Publication year
2011Source
Head and Neck : Journal for the Sciences and Specialties of the Head and Neck, 33, 3, (2011), pp. 375-82ISSN
Publication type
Article / Letter to editor
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Organization
Radiation Oncology
Medical Oncology
Journal title
Head and Neck : Journal for the Sciences and Specialties of the Head and Neck
Volume
vol. 33
Issue
iss. 3
Page start
p. 375
Page end
p. 82
Subject
ONCOL 3: Translational researchAbstract
BACKGROUND: Tumor volume is an important predictor of outcome in radiotherapy alone. Its significance in concomitant chemoradiation (CCRT) is much less clear. We analyzed the prognostic value of primary tumor volume for advanced head and neck squamous cell carcinoma (HNSCC) treated with CCRT. METHODS: Three hundred sixty patients treated with definitive CCRT for advanced HNSCC were selected. The pretreatment MRI or CT scan was used to calculate the primary tumor volume. Median follow-up was 19.8 months. RESULTS: The average primary tumor volume was 37.0 cm(3) (range, 2.1-182.7 cm(3); median, 28.7 cm(3)). Multivariate analysis showed a significant effect of tumor volume on local control. The hazard ratio for a local recurrence increased by 14% per 10 cm(3) volume increase (95% CI, 8% to 21%). There was no significant independent effect of T and N status on local control. CONCLUSION: For advanced HNSCC, tumor volume is more powerful for predicting outcome after CCRT than TNM status.
This item appears in the following Collection(s)
- Academic publications [238441]
- Faculty of Medical Sciences [90373]
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