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Publication year
2010Source
European Journal of Cell Biology, 89, 6, (2010), pp. 415-27ISSN
Annotation
01 juni 2010
Publication type
Article / Letter to editor
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Organization
Dermatology
Pathology
Anatomy
Donders Centre for Cognitive Neuroimaging
Former Organization
F.C. Donders Centre for Cognitive Neuroimaging
Journal title
European Journal of Cell Biology
Volume
vol. 89
Issue
iss. 6
Page start
p. 415
Page end
p. 27
Subject
130 000 Cognitive Neurology & Memory; 130 030 The schema-consolidation hypothesis; DCN 2: Functional Neurogenomics; NCMLS 1: Infection and autoimmunity; ONCOL 3: Translational researchAbstract
Adhesion molecules endow tumor cells with the necessary cell-cell contacts and cell-matrix interactions. As such, adhesion molecules are involved in cell signalling, proliferation and tumor growth. Rearrangements in the adhesion repertoire allow tumor cells to migrate, invade and form metastases. Besides these membrane-bound adhesion molecules several soluble adhesion molecules are detected in the supernatant of tumor cell lines and patient body fluids. Truncated soluble adhesion molecules can be generated by several conventional mechanisms, including alternative splicing of mRNA transcripts, chromosomal translocation, and extracellular proteolytic ectodomain shedding. Secretion of vesicles (ectosomes and exosomes) is an alternative mechanism mediating the release of full-length adhesion molecules. Soluble adhesion molecules function as modulators of cell adhesion, induce proteolytic activity and facilitate cell signalling. Additionally, adhesion molecules present on secreted vesicles might be involved in the vesicle-target cell interaction. Based on currently available data, released soluble adhesion molecules contribute to cancer progression and therefore should not be regarded as unrelated and non-functional side products of tumor progression.
This item appears in the following Collection(s)
- Academic publications [238441]
- Donders Centre for Cognitive Neuroimaging [3824]
- Electronic publications [122523]
- Faculty of Medical Sciences [90373]
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