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| Title: | Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. |
| Author(s): | Thorleifsson, G.
Walters, G.B.
Gudbjartsson, D.F.
Steinthorsdottir, V.
Sulem, P.
Helgadottir, A.
Styrkarsdottir, U.
Gretarsdottir, S.
Thorlacius, S.
Jonsdottir, I.
Jonsdottir, T.
Olafsdottir, E.J.
Olafsdottir, G.H.
Jonsson, T.
Jonsson, F.
Borch-Johnsen, K.
Hansen, T.
Andersen, G.
Jorgensen, T.
Lauritzen, T.
Aben, K.K.H. (217174302)
Verbeek, A.L.M. (070533687)
Roeleveld, N. (069298041)
Kampman, E. (073765430)
Yanek, L.R.
Becker, L.C.
Tryggvadottir, L.
Rafnar, T.
Becker, D.M.
Gulcher, J.
Kiemeney, L.A.L.M. (105132063)
Pedersen, O.
Kong, A.
Thorsteinsdottir, U.
Stefansson, K. |
| Publication year: | 2009 |
| Document type: | Article / Letter to editor |
| Journal: | Nature Genetics |
| ISSN: | 1061-4036 |
| Volume: | vol. 41 |
| Issue: | iss. 1 |
| Start page: | p. 18 |
| End page: | p. 24 |
| Abstract: | Obesity results from the interaction of genetic and environmental factors. To search for sequence variants that affect variation in two common measures of obesity, weight and body mass index (BMI), both of which are highly heritable, we performed a genome-wide association (GWA) study with 305,846 SNPs typed in 25,344 Icelandic, 2,998 Dutch, 1,890 European Americans and 1,160 African American subjects and combined the results with previously published results from the Diabetes Genetics Initiative (DGI) on 3,024 Scandinavians. We selected 43 variants in 19 regions for follow-up in 5,586 Danish individuals and compared the results to a genome-wide study on obesity-related traits from the GIANT consortium. In total, 29 variants, some correlated, in 11 chromosomal regions reached a genome-wide significance threshold of P < 1.6 x 10(-7). This includes previously identified variants close to or in the FTO, MC4R, BDNF and SH2B1 genes, in addition to variants at seven loci not previously connected with obesity. |
| Subject: | NCEBP 1: Molecular epidemiology
ONCOL 5: Aetiology, screening and detection |
| Organization: | Urology
UMCN Extern
Epidemiology, Biostatistics & HTA |
| Appears in Collections: | Academic bibliography
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Please use this identifier to cite or link to this item:
http://hdl.handle.net/2066/80634
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