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| Title: | Lower atovaquone/proguanil concentrations in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir. |
| Author(s): | Luin, M. van (314325905)
Ende, M.E. van der
Richter, C.
Visser, M. de
Faraj, D.
Ven, A.J.A.M. van der (142704113)
Gelinck, L.
Kroon, F.
Wit, F.W.
Schaik, R.H. van
Kuks, P.F.M.
Burger, D.M. (119962306) |
| Publication year: | 2010 |
| Document type: | Article / Letter to editor |
| Journal: | AIDS |
| ISSN: | 0269-9370 |
| Volume: | vol. 24 |
| Issue: | iss. 8 |
| Start page: | p. 1223 |
| End page: | p. 1226 |
| Abstract: | HIV-infected travellers frequently use atovaquone/proguanil as malaria prophylaxis. We compared atovaquone/proguanil pharmacokinetics between healthy volunteers and HIV-infected patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir. The geometric mean ratio (95% confidence interval) area under the curve (AUC)0-->t for atovaquone relative to the healthy volunteers was 0.25 (0.16-0.38), 0.26 (0.17-0.41) and 0.54 (0.35-0.83) for patients on efavirenz, lopinavir/ritonavir and atazanavir/ritonavir, respectively. Proguanil plasma concentrations were also significantly lower (38-43%). Physicians should be alert for atovaquone/proguanil prophylaxis failures in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir. |
| Subject: | N4i 2: Invasive mycoses and compromised host
N4i 3: Poverty-related infectious diseases
NCEBP 13: Infectious diseases and international health |
| Subject: | NCEBP 13: Infectious diseases and international health |
| Organization: | Clinical Pharmacy
UMCN Extern
General Internal Medicine |
| Appears in Collections: | Academic bibliography
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Please use this identifier to cite or link to this item:
http://hdl.handle.net/2066/87324
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