Distortions in rest-activity rhythm in aging relate to white matter hyperintensities
Publication year
2008Author(s)
Number of pages
7 p.
Source
Neurobiology of Aging, 29, 8, (2008), pp. 1265-1271ISSN
Publication type
Article / Letter to editor
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Organization
SW OZ DCC NRP
Journal title
Neurobiology of Aging
Volume
vol. 29
Issue
iss. 8
Languages used
English (eng)
Page start
p. 1265
Page end
p. 1271
Subject
DI-BCB_DCC_Theme 3: Plasticity and Memory; Neuropsychology and rehabilitation psychology; Neuro- en revalidatiepsychologieAbstract
Distortions in the rest–activity rhythm in aging are commonly observed. Neurodegenerative changes of the suprachiasmatic nucleus have been proposed to underlie this disrupted rhythm. However, based on previous studies, it can be proposed that white matter hyperintensities (WMH) may also play a role in the altered rest–activity rhythm in aging. The present study focused on the rest–activity rhythm, as assessed with actigraphy, and WMH in nondemented aging. With regard to the rest–activity rhythm, the interdaily stability (IS), intradaily variability (IV) and the amplitude (AMP) of the rhythm were of interest. The white matter hyperintensities were examined separately for the periventricular (PVH) and deep white matter (DWMH) regions, while distinguishing between the various locations within these regions (e.g. occipital PVH). The results indicated that frontal DWMH related to both IS and AMP. A reduction in the most active 10-h period mediated the relationship between frontal DWMH and AMP. Possible underlying mechanisms of these associations are discussed.
This item appears in the following Collection(s)
- Academic publications [238441]
- Electronic publications [122536]
- Faculty of Social Sciences [29483]
- Open Access publications [97529]
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