Mycobacterium noviomagense sp. nov.; clinical relevance evaluated in 17 patients.
Publication year
2009Source
International Journal of Systematic and Evolutionary Microbiology, 59, Pt 4, (2009), pp. 845-9ISSN
Publication type
Article / Letter to editor
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Organization
Pulmonary Diseases
Medical Microbiology
Journal title
International Journal of Systematic and Evolutionary Microbiology
Volume
vol. 59
Issue
iss. Pt 4
Page start
p. 845
Page end
p. 9
Subject
N4i 3: Poverty-related infectious diseasesAbstract
Eighteen isolates of a nonchromogenic, slowly growing, non-tuberculous species of the genus Mycobacterium were cultured from respiratory specimens obtained over the last eight years from 17 patients in the Netherlands. These isolates were grouped because they revealed a unique 16S rRNA gene sequence and were related to Mycobacterium xenopi. None of the 17 patients met the American Thoracic Society diagnostic criteria for non-tuberculous mycobacterial disease, which distinguishes the novel isolates from the related species, M. xenopi. A polyphasic taxonomic approach, including identification by biochemical and phenotypical analysis, hsp65 gene sequencing and PCR restriction enzyme pattern analysis, and sequence analyses of the rpoB gene and 16S-23S internal transcribed spacer supported the separate species status of the novel isolates. The name Mycobacterium noviomagense sp. nov. is proposed for the novel strains. The type strain is NLA000500338(T) (=DSM 45145(T)=CIP 109766(T)). A more distinctive taxonomy of NTM is a prerequisite for the assessment of their clinical relevance.
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- Academic publications [238441]
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- Faculty of Medical Sciences [90373]
- Open Access publications [97509]
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