Increased dependence of action selection on recent motor history in Parkinson's disease.
Publication year
2009Source
The Journal of Neuroscience, 29, 19, (2009), pp. 6105-13ISSN
Publication type
Article / Letter to editor
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Organization
Neurology
PI Group Systems Neurology
Psychiatry
Donders Centre for Cognitive Neuroimaging
PI Group Predictive Brain
Former Organization
F.C. Donders Centre for Cognitive Neuroimaging
SW OZ NICI CO
Journal title
The Journal of Neuroscience
Volume
vol. 29
Issue
iss. 19
Page start
p. 6105
Page end
p. 13
Subject
111 000 Intention & Action; 111 008 Body schema deficits in Parkinson's disease; 170 000 Motivational & Cognitive Control; 180 000 Predictive Brain; DCN 1: Perception and Action; DCN 2: Functional NeurogenomicsAbstract
It is well known that the basal ganglia are involved in switching between movement sequences. Here we test the hypothesis that this contribution is an instance of a more general role of the basal ganglia in selecting actions that deviate from the context defined by the recent motor history, even when there is no sequential structure to learn or implement. We investigated the effect of striatal dopamine depletion [in Parkinson's disease (PD)] on the ability to switch between independent action plans. PD patients with markedly lateralized signs performed a hand laterality judgment task that involved action selection of their most and least affected hand. Trials where patients selected the same (repeat) or the alternative (switch) hand as in a previous trial were compared, and this was done separately for the most and least affected hand. Behaviorally, PD patients showed switch-costs that were specific to the most affected hand and that increased with disease severity. Functional magnetic resonance imaging (fMRI) showed that this behavioral effect was related to the state of the frontostriatal system: as disease severity increased, contributions of the basal ganglia to the selection process and their effective connectivity with the medial frontal cortex (MFC) decreased, whereas involvement of the MFC increased. We conclude that the basal ganglia are important for rapidly switching toward novel motor plans even when there is no sequential structure to learn or implement. The enhanced MFC activity may result either from reduced focusing abilities of the basal ganglia or from compensatory processes.
This item appears in the following Collection(s)
- Academic publications [238441]
- Donders Centre for Cognitive Neuroimaging [3824]
- Electronic publications [122544]
- Faculty of Medical Sciences [90373]
- Open Access publications [97535]
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