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| Title: | Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancer. |
| Author(s): | Stacey, S.N.
Manolescu, A.
Sulem, P.
Thorlacius, S.
Gudjonsson, S.A.
Jonsson, G.F.
Jakobsdottir, M.
Bergthorsson, J.T.
Gudmundsson, J.
Aben, K.K.H. (217174302)
Strobbe, L.J.
Swinkels, D.W. (074142771)
Engelenburg, K.C.A. van
Henderson, B.E.
Kolonel, L.N.
Marchand, L. le
Millastre, E.
Andres, R.
Saez, B.
Lambea, J.
Godino, J.
Polo, E.
Tres, A.
Picelli, S.
Rantala, J.
Margolin, S.
Jonsson, T.
Sigurdsson, H.
Jonsdottir, T.
Hrafnkelsson, J.
Johannsson, J.
Sveinsson, T.
Myrdal, G.
Grimsson, H.N.
Sveinsdottir, S.G.
Alexiusdottir, K.
Saemundsdottir, J.
Sigurdsson, A.
Kostic, J.
Gudmundsson, L.
Kristjansson, K.
Masson, G.
Fackenthal, J.D.
Adebamowo, C.
Ogundiran, T.
Olopade, O.I.
Haiman, C.A.
Lindblom, A.
Mayordomo, J.I.
Kiemeney, L.A.L.M. (105132063)
Gulcher, J.R.
Rafnar, T.
Thorsteinsdottir, U.
Johannsson, O.T.
Kong, A.
Stefansson, K. |
| Publication year: | 2008 |
| Document type: | Article / Letter to editor |
| Journal: | Nature Genetics |
| ISSN: | 1061-4036 |
| Volume: | vol. 40 |
| Issue: | iss. 6 |
| Start page: | p. 703 |
| End page: | p. 706 |
| Abstract: | We carried out a genome-wide association study of breast cancer predisposition with replication and refinement studies involving 6,145 cases and 33,016 controls and identified two SNPs (rs4415084 and rs10941679) on 5p12 that confer risk, preferentially for estrogen receptor (ER)-positive tumors (OR = 1.27, P = 2.5 x 10(-12) for rs10941679). The nearest gene, MRPS30, was previously implicated in apoptosis, ER-positive tumors and favorable prognosis. A recently reported signal in FGFR2 was also found to associate specifically with ER-positive breast cancer. |
| Subject: | UMCN 1.2: Molecular diagnosis, prognosis and monitoring |
| Organization: | Urology
Surgery
Clinical Chemistry
Epidemiology, Biostatistics & HTA
UMCN Extern |
| Appears in Collections: | Academic bibliography
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Please use this identifier to cite or link to this item:
http://hdl.handle.net/2066/70749
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