Article / Letter to editor (Seminars in Immunology, vol. 38, (2018), pp. 3-14)
OLT1177, a beta-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation
Marchetti, C.; Swartzwelter, Benjamin; Gamboni, Fabia; Neff, C.P.; Richter, Katrin; Azam, T.; Joosten, L.A.B. ; Dinarello, C.A.
2018, Article / Letter to editor (vol. 115, iss. 7, (2018), pp. E1530-E1539)
Role of glutathione metabolism in host defense against Borrelia burgdorferi infection
Kerstholt, M ; Vrijmoeth, H.D. ; Lachmandas, E.L.; Oosting, M. ; Lupse, M.; Flonta, M.; Dinarello, C.A. ; Netea, M.G. ; Joosten, L.A.B.
2018, Article / Letter to editor (Proceedings of the National Academy of Sciences USA, vol. 115, iss. 10, (2018), pp. E2320-E2328)
Interleukin-32 upregulates the expression of ABCA1 and ABCG1 resulting in reduced intracellular lipid concentrations in primary human hepatocytes
Damen, M.S.M.A. ; Dos Santos, J.C. ; Hermsen, R. ; van der Vliet, J.A. ; Netea, M.G. ; Riksen, N.P. ; Dinarello, C.A. ; Joosten, L.A.B. ; Heinhuis, B.
2018, Article / Letter to editor (Atherosclerosis, vol. 271, (2018), pp. 193-202)
Treatment of HIV-Infected Individuals with the Histone Deacetylase Inhibitor Panobinostat Results in Increased Numbers of Regulatory T Cells and Limits &ITEx Vivo&IT Lipopolysaccharide-Induced Inflammatory Responses
Brinkmann, C.R.; Hojen, J.F.; Rasmussen, T.A.; Kjaer, A.; Olesen, R.; Denton, Paul W.; Dinarello, C.A. ; Tolstrup, M.
2018, Article / Letter to editor (Msphere, vol. 3, iss. 1, (2018), article e00616-17)
Introduction to the interleukin-1 family of cytokines and receptors: Drivers of innate inflammation and acquired immunity
Dinarello, C.A.
2018, Article / Letter to editor (Immunological Reviews, vol. 281, iss. 1, (2018), pp. 5-7)
Overview of the IL-1 family in innate inflammation and acquired immunity
Dinarello, C.A.
2018, Article / Letter to editor (Immunological Reviews, vol. 281, iss. 1, (2018), pp. 8-27)
Human Interleukin-32 gamma Plays a Protective Role in an Experimental Model of Visceral Leishmaniasis in Mice
Gomes, R.S.; Teodoro Silva, Muriel Vilela; Dos Santos, J.C. ; Linge, Christine van; Reis, Juliana Machado; Teixeira, M.M.; Dinarello, C.A. ; Joosten, L.A.B. ; Ribeiro-Dias, F.
2018, Article / Letter to editor (Infection and Immunity, vol. 86, iss. 5, (2018), article e00796-17)
Suppression of inflammation and acquired immunity by IL-37
Cavalli, G.; Dinarello, C.A.
2018, Article / Letter to editor (Immunological Reviews, vol. 281, iss. 1, (2018), pp. 179-190)
The Inter-Relationship of Platelets with Interleukin-1 beta-Mediated Inflammation in Humans
Tunjungputri, R.N.; Li, Yang; Groot, P.G. de ; Dinarello, C.A. ; Smeekens, S.P. ; Jaeger, M. ; Doppenberg-Oosting, M. ; Lemmers, H.L.M. ; Kumar, V. ; Joosten, L.A.B. ; Netea, M.G. ; Ven, A.J.A.M. van der ; Mast, Q. de et al. sine al.
2018, Article / Letter to editor (Thrombosis and Haemostasis, vol. 118, iss. 12, (2018), pp. 2112-2125)
IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatment
Mercurio, Laura; Morelli, M.; Scarponi, Claudia; Eisenmesser, E.Z.; Doti, Nunzianna; Pagnanelli, Gianluca; Dinarello, C.A. ; Albanesi, Cristina; Madonna, Stefania
2018, Article / Letter to editor (Cell Death and Disease, vol. 9, (2018), article 1104)
NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis
Marchetti, C.; Swartzwelter, Benjamin; Koenders, M.I. ; Azam, T.; Tengesdal, I.W. ; Powers, Nick; Graaf, D.M. de ; Dinarello, C.A. ; Joosten, L.A.B.
2018, Article / Letter to editor (Arthritis Research & Therapy, vol. 20, (2018), article 169)
The selective ROCK2 inhibitor KD025 reduces IL-17 secretion in human peripheral blood mononuclear cells independent of IL-1 and IL-6
Tengesdal, I.W. ; Kitzenberg, D.; Li, S.; Nyuydzefe, M.S.; Weiss, J.M.; Zhang, J.; Waksal, S.D.; Zanin-Zhorov, A.; Dinarello, C.A.
2018, Article / Letter to editor (European Journal of Immunology, vol. 48, iss. 10, (2018), pp. 1679-1686)
Interleukin-37 treatment of mice with metabolic syndrome improves insulin sensitivity and reduces pro-inflammatory cytokine production in adipose tissue
Ballak, D.B.; Li, Suzhao; Cavalli, G.; Stahl, J.; Tengesdal, Isak W. ; Diepen, Janna A. van ; Kluck, Viola ; Tack, C.J.J. ; Stienstra, R. ; Seals, D.R.; Dinarello, C.A. et al. sine al.
2018, Article / Letter to editor (Journal of Biological Chemistry, vol. 293, iss. 37, (2018), pp. 14224-14236)
Indeed, IL-18 is more than an inducer of IFN-gamma
Dinarello, C.A. ; Kaplanski, G.
2018, Article / Letter to editor (Journal of Leukocyte Biology, vol. 104, iss. 2, (2018), pp. 237-238)
An Interleukin-1 Signature in Breast Cancer Treated with Interleukin-1 Receptor Blockade: Implications for Treating Cytokine Release Syndrome of Checkpoint Inhibitors
Dinarello, C.A.
2018, Article / Letter to editor (Cancer Research, vol. 78, iss. 18, (2018), pp. 5200-5202)
Human Alpha-1-Antitrypsin (hAAT) therapy reduces renal dysfunction and acute tubular necrosis in a murine model of bilateral kidney ischemia-reperfusion injury
Maicas Blasco, N. ; Vlag, J. van der ; Bublitz, J.; Florquin, S.; Bakker-van Bebber, M.A.H. ; Dinarello, C.A. ; Verweij, V.G.M. ; Masereeuw, R. ; Joosten, L.A.B. ; Hilbrands, L.B.
2017, Article / Letter to editor (PLoS One, vol. 12, iss. 2, (2017), article e0168981)
IL-1 Inhibition and Vascular Function in CKD
Nowak, K.L.; Chonchol, M.; Ikizler, T.A.; Farmer-Bailey, H.; Salas, N.; Chaudhry, R.; Wang, W.; Smits, G.; Tengesdal, I.; Dinarello, C.A. ; Hung, A.M. et al. sine al.
2017, Article / Letter to editor (Journal of the American Society of Nephrology, vol. 28, iss. 3, (2017), pp. 971-980)
IL-18 binding protein reverses the life-threatening hyperinflammation of a baby with the NLRC4 mutation
Novick, D.; Dinarello, C.A.
2017, Article / Letter to editor (Journal of Allergy and Clinical Immunology, vol. 140, iss. 1, (2017), pp. 316)
IL-37 Causes Excessive Inflammation and Tissue Damage in Murine Pneumococcal Pneumonia
Schauer, A.E.; Klassert, T.E.; Lachner, C. von; Riebold, D.; Schneeweiss, A.; Stock, M.; Muller, M.M.; Hammerschmidt, S.; Bufler, P.; Seifert, U.; Dietert, K.; Dinarello, C.A. ; Nold, M.F.; Gruber, A.D.; Nold-Petry, C.A.; Slevogt, H. et al. sine al.
2017, Article / Letter to editor (Journal of Innate Immunity, vol. 9, iss. 4, (2017), pp. 403-418)
Implication of the intestinal microbiome as a potential surrogate marker of immune responsiveness to experimental therapies in autoimmune diabetes
Needell, J.C.; Dinarello, C.A. ; Ir, D.; Robertson, C.E.; Ryan, S.M.; Kroehl, M.E.; Frank, D.N.; Zipris, D.
2017, Article / Letter to editor (PLoS One, vol. 12, iss. 3, (2017), article e0173968)
NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma
Zhai, Z.; Liu, W; Kaur, M.; Luo, Y.; Domenico, J.; Samson, J.M.; Shellman, Y.G.; Norris, D.A.; Dinarello, C.A. ; Spritz, R.A.; Fujita, M. et al. sine al.
2017, Article / Letter to editor (Oncogene, vol. 36, iss. 27, (2017), pp. 3820-3830)
Interleukin-37 suppresses the inflammatory response to protect cardiac function in old endotoxemic mice
Li, Jilin; Zhai, Y.; Ao, L.; Hui, H.; Fullerton, D.A.; Dinarello, C.A. ; Meng, X.
2017, Article / Letter to editor (Cytokine, vol. 95, (2017), pp. 55-63)
Vorinostat plus tacrolimus/methotrexate to prevent GVHD after myeloablative conditioning, unrelated donor HCT
Choi, S.W.; Braun, T.; Henig, I.; Gatza, E.; Magenau, J.; Parkin, B.; Pawarode, A.; Riwes, M.; Yanik, G.; Dinarello, C.A. ; Reddy, P. et al. sine al.
2017, Article / Letter to editor (Blood, vol. 130, iss. 15, (2017), pp. 1760-1767)

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