One to 2-year surveillance intervals reduce risk of colorectal cancer in families with Lynch syndrome.
Fulltext:
87226.pdf
Embargo:
until further notice
Size:
482.4Kb
Format:
PDF
Description:
Publisher’s version
Publication year
2010Author(s)
Source
Gastroenterology, 138, 7, (2010), pp. 2300-6ISSN
Annotation
01 juni 2010
Publication type
Article / Letter to editor
Display more detailsDisplay less details
Organization
Gastroenterology
Tumorimmunology
Journal title
Gastroenterology
Volume
vol. 138
Issue
iss. 7
Page start
p. 2300
Page end
p. 6
Subject
ONCOL 1: Hereditary cancer and cancer-related syndromesAbstract
BACKGROUND & AIMS: Two percent to 4% of all cases of colorectal cancer (CRC) are associated with Lynch syndrome. Dominant clustering of CRC (non-Lynch syndrome) accounts for 1%-3% of the cases. Because carcinogenesis is accelerated in Lynch syndrome, an intensive colonoscopic surveillance program has been recommended since 1995. The aim of the study was to evaluate the effectiveness of this program. METHODS: The study included 205 Lynch syndrome families with identified mutations in one of the mismatch repair genes (745 mutation carriers). We also analyzed data from non-Lynch syndrome families (46 families, 344 relatives). Patients were observed from January 1, 1995, until January 1, 2009. End points of the study were CRC or date of the last colonoscopy. RESULTS: After a mean follow-up of 7.2 years, 33 patients developed CRC under surveillance. The cumulative risk of CRC was 6% after the 10-year follow-up period. The risk of CRC was higher in carriers older than 40 years and in carriers of MLH1 and MSH2 mutations. After a mean follow-up of 7.0 years, 6 cases of CRC were detected among non-Lynch syndrome families. The risk of CRC was significantly higher among families with Lynch syndrome, compared with those without. CONCLUSIONS: With surveillance intervals of 1-2 years, members of families with Lynch syndrome have a lower risk of developing CRC than with surveillance intervals of 2-3 years. Because of the low risk of CRC in non-Lynch syndrome families, a less intensive surveillance protocol can be recommended.
This item appears in the following Collection(s)
- Academic publications [238433]
- Electronic publications [122508]
- Faculty of Medical Sciences [90366]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.