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Publication year
2008Author(s)
Source
Nature Genetics, 40, 3, (2008), pp. 281-3ISSN
Publication type
Article / Letter to editor
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Organization
Experimental Plant Ecology
Clinical Chemistry
Health Evidence
Urology
Former Organization
Epidemiology, Biostatistics & HTA
Journal title
Nature Genetics
Volume
vol. 40
Issue
iss. 3
Page start
p. 281
Page end
p. 3
Subject
IGMD 7: Iron metabolism; N4i 1: Pathogenesis and modulation of inflammation; NCEBP 1: Molecular epidemiology; ONCOL 1: Hereditary cancer and cancer-related syndromes; ONCOL 3: Translational research; ONCOL 5: Aetiology, screening and detection; Plant Ecology; UMCN 1.2: Molecular diagnosis, prognosis and monitoringAbstract
We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease.
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- Electronic publications [122523]
- Faculty of Medical Sciences [90373]
- Faculty of Science [34986]
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