|
|
DSpace at RU >
University Library >
Academic bibliography >
Files in This Item:
| File |
Description |
Size | Format |
|---|
 | publisher's version | 180.52 kB | Adobe PDF | Under Embargo
|
|
| Title: | Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. |
| Author(s): | Gudmundsson, J.
Sulem, P.
Rafnar, T.
Bergthorsson, J.T.
Manolescu, A.
Gudbjartsson, D.
Agnarsson, B.A.
Sigurdsson, A.
Benediktsdottir, K.R.
Blondal, T.
Jakobsdottir, M.
Stacey, S.N.
Kostic, J.
Kristinsson, K.T.
Birgisdottir, B.
Ghosh, S.
Magnusdottir, D.N.
Thorlacius, S.
Thorleifsson, G.
Zheng, S.L.
Sun, J.
Chang, B.L.
Elmore, J.B.
Breyer, J.P.
McReynolds, K.M.
Bradley, K.M.
Yaspan, B.L.
Wiklund, F.
Stattin, P.
Lindstrom, S.
Adami, H.O.
McDonnell, S.K.
Schaid, D.J.
Cunningham, J.M.
Wang, L. (340412437)
Cerhan, J.R.
Sauver, J.L. St
Isaacs, S.D.
Wiley, K.E.
Partin, A.W.
Walsh, P.C.
Polo, S.
Ruiz-Echarri, M.
Navarrete, S.
Fuertes, F.
Saez, B.
Godino, J.
Weijerman, P.C.
Swinkels, D.W. (074142771)
Aben, K.K.H. (217174302)
Witjes, J.A.M.
Suarez, B.K.
Helfand, B.T.
Frigge, M.L.
Kristjansson, K.
Ober, C.
Jonsson, E.
Einarsson, G.V.
Xu, J.
Gronberg, H.
Smith, J.R.
Thibodeau, S.N.
Isaacs, W.B.
Catalona, W.J.
Mayordomo, J.I.
Kiemeney, L.A.L.M. (105132063)
Barkardottir, R.B.
Gulcher, J.R.
Thorsteinsdottir, U.
Kong, A.
Stefansson, K. |
| Publication year: | 2008 |
| Document type: | Article / Letter to editor |
| Journal: | Nature Genetics |
| ISSN: | 1061-4036 |
| Volume: | vol. 40 |
| Issue: | iss. 3 |
| Start page: | p. 281 |
| End page: | p. 283 |
| Abstract: | We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease. |
| Subject: | UMCN 1.2: Molecular diagnosis, prognosis and monitoring |
| Organization: | UMCN Extern
Epidemiology, Biostatistics & HTA
Analytical Chemistry
Urology
Clinical Chemistry
Experimental Plant Ecology |
| Appears in Collections: | Academic bibliography
|
|
Please use this identifier to cite or link to this item:
http://hdl.handle.net/2066/70723
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
|
|
