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Publication year
2010Source
Nature Genetics, 42, 8, (2010), pp. 665-7ISSN
Annotation
01 augustus 2010
Publication type
Article / Letter to editor
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Organization
Laboratory of Hematology
Haematology
Human Genetics
Tumorimmunology
Journal title
Nature Genetics
Volume
vol. 42
Issue
iss. 8
Page start
p. 665
Page end
p. 7
Subject
NCMLS 2: Immune Regulation; NCMLS 6: Genetics and epigenetic pathways of disease; ONCOL 1: Hereditary cancer and cancer-related syndromes; ONCOL 3: Translational researchAbstract
In myelodysplastic syndromes (MDS), deletions of chromosome 7 or 7q are common and correlate with a poor prognosis. The relevant genes on chromosome 7 are unknown. We report here that EZH2, located at 7q36.1, is frequently targeted in MDS. Analysis of EZH2 deletions, missense and frameshift mutations strongly suggests that EZH2 is a tumor suppressor. As EZH2 functions as a histone methyltransferase, abnormal histone modification may contribute to epigenetic deregulation in MDS.
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