Parent of origin effects in attention/deficit hyperactivity disorder (ADHD): analysis of data from the international multicenter ADHD genetics (IMAGE) program.
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Publication year
2008Author(s)
Source
American Journal of Medical Genetics. Part B : Neuropsychiatric Genetics, 147B, 8, (2008), pp. 1495-500ISSN
Publication type
Article / Letter to editor
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Organization
Human Genetics
Psychiatry
Health Evidence
Former Organization
Epidemiology, Biostatistics & HTA
Journal title
American Journal of Medical Genetics. Part B : Neuropsychiatric Genetics
Volume
vol. 147B
Issue
iss. 8
Page start
p. 1495
Page end
p. 500
Subject
DCN 1: Perception and Action; DCN 2: Functional Neurogenomics; DCN 3: Neuroinformatics; IGMD 3: Genomic disorders and inherited multi-system disorders; NCEBP 1: Molecular epidemiology; NCEBP 9: Mental health; NCMLS 6: Genetics and epigenetic pathways of disease; ONCOL 3: Translational research; UMCN 3.2: Cognitive neurosciences; UMCN 5.1: Genetic defects of metabolism; UMCN 5.2: Endocrinology and reproductionAbstract
There are conflicting reports suggesting that the parental origin of transmitted risk alleles may play a role in the etiology of attention deficit/hyperactivity disorder (ADHD). A recent report by Hawi and colleagues observed a generalized paternal over-transmission of alleles associated with ADHD. This was not replicated in more recent studies. Using data from a large multicenter study we examined the overall and gene-specific parent of origin effect in 554 independent SNPs across 47 genes. Transmission disequilibrium and explicit parent of origin test were performed using PLINK. Overall parent of origin effect was tested by Chi-square. There was no overall parent of origin effect in the IMAGE sample (chi(1)(2) = 1.82, P = 0.117). Five markers in three genes, DDC, TPH2, and SLC6A2 showed nominal association (P < 0.01) with ADHD combined subtype when restricted to maternal or paternal transmission only. Following the initial report by Hawi and co-workers three studies, including this one, found no evidence to support an overall parent of origin effect for markers associated with ADHD. We cannot however, exclude gene-specific parent of origin effect in the etiology ADHD.
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- Academic publications [238441]
- Electronic publications [122508]
- Faculty of Medical Sciences [90373]
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