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| Title: | Early treatment of candidemia in adults: a review |
| Author(s): | Ostrosky-Zeichner, L.
Kullberg, B.J. (074528858)
Bow, E.J.
Hadley, S.
Leon, C.
Nucci, M.
Patterson, T.F. (298205351)
Perfect, J.R. |
| Publication year: | 2011 |
| Document type: | Article / Letter to editor |
| Journal: | Medical Mycology |
| ISSN: | 1369-3786 |
| Volume: | vol. 49 |
| Issue: | iss. 2 |
| Start page: | p. 113 |
| End page: | p. 120 |
| Annotation: | Ostrosky-Zeichner, Luis Kullberg, Bart Jan Bow, Eric J Hadley, Susan Leon, Cristobal Nucci, Marcio Patterson, Thomas F Perfect, John R Research Support, Non-U.S. Gov't Review England Med Mycol. 2011 Feb;49(2):113-20. Epub 2010 Sep 6. |
| Abstract: | Invasive candidiasis is associated with high mortality, particularly in adults. Retrospective studies show that shorter times to treatment are correlated with a lower risk of death. A number of factors can be used to predict which patients would benefit from antifungal prophylaxis or early (pre-emptive or empirical) therapy. Detection of the fungal cell wall component (1-->3)-beta-D-glucan (BDG) shows promise as an early biomarker of invasive fungal infection and may be useful in identifying patients who would benefit from early antifungal treatment. To date, no consistent early treatment strategy has evolved. Proof-of-concept studies are needed to assess the role of pre-emptive and empirical therapy in ICU patients and the relevance of BDG as an early marker of infection. |
| Subject: | N4i 2: Invasive mycoses and compromised host
NCMLS 1A: Infection and autoimmunity |
| Organization: | UMCN Extern
General Internal Medicine |
| Appears in Collections: | Academic bibliography
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Please use this identifier to cite or link to this item:
http://hdl.handle.net/2066/95838
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