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| Title: | Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility. |
| Author(s): | Gudmundsson, J.
Sulem, P.
Gudbjartsson, D.F.
Blondal, T.
Gylfason, A.
Agnarsson, B.A.
Benediktsdottir, K.R.
Magnusdottir, D.N.
Orlygsdottir, G.
Jakobsdottir, M.
Stacey, S.N.
Sigurdsson, A.
Wahlfors, T.
Tammela, T.
Breyer, J.P.
McReynolds, K.M.
Bradley, K.M.
Saez, B.
Godino, J.
Navarrete, S.
Fuertes, F.
Murillo, L.
Polo, E.
Aben, K.K.H. (217174302)
Oort, I.M. van (31466811X)
Suarez, B.K.
Helfand, B.T.
Kan, D.
Zanone, C.
Frigge, M.L.
Kristjansson, K.
Gulcher, J.R.
Einarsson, G.V.
Jonsson, E.
Catalona, W.J.
Mayordomo, J.I.
Kiemeney, L.A.L.M. (105132063)
Smith, J.R.
Schleutker, J.
Barkardottir, R.B.
Kong, A.
Thorsteinsdottir, U.
Rafnar, T.
Stefansson, K. |
| Publication year: | 2009 |
| Document type: | Article / Letter to editor |
| Journal: | Nature Genetics |
| ISSN: | 1061-4036 |
| Volume: | vol. 41 |
| Issue: | iss. 10 |
| Start page: | p. 1122 |
| End page: | p. 1126 |
| Abstract: | We report a prostate cancer genome-wide association follow-on study. We discovered four variants associated with susceptibility to prostate cancer in several European populations: rs10934853[A] (OR = 1.12, P = 2.9 x 10(-10)) on 3q21.3; two moderately correlated (r2 = 0.07) variants, rs16902094[G] (OR = 1.21, P = 6.2 x 10(-15)) and rs445114[T] (OR = 1.14, P = 4.7 x 10(-10)), on 8q24.21; and rs8102476[C] (OR = 1.12, P = 1.6 x 10(-11)) on 19q13.2. We also refined a previous association signal on 11q13 with the SNP rs11228565[A] (OR = 1.23, P = 6.7 x 10(-12)). In a multivariate analysis using 22 prostate cancer risk variants typed in the Icelandic population, we estimated that carriers in the top 1.3% of the risk distribution are at a 2.5 times greater risk of developing the disease than members of the general population. |
| Subject: | NCEBP 1: Molecular epidemiology
ONCOL 5: Aetiology, screening and detection |
| Subject: | ONCOL 5: Aetiology, screening and detection |
| Organization: | Urology
UMCN Extern
Epidemiology, Biostatistics & HTA |
| Appears in Collections: | Academic bibliography
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Please use this identifier to cite or link to this item:
http://hdl.handle.net/2066/80628
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